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		题名	作者	年代	出处	被引量
	1	Surveying of the deformed terraces and crust shortening rate in the northwestern Tarim Basin显示文摘Relief surveying and chronology study were carried out on the deformed river terraces across the Artushi anticline belt in the northwestern Tarim Basin. The crust shortening rate of this anticline belt since late Pleistocene was calculated to be up to 5-6 mm/a. The total crust shortening rate from the northwestern Tarim Basin to southwestern Tianshan since late Pleistocene was estimated to be over 10 mm/a.	SHEN Jun WANG Yipeng ZHAO Ruibing LI Jun D.Burbank K.Share	2001	Chinese Science Bulletin2001，46，12：	13
	2	C19orf66 Inhibits Japanese Encephalitis Virus Replication by Targeting-1 PRF and the NS3 Protein显示文摘The Japanese encephalitis serogroup of the neurogenic Flavivirus has a specific feature that expresses a non-structural protein NS1'produced through a programmed-1 ribosomal frameshifting(-1 PRF).Herein,C19orf66,a novel member of interferon-stimulated gene(ISG)products,exhibited significant activity of antagonizing Japanese encephalitis virus(JEV)infection.Overexpression of C19orf66 in 293T cells significantly inhibited JEV replication,while knock-down of endogenous C19orf66 in HeLa cells and A549 cells significantly increased virus replication.Notably,C19orf66 had an inhibitory effect on frameshift production of JEV NS1'.The inhibition was more significant when C19orf66 and JEV NS1-NS2A were co-expressed in the 293T cells.Both C19orf66-209 and C19orf66-Zinc^(mut) did not significantly change the NS1'to NS1 ratio and had weaker antiviral effects than C19orf66.Similarly,C19orf66-209 and C19orf66-Zinc^(mut) had no significant effect on the expression of the JEV NS3 protein,whose expression was down-regulated by C19orf66 via the lysosome-dependent pathway.These findings suggest that C19orf66 may possess at least two different mechanisms of antagonizing JEV infection.This study identified C19orf66 as a novel interferon-stimulated gene product that can inhibit JEV replication by targeting-1 PRF and the NS3 protein.The study provides baseline information for the future development of broad-spectrum antiviral agents against JEV.	Du Yu Yundi Zhao Junhui Pan Xingmiao Yang Zhenjie Liang Shengda Xie Ruibing Cao	2021	Virologica Sinica2021，36，6：	0

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