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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Selection of Judging Indicators for Surface Morphology of Soil Crack under Different Development Degrees in Yuanmou Arid-Hot Valley Region显示文摘Quantification of complicated surface morphology of soil crack is a prerequisite and key to soil crack study. This paper takes soil crack quads in Yuanmou arid-hot valley region as examples, selecting several morphological indicators, and analyzes the soil crack's morpho-logical features under various development degrees. By statistic analysis, three quantitative indicators for surface morphology are selected, namely soil crack area density, area weighted mean fractal dimension and connectivity index R, which can not only express the development intensity of soil cracks, but also effectively describe its morphological complexity and connectivity. The research results set a good base for the establishment of soil crack assessment system in Yuanmou arid-hot valley region. | XIONG Donghong LU Xiaoning XIAN Jishen ZHOU Hongyi YANG Zhongi | 2008 | Wuhan University Journal of Natural Sciences2008，13，3： | 5 |
| 3 | Finite Frequency Fuzzy H∞Control for Uncertain Active Suspension Systems With Sensor Failure显示文摘This paper investigates the problem of finite frequency fuzzy H_∞ control for uncertain active vehicle suspension systems, in which sensor failure is taken into account. TakagiSugeno(T-S) fuzzy model is established for considered suspension systems. In order to describe the sensor fault effectively, a corresponding model is introduced. A vital performance index,H_∞ performance, is utilized to measure the drive comfort. In the framework of Kalman-Yakubovich-Popov theory, the H_∞ norm from external perturbation to controlled output is optimized effectively in the frequency domain of 4 Hz-8 Hz to enhance ride comfort level. Meanwhile, three suspension constrained requirements, i.e., ride comfort level, manipulation stability,suspension deflection are also guaranteed. Furthermore, sufficient conditions are developed to design a fuzzy controller to guarantee the desired performance of active suspension systems. Finally, the proposed control scheme is applied to a quarter-vehicle active suspension, and simulation results are given to illustrate the effectiveness of the proposed approach. | Zhenxing Zhang Hongyi Li Chengwei Wu Qi Zhou | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，4： | 4 |
| 4 | Optimization of broadband omnidirectional antireflection coatings for solar cells显示文摘Broadband and omnidirectional antireflection coating is generally an effective way to improve solar cell efficiency, because the destructive interference between the reflected and incident light can maximize the light transmission into the absorption layer. In this paper, we report the incident quantum efficiency ηin, not incident energy or power, as the evaluation function by the ant colony algorithm optimization method, which is a swarm-based optimization method. Also, SPCTRL2 is proposed to be incorporated for accurate optimization because the solar irradiance on a receiver plane is dependent on position, season, and time. Cities of Quito, Beijing and Moscow are selected for two-and three-layer antireflective coating optimization over λ = [300,1100] nm and θ = [0°, 90°]. The ηin increases by 0.26%, 1.37% and 4.24% for the above 3 cities, respectively, compared with that calculated by other rigorous optimization algorithms methods, which is further verified by the effect of position and time dependent solar spectrum on the antireflective coating design. | Xia Guo Qiaoli Liu Huijun Tian Ben Li Hongyi Zhou Chong Li Anqi Hu Xiaoying He | 2019 | Journal of Semiconductors2019，40，3： | 4 |
| 5 | HEIHE WATERSHED ALLIED TELEMETRY EXPERIMENTAL RESEARCH (HiWATER): Scientific Objectives and Experimental Design显示文摘 | Li Xin Cheng Guodong Liu Shaomin Xiao Qing Ma Mingguo Jin Rui Che Tao Liu Qinhuo Wang Weizhen Qi Yuan Wen Jianguang Li Hongyi Zhu Gaofeng Guo Jianwen Ran Youhua Wang Shuoguo Zhu Zhongli Zhou Jian Hu Xiaoli Xu Ziwei | 2013 | Bulletin of the American Meteorological Society2013，，8： | 3 |
| 6 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 7 | Rainfall infiltration on hilly slopes under various lithology and its effect on tree growth in the dry-hot valley显示文摘Revegetation is very difficult in dry-hot valleys in China. Rainfall infiltration capability on hilly slopes is one of the key factors determining soil moisture conditions and tree growth in the dry-hot valley. Low rainfall infiltration often results in soil drought on slopes under the dry-hot valleys climate. Rainfall infiltration capability varies greatly with the difference of slope lithologic porosity. The infiltration rates of five lithologic slope-types, Schist Slope, Grit Slope, Gravel Slope, the slightly eroded Mudstone Slope and the intensively eroded Mudstone Slope, are 1.40-8.67, 6.33, 0.69-2.20, 0.6-1.3 and 0.03-0.63 mm/min, respectively. With its viscid compact soil body and low infiltration capability which causes little infiltrating rainfall, mudstone slope can afford little effective supply to soil water and leads to serious drought of soil in dry seasons, resulting in cessation of growth or even wide-spread death of trees due to physiological damage for the excessive deficit of water in dry season and also the low productivity of stands. Hence, it is extremely difficult to restore vegetation on this type of slope. The other four lithologic slope-types, however, with well-developed soil crevice, high infiltration capability and thus more infiltrating rainfall, can afford more available soil water supply and the trees on them can obtain better growth and relatively higher productivity, compared with those on Mudstone Slope. Revegetation in dry-hot valleys is controlled by the soil moisture conditions of different slope-types, and it can be implemented by relying on the dominative life-form plant species, the suitable spatial arrangement of different life-forms of arbor-shrub-herb species, and the establishment of ecological community relationship between vegetation and soil moisture in habits. On the other hand, ground making measures for forestation and the runoff-collecting engineering measures to increase the rainfall infiltration are the major keys of revegetation techniques in dry-hot valleys. | YANG Zhong, XIONG Donghong, ZHOU Hongyi & ZHANG Xinbao Institute of Mountain Hazards and Environment, Chinese Academy of Sciences and Ministry of Water Resources, Chengdu 610041, China | 2003 | Science China(Technological Sciences)2003，46，z1： | 3 |
| 8 | Coherent state and normal ordering method for transiting Hermite polynomials to Laguerre polynomials显示文摘By virtue of the coherent state representation and the operator ordering method we find a new approach for transiting Hermite polynomials to Laguerre polynomials.We also derive the new reciprocal relation of Laguerre polynomials n=0(1) n l n L n(x) = x l l!,and its application in deriving the sum rule of the Wingner function of Fock states is demonstrated.Some new expansion identities about the operator Laguerre polynomial are also derived.This opens a new route of deriving mathematical polynomials formulas by virtute of the quantum mechanical representations and operator ordering technique. | FAN HongYi ZHOU Jun | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，4： | 3 |
| 9 | Sodium citrate and biochar synergistic improvement of nanoscale zero-valent iron composite for the removal of chromium(Ⅵ)in aqueous solutions显示文摘Sodium citrate(SC)is a widely-used food and industrial additive with the properties of com-plexation and microbial degradation.In the present study,nano-zero-valent iron reaction system(SC-nZVI@BC)was successfully established by modifying nanoscale zero-valent iron(nZVI)with SC and biochar(BC),and was employed to remove Cr(Ⅵ)from aqueous solu-tions.The nZVI,SC-nZVI and SC-nZVI@BC were characterized and compared using X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),thermogravimetric analy-ses(TGA),vibrating sample magnetometer(VSM),scanning electron microscope(SEM),X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS).The results showed that nZVI was successfully loaded on the biochar,and both the agglomeration and surface pas-sivation problems of nanoparticles were well resolved.The dosage of SC,C∶Fe,initial pH and Cr(Ⅵ)concentration demonstrated direct effects on the removal efficiency.The maximum Cr(Ⅵ)removal rate and the removal capacity within 60 min were 99.7%and 199.46 mg/g,respectively(C∶Fe was 1∶1,SC dosage was 1.12 mol.%,temperature was 25℃,pH=7,and the original concentration of Cr(Ⅵ)was 20 mg/L).The reaction confirmed to follow the pseudo-second-order reaction kinetics,and the order of the reaction rate constant k was as follows:SC-nZVI@BC>nZVI@BC>SC-nZVI>nZVI.In addition,the mechanism of Cr(Ⅵ)removal by SC-nZVI@BC mainly involved adsorption,reduction and co-precipitation,and the reduction of Cr(Ⅵ)to Cr(Ⅲ)by nano Fe0 played a vital role.Findings from the present study demon-strated that the SC-nZVI@BC exhibited excellent removal efficiency toward Cr(Ⅵ)with an improved synergistic characteristic by SC and BC. | Hongyi Zhou Mengyao Ye Yongkang Zhao Shams Ali Baig Ning Huang Mengyan Ma | 2022 | Journal of Environmental Sciences2022，34，5： | 3 |
| 10 | Implementation of a reference-scaled average bioequivalence approach for highly variable generic drug products of agomelatine in Chinese subjects显示文摘The aim of this study was to apply the reference-scaled average bioequivalence(RSABE)approach to evaluate the bioequivalence of 2 formulations of agomelatine,and to investigate the pharmacokinetic properties of agomelatine in Chinese healthy male subjects.This was performed in a single-dose,randomized-sequence,open-label,four-way crossover study with a one-day washout period between doses.Healthy Chinese males were randomly assigned to receive 25 mg of either the test or reference formulation.The formulations were considered bioequivalent if 90% confidence intervals(CIs)for the log-transformed ratios and ratio of geometric means(GMR)of AUC and C_(max) of agomelatine were within the predetermined bioequivalence range based on RSABE method.Results showed that both of the90% CIs for the log-transformed ratios of AUC and C_(max) of 7-desmethyl-agomelatine and 3-hydroxyagomelatine were within the predetermined bioequivalence range.The 90% CIs for natural logtransformed ratios of C_(max) ,AUC_(0–t)and AUC_(0–∞) of agomelatine(104.42–139.86,101.33–123.83 and97.90–117.94)were within the RSABE acceptance limits,and 3-hydroxy-agomelatine(105.55–123.03,101.95–109.10 and 101.72–108.70)and 7-desmethyl-agomelatine(104.50–125.23,102.36–111.50 and101.62–110.64)were within the FDA bioequivalence definition intervals(0.80–1.25 for AUC and0.75–1.33 for C_(max)).The RSABE approach was successful in evaluating the bioequivalence of these two formulations. | Fang Tang Rui Zhou Zeneng Cheng Guoping Yang Aiqiao Chen Zhi Liu Hongyi Tan Shuang Yang Sanwang Li Lingli Mu Peng Yu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 2 |
| 11 | Radial Anisotropy in the Crust beneath the Northeastern Tibetan Plateau from Ambient Noise Tomography显示文摘Through analysis of Rayleigh wave and Love wave Green's functions estimated from ambient noise tomography, we obtain radial anisotropy and shear wave velocity structure beneath the northeastern Tibetan Plateau. With two hundred and twenty three broadband seismic stations deployed by China Earthquake Administration, a collaborative seismic experiment of northern Tibet(ACSENT) experiment and northeastern Tibet seismic(NETS) experiment provide the unprecedented opportunity to resolve the spatial distribution of the radial anisotropy within the crust of the northeastern Tibetan Plateau. Discrepancies between Love(sh) and Rayleigh(sv) wave velocities show complex anisotropic patterns associated with the dynamic processes of the collision between the Indian and Eurasian plates:(1) In the upper crust, V_(sv)>V_(sh) anisotropy is dominant throughout the study area which probably reflects fossil microcracks induced by the uplift, folding and erosion geodynamic processes;(2) in the middle crust, V_(sh)>V_(sv) observed beneath the Songpan-Ganzi terrane and the northwestern Qilian orogen correlates well with a mid-crustal low velocity zone(LVZ);(3) at depths deeper than 40 km, V_(sh)>V_(sv) is still found in the Songpan-Ganzi terrane. This anisotropy could be caused by the sub-horizontal alignment of anisotropic minerals that has followed the collision between India and Eurasia. However, the northwestern Qilian orogen is associated with V_(sv)>V_(sh) anisotropy which may be related to the vertically aligned seismic anisotropic minerals caused by the crustal thickening. | Jing Tan Hongyi Li Xinfu Li Ming Zhou Longbin Ouyang Sanjian Sun Dan Zheng | 2015 | Journal of Earth Science2015，26，6： | 2 |
| 12 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 13 | A study of secondary emission properties of the molybdenum cathode doped with RE2O3 显示文摘 | Wang Jinshu Li Hongyi Zhou Meiling | 2003 | Applied Surface Science2003，215，： | 1 |
| 14 | Creep behavior of high density polyethylene films having well-defined morpholohies of stacked lamellae with and without an observable row-nucle-ated fibril structure 显示文摘 | Hongyi Zhou Garth L Wilkes | 1998 | Polymer1998，39，16： | 1 |
| 15 | Effects of Land Use Change on the Ecosystem Services Value in the Dry-Hot Valley显示文摘The objective of the study reported here was to determine whether LANDSAT TM images could be used to quantify changes in land-use and ecosystem services in Yuanmou County. The sizes of six land use/land cover(LUCC) categories were estimated in Yuanmou County according to the LANDSAT TM images in the summer of 1986 and 2005. Coefficients published by Xie Gaodi and co-workers in 2003 were used to value changes in ecosystem services delivered by each land use/land cover category,and the ecosystem services sensitivity analysis was conducted to de-termine the effect of manipulating these coefficients on the estimated values. The im-portant results are summarized as followings. ① The estimated size of cultivated land,pasture land,water area and unused land decreased by 6.39%,1.35%,2.25% and 10.67% respectively between 1986 and 2005. By contrast,the estimated size of forest land and construction land increased by about 2.23% and 71.15% respectively between 1986 and 2005. ② The total ecosystem services value(EVS) of the study area in-creased from 2 142 132 609.46 yuan to 2 146 416 621.00 yuan,with the net increase of 4 284 011.54 yuan during the 20-year time period. ③ The coefficient sensitivity(CS) of the study are less than unity in all cases(CS ∧1) . This indicates that the total eco-system values estimated for the study area are relatively inelastic with respect to the ecosystem service coefficients. While this implies that our estimates are robust and the coefficient is reasonable,highly under or over valued coefficients can substantially affect the veracity of estimated changes in ecosystem service values overtime even when the CS are less than unity(CS ∧1) . | ZHOU Hongyi XIONG Donghong YANG Zhong HE Xiubin | 2007 | Wuhan University Journal of Natural Sciences2007，12，4： | 1 |
| 16 | Amplification /Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer显示文摘 | Sen Subrata Zhou Hongyi Zhang Ruodan | 2002 | National Cancer Institute2002，94，： | 1 |
| 17 | Structure relationship for catalytic dechlorination rate of dichlorobenzenes in water 显示文摘 | Xu Xinhua Zhou Hongyi Wang Dahui | 2005 | Chemosphere2005，58，11： | 1 |
| 18 | Robust exponential stability for uncertain stochastic neural networks with discrete and dis- tributed time-varying delays 显示文摘 | Li Hongyi Chen Bing Zhou Qi | 2008 | Physics Letters A2008，372，19： | 1 |
| 19 | Application of artificial neural network approach and remotely sensed imagery for regional tal quality evaluation显示文摘 | Zhou Shi Hongyi Li | 2007 | Environ Monit Assess2007，，128： | 1 |
| 20 | Study on direct seeding foresta tion on shifting sandy land with peat显示文摘 | Sun Hongyi Zhou Jixia | 2009 | Journal of Japan Peat Society2009，8，1： | 1 |
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