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| 1 | Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing显示文摘Niacin metal-organic frameworks(MOFs)encapsulated microcapsules with alginate shells and copper-/zinc-niacin framework cores were in situ synthesized by using a microfuidic electrospray approach for wound healing.As the alginate shells were bacteriaresponsively degradable,the niacin MOFs encapsulated microcapsules could intelligently,controllably,and programmably release calcium,copper,and zinc ions,depending on the degree of infections.Te released ions could not only kill microbes by destroying their membrane and inducing the outfow of nutrient substance,but also activate copper/zinc superoxide dismutase(Cu/ZnSOD)to eliminate oxygen free radicals and rescue the cells from oxidative stress injury.Furthermore,the simultaneously released niacin could promote hemangiectasis and absorption of functional metal ions.Tus,the niacin MOFs encapsulated microcapsules were imparted with outstanding antibacterial,antioxidant,and angiogenesis properties.Based on an in vivo study,we have also demonstrated that the chronic wound healing process of an infected full-thickness skin defect model could be signifcantly enhanced by using the niacin MOFs encapsulated microcapsules as therapeutic agent.Terefore,the microfuidic electrospray niacin MOFs encapsulated microcapsules are potential for clinical applications. | Guopu Chen Yunru Yu Xiuwen Wu Gefei Wang Guosheng Gu Feng Wang Jianan Ren Huidan Zhang Yuanjin Zhao | 2019 | Research2019，，1： | 21 |
| 2 | Bioinspired Adhesive and Antibacterial Microneedles for Versatile Transdermal Drug Delivery显示文摘Microneedles have attracted increasing interest among various medical fields due to their painless,noninvasive,and efficient way of drug delivery.However,practical applications of these microneedles in different epidermal locations and environments are still restricted by their low adhesion and poor antimicrobial activity.Here,inspired by the antibacterial strategy of Paenibacillus polymyxa and adhesion mechanisms of mussel byssi and octopus tentacles,we develop hierarchical microneedles with multifunctional adhesive and antibacterial abilities.With polydopamine hydrogel as the microneedle base and a loop of suctioncup-structured concave chambers encircling each microneedle,the generated microneedles can fit the skin well;keep strong adhesion in dry,moist,and wet environments;and realize self-repair after being split into two parts.Besides,as polymyxin is loaded into both the hydrogel tips and the polydopamine base,the microneedles are endowed with excellent ability to resist common bacteria during storage and usage.We have demonstrated that these microneedles not only showed excellent adhesion when applied to knuckles and ideal antibacterial activity but also performed well in drug-sustained release and treatment for the osteoarthritis rat model.These results indicate that bioinspired multifunctional microneedles will break through the limitation of traditional methods and be ideal candidates for versatile transdermal drug delivery systems. | Xiaoxuan Zhang Guopu Chen Yunru Yu Lingyu Sun Yuanjin Zhao | 2020 | Research2020，，1： | 14 |
| 3 | Microfluidic Generation of Microsprings with Ionic Liquid Encapsulation for Flexible Electronics显示文摘Inspired by helical or spiral veins,which endow plants with excellent fexibility and elasticity to withstand storms,we present novel hollow microsprings with ionic liquid encapsulation for fexible and stretchable electronics.Te microsprings were generated by using a coaxial capillary microfuidic device to consecutively spin poly(vinylidene fuoride)(PVDF)presolution and an ionic liquid,which formed laminar fows in the coaxial injection microfuidic channels.Te fast phase inversion of PVDF helps to form the core-shell structure of a microfber and guarantees the in situ encapsulation of ionic liquid.Te hybrid microfber can then spiral and be further solidifed to maintain the helical structure with increasing fow rates of the injection fuids.Because of the feasible and precise control of the injection fuids during the microfuidic spinning,the resultant microsprings have controlled core-shell structures,helical pitches,and corresponding electromechanical properties.By further embedding them into stretchable flms,the simple paradigm of a fexible device shows great conductive performance in tensile tests and even motion cycles,which could be explored as a promising candidate in stretchable sensors,fexible electronics,and electronic skins. | Yunru Yu Jiahui Guo Lingyu Sun Xiaoxuan Zhang Yuanjin Zhao | 2019 | Research2019，，1： | 14 |
| 4 | Morphological Hydrogel Microfibers with MXene Encapsulation for Electronic Skin显示文摘Electronic skins with distinctive features have attracted remarkable attention from researchers because of their promising applications in flexible electronics.Here,we present novel morphologically conductive hydrogel microfibers with MXene encapsulation by using a multi-injection coflow glass capillary microfluidic chip.The coaxial flows in microchannels together with fast gelation between alginate and calcium ions ensure the formation of hollow straight as well as helical microfibers and guarantee the in situ encapsulation of MXene.The resultant hollow straight and helical MXene hydrogel microfibers were with highly controllable morphologies and package features.Benefiting from the easy manipulation of the microfluidics,the structure compositions and the sizes of MXene hydrogel microfibers could be easily tailored by varying different flow rates.It was demonstrated that these morphologically conductive MXene hydrogel microfibers were with outstanding capabilities of sensitive responses to motion and photothermal stimulations,according to their corresponding resistance changes.Thus,we believe that our morphologically conductive MXene hydrogel microfibers with these excellent features will find important applications in smart flexible electronics especially electronic skins. | Jiahui Guo Yunru Yu Dagan Zhang Han Zhang Yuanjin Zhao | 2021 | Research2021，，1： | 12 |
| 5 | Bio-inspired clamping microneedle arrays from flexible ferrofluid-configured moldings显示文摘Microneedle(MN)arrays have demonstrated value for cosmetics,diagnosis,transdermal drug delivery,and other biomedical areas.Much effort has been devoted to developing simple stratagem for creating versatile moldings and generating functional MN arrays.Here,inspired by the serrated microstructure of mantises’forelegs,we present a novel serration-like clamping MN array based on ferrofluidconfigured moldings.Benefiting from the flexibility and versatility of ferrofluids,negative microhole array moldings with various sizes and angles toward the midline could be created easily.The corresponding biocompatible polymer MN arrays with both isotropic and anisotropic structures could then be produced feasibly and cost-effectively by simply replicating these moldings.It was found that the resultant serrated clamping MN arrays had the ability to adhere to skin firmly,enabling them to be used over a relatively long time and while the recipient was moving.This proposed technology performed well in minimally invasive drug administration and sustained glucocorticoids release during treatment for imiquimod-induced psoriasis in mice.These features indicated that such MN arrays could play important roles in wearable transdermal drug delivery systems and in other applications. | Xiaoxuan Zhang Fengyuan Wang Yunru Yu Guopu Chen Luoran Shang Lingyu Sun Yuanjin Zhao | 2019 | Science Bulletin2019，64，15： | 11 |
| 6 | Stomatocyte structural color-barcode micromotors for multiplex assays显示文摘Artificial micromotors have a demonstrated value in the biomedical area.Attempts to develop this technology tend to impart micromotors with novel functions to improve the values.Herein,we present novel structural color-barcode micromotors for the multiplex assays.We found that,by rapidly extracting solvent and assembling monodispersed nanoparticles in droplets,it could form stomatocyte colloidal crystal clusters,which not only showed striking structural colors and characteristic reflection peaks due to their ordered nanoparticles arrangement,but also provided effective cavities for the integration of functional elements.Thus,the micromotors with catalysts or magnetic elements in their cavities,as well as with the corresponding structural color coding,could be achieved by using the platinum and ferric oxide dispersed pre-gel to fill and duplicate the stomatocyte colloidal crystal clusters.We have demonstrated that the self-movement of these structural color-barcode micromotors could efficiently accelerate the mixing speed of the detection sample and greatly increase the probe-target interactions towards faster and more sensitive single or multiplex detection,and the magnetism of these barcode micromotors enables the flexible collection of the micromotors,which could facilitate the detection processes.These features make the stomatocyte structural color-barcode micromotors ideal for biomedical applications. | Lijun Cai Huan Wang Yunru Yu Feika Bian Yu Wang Keqing Shi Fangfu Ye Yuanjin Zhao | 2020 | National Science Review2020，7，3： | 7 |
| 7 | Characterization of Methylocystis strain JTA1 isolated from aged refuse and its tolerance to chloroform显示文摘To accelerate the efficiency of methane biodegradation in landfills,a Gram-negative,rod-shaped,non-motile,non-spore-forming bacterium,JTA1,which can utilize methane as well as acetate,was isolated from the Laogang MSW landfills,Shanghai,China.Strain JTA1 was a member of genus Methylocystis on the basis of 16S rRNA and pmoA gene sequence similarity.The maximum specific cell growth rates(μmax=0.042 hr-1,R2=0.995) was derived through Boltzmann simulation,and the apparent half-saturation constants(Km(app)=7.08mmol/L,R2=0.982) was calculated according to Michaelis-Menton hyperbolic model,indicating that Methylocystis strain JTA1 had higher-affinity potential for methane oxidation than other reported methanotrophs.By way of adding the strain JTA1 culture,the methane consumption of aged refuse reached 115mL,almost two times of control experiment.In addition,high tolerance of Methylocystis strain JTA1 to chloroform could facilitate the methane oxidation of aged refuse bio-covers.At the chloroform concentration of 50mg/L,the methane-oxidation rate of bio-cover reached 0.114mL/(day·g),much higher than the highest rate,0.0135mL/(day·g),of reported bio-covers.In conclusion,strain JTA1 opens up a new possibility for environmental biotechnology,such as soil or landfills bioremediation and wastewater decontamination. | Tiantao Zhao Lijie Zhang Yunru Zhang Zhilin Xing Xuya Peng | 2013 | Journal of Environmental Sciences2013，25，4： | 7 |
| 8 | Fast-Suppressor Screening for New Components in Protein Trafficking,Organelle Biogenesis and Silencing Pathway in Arabidopsis thaliana Using DEX-Inducible FREE1-RNAi Plants显示文摘Membrane trafficking is essential for plant growth and responses to external signals.The plant unique FYVE domain-containing protein FREE1 is a component of the ESCRT complex(endosomal sorting complex required for transport).FREE1 plays multiple roles in regulating protein trafficking and organelle biogenesis including the formation of intraluminal vesicles of multivesicular body(MVB),vacuolar protein transport and vacuole biogenesis,and autophagic degradation.FREE1 knockout plants show defective MVB formation,abnormal vacuolar transport,fragmented vacuoles,accumulated autophagosomes,and seedling lethality.To further uncover the underlying mechanisms of FREE1 function in plants,we performed a forward genetic screen for mutants that suppressed the seedling lethal phenotype of FREE1-RNAi transgenic plants.The obtained mutants are termed as suppressors of free1(sof).To date,229 putative sof mutants have been identified.Barely detecting of FREE1 protein with M3plants further identified 84 FREE1-related suppressors.Also145 mutants showing no reduction of FREE1 protein were termed as RNAi-related mutants.Through next-generation sequencing(NGS)of bulked DNA from F2mapping population of two RNAi-related sof mutants,FREE1-RNAi T-DNA inserted on chromosome 1 was identified and the causal mutation of putative sof mutant is being identified similarly.These FREE1-and RNAi-related sof mutants will be useful tools and resources for illustrating the underlying mechanisms of FREE1 function in intracellular trafficking and organelle biogenesis,as well as for uncovering the new components involved in the regulation of silencing pathways in plants. | Qiong Zhao Caiji Gao PoShing Lee Lin Liu Shaofang Li Tangjin Hu Jinbo Shen Shuying Pan Hao Ye Yunru Chen Wenhan Cao Yong Cui Peng Zeng Sheng Yu Yangbin Gao Liang Chen Beixin Mo Xin Liu Shi Xiao Yunde Zhao Silin Zhong Xuemei Chen Liwen Jiang | 2015 | Journal of Genetics and Genomics2015，42，6： | 4 |
| 9 | Biomimetic intestinal barrier based on microfluidic encapsulated sucralfate microcapsules显示文摘Intestinal barriers play an important role in preventing intestinally derived diseases,and maintaining their function is a promising approach to prevent and treat those diseases.Here,inspired by the protection effect of intestinal barriers in live organisms and the mucosa adhesive property of sucralfate,we present a biomimetic intestinal barrier based on microfluidic encapsulated sucralfate microcapsules.Benefiting from the flexible selectivity and precise control of microfluidic electrospray flows,the generated microcapsules were imparted with stomach-tolerant dietary-fibre shells and controllable released sucralfate cores,both of which could contribute to forming a continuous biomimetic intestinal barrier on the intestine.Through in vitro adhesive study,in vivo computed tomography(CT)imaging and in vivo imaging system(IVIS)methods,we have demonstrated that the microcapsule-derived biomimetic intestinal barrier can effectively block food fermentation in the gut,reduce generation of fat,decrease disease risk indexes,and prevent obesity.These features make the microfluidic encapsulated sucralfate microcapsules and their resultant biomimetic intestinal barrier an approach for treating obesity and other intestinal diseases. | Cheng Zhao Yunru Yu Xiaoxuan Zhang Xiuwen Wu Jianan Ren Yuanjin Zhao | 2019 | Science Bulletin2019，64，19： | 4 |
| 10 | Colorectal Glandular-Neuroendocrine Mixed Tumor: Pathologic Spectrum and Clinical Implications显示文摘 | Yunru Li Annie Yau David Schaeffer Anthony Magliocco Xianyong Gui Stefan Urbanski Ranjit Waghray David Owen Zu-hua Gao | 2011 | The American Journal of Surgical Pathology2011，，3： | 2 |
| 11 | Living Materials for Regenerative Medicine显示文摘Regenerative medicine has been attracting tremendous attention during the past few decades because it is promising in overcoming the limitations of donor shortage and immune complications in direct transplantations.The ongoing progress in this field calls for the rapid growth of living materials,which consist of live biological agents and can be designed together with synthetic materials to meet the application demands of regenerative medicine.In this review,we present a summary of the state-of-the-art progress of living materials that are applied in regenerative medicine.We first introduce the advanced engineering approaches that are employed to prepare living materials containing live cells,typically including genetic engineering,cell coating,microfluidics,and bioprinting,etc.Afterwards,we enumerate different application aspects of living materials in regenerative medicine,including tissue scaffold,cell therapy,tissue models,and so on.Finally,we give a concise conclusion and provide a perspective of this field. | Yunru Yu Qiao Wang Chong Wang Luoran Shang | 2021 | Engineered Regeneration2021，2，1： | 2 |
| 12 | Inhibition of the replication of hepatitis B virus in vitro by emodin显示文摘 | Shuangsuo D Zhengguo Z Yunru C | 2006 | Med Sci Monit2006，12，9： | 1 |
| 13 | Effect of hapten structures on specific and sensitive enzyme-linked immunosorbent assays for N-methylcarbamate insecticide metolcarb显示文摘 | ZHANG Qi WU Yunru WANG Limin | 2008 | Analytica Chimica Acta2008，625，1： | 1 |
| 14 | Predicting the activity of antimicrobial peptides with amino acid topological information显示文摘 | SHU Mao YU Rui ZHANG Yunru | 2013 | Medicinal Chemistry2013，9，1： | 1 |
| 15 | Apoptosis Induced by Caudatin in Human Hepatoma Cell Line SMMC7721 显示文摘 | Peng Yunru Li Youbin Liu Xiaodong | 2008 | Chin J Nat Med2008，6，3： | 1 |
| 16 | Inhibition of the repli- eation of hepatitis B virus in vitro by emodin 显示文摘 | Shuangsuo D Zhengguo Z Yunru C | 2006 | Med Sei Monit2006，12，9： | 1 |
| 17 | In Situ 3D Bioprinting Living Photosynthetic Scaffolds for Autotrophic Wound Healing显示文摘Three-dimensional(3D)bioprinting has been extensively explored for tissue repair and regeneration,while the insufficient nutrient and oxygen availability in the printed constructs,as well as the lack of adaptive dimensions and shapes,compromises the overall therapeutic efficacy and limits their further application.Herein,inspired by the natural symbiotic relationship between salamanders and algae,we present novel living photosynthetic scaffolds by using an in situ microfluidic-assisted 3D bioprinting strategy for adapting irregular-shaped wounds and promoting their healing.As the oxygenic photosynthesis unicellular microalga(Chlorella pyrenoidosa)was incorporated during 3D printing,the generated scaffolds could produce sustainable oxygen under light illumination,which facilitated the cell proliferation,migration,and differentiation even in hypoxic conditions.Thus,when the living microalgae-laden scaffolds were directly printed into diabetic wounds,they could significantly accelerate the chronic wound closure by alleviating local hypoxia,increasing angiogenesis,and promoting extracellular matrix(ECM)synthesis.These results indicate that the in situ bioprinting of living photosynthetic microalgae offers an effective autotrophic biosystem for promoting wound healing,suggesting a promising therapeutic strategy for diverse tissue engineering applications. | Xiaocheng Wang Chaoyu Yang Yunru Yu Yuanjin Zhao | 2022 | Research2022，，3： | 1 |
| 18 | Bio-inspired dual-adhesive particles from microfluidic electrospray for bone regeneration显示文摘Bioadhesive hydrogels have demonstrated great potential in bone regeneration.However,the relatively simple adhesion mechanism and lack of intricate structural design restrict their further applications.Herein,inspired by multiple adhesion mechanisms of pollen particles and marine mussels,we present a novel type of dual-adhesive hydrogel particles fabricated from microfluidic electrospray for bone regeneration.As the particles are rapidly solidified via liquid nitrogen-assisted cryogelation,they exhibit pollen-mimicking hierarchical porous morphology and gain structure-related adhesion.Besides,the particles are further coated by polydopamine(PDA)to achieve molecular-level adhesion especially to physiological wet surfaces of bone issues.Benefiting from such dual-adhesion mechanisms,the particles can strongly adhere to bone tissue defects,and function as porous scaffolds.Moreover,the dual-adhesive particles can serve as effective vehicles to release key growth factors more than two weeks.In vitro experiments showed that the growth factors-loaden particles have excellent biocompatibility and more significantly promote angiogenesis(~2-fold)and osteogenic differentiation(~3-fold)than control.In vivo experiments indicated that the dual-adhesive particles could significantly enhance bone regeneration(~4-fold)than control by coupling osteogenesis and angiogenesis effects.Based on these features,the bio-inspired dual-adhesive particles have great potentials for bone repair and wound healing applications. | Lei Yang Xiaocheng Wang Yunru Yu Luoran Shang Wei Xu Yuanjin Zhao | 2023 | Nano Research2023，16，4： | 1 |
| 19 | The synthesis of ehitin-g-poly(vinyl acetate)copoly-mers with a redox initiator 显示文摘 | Don Trongming Chen Yunru Chu Wenyen | 2002 | Journal of Polymer Research2002，9，4： | 1 |
| 20 | Predicting theactivity of ACE inhibitory peptides with a novel mode of pseudoamino acid composition显示文摘 | SHU Mao CHENG Xiaoming ZHANG Yunru | 2011 | Protein and Peptide Letters2011，18，12： | 1 |
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