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| 1 | 丝路咽喉——河西走廊显示文摘河西走廊,地处甘肃西部黄河以西。南与青藏高原北缘的祁连山脉接壤,东临黄土高原,西与塔里木盆地交界,北与内蒙古高原南缘隆起的北山山地相连,是一条长1000多公里、宽数公里至百余公里的狭长地带,因形似走廊而得名。
特殊的地理位置赋予河西走廊重要的历史职能。河西走廊虽然处于峰峦叠嶂的祁连山和主要为戈壁、沙漠的内蒙古高原的夹峙之下,但走廊之上,却是绿洲相连,地下水源充沛,资源丰富,物产富饶,自古以来即为中原通西域的首选之路。自3000多年前起,河西走廊就成为中国内地通往西域地区的必经通道,神秘的“玉石之路”和周穆王西巡,沟通了中原与西域地区的联系。自公元前121年开始,成为闻名于世的丝绸之路的主干路段。由于历史的原因,这里成为华夏文明与两河文明、印度文明、地中海文明的交汇区。正是在东西方文明的交流融会过程中,河西走廊得以长期吸纳这条道路上荟萃的各种文明,促进了自身经济、文化的繁荣和发展,并形成了独特的河西文化。 | 邵如林 Zhao Dengming | 2014 | 丝绸之路2014，，11： | 2 |
| 2 | A fuzzy programming approach for supply chain network design 显示文摘 | Ji Xiaoyu Zhao Xiande Zhou Dengming | 2007 | International Journal of Uncertainty Fuzziness and Knowledge-Based Systems2007，15，2： | 1 |
| 3 | Expression and possible role of Smad3 in postnecrotizing enterocolitis stricture显示文摘Objective To investigate the expression of Smad3(mothers against decapentaplegic homolog 3)protein in postnecrotizing enterocolitis stricture and its possible mechanism of action.Methods We used immunohistochemistry to detect the expression characteristics of Smad3 and nuclear factor kappa B(NF-κB)proteins in human postnecrotizing enterocolitis stricture.We cultured IEC-6(crypt epithelial cells of rat small intestine)in vitro and inhibited the expression of Smad3 using siRNA technique.Quantitative PCR,western blotting,and ELISA were used to detect the changes in transforming growth factor-β1(TGF-β1),NF-κB,tumor necrosis factor-α(TNF-α),vascular endothelial growth factor(VEGF),and zonula occludens-1(ZO-1)messenger RNA(mRNA)and protein expressions in IEC-6 cells.CCK8 kit and Transwell cellular migration were used to detect cell proliferation and migration.Changes in epithelial-mesenchymal transition(EMT)markers(E-cadherin and vimentin)in IEC-6 cells were detected by immunofluorescence technique.Results The results showed that Smad3 protein and NF-κB protein were overexpressed in narrow intestinal tissues and that Smad3 protein expression was positively correlated with NF-κB protein expression.After inhibiting the expression of Smad3 in IEC-6 cells,the mRNA expressions of NF-κB,TGF-β1,ZO-1,and VEGF decreased,whereas the mRNA expression of TNF-αdid not significantly change.TGF-β1,NF-κB,and TNF-αprotein expressions in IEC-6 cells decreased,whereas ZO-1 and intracellular VEGF protein expressions increased.IEC-6 cell proliferation and migration capacity decreased.There was no significant change in protein expression levels of EMT markers E-cadherin and vimentin and also extracellular VEGF protein expression.Conclusions We suspect that the high expression of Smad3 protein in postnecrotizing enterocolitis stricture may promote the occurrence and development of secondary intestinal stenosis.The mechanism may be related to the regulation of TGF-β1,NF-κB,TNF-α,ZO-1,and VEGF mRNA and protein expression.This may also be related to the ability of Smad3 to promote epithelial cell proliferation and migration. | Rui Chen Chengjie Lv Xiaoxia Zhao Dong Ma Dengming Lai Yun Zhao Luyin Zhang Jinfa Tou | 2022 | World Journal of Pediatric Surgery2022，5，1： | 0 |
| 4 | 传播丝绸之路文化的杰出人物显示文摘鸠摩罗什,出生于古代西域的龟兹国,是东晋时后秦的一位高僧,译经家。 他7岁随母出家,初学小乘经典。9岁随母赴罽宾(今克什米尔地区)从盘头达多诵读杂藏、阿含等经。12岁与母返龟兹途中,在疏勒驻留年余,修习阿毗昙及六足论,从大乘僧人﹑莎车王子须利耶苏摩诵读《中论》﹑《百论》和《十二门论》,复从佛陀耶舍授读《十诵律》等。后佛陀耶舍一直和他合作翻译佛经。鸠摩罗什为人开朗,秉性坦率,虚己善诱,专以大乘教人,而善于辨析义理,应机领会,独具神解。罗什回龟兹后,广习大乘经论,讲经说法,成为中观大师,名声大震西域,在汉地也有传闻。前秦建元十八年(382),苻坚遣吕光攻伐焉耆,继灭龟兹,劫鸠摩罗什至凉州。三年后,姚苌杀苻坚,灭前秦,吕光遂割据凉州,自立为凉主,鸠摩罗什随吕光滞留凉州近17年。后秦弘始三年(401),姚兴攻伐后凉,亲迎鸠摩罗什入长安,入逍遥园西明阁,鸠摩罗什(344~413) 以国师礼待,并在长安组织了规模宏大的译场,请鸠摩罗什主持译经事业。此后10多年间,鸠摩罗什悉心从事译经和说法。 | 本刊编辑部 Zhao Dengming | 2014 | 丝绸之路2014，，11： | 0 |
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