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| 1 | Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms显示文摘Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow diverters.Glycoprotein IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications afterwards.We sought to determine the safety of tirofiban and DAPT in these cases.Methods We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow diversion.The tirofiban-DAPT protocol used is described.Data regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and analysed.results One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 electively.Minor and major haemorrhagic events were recognised in 20%(30/148)aneurysms.Only 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 EVD-related.The average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were symptomatic.Most haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was documented.Concomitant administration of heparin did not increase haemorrhagic events.Conclusion The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was safe.Tirofiban and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications. | Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa Pascal Jabbour David M Hasan | 2019 | Stroke & Vascular Neurology2019，4，1： | 17 |
| 2 | Genotyping and pathotyping of diversified strains of infectious bronchitis viruses circulating in Egypt显示文摘AIM: To characterize the circulating infectious bronchitis virus(IBV) strains in Egypt depending on the sequence of the spike-1(S1) gene [hypervariable region-3(HVR-3)] and to study the pathotypic features of these strains.METHODS: In this work, twenty flocks were sampled for IBV detection using RRT-PCR and isolation of IBV in specific pathogen free(SPF) chicks during the period from 2010 to 2015. Partial sequencing and phylogenetic analysis of 400 bp representing the HVR-3 of the S1 gene was conducted. Pathotypic characterization of one selected virus from each group(Egy/Var-Ⅰ, Egy/Var-Ⅱ and classic) was evaluated in one day old SPF chicks. The chicks were divided into 4 groups 10 birds each including the negative control group. Birds were inoculated at one day by intranasal instillation of 105EID50/100 μL of IBV viruses [IBV-EG/1212B-2012(Egy/Var-Ⅱ), IBV/EG/IBV1-2011(Egy/Var-Ⅰ) and IBV-EG/11539F-2011(classic)], while the remaining negative control group was kept uninfected. The birds were observed for clinical signs, gross lesions and virus pathogenicity. The real-time rR TPCR test was performed for virus detection in the tissues. Histopathological examinations were evaluated in both trachea and kidneys.RESULTS: The results revealed that these viruses were separated into two distinct groups; variant(GI-23) and classic(GI-1), where 16 viruses belonged to a variant group, including 2 subdivisions [Egy/Var-Ⅰ(6 isolates) and Egy/Var-Ⅱ(10 isolates)] and 4 viruses clustered to the classic group(Mass-like). IBV isolates in the variant group were grouped with other IBV strains from the Middle East. The variant subgroup(Egy/Var-Ⅰ) was likely resembling the original Egyptian variant strain(Egypt/Beni-Suif/01) and the Israeli strain(IS/1494/2006). The second subgroup(Egy/Var-Ⅱ) included the viruses circulating in the Middle East(Ck/EG/BSU-2 and Ck/EG/BSU-3/2011) and the Israeli strain(IS/885/00). The two variant subgroups(Egy/Var-Ⅰ and Egy/Var-Ⅱ) found to be highly pathogenic to SPF chicks with mortalities up to 50% than those of the classic group which was of low virulence(10% mortality). Pathogenicity indices were 25(Egy/Var-Ⅱ), 24(Egy/Var-Ⅰ) and 8(classic); with clinical scores 3, 2 and 1 respectively.CONCLUSION: These findings indicated that the recent circulating Egyptian IBVs have multiple heterogeneous origins in marked diversifying nature of their spread, with high pathotype in specific pathogen free chicks. | Ali Zanaty Abdel-Satar Arafa Naglaa Hagag Magdy El-Kady | 2016 | World Journal of Virology2016，5，3： | 3 |
| 3 | Determining the number of clusters for kernelized fuzzy C-means algorithms for automatic medical image seg- mentation显示文摘 | Zanaty E A | 2012 | Egyptian Informatics Journal2012，13，： | 1 |
| 4 | Plasmapheresis and pregnancy outcome in patients with antiphospholipid syndrome显示文摘 | E1-Haieg DO Zanati MF E1-Foual FM | 2007 | Int J Gynaecol Obstet2007，99，3： | 1 |
| 5 | Kinetic study for copper adsorption onto soil minerals in the absence and presence of humic acid显示文摘 | Zanaty R. Komy Ali M. Shaker Said E.M. Heggy Mohamed E.A. El-Sayed | 2013 | Chemosphere2013，，： | 1 |
| 6 | Plasmapheresis and pregnancy outcome in patients with antiphospholipid syndrome显示文摘 | El-Haieg D O Zanati M F El-Foual F M | 2007 | Intern J Gyneco Obstet2007，99，3： | 1 |
| 7 | Capsule endoscopy regional transit abnormality revisited 显示文摘 | TANG S J ZANATI S DUBCENCO E | 2004 | Gastrointest Endosc2004，60，6： | 1 |
| 8 | Endoscopic Mucosal Resection Outcomes and Prediction of Submucosal Cancer From Advanced Colonic Mucosal Neoplasia显示文摘 | Alan Moss Michael J. Bourke Stephen J. Williams Luke F. Hourigan Gregor Brown William Tam Rajvinder Singh Simon Zanati Robert Y. Chen Karen Byth | 2011 | Gastroenterology2011，，7： | 1 |
| 9 | Support vector machines (SVMs) with universal kernels显示文摘 | Zanaty E A Afifi A | 2011 | Applied Artificial Intelligence2011，25，7： | 1 |
| 10 | A Watershed Approach for Improv-ing Medical Image Segmentation显示文摘 | Zanaty E A Afifi A | 2013 | Computer Methods in Biomechanics and Biomedical Engineering2013，16，12： | 1 |
| 11 | Precut Papillotomy Versus Persistence in Difficult Biliary Cannulation: A Prospective Randomized Trial显示文摘 | S.-J. Tang G. Haber P. Kortan S. Zanati M. Cirocco M. Ennis A. Elfant D. Scheider H. Ter J. Dorais | 2005 | Endoscopy2005，，01： | 1 |
| 12 | Laparoscopic Hys- terectomy of Large Uteri with Uterine Artery Coagulation at Its Origin显示文摘 | Roman H Zanati J Friederich L | 2008 | JSLS2008，12，1： | 1 |
| 13 | Treatment of blister-like aneurysms with the pipeline embolization device显示文摘 | Chalouhi N Zanaty M Tjoumakaris S | 2014 | Neurosurgey2014，74，： | 1 |
| 14 | Laparoscopic hyster-ectomy of large uteri with uterine Artery coagulation at its or-igin显示文摘 | Roman H Zanati J Friederich L | 2008 | JSLS2008，12，1： | 1 |
| 15 | Peroxisome proliferator activated receptor 2 gene Prol2Ala gene polymorphism in type 2 diabetes and its relationship with diabetic nephropathy显示文摘 | Azab M M Abdel-Azeez H A Zanaty M F | 2014 | Linical Chemistry and Laboratory Medicine2014，60，5： | 1 |
| 16 | Capsule endoscope regional transit abnormality revisited显示文摘 | TANG SJ ZANATI S DUBCENCO E | 2004 | Gastrointest Endosc2004，60，6： | 1 |
| 17 | Nonoperative treatment of closed total talus dislocation without fracture: A case report and literature review显示文摘 | Rhanim A Zanati RE Yoanes Ouchrif | 2014 | J Clin Orthop Trauma2014，5，3： | 1 |
| 18 | Paroxysm proliferators activated receptorγ2 gene Pro12Ala gene polymorphism in type 2 diabetes and its relationship with diabetic nephropathy显示文摘 | Azab MM Abdel-Azeez HA Zanaty MF | 2014 | Cline Lab2014，60，5： | 1 |
| 19 | treatment of ruptured in- tracranial aneurysms with the pipeline embolization device 显示文摘 | Chalouhi N Zanaty M Whiting A | 2015 | Neurosurgery2015，76，2： | 1 |
| 20 | On the cyclic decomposition of complete graphs into almost-bipartite graphs显示文摘 | Blinco A Zanati EI S Vanden Eynden C | 2004 | Discrete Math(S 0012-365X)2004，284，： | 1 |
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