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| 1 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 2 | The DTH8-Hd1 Module Mediates Day-Length-Dependent Regulation of Rice Flowering显示文摘Photoperiodic flowering 是最重要的小径之一在米饭(Oryza sativa ) 管理 flowering,在哪个标题日期 1 (Hd1 ) , Arabidopsis CONSTANS 基因的 ortholog,编码一个枢轴的管理者。Hd1 在短天的条件(SD ) 下面支持 flowering,但是镇压在由调整领导日期 3a (Hd3a ) 的表示的长天的条件(LD ) 下面的 flowering,在米饭的 FLOWERING 地点 T (英尺) ortholog。然而, Hd1 怎么响应天长度改变它的规章的活动的分子的机制仍然保持大部分未知。在这研究,我们证明在由 Hd1 的 LD 的 flowering 的压抑依赖于到领导 8 的抄写因素天(DTH8 ) 。DTH8 功能的损失由 Hd1 导致 Hd3a 的激活,导致早 flowering。我们发现 Hd1 直接与 DTH8 交往并且 DTH8-Hd1 建筑群的形成为由在 LD 的 Hd1 的 Hd3a 的 transcriptional 压抑是必要的,含有 Hd1 功能的开关被 DTH8 在 LD 而非在 SD 调停。而且,我们表明 DTH8 与 Hd3a 倡导者联系在 Hd3a 地点调制 H3K27 trimethylation (H3K27me3 ) 的水平。面对 DTH8-Hd1 建筑群, H3K27me3 水平在 Hd3a 被增加,而 DTH8 功能的损失在 Hd3a 导致了减少的 H3K27me3 水平。一起拿,我们的调查结果显示响应天长度, DTH8 在调停起一个关键作用 ? 由通过到在 photoperiodic flowering 的形状 epigenetic 修正的 DTH8-Hd1 模块的 Hd1 的 Hd3a 的 transcriptional 规定。 | Anping Dul Wei Tian Menghao Wei Wei Yan Hang He Da Zhou Xi Huang Shigui Li Xinhao Ouyang | 2017 | Molecular Plant2017，10，7： | 21 |
| 3 | A Review on Graphene-Based Gas/Vapor Sensors with Unique Properties and Potential Applications显示文摘Graphene-based gas/vapor sensors have attracted much attention in recent years due to their variety of structures, unique sensing performances, room-temperature working conditions, and tremendous application prospects, etc.Herein, we summarize recent advantages in graphene preparation, sensor construction, and sensing properties of various graphene-based gas/vapor sensors, such as NH_3, NO_2, H_2, CO, SO_2, H_2S, as well as vapor of volatile organic compounds.The detection mechanisms pertaining to various gases are also discussed. In conclusion part, some existing problems which may hinder the sensor applications are presented. Several possible methods to solve these problems are proposed, for example, conceived solutions, hybrid nanostructures, multiple sensor arrays, and new recognition algorithm. | Tao Wang Da Huang Zhi Yang Shusheng Xu Guili He Xiaolin Li Nantao Hu Guilin Yin Dannong He Liying Zhang | 2016 | Nano-Micro Letters2016，8，2： | 18 |
| 4 | 中西医医学生在叙事医学上的不同视野显示文摘医学作为一种实践科学还是治疗艺术,在现在的医学界有广泛的争论。很多人认为,医学必须要求医生在自身建立叙事情感并且更深入地挖掘病人的内心。文中的调查研究活动以台湾某教学医院的学生为研究对象,开展叙事医学项目的系列活动,采用问卷调查和量表研究,并评估和比较了中西医学生对于叙事医学作为一种学习共情和医学专业精神的方法的不同认知。 | 张千会 周碧雯 Chien - Da Huang Kuo - Chen Liao Fu - Tsai Chuang | 2017 | 中国医学伦理学2017，30，10： | 14 |
| 5 | Experimental study on mechanism and protection of stress ulcer produced by explosive noise显示文摘INTRODUCTIONExplosivenoisemayproduceanenormousadverseeffectonhumanbodyandmind.Ithasbeenknownthatpepticulceroccuredmuchmorefre... | LIU Guo Shi 1, HUANG Yu Xin 1, LI Shuan Wei 2, PAN Bo Rong 3, WANG Xin 1, SUN Da Yong 1 and WANG Qing Li 1 | 1998 | World Journal of Gastroenterology1998，4，6： | 13 |
| 6 | Passive-source ocean bottom seismograph(OBS) array experiment in South China Sea and data quality analyses显示文摘Long-term passive source ocean bottom seismograph(OBS) observatory is challenging due to various technical difficulties. In order to gain experience in this field, and to reveal the lithospheric structure beneath the extinct ridge in the central South China Sea(SCS), we carried out a passive source OBS array experiment, which includes 18 OBSs, in the deep portion of SCS. Here we present the instrumentation, the OBS deployment and recovery of this experiment, and more importantly, the data quality evaluated by a number of approaches. Through processing and inspecting waveforms from global, regional and local earthquakes, we find that most of recovered OBSs have good data quality with discernible main phases. The ambient noise analyses of OBS recordings show that their noise is higher than the global average, and the horizontal component is noisier than the vertical, indicating current impacts on horizontal components are more severe. In the period range of 5–10 s, there is a noise notch for the SCS OBSs, and noise levels of horizontal components are comparable to the vertical. This feature, which is not seen at OBS stations in open ocean, suggests the distant sources for double frequency microseism in this marginal sea are not significant. In addition, we successfully determined the orientations for 7 OBSs by investigating their Rayleigh wave polarizations; and we demonstrated the dispersion feature of Rayleigh waves through the frequency-time analysis. Finally, we summarized lessons learned from this experiment regarding the passive source OBS investigations in SCS. | Chenguang Liu Qingfeng Hua Yanliang Pei Ting Yang Shaohong Xia Mei Xue Ba Manh Le Da Huo Fang Liu Haibo Huang | 2014 | Chinese Science Bulletin2014，59，33： | 11 |
| 7 | Applying the China-PAR Risk Algorithm to Assess 10-year Atherosclerotic Cardiovascular Disease Risk in Populations Receiving Routine Physical Examinations in Eastern China显示文摘Objective To assess the 10-year Atherosclerotic Cardiovascular Disease(ASCVD) risk score among adults in eastern China using the China-PAR equation which formulated primarily for the Chinese population. Methods Data from 72,129 individuals from 35-74 years old who received routine physical examinations in eastern China were analyzed in this study. The 10-year risk scores were calculated using the China-PAR equation. The chi-square test and logistic regression were then performed to evaluate the association between the selected risk factors and overall CVD risk. Results The mean 10-year ASCVD risk scores were 3.82% ± 3.76% in men and 1.30% ± 1.65% in women based on the China-PAR equation. Overall, 20% of men and 3.5% of women were intermediate-risk, and 7.3% of men and 0.3% of women were high-risk. Waist to hip ratio(WHR) [OR = 1.16(CI 95% = 1.06-1.26)], waist to height ratio(WHtR) [OR = 1.16(CI 95% = 1.05-1.28)], non-high-density lipoprotein cholesterol(non-HDL-C) [OR = 1.23(CI 95% = 1.09-1.39)], and total cholesterol(TC)/HDL-C [OR = 1.68(CI 95% = 1.46-1.94)] were more strongly associated with CVD risk than body-mass index(BMI), waist circumference(WC), and TC alone. Conclusion Male-specific prevention and treatment strategies for ASCVD are needed in eastern China. In addition, WHR, WHtR, non-HDL-C, and TC/HDL-C which not included in the the China-PAR equation were also independently associated with 10-year ASCVD risk score categories. | LI Hui Hua HUANG Shan LIU Xing Zhen ZOU Da Jin | 2019 | Biomedical and Environmental Sciences2019，32，2： | 9 |
| 8 | 电针减少大鼠神经元缺血性损伤并增强碱性成纤维生长因子的表达显示文摘采用线栓法MCAO缺血动物模型 ,观察了不同时程电针对局灶性脑缺血大鼠脑梗死、脑肿胀、纹状体 ,皮层神经元数量的影响 ,同时观察了缺血再灌注和电针对碱性成纤维生长因子 (bFGF)免疫活性在纹状体梗死周边区和额顶叶皮质表达的影响。结果表明 :在中动脉阻塞引起的脑缺血后 ,可见受损脑侧有明显的脑梗死 ,脑肿胀 ,神经元丢失 ,并伴随有显著的bFGF免疫活性物质表达增加。在纹状体梗死周边区 ,bFGF免疫活性物质主要位于星型胶质细胞 ,但在紧临梗塞的区域 ,一些神经元中也有bFGF表达。在额顶叶皮质 ,神经元中有非常显著的bFGF免疫活性增加。对于减少脑梗塞和脑肿胀 ,无论是缺血或再灌期间电针均能取得显著性效果 ,并且 ,对于减少脑肿胀 ,再灌期间电针作用可能较强。缺血再灌后 ,在纹状体梗死周边区和额顶叶皮质bFGF免疫活性表达增加。缺血或再灌期间电针均能进一步上调bFGF免疫活性表达。结果提示 ,在纹状体 ,胶质细胞可能通过表达bFGF起到神经保护作用 ;在额顶叶皮质 ,神经元可能主要通过分泌bFGF而实现自我保护。电针的神经保护效应可能部分通过增强内源性bFGF表达实现。 | 欧阳伟 HUANG YL DA CD | 2000 | 山西医科大学学报2000，，z1： | 9 |
| 9 | Electrochemical sensing of DNA immobilization and hybridization based on carbon nanotubes/nano zinc oxide/chitosan composite film显示文摘一个新奇电气化学的脱氧核糖核酸生物传感器基于氧化锌(ZnO ) ,为脱氧核糖核酸固定和提高的杂交察觉的 nanoparticles 和多围的碳 nanotubes (MWNT ) 被介绍。MWNTs/nano ZnO/chitosan 合成电影修改了玻璃化炭黑电极(MWNTs/ZnO/CHIT/GCE ) 被制作,脱氧核糖核酸探针在电极表面上被使不能调动。杂交事件被微分脉搏 voltammetry (DPV ) 作为指示物用亚甲蓝(MB ) 监视。传感器能有效地区别不同脱氧核糖核酸序列与有关在转基因的玉米轻拍基因,与 2.8 ×的检测极限 10 ? 目标顺序的 12 mol/L。 | Wei Zhang Tao Yang Da Ming Huang Kui Jiao | 2008 | Chinese Chemical Letters2008，19，5： | 8 |
| 10 | Effects of yaw-roll coupling ratio on the lateral-directional departure prediction and restraint显示文摘The experimental data obtained from yaw-roll coupled wind tunnel tests are used for lateral-directional departure prediction,by linearizing the_b model to extract nominal dynamic derivatives at each coupling ratio.The prediction results are compared with those of the existing engineering methods which are based on the conventional aerodynamic derivatives.The comparison shows that the yaw-roll coupling ratio has a great influence on the departure susceptibility.The departure resistance will loss in partial region of the coupling ratio when the angle of attack is higher than a critical value.According to the stable and unstable regions of coupling ratio,a two-segment stability augmentation system with two different feedback gain matrices is obtained by pole-placement method.The two-segment stability augmentation system is used in the simulations of straight and level flight,steady turn,spin recovery and Herbst maneuver.The simulation results are also compared with the applications of a fixed-gain stability augmentation system designed by the conventional aerodynamic derivatives.When the yaw-roll coupling effects are fully considered,the two-segment stability augmentation system is more effective for departure restraint and can provide a better flying quality with less control energy. | Lin SHEN Da HUANG Genxing WU | 2019 | Chinese Journal of Aeronautics2019，32，10： | 8 |
| 11 | Effects of yaw-roll coupling ratio on lateraldirectional aerodynamic characteristics显示文摘Experimental investigation of large amplitude yaw-roll coupled oscillations was conducted in a low-speed wind tunnel using an aircraft configuration model. A special test rig was designed and constructed to provide different coupled motions from low to high angles of attack.A parameter ‘‘coupling ratio' was introduced to indicate the extent of yaw-roll coupling. At each pitch angle, seven coupling ratios were designed to study the yaw-roll coupling effects on the lateraldirectional aerodynamic characteristics systematically. At high angles of attack, the damping characteristics of yawing and rolling moments drastically varied with coupling ratios. In the coupled motions with the rotation taking place about the wind axis, the lateral-directional aerodynamic moments exhibited unsteady characteristics and were different from the ‘‘quasi-steady' results of the rotary balance tests. The calculated results of the traditional aerodynamic derivative method were also compared with the experimental data. At low and very high angles of attack, the aerodynamic derivative method was applicative. However, within a wide range of angles of attack, the calculated results of aerodynamic derivative method were inconsistent with the experimental data, due to the drastic changes of damping characteristics of lateral-directional aerodynamic moments with yaw-roll coupling ratios. | Lin SHEN Da HUANG Genxing WU | 2019 | Chinese Journal of Aeronautics2019，32，2： | 7 |
| 12 | Determination of Partial Molar Volumes of EPA and DHA Ethyl Esters in Supercritical Carbon Dioxide显示文摘The use of supercritical-fluid chromatography for determining partial molar volumes of ethyl esters of cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and cis -4,7,10,13,16,19- docosa-hexaenoic acid (DHA) in supercritical carbon dioxide is presented and discussed. Partial molar volumes of EPA and DHA esters are obtained from the variation of the retention properties with the density of mobile phase at 313.15 K, 323.15 K, 333.15 K and in the pressure range from 9 MPa to 21 MPa. | Mei HUANG, Xian Da WANG, Ren Tian XIONG, Ping Dong WU, Qi Long REN* National Laboratory of Secondary Resources Chemical Engineering, Zhejiang University, Hangzhou 310027 | 2002 | Chinese Chemical Letters2002，13，1： | 6 |
| 13 | Reactivation of a huge ancient landslide by surface water infiltration显示文摘An ancient landslide, situated in Deqin County, Yunnan Province, China, was used to investigate the reactivation by water infiltration. This study considers the infiltration process and landslide stability using finite-element method(FEM)-based models. The results show that the reactivation of old landslide deposit was triggered by the long-term leakage of diversion ditch before October 2012, and the reactivation was triggered again by the intense rainfall on 7-9 October 2012. The old cracks, which formed in the earlier reactivation of landslide, played a key role for the rainfall infiltration. They offered a preferential path for much more rainfall to infiltrate fast into deep soil, and caused wetting front to move down faster in landslide. The old slip zone with lower permeability was another important factor to cause the infiltrated water to accumulate and form a high pore water pressure above slip zone. Then the high pore water pressure decreased the shear strength of slip zone and triggered the reactivation of the old landslide deposit again. | TU Guo-xiang HUANG Da DENG Hui | 2019 | Journal of Mountain Science2019，16，4： | 6 |
| 14 | Inflammation inhibitory effects of sirolimus and paclitaxel-eluting stents on interleukin-1β-induced coronary artery in-stent restenosis in pigs显示文摘背景冠的动脉 in-stent 狭窄(ISR ) 和迟了的 stent 血栓作为 stenting 的重要复杂并发症留下。对 sirolimus 和 paclitaxel-eluting stents 的发炎反应在 interleukin (IL ) 劝诱的一个猪狭窄模特儿被调查 -1.Methods 微型猪(n=12;2-3 月旧、称的 25-30 kg ) 受到 thoracotomy。中间的左前面的下降冠的动脉和左降声调符号的片断(10 公里) 冠的动脉被暴露并且无菌地包了,一个棉花网孔与 IL-1 (5 g ) 浸泡了。在 2 个星期以后,动物是 anesthetized,量的冠的动脉 X 线摄影法(QCA ) 被执行。狭窄地点为 stent 插入被使随机化进三个组:一个 sirolimus-eluting stent (SES ) 组(FirebirdTM, n=7 ) ,一个 paclitaxel-eluting stent (足) 组(TAXUSTM, n=9 ) ,并且一个赤裸金属的 stent (BMS ) 组(YINYITM, Dalian Yinyi Biomaterials 发展有限公司,中国, n=8 ) 。三不同 stents 随机被植入进狭窄片断。单核白血球 chemoattractant protein-1 (MCP-1 ) 的表示,肿瘤坏死 factor-alpha (TNF-) , P-selectin 和脉管的房间粘附 molecule-1 (VCAM-1 ) 被 .Results QCA 显示出的反向的联合抄写的聚合酶链反应(RT-PCR ) 决定在 IL-1 的严重狭窄对待片断。SES 和足组晚显示出更低的 1 月的 angiographic 在 stent 和损害以内的腔损失(LLL ) 与由后续 QCA 的 BMS (P 0.05 ) 相比。SES 在由后续 QCA 在猪减少 1 月的发炎损害比足的显示出更低的 LLL ((0. | ZHOU Xu-chen HUANG Rong-chong ZHANG Bo YIN Da LIANG Bin WANG Shao-peng GUAN Qi-gang SUN Xi-zhuo MIAO Zhi-lin HE Xue-zhi HAN Feng-tong CHENG Ying ZHANG Li ZENG Ding-yin | 2010 | Chinese Medical Journal2010，，17： | 6 |
| 15 | NECK LEAF 1, a GATA type transcription factor, modulates organogenesis by regulating the expression of multiple regulatory genes during reproductive development in rice显示文摘在 monocot 米饭种类 Oryza sativa L. ,最惹人注目的词法过程之一在繁殖开发期间是有上面的 internodes (合众国际社) 的顺序的延伸的圆锥花序开发的同时发生。阐明内在的分子的机制,我们克隆米饭基因颈叶 1 (NL1 ) ,什么时候变异,它在 flowering 时间,有簇叶丛生的苞的更小的圆锥花序和反常合众国际社延伸模式导致延期。NL1 基因与一个单个锌手指领域,和它的抄本编码一个 GATA 类型抄写因素在苞 primordia 主要被检测,它通常在野类型的植物堕落。在转基因的植物的 NL1 的 Overexpression 经常产生严重生长延迟,不太植物的 phytomers 和更小的叶子,建议 NL1 起在器官区别的一个重要作用。PLASTOCHRON1 (PLA1 ) 的新奇变异的等位基因,知道在调整叶开始起一个关键作用的基因,在这研究被识别。基因分析表明了在 nl1 和 pla1 之间的一个相互作用,与 PLA1 在上游的代理的 NL1。表示水平和 PLA1 的空间模式被发现在 nl1 被改变变异。而且, flowering, Hd3a 和 OsMADS1 的二个管理者的表示,也在 nl1 异种被影响。根据这些调查结果,我们建议 NL1 是通过在米饭在繁殖开发期间调整 PLA1 和另外的规章的基因的表示调制并且协调 organogenesis 的一个内在的因素。 | Liping Wang Hengfu Yin Qian Qian Jun Yang Chaofeng Huang Xiaohe Hu Da Luo | 2009 | Cell Research2009，19，5： | 6 |
| 16 | Regulatory effects of electro-acupuncture at Zusanfi on ir-SP content in rat pituitary gland and peripheral blood and their immunity显示文摘INTRODUCTIONIt has been reported in many studies that electro-acupuncture(EA)can positively regulate erythrocyticimmunity and T-lymphocytic subgroups.Nevertheless,its mechanism remains to be explored.In thepresent study,a multi-group,multi-stepped and multi-indexed observation was conducted on the effects of EA | Wei Gao Yu Xin Huang Hong Chen Da Yong Song Qin Li Wang Department of Gastroenterology Medical Affair Office,Tangdu Hospital,4th Military Medical University,Xi’an 710038,Shanxi Province,China Department of Gastroenterology,Chinese PLA General Hospital of Guangzhou Command Area,Guangzhou 510210,Guangdong Province,China | 2000 | World Journal of Gastroenterology2000，6，4： | 5 |
| 17 | Cyclic load testing of pre-stressed rock anchors for slope stabilization显示文摘The objective of this research was to assess the characteristics of seismic induced damage and the deformation patterns of pre-stressed cement-grouted cables that are used for rock slope stabilization projects subjected to quasi-static cyclic loading.The experimental configuration includes the installation of 15 pre-stressed cables in a slope model made of concrete blocks(theoretically rigid rock mass) on top of a pre-existing sliding surface.The study showed that:(i) The pre-stressed cables exhibited great seismic performance.Rapid displacement of the model blocks was observed after the complete loss of the initial pre-stress load under continued applied cyclic loads and exceedance of the state of equilibrium,which implies the higher the initial pre-stress load,the better the seismic performance of the rock anchor;(ii) The failure of the pre-stressed cables was due to fracture at the connection of the tendons and cable heads under cyclic loading.The sequence of failure had a distinct pattern.Failure was first observed at the upper row of cables,which experienced the most severe damage,including the ejection of cable heads.No evidence of de-bonding was observed during the cyclic loading;(iii) The stress distribution of the bond length for pre-stressed cables was highly non-uniform.High stress concentrations were observed at both the fixed end and the free end of the bond length both before and immediately after the state of equilibrium is exceeded.The results obtained can be used to evaluate the overall performance of pre-stressed rock anchors subject to seismic loading and their potential as rockfall prevention and stabilization measures. | ZHENG Da LIU Fang-zhou JU Neng-pan FROST J.David HUANG Run-qiu | 2016 | Journal of Mountain Science2016，13，1： | 5 |
| 18 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 19 | A spirocyclic oxindole analogue:Synthesis and antitumor activities显示文摘spirocyclic oxindole 类似物 spiro 的新合成[piperidine-4,3-pyrrolo [2,3-b ] 吡啶]-2(1H)-one 1 被描述。关键步由羧基的酰胺和芳基氯化物的 intramolecular BuchwaldHartwig amidation 包含 arylacetonitrile 的 dialkylation 和 azaoxindole 戒指的环合。一个小图书馆被 1 的减少的胺化作用与各种各样的醛获得并且对人的肺癌症房间 A549,人的肝癌症房间 BEL7402,和人的结肠癌房间 HCT-8 被屏蔽。结果显示出 2 有的图书馆混合物的那个大多数一些禁止的活动。2-(Trifluoromethoxy ) benzylic 代替了 spirocyclic azaoxindole 2e 对人的肺癌症房间 A-549 作为一个 nanomolar 禁止者被识别(IC50 = 50 nmol/L ) 。 | Hui Hong Long Jiang Huang Da Wei Teng | 2011 | Chinese Chemical Letters2011，22，9： | 5 |
| 20 | An AGAMOUS-like factor is associated with the origin of two domesticated varieties in Cymbidium sinense (Orchidaceae)显示文摘Cymbidium has been artificially domesticated for centuries in Asia,which produced numerous cultivated varieties.Flowers with stamenoid tepals or those with multiple tepals have been found in different species of Cymbidium;however,the molecular basis controlling the formation of these phenotypes is still largely unknown.Previous work demonstrated that AGAMOUS/AG lineage MADS genes function in floral meristem determinacy as well as in reproductive organs development in both dicots and monocots,indicating a possible relationship with the origin of two flower varieties in Cymbidium.Here,we characterized and analyzed two AG lineage paralogues,CsAG1 and CsAG2,from Cymbidium sinense,both of which were highly expressed in the gynostemium column of a standard C.sinense.Interestingly,we detected ectopic expression of CsAG1 rather than CsAG2 in all floral organs of a stamenoid-tepal variety and significant down-regulation of CsAG1 in a variety with multiple tepals.Over-expression of CsAG1 in wild type Arabidopsis resulted in petal-to-stamen homeotic conversion,suggesting a conserved C-function of CsAG1 in the development of Cymbidium flower.Altogether,our results supported a hypothesis that disruption of a single AG-like factor would be associated with the formation of two domesticated varieties in C.sinense. | Shihao Su Xiaoyu Shao Changfa Zhu Jiayin Xu Yuhuan Tang Da Luo Xia Huang | 2018 | Horticulture Research2018，5，1： | 4 |
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