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| 1 | 针对Beta冠状病毒的疫苗设计显示文摘新型冠状病毒是Beta-CoV谱系B的成员,与严重急性呼吸系统综合征冠状病毒(SARS-CoV)基因组序列有75%至80%同源性。疫苗是控制正在流行的COVID-19和既往MERS/SARS等冠状病毒感染的有效措施。刺突受体结合结构域(RBD)是冠状病毒疫苗的理想靶点,但RBD有限的免疫原性限制了针对该结构域的疫苗研发。 | 安华英(编译) Dai L Zheng T Xu K | 2020 | 中华医学杂志2020，100，32： | 27 |
| 2 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer:results from a multicenter study in China显示文摘To evaluate whether prostate volume(PV)would provide additional predictive utility to the prostate health index(phi)for predicting prostate cancer(PCa)or clinically significant prostate cancer,we designed a prospective,observational multicenter study in two prostate biopsy cohorts.Cohort 1 included 595 patients from three medical centers from 2012 to 2013,and Cohort 2 included 1025 patients from four medical centers from 2013 to 2014.Area under the receiver operating characteristic curves(AUC)and logistic regression models were used to evaluate the predictive performance of PV-based derivatives and models.Linear regression analysis showed that both total prostate-specific antigen(tPSA)and free PSA(fPSA)were significantly correlated with PV(all P<0.05).[-2]proPSA(p2PSA)was significantly correlated with PV in Cohort 2(P<0.001)but not in Cohort 1(P=0.309),while no significant association was observed between phi and PV.When combining phi with PV,phi density(PHID)and another phi derivative(PHIV,calculated as phi/PV°5)did not outperform phi for predicting PCa or clinically significant PCa in either Cohort 1 or Cohort 2.Logistic regression analysis also showed that phi and PV were independent predictors for both PCa and clinically significant PCa(all P<0.05);however,PV did not provide additional predictive value to phi when combining these derivatives in a regression model(all models vs phi were not statistically significant,all P>0.05).In conclusion,PV-based derivatives(both PHIV and PHID)and models incorporating PV did not improve the predictive abilities of phi for either PCa or clinically significant PCa. | Da Huang Yi-Shuo Wu Ding-Wei Ye Jun Qi Fang Liu Brian T Helfand Siqun L Zheng Qiang Ding Dan-Feng Xu Rong Na Jian-Feng Xu Ying-Hao Sun | 2020 | Asian Journal of Andrology2020，22，5： | 2 |
| 5 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 6 | Comparison of the survival of human biopsied embryos after eryopreservation with four different methods using non - transferable embryos 显示文摘 | ZHENG W T ZHUANG G L ZHOU C Q | 2005 | Hum Reprod2005，20，6： | 1 |
| 7 | Flavonoids as superoxide scavengers and antioxidants显示文摘 | CHEN Y T ZHENG R L JIA Z J JU Y | 1990 | Free Radical Biology and Medicine1990，9，1： | 1 |
| 8 | Adsorption of single Li and the formation of small Li clusters on graphene for the anode of lithium-ion batteries 显示文摘 | FAN X F ZHENG W T KOU J L | 2013 | ACS Applied Materials And Inter- faces2013，16，5： | 1 |
| 9 | Ground - level ozone in the Pearl River Delta region: Analysis of data from a recently estab- lished regional air quality monitoring network 显示文摘 | Zheng J Y Zhong L J Wang T | 2010 | Atmospheric En- vironment2010，44，6： | 1 |
| 10 | Occurrence and quantification of fungi and detection of mycotoxigenic fungi in drinking water in Xiamen City, China显示文摘 | Al-gabr H M Zheng T L Yu X | 2014 | Science of the Total Environment2014，466，： | 1 |
| 11 | MicroRNA-9 suppresses theproliferation, invasion and metastasis of gastric cancercells through targeting cyclin dl and etsl 显示文摘 | Zheng L’Qi T Yang D | 2013 | PLoS One2013，，55： | 1 |
| 12 | Berry phase in a composite system显示文摘 | Wang L C Zheng T Y | 2004 | Phys Rev Lett2004，92，15： | 1 |
| 13 | A new acoustic model for valveless pulsejets and its application to optimization thrust显示文摘 | Zheng F Ordon R L Scharton T D | 2008 | Journal of Engineering for Gas Turbines and Power2008，130，04： | 1 |
| 14 | Organochlorine micropollutants in the Jiulong River Estuary and Western Xiamen Sea, China 显示文摘 | Maskaoui K Zhou J L Zheng T L | 2005 | Marine Pollution Bulletin2005，51，812： | 1 |
| 15 | Extremely high prevalence of neural tube defects in a 4 - county area in Shanxi Province, China 显示文摘 | Li Z Ren A Zhang L Ye R Li S Zheng J Hong S Wang T Li Z | 2006 | Birth Defects Res A Clin Mol Teratol2006，76，4： | 1 |
| 16 | Vascular imaging adds value in in- vestigation of basal ganglia hemorrhage 显示文摘 | Zheng T Wang S Barras L | 2012 | J Clin Neurosci2012，19，2： | 1 |
| 17 | Segmentation of greenvegetation of crop canopy images based on mean shift andfisher linear discriminant显示文摘 | Zheng L Y Shi D M Zhang J T | 2010 | Pattern Recognition Letters2010，31，： | 1 |
| 18 | Crustal structure across the Yanshan belt at the northern margin of the North China Craton 显示文摘 | Zheng T Y Chen L Zhao L | 2007 | Physics of the Earth and Planetary Interiors2007，161，： | 1 |
| 19 | Remnant-like particles accelerate endothelial progenitor cells senescence and induce cellular dysfunction via an oxidative mechanism显示文摘 | Liu L Wen T Zheng XY | 2009 | J Atherosclerosis2009，202，2： | 1 |
| 20 | Frictional effects of interface bonding energy in blister testing显示文摘 | Zheng M Su Y J Chen L Q Zhang T Y | 1999 | Theoretical and Applied Fracture Mechanics1999，32，： | 1 |
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