| 2 | Ensure preparation and capsule endoscopy:A two-center prospective study显示文摘AIM:To compare small bowel(SB) cleanliness and capsule endoscopy(CE) image quality following Ensure,polyethylene glycol(PEG) and standard preparations.METHODS:A preparation protocol for CE that is both efficacious and acceptable to patients remains elusive.Considering the physiological function of the SB as a site for the digestion and absorption of food and not as a stool reservoir,preparation consisting of a liquid,fiber-free formula ingested one day before a CE study might have an advantage over other kinds of preparations.We conducted a prospective,blind-topreparation,two-center study that compared four types of preparations.The participants' demographic and clinical data were collected.Gastric and SB transit times were calculated.The presence of bile in the duodenum was scored by a single,blinded-to-preparation gastroenterologist expert in CE,as was cleanliness within the proximal,middle and distal part of the SB.A four-point scale was used(grade 1 = no bile or residue,grade 4 ≥ 90% of lumen full of bile or residual material).RESULTS:The 198 consecutive patients who were referred to CE studies due to routine medical reasons were divided into four groups.They all observed a 12-h overnight fast before undergoing CE.Throughout the 24 h preceding the fast,control group 1(n = 45 patients) ate light unrestricted meals,control group 2(n = 81) also ate light meals but free of fruits and vegetables,the PEG group(n = 50) ate unrestricted light meals and ingested the PEG preparation,and the Ensure group(n = 22) ingested only the Ensure formula.Preparation with Ensure improved the visualization of duodenal mucosa(a score of 1.76) by decreasing the bile content compared to preparation with PEG(a score of 2.9)(P = 0.053).Overall,as expected,there was less residue and stool in the proximal part of the SB than in the middle and distal parts in all groups.The total score of cleanliness throughout the length of the SB showed some benefit for Ensure(a score of 1.8) over control group 2(a score of 2)(P = 0.06).The cleanliness grading of the proximal and distal parts of the SB was similar in all four groups(P = 0.6 for both).The cleanliness in the middle part of the SB in the PEG(a score of 1.8) and Ensure groups(a score of 1.7) was equally better than that of control group 2(a score of 2.1)(P = 0.057 and P = 0.07,respectively).All 50 PEG patients had diarrhea as an anticipated side effect,compared with only one patient in the Ensure group.CONCLUSION:Preparation with Ensure,a liquid,fiber-free formula has advantages over standard and PEG preparations,with significantly fewer side effects than PEG. | Eva Niv Baruch Ovadia Yulia Ron Ervin Santo Elisabeth Mahajna Zamir Halpern Zvi Fireman | 2013 | World Journal of Gastroenterology2013，19，8： | 1 |
| 3 | Significance of low level infliximab in the absence of anti-infliximab antibodies显示文摘AIM:To evaluate the prevalence of double negative(DN)sera and the mechanisms responsible for DN status.METHODS:Sera of inflammatory bowel disease patients treated with infliximab(IFX)were tested for drug/antibodies to infliximab(ATI)trough levels and the proportion of DN results was compared between a commercially available double antigen ELISA(with labeled IFX as the detection antibody)and an antilambda ELISA(with anti-human lambda chain detection antibody).Repeat testing with lower than customary serum dilution(1:10)was performed.Patients with DN status were matched with IFX+/ATI-controls and were followed-up for subsequent development of nontransient ATI to investigate if DN status precedes ATI.RESULTS:Of 67 sera obtained at time of loss of response,only 6/67(9%)were DN by anti-lambda ELISA compared to 27/67(40%)with double antigen ELISA(P<0.001,Fisher’s Exact test).Of the latter27 sera,22%were also DN by anti-lambda ELISA,whereas 44%were actually IFX positive(IFX+ATI-),30%were ATI positive(IFX-ATI+)and 4%were double positive(IFX+ATI+).Re-testing using a 1:10 dilution converted most DN results into IFX+and/or ATI+status.Patients with DN status had shorter survival free of non-transient ATI compared with matched controls(log rank test,P<0.001).In 9/30(30%)of these patients,non transient ATI occurred before and after the event at which the DN serum was obtained,supporting the view that a DN result may represent aparticular time-point along the two curves of ATI titer rise and infliximab drug level decline.CONCLUSION:DN status may result from false negative detection of IFX or ATI by double antigen ELISA,suggesting a transitional state of low-level immunogenicity,rather than non-immunological clearance. | Bella Ungar Adi Anafy Henit Yanai Yulia Ron Miri Yavzori Orit Picard Ella Fudim Ronen Loebstein Uri Kopylov Yehuda Chowers Iris Dotan Rami Eliakim Shomron Ben-Horin | 2015 | World Journal of Gastroenterology2015，21，6： | 0 |
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