|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of autophagy in cardiac hypertrophy显示文摘Autophagy 从更低的优核质在自然被保存到哺乳动物并且是一重要自我吃, degradative processthat 贡献过剩材料的消除。心脏的肥大被过量 proteinsynthesis,增加的 cardiomyocyte 尺寸,和变厚的室的墙首先描绘并且是支持 arrhythmiaand 心失败的一个主要风险因素。在最近的年里, cardiomyocyte autophagy 被认为在控制 hypertrophicresponse 起一个作用。然而,在心脏的肥大的 cardiomyocyte autophagy 的有益或加重的角色仍然是在心脏的肥大的 cardiomyocyte autophagy 的准确机制进一步要求的 controversial.The 学习。在这评论,我们在心脏的肥大与 autophagy 联系的 summarizethe 争吵并且在心脏的肥大的 thedevelopment 提供卓见进 autophagy 的角色。我们断定未来研究应该强调在 autophagy andthe 之间的关系心脏的肥大的不同阶段,以及 autophagic 流动和选择 autophagy。Autophagy 将是为心脏的肥大的一个 potentialtherapeutic 目标。 | Lanfang Li Jin Xu Lu He Lijun Peng Qiaoqing Zhong Linxi Chen Zhisheng Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 30 |
| 2 | Status quo of soil petroleum contamination and evolution of bioremediation显示文摘Along with the rapid development of oil industries internationally,petroleum prospecting and exploitation activities are growing intensively.Especially in China,with the fastest economic growth in the world and shortage of petroleum resources,we are leading the practices of petroleum deep exploitation.Obviously,the risk of damage to the natural environment from these activities is high.Oil contamination in soils and groundwater is becoming a big issue along with pesticide pollution,which makes organic pollution prevention and control (OPPC) much more complex.In this paper,based on recent research on oil-contaminated soil at home and abroad,we make comments on the remediation technologies for polluted soil,emphasizing bioremediation techniques and degradation mechanisms in order to push forward research into bound organic pollution prevention and control (OPPC),especially in China. | Du Weidong Wan Yunyang Zhong Ningning Fei Jiajia ZhangZhihuan Chen Lijun Hao Jiming | 2011 | Petroleum Science2011，8，4： | 19 |
| 3 | Experimental and numerical studies on the sluggish diffusion in face centered cubic Co-Cr-Cu-Fe-Ni high-entropy alloys显示文摘On purpose of studying the sluggish diffusion of high-entropy alloys, three different face centered cubic Co-Cr-Cu-Fe-Ni high-entropy alloys were prepared, and assembled into three groups of sandwichtype diffusion multiple annealed at 1273, 1323, and 1373 K respectively. By means of the electron probe microanalyzer technique and recently developed numerical inverse method, the compositiondependent interdiffusivities at different temperatures were effectively evaluated by minimizing the residual between the model-predicted compositions/interdiffusion fluxes and the respectively experimental ones. After that, the tracer diffusivities were predicted based on the assessed mobility parameters and thermodynamic descriptions with the simplified ideal solution model. The comprehensive comparison between the interdiffusivities/tracer diffusivities in the Co-Cr-Cu-Fe-Ni high-entropy alloys and those in sub-binary, ternary, quaternary and other quinary alloys indicates that the sluggish diffusion exists in interdiffusion instead of tracer diffusion for the present Co-Cr-Cu-Fe-Ni high-entropy alloys. | Rui Wang Weimin Chen Jing Zhong Lijun Zhang | 2018 | Journal of Materials Science & Technology2018，34，10： | 6 |
| 4 | Definition and sturcture characteristics of pores in mylonitized organic-rich shales显示文摘Gas shales with a high gas content were drilled in the Lower Cambrian Lujiaping Formation in the northeastern Sichuan Basin,close to the Chengkou Fault in the Dabashan arc-like thrust fold belt.The equivalent vitrinite reflectance values of organic matters are over 4.0%Ro.The pore structures of the shales were investigated based on microscopy,field emission scanning electron microscopy(FESEM)observations,and low temperature N2 adsorption analysis.The study suggests that cleavages,comprising clay minerals mixed up with organic matter and other insoluble residues,were developed in the rock layers.The clay minerals are directionally arranged,displaying a mylonitized texture.Abundant nanometer-size organic matter and clay mineral particles are well mixed in the cleavage domains,which developed the mylonitized pore system that consists of nanometer-size intergranular pore spaces,aggregate pore spaces in clay mineral flakes and pore network.This mylonitized pore system has high specific surface area,high methane adsorption capacity,and high capillary pressure,which collectively contributes to the preservation of shale gas in such a complex tectonic area.The discovery of the mylonitized pore structure in organic-rich shales may reveal a new mechanism of shale gas enrichment in complex tectonic areas with over-mature organic matter in the northeastern part of Sichuan Basin. | MA Yong ZHONG NingNing HAN Hui LI DaHua ZHANG Yi CHENG LiJun | 2014 | Science China Earth Sciences2014，57，12： | 5 |
| 5 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 6 | 6.5 wt%Si high silicon steel sheets prepared by composite electrodeposition in magnetic field显示文摘A new preparation method of near-net-shape 6.5 wt% Si high silicon steel sheets was proposed by combining composite electrodeposition(CED) and diffusion annealing under magnetic field. The obtained sheets were characterized by scanning electron microscopy, energy dispersive spectrometry, analytical balance and a silicon steel material measurement system. The results show that the surface morphology,the elemental distribution, the cathode current efficiency and the silicon content of coatings were obviously influenced by the micro and macro magnetohydrodynamics(MHD) flows under magnetic field.With the effect of magnetic field, the silicon particles content of coatings showed an increasing trend and the diffusion process showed that an approximately uniform 6.5 wt% silicon steel sheet has been successfully obtained. The magnetism measurement showed that the high silicon steel sheet has the lower iron loss, and the iron loss further decreased under magnetic field. The new method proposed in this article,which is more environmentally friendly and low energy consumption, is feasible to prepare high silicon steel sheets. | Minghu Peng Yunbo Zhong Tianxiang Zheng Lijun Fan Junfeng Zhou Weili Ren Zhongming Ren | 2018 | Journal of Materials Science & Technology2018，34，12： | 3 |
| 7 | Synchronous breast cancer and breast lymphoma:two case reports and literature review显示文摘Synchronous breast cancer and breast lymphoma are rare. It is of high rate of misdiagnosis in clinical practice. Here we present two cases with this presentation. They are both middle-aged women, with stage I invasive ductal carcinoma of the breast. One patient happened to have primary breast lymphoma(PBL); the other was secondary breast lymphoma(SBL). Their pathology and immunohistochemistry(IHC) findings supported the diagnosis of multiple primary carcinoma. Both patients had a surgery. Then they both received CHOP regime chemotherapy and subsequent endocrine therapy. | Jia Zhong Lijun Di Wen Zheng | 2014 | Chinese Journal of Cancer Research2014，26，3： | 3 |
| 8 | Biomolecule-assisted Solvothermal Synthesis of Bismuth Sulfide Nanorods显示文摘A simple biomolecule-assisted synthetic route has been successfully developed to prepare bismuth sulfide(Bi 2 S 3 ) nanorods under solvothermal conditions.In the synthetic system,pentahydrate bismuth nitrate was employed to supply Bi source and L-cystine was used as sulfide source and complexing agent.The morphology,structure,and phase composition of the as-prepared Bi 2 S 3 products were characterized by X-ray diffraction(XRD),energy dispersion spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS),field-emission scanning electron microscopy(FESEM),transmission electron microscopy(TEM),selected area electron diffraction(SAED),and high-resolution transmission electron microscopy(HRTEM).The experimental results show that the nanorods have uniform diameter of 100-200 nm and length of 2-4 μm.The possible formation mechanism for the bismuth sulfide nanorods was discussed. | Jiasong Zhong Weidong Xian Lijun Liu Xinyu Yan Wen Cai Jingfeng Zhang Xiaojuan Liang | 2010 | Journal of Materials Science & Technology2010，26，5： | 3 |
| 9 | Vanadyl ions binding to GroEL (HSP60) and inducing its depolymerization显示文摘Several vanadium compounds have been known for the hypoglycemic and anticancer effects. However, the mechanisms of the pharmacological and toxicological effects were not clear. In this work, we in- vestigated the potential targets of vanadium in mitochondria. Vanadyl ions were found to bind to mi- tochondria from rat liver with a stoichiometry of 244±58 nmol/mg protein and an apparent dissocia- tion constant (Kd) of (2.0±0.8)×10·16 mol/L. Using size exclusion chromatography, a vanadium-binding protein was isolated and identified to be the 60-kDa heat shock protein (HSP60) by mass spectrometry analysis and immunoassays. Additionally, binding of vanadyl ions was found to result in depolymeri- zation of homo-oligomeric HSP60 (GroEL). HSP60 is an indispensable molecular chaperone and in- volved in many kinds of pathogenesis of inflammatory and autoimmune diseases, e.g. type 1 diabetes. Our results suggested that HSP60 could be a novel important target involved in the biological and/or toxicological effects of vanadium compounds. | LEI WanHua LIU HuiXue ZHONG LiJun YANG XiaoDa WANG Kui | 2007 | Chinese Science Bulletin2007，52，20： | 2 |
| 10 | Epstein-Barr 病毒的从潜伏的膜蛋白质 2 的重叠 epitopes (LMP2 ) 的空想地熔化的抗原富人作为一支潜在的疫苗和诊断代理人显示文摘Epstein-Barr 病毒(EBV ) 在全世界是流行的并且在人与几恶意的疾病被联系。(LMP2 ) 潜伏的膜蛋白质 2 在联系 EBV 的 tumors; 的致病 EBV 起一个关键作用;因此, LMP2 被认为是一个潜在的 immunodiagnostic 和 immunotherapeutic 目标。multi-epitope-based 抗原是为治疗学的疫苗的一种有希望的选择并且如此的恶意诊断。在这研究,我们系统地屏蔽了细胞毒素的 T 淋巴细胞(CTL ) ,助手 T 房间(Th ) 和在用生物信息学的 EBV-LMP2 以内的 B 房间 epitopes。基于屏幕,在 T 房间和 B 房间的重叠 epitopes 的二个肽富人被选择构造为叫作 EBV-LMP2m 的妄想的 multi-epitope 蛋白质包含顺序的 plasmid,它 LMP2aa195~232 和 LMP2aa419~436 是镇静的。EBV-LMP2m 蛋白质在 E 被表示。在原核生物的 codon 优化以后的 coli BL21 (DE3 ) 。在 BALB/c 老鼠的净化的妄想的抗原的接种在阴道粘液而且特定的 CTL 回答在浆液和能分泌的 IgA 导致了特定的 IgG 的高水平不仅。由把净化的 EBV-LMP2m 用作抗原,在 202 鼻咽的癌(NPC ) 的浆液标本的特定的 IgG 的存在病人们有效地与 52.84 % 被检测;敏感和 95.40 %特性,基于 VCA-IgA 在传统的察觉方法上代表改进, 60.53 %敏感和 76.86 %特性) 。上述结果显示 EBV-LMP2m 可以为 NPC 病人为联系 EBV 的肿瘤而且一个诊断代理人被用作潜在的目标抗原不仅。 | Xiaoyun Lin Shao Chen Xiangyang Xue Lijun Lu Shanli Zhu Wenshu Li Xiangmin Chen Xiaozhi Zhong Pengfei Jiang Torsoo Sophia Sename Yi Zheng Lifang Zhang | 2016 | Cellular & Molecular Immunology2016，13，4： | 2 |
| 11 | H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair显示文摘Chondrocyte differentiation is a critical process for endochondral ossification,which is responsible for long bone development and fracture repair.Considerable progress has been made in understanding the transcriptional control of chondrocyte differentiation;however,epigenetic regulation of chondrocyte differentiation remains to be further studied.NSD1 is a H3K36(histone H3 at lysine 36)methyltransferase.Here,we showed that mice with Nsd1 deficiency in Prx1+mesenchymal progenitors but not in Col2+chondrocytes showed impaired skeletal growth and fracture healing accompanied by decreased chondrogenic differentiation.Via combined RNA sequencing(RNA-seq)and chromatin immunoprecipitation sequencing(ChIP-seq)analysis,we identified sex determining region Y box 9(Sox9),the key transcription factor of chondrogenic differentiation,as a functional target gene of NSD1.Mechanistically,NSD1 regulates Sox9 expression by modulating H3K36me1 and H3K36me2 levels in the Sox9 promoter region,constituting a novel epigenetic regulatory mechanism of chondrogenesis.Moreover,we found that NSD1 can directly activate the expression of hypoxia-inducible factor 1α(HIF1α),which plays a vital role in chondrogenic differentiation through its regulation of Sox9 expression.Collectively,the results of our study reveal crucial roles of NSD1 in regulating chondrogenic differentiation,skeletal growth,and fracture repair and expand our understanding of the function of epigenetic regulation in chondrogenesis and skeletal biology. | Rui Shao Zhong Zhang Zhan Xu Huiling Ouyang Lijun Wang Hongwei Ouyang Matthew Greenblatt Xi Chen Weiguo Zou | 2021 | Bone Research2021，9，3： | 2 |
| 12 | Structural Characteristics of Vessels in Three Families of Cycadopsida显示文摘 | Yuyuan Huang Wenbo Liao Xiaoqing Zhong Lijun Wei Hongda Zhang Yuanfeng Lu | 2010 | Journal of Life Sciences2010，4，7： | 2 |
| 13 | Influen- cing factors on the formation of the low minority carrier life- time zone at the bottom of seed-assisted cast ingots 显示文摘 | Zhong Genxiang Huang Xinming Liu Lijun | 2014 | J Cryst Growth2014，402，： | 1 |
| 14 | Acupuncture modulates temporal neural responses in wide brain networks:evidence from fMRI study 显示文摘 | Lijun Bai Jie Tian Chonggtmng Zhong etc | 2010 | Molecular Pain2010，6，： | 1 |
| 15 | Grindability evaluation of advanced ceramics 显示文摘 | Yu Aibing Zhong Lijun Tian Xinli | 2004 | Materials Science Forum2004，，： | 1 |
| 16 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 17 | BDNF induces late-phase LTP of C-fiber evoked field potentials in rat spinal dorsal horn显示文摘 | Zhou Lijun Zhong Yi Ren Wenjie | 2008 | Exp Neurol2008，212，2： | 1 |
| 18 | StructureandmagneticpropertiesofFeSiAl-basedsoftmagneticcompositewithAlNandAl2O3insulatinglayerpreparedbyselectivenitridationandoxidation显示文摘 | Zhong Xiaoxi Liu Ying LiJun etal | 2012 | JournalofMagnetismand Magnetic Materials2012，，324： | 1 |
| 19 | Fabri- cation of hetero-binary and honeycomb photonic crystals by one-step holographic lithography 显示文摘 | Lijun Wu Yongchun Zhong Kam Sing Wong | 2006 | Applied Physics Letters2006，88，： | 1 |
| 20 | A novel computational framework for establishment of atomic mobility database directly from composition profiles and its uncertainty quantification显示文摘In this work,a novel computational framework for establishment of atomic mobility database directly from the experimental composition profiles and its uncertainty quantification was developed by merging the Bayesian inference with the Markov chain Monte Carlo algorithm into the latest version of the Hit DIC software.By treating the simulation of composition profiles with the composition-dependent coefficients as the forward problem,the inverse coefficient problem that provides the potential way to compute the atomic mobilities directly from composition profiles can be postulated.The values and uncertainties of the atomic mobility parameters of interest were assessed by means of Bayesian inference,where the composition profiles were consumed directly.Benchmark tests that consider the number of diffusion couples and the noise levels were conducted.Practical application of the current framework in determination of atomic mobility descriptions of fcc Ni-Ta and Ni-Al-Ta alloys was performed.Further discussion about the results of the benchmark tests and practical study case indicated that the present computational framework together with numbers of composition profiles from the multiple diffusion couples can help to establish the high-quality atomic mobility database of the target multicomponent alloys. | Jing Zhong Lijun Zhang Xiaoke Wu Li Chen Chunming Deng | 2020 | Journal of Materials Science & Technology2020，47，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员