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| 1 | Cytogenetic biodosimetry for radiation accidents in China显示文摘Cytogenetic indicators,especially dicentric chromosomes,have been globally considered the gold standard of biological dose estimation for more than 60 years.The application of these indicators to biological dose estimation in victims of radiation accidents in China has undergone approximately 40 years of development and thus provides more accurate information for the clinical diagnosis and patients’treatment.This paper reviews the application and future development of cytogenetic indicators,including chromosomal aberrations(dicentric chromosomes and chromosomal translocations),cytokinesis-block micronuclei,nucleoplasmic bridges,and premature condensation chromosome ring,as biodosimeters in China. | Lin Han Yu Gao Ping Wang Yumin Lyu | 2020 | Radiation Medicine and Protection2020，1，3： | 4 |
| 2 | Follow-up of two victims of a 60Co-source radiation accident in 1986, Kaifeng, Henan Province, China显示文摘Objective:To explore the late effects of acute radiation exposure through the follow-up of two victims of a 60Cosource radiation accident,who suffered moderate acute radiation sickness of bone marrow type.Methods:On May 26,1986,a power failure occurred suddenly at an irradiation plant in Kaifeng,Henan Province,China,during which two workers at the site,named Liang and Yan,accidentally entered the 60Co-source irradiation cell in service.Long-term medical observations were carried out on them following the accident.Results:The late effects of the accident on Liang and Yan were observed.The main manifestations of Liang were hypomnesia and visual impairment.A typical radiation-induced cataract developed 2 years after exposure.Local cutaneous radiation injury and resultant five operations were performed within a period of five years after exposure.The decrease in the number and low viability of his sperms was found 1 year after exposure.The decrease in his leukocytes and platelets occurred during 1–5 years after exposure.He died from intrahepatic cholangiocarcinoma 21 years after exposure.For Yan,the main manifestations included headache,dizziness,fatigue,insomnia,and susceptibility to cold just after exposure.She had intermittent menolipsis at age 41.The leukocytes was fluctuating in the range of(3.1–3.9)109/L 14–24 years after exposure.A decrease in estradiol(reproductive hormone)and an increase in follicle-stimulating hormone were observed.Thyroid nodules were detected by thyroid ultrasound 21 years after exposure.She died from acute myeloid leukemia(AML)32 years after exposure.Conclusions:Follow-up of victims exposed to a high activity radiation source should focus on the organs sensitive to radiation and on the radiation-induced carcinogenesis. | Fengling Zhao Jifeng Yang Yumin Lyu Quanfu Sun Baohua Fu | 2020 | Radiation Medicine and Protection2020，1，4： | 0 |
| 3 | Alterations of mtDNA copy number and 4977 bp deletion induced by ionizing radiation in human peripheral blood显示文摘Alterations of mitochondria DNA(mtDNA)4977 bp common deletion(CD)and mtDNA copy number induced by ionizing radiation were observed in human different cell lines and total body irradiation patients.However,only few experiments have evaluated the levels of the CD and mtDNA copy number in human peripheral blood exposed to ionizing radiation till now.The aim of this study is to analyze the mtDNA alterations in irradiated human peripheral blood from healthy donors as well as to explore their feasibility as biomarkers for constructing new biodosimeter.Peripheral blood samples were collected from six healthy donors,and exposed to 60Co gamma ray with the doses of 0 Gy,1 Gy,2 Gy,3 Gy,4 Gy and 5 Gy.Levels of the CD and mtDNA copy number in irradiated samples after 2h or 24h incubation were detected using TaqMan real-time PCR,and the CD ratio was calculated.The results showed that the mean of the CD ratio and the CD copy number exhibited a dose-dependent increase 2 h in the dose range from 0–5 Gy,and of the mtDNA copy number significantly increased 24 h in irradiated groups compared with 0 Gy group after irradiation.It indicates that the parameters in human peripheral blood may be considered as molecular biomarkers to applying construction of new biodosimeter. | LIU Yulong WANG Ping HAN Lin ZHAO Fengling GUO Fei WANG Xiai LYU Yumin | 2013 | Nuclear Science and Techniques2013，24，6： | 0 |
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