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| 1 | Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas显示文摘the bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin.Consequently,preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular,histological and pathophysiological features.Intraepithelial neoplasms are reported in biliary tract,as biliary intraepithelial neoplasm(BilIN),and in pancreas,as pancreatic intraepithelial neoplasm(PanIN).Both can evolve to invasive carcinomas,respectively cholangiocarcinoma(CCA)and pancreatic ductal adenocarcinoma(PDAC).Intraductal papillary neoplasms arise in biliary tract and pancreas.Intraductal papillary neoplasm of the biliary tract(IPNB)share common histologic and phenotypic features such as pancreatobiliary,gastric,intestinal and oncocytic types,and biological behavior with the pancreatic counterpart,the intraductal papillary mucinous neoplasm of the pancreas(IPMN).All these neoplastic lesions exhibit similar immunohistochemical phenotypes,suggesting a common carcinogenic process.Indeed,CCA and PDAC display similar clinic-pathological features as growth pattern,poor response to conventional chemotherapy and radiotherapy and,as a consequence,an unfavorable prognosis.The objective of this review is to discuss similarities and differences between the neoplastic lesions of the pancreas and biliary tract with potential implications on a common origin from similar stem/progenitor cells. | Piera Zaccari Vincenzo Cardinale Carola Severi Federica Pedica Guido Carpino Eugenio Gaudio Claudio Doglioni Maria Chiara Petrone Domenico Alvaro Paolo Giorgio Arcidiacono Gabriele Capurso | 2019 | World Journal of Gastroenterology2019，25，31： | 6 |
| 2 | Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified显示文摘Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (i.e., dysbiosis). The gut microbiota is a complex ecosystem in which microbes coexist and interact with the human host. Indeed, the resident gut bacteria are needed for multiple vital functions, such as nutrient and drug metabolism, the production of energy, defense against pathogens, the modulation of the immune system and support of the integrity of the gut mucosal barrier. The bacteria are collected in communities that vary in density and composition within each segment of the gastrointestinal (GI) tract. Therefore, every change in the gut ecosystem has been connected to an increased susceptibility or exacerbation of various GI disorders. The aim of this review is to summarize the recently available data on PPI-related microbiota alterations in each segment of the GI tract and to analyze the possible involvement of PPIs in the pathogenesis of several specific GI diseases. | Giovanni Bruno Piera Zaccari Giulia Rocco Giulia Scalese Cristina Panetta Barbara Porowska Stefano Pontone Carola Severi | 2019 | World Journal of Gastroenterology2019，25，22： | 4 |
| 3 | Pebble bed thermal mechanical theoretical model:Application at the geometry of test blanket module of ITER-FEAT nuclear fusion reactor显示文摘 | Aquaro D Zaccari N | 2005 | Fusion Engineering and Design2005，75，： | 1 |
| 4 | Effect of halothane and N2O on the oxidative activity of human neutrophils显示文摘 | Welch WD Zaccari J | 1982 | Anesthesiology1982，57，3： | 1 |
| 5 | Analysis and comparison of the luminol-dependent chemiluminescence responses of alveolar macrophages and neutrophils 显示文摘 | Welch W D Graham C W Zaccari J | 1980 | Journal of the Reticuloendothelial Society1980，28，3： | 1 |
| 6 | Immunoregulatory T cells in HBV-induced chronic liver disease as defined by monoclonal antibodies显示文摘 | Barnaba V Zaccari C Levrereo M | 1983 | Clin Immunol Immunopathol1983，26，1： | 1 |
| 7 | Analysis and comparison of the luminol dependent chemiluminescence responses of alveolar macrophages and neutrophils显示文摘 | Welch W D Graham C W Zaccari J | 1980 | J Reticuloendothel Soc1980，28，3： | 1 |
| 8 | Pebble bed thermal mechanical theoretical model: Application at the geometry of test blanket module of ITER-FEAT nuclear fusion reactor 显示文摘 | Aquaro D Zaccari N | 2005 | Fusion Engineering and Design2005，75，： | 1 |
| 9 | Numerical and experimental analysis of the impact of a nuclear spent fuel cask显示文摘 | AQUARO D ZACCARI N DI PRINZIO M | | 0，，： | 1 |
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