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| 1 | Soil hydraulic conductivity as affected by vegetation restoration age on the Loess Plateau,China显示文摘The Loess Plateau of China has experienced extensive vegetation restoration in the past several decades,which leads to great changes in soil properties such as soil bulk,porosity,and organic matter with the vegetation restoration age.And these soil properties have great effect on the soil infiltration and soil hydraulic conductivity.However,the potential changes in soil hydraulic conductivity caused by vegetation restoration age have not been well understood.This study was conducted to investigate the changes in soil hydraulic conductivity under five grasslands with different vegetation restoration ages(3,10,18,28 and 37 years)compared to a slope farmland,and further to identify the factors responsible for these changes on the Loess Plateau of China.At each site,accumulative infiltration amount and soil hydraulic conductivity were determined using a disc permeameter with a water supply pressure of –20 mm.Soil properties were measured for analyzing their potential factors influencing soil hydraulic conductivity.The results showed that the soil bulk had no significant changes over the initial 20 years of restoration(P>0.05);the total porosity,capillary porosity and field capacity decreased significantly in the grass land with 28 and 37 restoration ages compared to the slope farmland;accumulative infiltration amount and soil hydraulic conductivity were significantly enhanced after 18 years of vegetation restoration.However,accumulative infiltration amount and soil hydraulic conductivity fluctuated over the initial 10 years of restoration.The increase in soil hydraulic conductivity with vegetation restoration was closely related to the changes in soil texture and structure.Soil sand and clay contents were the most influential factors on soil hydraulic conductivity,followed by bulk density,soil porosity,root density and crust thickness.The Pearson correlation coefficients indicated that the soil hydraulic conductivity was affected by multiply factors.These results are helpful to understand the changes in hydrological and erosion processes response to vegetation succession on the Loess Plateau. | REN Zongping ZHU Liangjun WANG Bing CHENG Shengdong | 2016 | Journal of Arid Land2016，8，4： | 9 |
| 2 | A hydrophilic fluorescent polymer containing naphthalimide moiety as chemosensor for microbioreactors显示文摘A novel hydrophilic copolymer P(NI-HEMA) containing the pendant group of naphthalimide moiety has been prepared. In the aqueous buffer solution, its film on the glass substrate shows an obvious fluorescence change and excellent linear relevance in the pH range of 5.8-8.0. Specifically, using the isobestic point at 406 nm as excitation wavelength can avoid the UV irradiation and the tedious calibration process. The film stability and hydrophilicity of copolymer P(NI-HEMA) were studied. Because of the easy synthesis, low price and high linear relevance to pH, the hydrophilic chemosensor film of P(NI- HEMA) could be potentially applied as a low-cost pH indicator for high-throughput bioprocessing in microreactors. | SHEN LiangJun ZHU WeiHong MENG XianLe GUO ZhiQian TIAN He | 2009 | Science China Chemistry2009，52，6： | 2 |
| 3 | Efficacy and safety of chemotherapy combined with bevacizumab in Chinese patients with metastatic colorectal cancer:A prospective,multicenter,observational,non-interventional phaseⅣtrial显示文摘Objective:Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer(mCRC)worldwide and was approved in China in 2010.However,there are limited real-world data on the efficacy and safety of chemotherapy regimens combined with bevacizumab in Chinese patients with mCRC.This observational,phase IV trial study aimed to obtain more experience on the efficacy and safety of bevacizumab combined with chemotherapy in Chinese mCRC patients.Methods:Between September 2013 and November 2016,patients with histologically confirmed mCRC were enrolled in a prospective,multicenter,observational,non-interventional phase IV trial at 26 centers across China.Eligible patients received different chemotherapeutic regimens combined with bevacizumab.The efficacy and safety data in the intention-to-treat study population were analyzed.Results:A total of 611 patients were included in the efficacy analysis.The median overall survival and median progression-free survival was 18.00 and 10.05 months,respectively.The objective response rate was 21.00%and disease control rate was 89.40%.In subgroup analyses,the survival differences were observed according to metastatic status,duration of treatment and elevation in blood pressure.A total of 613 patients were evaluable for safety assessments.And 569(92.82%)patients reported at least one adverse event(AE),and 151(24.63%)experienced grade 3 or higher AEs.The incidence of bevacizumab-associated AEs of special interest was reported in 31(5.06%)patients with hypertension(n=12),abscesses and fistulae(n=7),bleeding(n=6),proteinuria(n=3),gastrointestinal perforation(n=2)and venous thrombotic events(n=1).Conclusions:This observational phase IV trial broadens our experience and knowledge of bevacizumab in the Chinese population and provides a good indication of its overall efficacy and safety.Bevacizumab in combination with chemotherapy offers clinical benefits to Chinese patients with mCRC and has an acceptable and manageable safety profile. | Fenghua Wang Guanghai Dai Yanhong Deng Yong Tang Wei Wang Zuoxing Niu Feng Bi Liangjun Zhu Zengqing Guo Jin Yan Bing Hu Min Tao Shujun Yang Suzhan Zhang Lu Wen Ruihua Xu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 2 |
| 4 | Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice显示文摘Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate. | Shicheng Zhu Hanjing Song Liangjun Zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang Zhong-Min Dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing Zhu | 2022 | Journal of Genetics and Genomics2022，49，1： | 2 |
| 5 | Field enhancement sample stacking for analysis of organic acids in traditional Chinese medicine by capillary electrophoresis显示文摘 | Qianqian Zhu Xueqin Xu Yuanyuan Huang Liangjun Xu Guonan Chen | 2012 | Journal of Chromatography A2012，，： | 1 |
| 6 | Effect of Mo 2 C content on the structure and photocatalytic property of Mo 2 C/TiO 2 catalysts显示文摘 | Huiquan Li Wenshan Hong Yumin Cui Suhua Fan Liangjun Zhu | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 7 | Simultaneous detection of porcine circovirus type 2, classical swine fever virus, porcine parvovirus and porcine reproductive and respiratory syndrome virus in pigs by multiplex polymerase chain reaction显示文摘 | Yonghou Jiang Hanwu Shang Hui Xu Liangjun Zhu Weijie Chen Lingyan Zhao Li Fang | 2008 | The Veterinary Journal2008，，2： | 1 |
| 8 | Gelation of silk sericin and physical properties of the gel显示文摘 | Zhu Liangjun Mitsuo Arai Kiyoshi Hirabayashi | 1995 | J Seric Sci Jpn1995，64，5： | 1 |
| 9 | Characterization of CIbl gene promoter from silkworm, Bombyx mori 显示文摘 | Zhao Qiaoling Shen Xingjia Zhu Liangjun | 2007 | Zeitschrift fur Natuforschung2007，62，： | 1 |
| 10 | Spatial and temporal patterns of the sensitivity of radial growth response by Picea schrenkiana to regional climate change in the Tianshan Mountains显示文摘Climate change significantly impacts forest ecosystems in arid and semi-arid regions.However,spatiotemporal patterns of climate-sensitive changes in individual tree growth under increased climate warming and precipitation in north-west China is unclear.The dendrochronological method was used to study climate response sensitivity of radial growth of Picea schrenkiana from 158 trees at six sites during 1990-2020.The results show that climate warming and increased precipitation significantly promoted the growth of trees.The response to temperature first increased,then decreased.However,the response to increased precipitation and the self-calibrating Palmer Drought Severity Index(scPDSI)increased significantly.In most areas of the Tianshan Mountains,the proportion of trees under increased precipitation and scPDSI positive response was relatively high.Over time,small-diameter trees were strongly affected by drought stress.It is predicted that under continuous warming and increased precipitation,trees in most areas of the Tianshan Mountains,especially those with small diameters,will be more affected by precipitation. | Zhongtong Peng Yuandong Zhang Liangjun Zhu Mingming Guo Qingao Lu Kun Xu Hui Shao Qifeng Mo Shirong Liu | 2023 | Journal of Forestry Research2023，34，6： | 1 |
| 11 | Relationship between adhesive properties and structure of sericin in cocoon filaments显示文摘 | ZHU Liangjun ARAI Mitsuo HIRABAYASHI Kiyoshi | 1995 | J Seric Sci Jpn1995，64，42： | 1 |
| 12 | Field enhancement sample stacking for analysis of organic acids in traditional Chinese medicine by capillary electrophoresis显示文摘 | Qianqian Zhu Xueqin Xu Yuanyuan Huang Liangjun Xu Guonan Chen | 2012 | Journal of Chromatography A2012，，： | 1 |
| 13 | Monitoring of organochlorine pesticides in the urban air of Dalian, China with semipermeable membrane devices显示文摘The concentrations of 28 organochlorine pesticides(OCPs)in the urban air of Dalian,China were measured using semipermeable membrane devices(SPMDs)for the first time.Alpha-hexachlorocyclohexane(a-HCH),b-HCH,pentachlorobenzene(PentCB),hexachlorobenzene(HexCB),4,40-dichlorodiphenyltrichloroethane(4,40-DDT),4,40-dichlorodiphenyldichloroethene,endosulfan-I and endosulfan-II were the predominant OCPs in the urban air of Dalian.The concentration of OCPs sequestrated by SPMDs(CSPMD)ranged from undetected to 56,772 pg SPMD-1and had a linear correlation with the reciprocal of the average ambient atmospheric temperature(1/T).The CSPMDof PentCB and HexCB had negative correlations with T,whereas the other detected OCPs had a positive correlation.The source of HCHs,DDTs,HexCB,PentCB,chlordane,and endosulfan in the air were also evaluated.The OCPs in the urban air of Dalian could be attributed to the seasonal usage of pesticides,combustion,volatilization of aged OCPs from soil,water,plants,and long-range atmospheric transport. | Xiuhua Zhu Taian Shi Bernhard Henkelmann Gerd Pfister Wei Wang Jun Mu Xiaoxiao Li Liangjun Han Karl-Werner Schramm | 2014 | Chinese Science Bulletin2014，59，24： | 1 |
| 14 | Gelation of silk sericin and physical properties of the gel显示文摘 | Zhu Liangjun Arai Mitsuo Hirabayashi Kiyoshi | 1995 | Seric Sci Jpn1995，64，5： | 1 |
| 15 | Preparation of nano-sized magnetic particles from spent pickling liquors by ultrasonic-assisted chemical co-precipitation显示文摘 | Bing Tang Liangjun Yuan Taihong Shi Linfeng Yu Youchun Zhu | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 16 | Divergent responses of Picea crassifolia Kom.in different forest patches to climate change in the northeastern Tibetan Plateau显示文摘Global climate changes have significantly affected tree growth and forest structures and functions in some arid and semi-arid regions,which are becoming warmer and wetter.Due to natural factors such as climate and terrain,some tree species may form different forest patches at the edges of their distribution areas.However,how forest patches of various sizes respond to climate change is unclear.In this study,we collected 203 tree cores from six different sizes of forest patches at the edge of the distribution area of Picea crassifolia Kom.in the northeast Tibetan Plateau.And we used the dendrochronology method to study the response of tree growth and resilience in different forest patches to climate change from 1961 to 2020.We simultaneously measured the contents of nonstructural carbohydrates(NSC),total nitrogen and total phosphorus of tree needles.Our results showed that the growth of trees in small-and medium-size forest patches(0.8–18.6 ha)has increased significantly.The early growing season(May–July)minimum temperature was the most important climate factor driving the growth of small-and medium-sized patch trees.The early growing season maximum temperature was the most important climate factor that inhibited the growth of trees in the largest patches(362.8 ha).The growth of individual trees in medium forest patches was better and the correlation with annual minimum temperature,maximum temperature,precipitation,actual evapotranspiration,and palmer drought severity index was stronger.The higher NSC content,stronger photosynthesis,and higher nitrogen utilization efficiency in leaves might be one of the reasons for the better growth of trees in moderate forest patches.In extreme drought years,as the forest patch area increased,the overall trend of tree growth resistance showed a unimodal pattern,with the highest at a forest patch area of 7.1 ha,while the overall trend of tree growth recovery was opposite.Therefore,we should strengthen the management of trees in large forest patches to cope with climate change. | Zhongtong Peng Qifeng Mo Liangjun Zhu Qingao Lu Jiaqing Cai Mingming Guo Kun Xu Yuandong Zhang | 2023 | Forest Ecosystems2023，10，6： | 0 |
| 17 | Comparative Study on Constitutive Models to Predict Flow Stress of Fe-Cr-Ni Preform Reinforced Al-Si-Cu-Ni-Mg Composite显示文摘The isothermal compression tests were carried out on Gleeble-3500 thermal-mechanical simulation machine in a temperature range of 298-473 K and strain rate range of 0.001-10 s^(-1). The experimental results show that the flow stress data are negatively correlated with temperature for temperature softening, and the strain rates sensitivity of this composite increases with elevating temperature. Based on the experimental data, Johnson-Cook, modified Johnson-Cook and Arrhenius constitutive models were established. The accuracy of these three constitutive models was analyzed and compared. The results show that the values predicted by Johnson-Cook model could not agree well with the experimental values. The prediction accuracy of Arrhenius model is higher than that of Johnson-Cook model but lower than that of the Modified Johnson-Cook model. | 周灵展 YANG Liming PENG Yinjiang FEI Liangjun ZHU Xiurong | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，3： | 0 |
| 18 | 植物个体大小、环境和功能性状共同决定了常绿针叶植物个体发育阶段的径向生长率显示文摘植株个体大小、环境及功能性状对于树木生长至关重要,然而在树木个体发育过程中其对树木生长的调控机制尚不清晰。本研究以中国东北常绿针叶树种红松(Pinus koraiensis)为研究对象,选择65株胸高直径(DBH)范围为0.3–100 cm的样树,测定当年的径向生长量、环境因素(光照、土壤养分和土壤水分)以及功能性状(叶、枝和根性状)。研究结果表明,径向生长率随DBH变化呈单峰模式,DBH为58 cm时达到峰值。结构方程模型的分析表明,当DBH<15 cm时,植株个体大小对径向生长存在直接的负影响,但通过增加光强而间接地促进其生长;当DBH为16–58 cm和59–100 cm时,植株大小对树木径向生长分别存在直接的正影响和负影响;当DBH<15 cm时,光照对径向生长的影响大于土壤因素,而当DBH>15 cm时,呈相反趋势;预测树木生长的最优性状随植株个体的增大依次由比叶面积转变为木质密度及细根氮含量。因此,植株个体大小、环境和功能性状共同驱动树木的径向生长,其相对影响随树木生长而变化,且树木径向生长的限制因素随树木生长由光照转变为土壤养分。 | Zhili Liu Kouki Hikosaka Fengri Li Liangjun Zhu Guangze Jin | 2021 | Journal of Plant Ecology2021，14，2： | 0 |
| 19 | In-depth analysis of de novo lipogenesis in non-alcoholic fatty liver disease:Mechanism and pharmacological interventions显示文摘Non-alcoholic fatty liver disease(NAFLD)is characterized by the abnormal buildup of lipids in the liver tissue.Non-alcoholic fatty liver(NAFL)may progress to non-alcoholic steatohepatitis.Triglycerides in the liver can originate from various sources,including de novo lipogenesis(DNL).Research indicates that DNL significantly escalates in NAFLD,worsening steatosis.However,the precise regulatory mechanism of DNL in the development of this disease is not fully understood.Therefore,the targeted reduction of DNL could be a crucial therapeutic strategy.Currently,numerous pharmaceutical agents targeting DNL have been developed,attracting significant attention.This review examines the mechanism of DNL upregulation in NAFLD,assessing its potential as a therapeutic target for hepatic steatosis.Furthermore,we thoroughly examine hepatocellular lipotoxicity and provide an extensive review of the application and limitations of relevant therapeutic drugs,with a focus on key enzymes involved in DNL.The implementation of these pharmacological strategies is expected to significantly improve the management and overall outcomes for patients with NAFLD. | Zhixian Zhu Xiaoxun Zhang Qiong Pan Liangjun Zhang Jin Chai | 2023 | Liver Research2023，7，4： | 0 |
| 20 | DNA repair-and nucleotide metabolism-related genes exhibit differential CHG methylation patterns in natural and synthetic polyploids (Brassica napus L.)显示文摘Polyploidization plays a crucial role in the evolution of angiosperm species.Almost all newly formed polyploids encounter genetic or epigenetic instabilities.However,the molecular mechanisms contributing to genomic instability in synthetic polyploids have not been clearly elucidated.Here,we performed a comprehensive transcriptomic and methylomic analysis of natural and synthetic polyploid rapeseeds(Brassica napus).Our results showed that the CHG methylation levels of synthetic rapeseed in different genomic contexts(genes,transposon regions,and repeat regions)were signi fi cantly lower than those of natural rapeseed.The total number and length of CHG-DMRs between natural and synthetic polyploids were much greater than those of CG-DMRs and CHH-DMRs,and the genes overlapping with these CHG-DMRs were signi fi cantly enriched in DNA damage repair and nucleotide metabolism pathways.These results indicated that CHG methylation may be more sensitive than CG and CHH methylation in regulating the stability of the polyploid genome of B.napus.In addition,many genes involved in DNA damage repair,nucleotide metabolism,and cell cycle control were significantly differentially expressed between natural and synthetic rapeseeds.Our results highlight that the genes related to DNA repair and nucleotide metabolism display differential CHG methylation patterns between natural and synthetic polyploids and reveal the potential connection between the genomic instability of polyploid plants with DNA methylation defects and dysregulation of the DNA repair system.In addition,it was found that the maintenance of CHG methylation in B.napus might be partially regulated by MET1.Our study provides novel insights into the establishment and evolution of polyploid plants and offers a potentialidea for improving the genomic stability of newly formed Brassica polyploids. | Liqin Yin Zhendong Zhu Liangjun Huang Xuan Luo Yun Li Chaowen Xiao Jin Yang Jisheng Wang Qiong Zou Lanrong Tao Zeming Kang Rong Tang Maolin Wang Shaohong Fu | 2021 | Horticulture Research2021，8，1： | 0 |
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