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| 1 | Heparin improves organ microcirculatory disturbances in caerulein-induced acute pancreatitis in rats显示文摘AIM: Microcirculatory disturbances are important early pathophysiological events in various organs during acute pancreatitis. The aim of the study was to evaluate changes in rnicroperfusion of the pancreas, liver, kidney, stomach,colon, skeletal muscle, and to investigate the influence of heparin on the organ rnicrocirculation in caerulein-induced experimental acute pancreatitis.METHODS: Acute pancreatitis was induced by 4 intraperitoneal injections of caerulein (Cn) (15 μg/kg). The organ microcirculation was measured by laser Doppler flowrnetry. Serum interleukin 6 and hernatocrit levels were analysed.RESULTS: Acute pancreatitis resulted in a significant drop of microperfusion in all examined organs. Heparin administration (2×2.5 mg/kg) improved the rnicrocirculation in pancreas (36.9±4% vs75.9±10%), liver (56.6±6% vs 75.2±16%), kidney (45.1±6% vs79.3±5%), stomach (65.2±8% vs78.1±19%), colon (69.8±6% vs 102.5±19%),and skeletal muscle (59.2±6% vs 77.9±13%). Heparin treatment lowered IL-6 (359.0±66 U/mL vs 288.5±58 U/mL) and hematocrit level (53±4% vs 46±3%).CONCLUSION: Hepadn administration has a positive influence on organ microcirculatory disturbances accompanying experimental Cn-induced acute pancreatitis. | Marek Dobosz Lucjanna Mionskowska Stanislaw Ha■ Sebastian Dobrowolski Dariusz Dymecki Zdzislaw Wajda | 2004 | World Journal of Gastroenterology2004，10，17： | 34 |
| 2 | Neutrophil engagement and septic challenge in acute experimental pancreatitis in rats显示文摘AIM: To investigate the influence of neutrophil adhesion molecule blockade with monoclonal antibody (MoAb CD11b) and E. coli lipopolysaccharide (LPS)administration on experimental acute pancreatitis (AP).METHODS: AP was induced by four ip injections of cerulein (Cn) at 1-h intervals. MoAb CD 11b and LPS were administered at the beginning of the experiment.RESULTS: The neutrophil count and chemiluminescence were diminished at the beginning of AP. The oxidative stress parameters were found within the pancreatic gland. MoAb CD 11b used for AP resulted in a significant reduction of pancreatic infiltration and pancreatitis oxidative stress parameters. Serum interleukin-6 (IL-6)was not detected in AP animals, whereas high serum IL-6 concentration was noted only in animals receiving LPS.CONCLUSION: Neutrophils are involved in pancreatic damage in the early stage of AP. Neutrophil infiltration reduction protects the pancreatic gland from destruction during AP. LPS does not change the early course of Cn pancreatitis in rats. | Stanisiaw Ha Marek Dobosz Jan J Kaczor Robert Rzepko Ewa Aleksandrowicz-Wrona Zdzislaw Wajda Zbigniew ledzi■ski Jacek Krajewski | 2005 | World Journal of Gastroenterology2005，11，41： | 7 |
| 3 | Rough sets显示文摘 | Zdzislaw Pawlak Jerzy Grzymala-Busse Roman Slowinski Wojciech Ziarko | 1995 | Communications of the ACM1995，，11： | 2 |
| 4 | Computer Simulation and Rapid Prototyping for the Reconstruction of the Mandible显示文摘 | Philipp Juergens Zdzislaw Krol Hans-Florian Zeilhofer Joerg Beinemann Kurt Schicho Rolf Ewers Clemens Klug | 2009 | Journal of Oral and Maxillofacial Surgery2009，，10： | 2 |
| 5 | Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis显示文摘 | Sahar A. Saddoughi Salih Gencer Yuri K. Peterson Katherine E. Ward Archana Mukhopadhyay Joshua Oaks Jacek Bielawski Zdzislaw M. Szulc Raquela J. Thomas Shanmugam P. Selvam Can E. Senkal Elizabeth Garrett‐Mayer Ryan M. De Palma Dzmitry Fedarovich Angen Liu | 2012 | EMBO Mol Med2012，，1： | 2 |
| 6 | Numerical Analysis of Erosion of the Rotor Labyrinth Seal in a Geothermal Turbine显示文摘 | Zdzislaw Mazur Gustavo Urquiza Fernando Sierra | 2002 | Geothermics2002，31，5： | 1 |
| 7 | Fast overcurrent protection system in the cw laser diode driver 显示文摘 | ANDRZEJ O ZDZISLAW S | 2000 | Proc SPIE2000，4237，： | 1 |
| 8 | Parameters affecting the isolation of collagen from squid (lllex aggenti- nus) skins 显示文摘 | Kolodziejska I Zdzislaw E S Niecikowska C | 1999 | Food Chem1999，66，2： | 1 |
| 9 | Rough Sets显示文摘 | Zdzislaw Pawlak | 1982 | Information and Computer Science1982，11，5： | 1 |
| 10 | Rough Sets and Intelligent Data Analysis显示文摘 | Pawlak Zdzislaw | 2002 | Information Sciences2002，147，14： | 1 |
| 11 | Parameters affecting the isolation of collagen from squid (Illex argentinus) skins 显示文摘 | Iona K Zdzislaw E S Celina N | 1999 | Food Chemistry1999，66，2： | 1 |
| 12 | Rudiments of rough sets 显示文摘 | Pawlak Zdzislaw Skowron Andrzej | 2007 | Information Sciences2007，177，1： | 1 |
| 13 | Rough sets显示文摘 | PAWLAK Zdzislaw | 1982 | International Journal of Computer and Information Sciences1982，11，5： | 1 |
| 14 | Polycyclic aromatic hydrocarbons in smoked fish-a critical review显示文摘 | Andrzej Stoyhwo zdzislawe Sikorski | 2005 | Food Chemistry2005，91，： | 1 |
| 15 | Rough sets and intelligent data analysis显示文摘 | Zdzislaw Pawlak | 2002 | Information Sciences2002，147，： | 1 |
| 16 | Rough sets theory and its applications to data analysis显示文摘 | PAWLAK Zdzislaw | 1998 | Cybernetics and Systems: An International Journal1998，29，： | 1 |
| 17 | Organic acids for performance enhancement in pig diets显示文摘 | Kirsi H Partanen Zdzislaw M | 1999 | Nutrition Research Reviews1999，12，： | 1 |
| 18 | Collagen in the tissues of squid (Illex argentius and Loligo Patagonica)-content and solubility 显示文摘 | Maria S Zdzislaw E S | 1987 | Journal of Food Biochemistry1987，11，2： | 1 |
| 19 | Rudiments of rough sets 显示文摘 | Pawlak Zdzislaw | 2007 | Information Sci- ences2007，177，1： | 1 |
| 20 | Rou^i Set theory and its application to data analysis显示文摘 | ZDZISLAW P | 1998 | Cybernetics and Systems1998，29，7： | 1 |
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