|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Erbin inhibits TGF-β1- induced EMT in renal tubular epithelial cells through an ERK-dependent pathway显示文摘 | Zhou Q Zeng R Xu C | 2012 | J Mol Med (Berl)2012，90，5： | 1 |
| 3 | A semi torsional spring analogy model for updating unstructured meshes in 3D moving domains显示文摘 | Zeng D H Ethier C R | 2005 | Finite Elements in Analysis and Design2005，41，1112： | 1 |
| 4 | Synergistic effect of CeO2 modified Pt/C catalysts on the alcohols oxidation显示文摘 | XU C W ZENG R SHEN P K | 2005 | Electrochimica Acta2005，51，： | 1 |
| 5 | A novel density-tunable nanoeomposites of CdTe quantum dots linked to dendrimer-tethered multiwall carbon nanotubes显示文摘 | Zeng Y L Tang C R Wang H W Jiang J H Tian M N Shen G L Yu R Q | 2008 | Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy2008，70，5： | 1 |
| 6 | An advanced SVPWM-based predict -tive current controller for three-phase inverters in distribute1 generation systems显示文摘 | ZENG Q R CHANG L C | 2008 | IEEE Transactions on Industrial Elec - tronics2008，55，3： | 1 |
| 7 | Influence of load frequency and ageing heat treatment on fatigue crack propagation rate of as-extruded AZ61 alloy 显示文摘 | ZENG R C KE W HAN E H | 2009 | International Journal of Fatigue2009，31，： | 1 |
| 8 | A crustal model of the ultrahigh-pressure Dabie Shan orogenic belt, China, derived from deep seismic refraction profiling显示文摘 | Wang C Y Zeng R S Mooney W D Hacker B R | 2000 | J Geophys Res2000，105，10： | 1 |
| 9 | Multiple interval map- ping for quantitative trait loci 显示文摘 | Kao C H Zeng Z B Teasdale R D | 1999 | Genetics1999，152，3： | 1 |
| 10 | A general polyploid model for analyzing gene segregation in qutcrossing tetraploid species显示文摘 | WU R L GALLO M M LITTEU R C ZENG Z B | 2001 | Genetics2001，159，： | 1 |
| 11 | Fractal dimension and lacunarity determined with X-ray computed tomography 显示文摘 | Gantzer C J Payton R L | 1996 | Soil Sci Soc Am J1996，60，： | 1 |
| 12 | Distribution of potentially hazardous trace elements in coals from Shanxi Province,China显示文摘 | Zhang J Y Zheng C G Ren D Y Chou C L Zeng R S Wang Z P Zhao F H Ge Y T | 2004 | Fuel2004，83，： | 1 |
| 13 | Fast ion transport and high capacitance of polystyrene-based hierarchical porous carbon electrode material for supercapacitors显示文摘 | Xu F Cai R J Zeng Q C | 2011 | J Mater Chem2011，21，6： | 1 |
| 14 | Progress and challenge for magnesium alloys as biomaterials 显示文摘 | ZENG R C DIETZEL W WITTE F | 2008 | Adv Eng Mater2008，10，： | 1 |
| 15 | Down-regulation of Gli tran- scription factor leads to the inhibition of migration and in- vasion of ovarian cancer cells via integrin beta4-mediated FAK signaling显示文摘 | Chen Q Xu R Zeng C | 2014 | PLoS One2014，9，88： | 1 |
| 16 | Modeling Topic Propagation over the lnternet 显示文摘 | Zeng J P Zhang S Y Wu C R | 2009 | Mathematical and Computer Modeling of Dynamic Sys- tems2009，15，1： | 1 |
| 17 | Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma显示文摘 | ZENG R C ZHANG W GAO E L | 2014 | Head Neck2014，36，： | 1 |
| 18 | Magnetic properties enhancement of Nd2Fel4B/ct-Fe nanocomposites by Ta substitution 显示文摘 | Zeng X R Shag H C Deng F ct al | 2009 | Physica B: Condensed Matter2009，404，20： | 1 |
| 19 | Potential relationship be- tween Hashimoto's thyroiditis and BRAF mutation status in pap- illary thyroid cancer显示文摘 | Zeng R C Jin L P Chen E D | 2015 | Head & neck2015，，： | 1 |
| 20 | Metabolic model for glycogen accumulating organisms in anaerobic/aerobic activated sludge systems显示文摘 | Zeng R J van Loosdrecht M C M Yuan Z G | 2003 | Biotechnol Bioeng2003，81，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员