|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 2 | 胸腔置管白介素-2联合顺铂治疗恶性胸腔积液的临床观察(英文)显示文摘Objective: The aim of our study was to explore the short-term effects and complication of interleukin-2 (IL-2) combining with Cisplatin in the treatment of malignant hydrothorax.Methods: Sixty-two cases patients with malignant hydrothorax were randomly divided into two groups.Observation group was 31 examples,thoracic cavity injection IL-2 and Cisplatin;31 cases in control group using Cisplatin alone intra-thoracic injection.The regime of every week for 1–4 weeks was used to observe short term effects and complications.Results: The total response rate in observe group was higher than that in control group (90.3% vs.68.1%),which had statistically significant difference (P < 0.05).The complications included gastrointestinal tract reaction,bone marrow inhibition,chest pain and fever.The incidence rates of chest pain and fever in observe group was slightly higher than that in control group,but there was no statistically significant difference (P > 0.05).Conclusion: The IL-2 combining with Cisplatin intra-thoracic injection for malignant hydrothorax has the features of good therapeutic effects and slight poisonous side effects,which is worth to be used in clinic. | Cheng Xu Zaijun Zhang Yuezhen Hu Yeyuan Wang Mingquan Li | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，1： | 3 |
| 3 | Biocompatible Nanocomplexes for Molecular Targeted MRI Contrast Agent显示文摘 | Zhijin Chen Dexin Yu Shaojie Wang Na Zhang Chunhong Ma Zaijun Lu | 2009 | Nanoscale Research Letters2009，，7： | 1 |
| 4 | Supply Deficit of m-Aminophenol | Wang Zaijun | 2007 | China Chemical Reporter2007，，10： | 1 |
| 5 | Chronology and paleoenvironmental records of a drill core in the central Tengger Desert of China显示文摘 | Zaijun Li Donghuai Sun Fahu Chen Fei Wang Yuebao Zhang Feng Guo Xin Wang Baofeng Li | 2014 | Quaternary Science Reviews2014，，： | 1 |
| 6 | Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β -Elemene显示文摘 | Meiwan Chen Jinming Zhang Siqin Yu Shengpeng Wang Zaijun Zhang Jianqiang Chen Jian Xiao Yitao Wang Yoshiyuki Kimura | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 7 | Stationary deck foam extinguishing system se-curity check discussion 显示文摘 | Wang Zaijun | 2007 | China Water Transport2007，11，： | 1 |
| 8 | A sensitive and highly stable electrochemical impedance immunosensor based on the formation of silica gel-ionic liquid biocompatible film on the glassycarbon electrode for the determination of aflatoxin B1 in bee pollen显示文摘 | LI Zaijun WANG Zhongyun SUN Xiulan | 2010 | Talanta2010，80，5： | 1 |
| 9 | Synthesis and evaluation of antibacterial activities of andrographolide analogues显示文摘 | Xiaojian Jiang Pei Yu Jie Jiang Zaijun Zhang Zhongli Wang Zhaoqi Yang Zhiming Tian Susan C. Wright James W. Larrick Yuqiang Wang | 2008 | European Journal of Medicinal Chemistry2008，，7： | 1 |
| 10 | 白藜芦醇及其衍生物在TNF-α诱导的人脐静脉内皮细胞中的抗炎作用显示文摘二苯乙烯类化合物,自1940年首次从毛藜芦根中分离出白藜芦醇以来就对此进行了广泛研究。这类化合物存在于许多植物中并具有广泛的生理活性,主要有抗氧化、抗肿瘤、抗淤血综合征(如脑炎、动脉粥样硬化、慢性炎症)等。白藜芦醇(trans-3,5,4’-trihydroxystiibene),是从中药虎杖中提取出来的一种二苯乙烯类化合物,同时也是一种非常重要的植物内毒素,在近年来的实验研究中已充分证明其具有很多有益的药理作用,如抗癌、心血管保护、神经保护、抗衰老和抗炎等等。大量研究证实其在抗动脉粥样硬化中起着非常重要的作用。近年来随着白藜芦醇的类似物的不断出现,研究者们发现其中一些二苯乙烯类化合物同样具有许多与白藜芦醇相似的药理活性且某些化合物的活性、选择性及稳定性均要强于白藜芦醇,故成为目前研究的热点。为了探讨白藜芦醇类似物中甲基化白藜芦醇和自藜芦醇苷的抗炎效应并阐明其作用机制,同时与白藜芦醇进行比较,我们首先用细胞黏附实验测定其是否具有抗细胞黏附的能力,然后对其相关的黏附分子的表达及NF—κB进行考察。 | Yan-Hui Deng Zaijun Zhang Deepa Alex He-Qing huang Yi-Tao Wang Simon Ming-Yuen Lee | 2009 | 中国药理通讯2009，26，2： | 1 |
| 11 | Elastic electron scattering on exotic light proton-rich nuclei显示文摘 | WANG Zaijun REN Zhongzhou | 2004 | Physical Review C2004，70，3： | 1 |
| 12 | Systematic study of charge form factors of elastic electron-nucleus scattering with the relativistic eikonal approximation显示文摘 | WANG Zaijun REN Zhongzhou | 2005 | Physical Review C2005，71，5： | 1 |
| 13 | REGγ drives Lgr5^(+) stem cells to potentiate radiation induced intestinal regeneration显示文摘Leucine-rich repeat containing G protein-coupled receptor 5(Lgr5), a marker of intestinal stem cells(ISCs), is considered to play key roles in tissue homoeostasis and regeneration after acute radiation injury. However, the activation of Lgr5 by integrated signaling pathways upon radiation remains poorly understood. Here, we show that irradiation of mice with whole-body depletion or conditional ablation of REGγ in Lgr5^(+) stem cell impairs proliferation of intestinal crypts, delaying regeneration of intestine epithelial cells. Mechanistically, REGγ enhances transcriptional activation of Lgr5 via the potentiation of both Wnt and Hippo signal pathways. TEAD4 alone or cooperates with TCF4, a transcription factor mediating Wnt signaling, to enhance the expression of Lgr5. Silencing TEAD4 drastically attenuated β-catenin/TCF4 dependent expression of Lgr5. Together, our study reveals how REGγ controls Lgr5 expression and expansion of Lgr5+stem cells in the regeneration of intestinal epithelial cells.Thus, REGγ proteasome appears to be a potential therapeutic target for radiation-induced gastrointestinal disorders. | Xiangzhan Zhu Minglei Yang Zaijun Lin Solomon Kibreab Mael Ya Li Lili Zhang Yaqi Kong Yaodong Zhang Yuping Ren Jianhui Li Zimeng Wang Ying Zhang Bo yang Tingmei Huang Fangxia Guan Zhenlong Li Robb E Moses Lei Li Bing Wang Xiaotao Li Bianhong Zhang | 2022 | Science China(Life Sciences)2022，65，8： | 0 |
| 14 | A novel molecular classification method for osteosarcoma based on tumor cell differentiation trajectories显示文摘Subclassification of tumors based on molecular features may facilitate therapeutic choice and increase the response rate of cancer patients.However,the highly complex cell origin involved in osteosarcoma(OS)limits the utility of traditional bulk RNA sequencing for OS subclassification.Single-cell RNA sequencing(sc RNA-seq)holds great promise for identifying cell heterogeneity.However,this technique has rarely been used in the study of tumor subclassification.By analyzing sc RNA-seq data for six conventional OS and nine cancellous bone(CB)samples,we identified 29 clusters in OS and CB samples and discovered three differentiation trajectories from the cancer stem cell(CSC)-like subset,which allowed us to classify OS samples into three groups.The classification model was further examined using the TARGET dataset.Each subgroup of OS had different prognoses and possible drug sensitivities,and OS cells in the three differentiation branches showed distinct interactions with other clusters in the OS microenvironment.In addition,we verified the classification model through IHC staining in 138 OS samples,revealing a worse prognosis for Group B patients.Furthermore,we describe the novel transcriptional program of CSCs and highlight the activation of EZH2 in CSCs of OS.These findings provide a novel subclassification method based on sc RNA-seq and shed new light on the molecular features of CSCs in OS and may serve as valuable references for precision treatment for and therapeutic development in OS. | Hao Zhang Ting Wang Haiyi Gong Runyi Jiang Wang Zhou Haitao Sun Runzhi Huang Yao Wang Zhipeng Wu Wei Xu Zhenxi Li Quan Huang Xiaopan Cai Zaijun Lin Jinbo Hu Qi Jia Chen Ye Haifeng Wei Jianru Xiao | 2023 | Bone Research2023，11，1： | 0 |
| 15 | A Method for Classification and Evaluation of Pilot’s Mental States Based on CNN显示文摘How to accurately recognize the mental state of pilots is a focus in civil aviation safety.The mental state of pilots is closely related to their cognitive ability in piloting.Whether the cognitive ability meets the standard is related to flight safety.However,the pilot’s working state is unique,which increases the difficulty of analyzing the pilot’s mental state.In this work,we proposed a Convolutional Neural Network(CNN)that merges attention to classify the mental state of pilots through electroencephalography(EEG).Considering the individual differences in EEG,semi-supervised learning based on improvedK-Means is used in themodel training to improve the generalization ability of the model.We collected the EEG data of 12 pilot trainees during the simulated flight and compared the method in this paper with other methods on this data.The method in this paper achieved an accuracy of 86.29%,which is better than 4D-aNN and HCNN etc.Negative emotion will increase the probability of fatigue appearing,and emotion recognition is also meaningful during the flight.Then we conducted experiments on the public dataset SEED,and our method achieved an accuracy of 93.68%.In addition,we combine multiple parameters to evaluate the results of the classification network on a more detailed level and propose a corresponding scoring mechanism to display the mental state of the pilots directly. | Qianlei Wang Zaijun Wang Renhe Xiong Xingbin Liao Xiaojun Tan | 2023 | Computer Systems Science & Engineering2023，46，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员