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| 1 | Peripheral blood indices to predict PFS/OS with anlotinib as a subsequent treatment in advanced small-cell lung cancer显示文摘Objective:In the phase II ALTER-1202(NCT03059797)trial,anlotinib significantly improved progression-free survival(PFS)and overall survival(OS)in patients with advanced small-cell lung cancer(SCLC)who underwent at least 2 previous chemotherapy cycles,when compared with a placebo group.To identify potential factors for predicting efficacy and prognosis with anlotinib treatment,we analyzed hematological indices at baseline and adverse events(AEs)over the course of anlotinib treatment.Methods:Data were collected from March 2017 to April 2019 from a randomized,double-blind,placebo-controlled,multicenter,phase II trial of anlotinib.Eligible patients were randomly assigned 2:1 to receive anlotinib or placebo until disease progression,intolerable toxicity,or withdrawal of consent.The patients received anlotinib(12 mg)or an analogue capsule(placebo)orally once daily for 14 days every 3 weeks.The hematological indices at baseline and AEs that occurred in the initial 2 treatment cycles were recorded.The Kaplan-Meier test and Cox regression model were used to assess survival differences.Results:A total of 82 patients(81 patients with complete data)were randomly assigned to receive anlotinib,with 38 receiving a placebo as a control.Multivariate analysis indicated that an elevated neutrophil to lymphocyte ratio>7.75 and lactate dehydrogenase>254.65 U/L at baseline were independent risk factors for PFS;basal elevated aspartate aminotransferase>26.75 U/L,neuron specific enolase>18.64 ng/mL,and fibrinogen>4.645 g/L were independent risk factors for OS.During treatment,elevatedγglutamyltransferase and hypophosphatemia were independent predictors for a poor PFS,and elevatedγ-glutamyl transferase and hypercholesterolemia were independent factors for OS.Conclusions:Our study preliminarily defined potential factors that affected the PFS and OS at baseline and during anlotinib treatment in patients with advanced SCLC.Our findings provide a basis for screening the dominant population and for dynamic efficacy monitoring with anlotinib therapy. | Cuicui Zhang Jing Wang Xinyue Wang Zhaoting Meng Ying Cheng Kai Li | 2022 | Cancer Biology & Medicine2022，19，8： | 1 |
| 2 | Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction显示文摘 | Hongjie Liu Zhaoting Wu Xianle Shi Wenzhi Li Chang Liu Dekun Wang Xiaoying Ye Lin Liu Jie Na Hong Cheng Lingyi Chen | 2013 | Developmental Biology2013，，1： | 1 |
| 3 | Numerical modeling on the interaction of internal solitary wave with slope-shelf and modal analysis显示文摘On the basis of a nonhydrostatic numerical model,the interaction of internal solitary wave with slope-shelf was studied.The breaking and polarity transformation were analyzed.A 'kink' structure,due to shoaling topography and higher nonlinear effect,was found to be generated by the leading wave before breaking.Coherent vortex shedding behind the leading wave was presented.The evolution characteristics of the modal structure were analyzed based on the empirical orthogonal function method.The modal structure was complicated due to the effect of the variable topography,especially when breaking occurred.In the performed experiments,the contributions to the total variance from higher mode jumped from no more than 20% to over 40%. | LI Qun XU Zhaoting CHEN Xu YU Jia | 2007 | Acta Oceanologica Sinica2007，26，6： | 1 |
| 4 | Distributed sparse recursive least-squares over networks 显示文摘 | Liu Zhaoting Liu Ying Li Chunguang | 2014 | IEEE Transactions on Signal Processing2014，62，6： | 1 |
| 5 | Wave drag of rapidly and horizontally moving Rankine ovoid in uniformly stratified fluid显示文摘A theory on the wave drag as the Rankine ovoids moving horizontally,uniformly and rapidly in uniformly vertical stratified fluid(or ocean)is presented.A mass source resulting from the theory in a uniform fluid is used to model a hydrodynamic interaction between the Rankine ovoid and stratification.Theoretical results show that there exists an asymptotic state of the drag in supercritical regimes where internal Froude numbers are large.When the Rankine ovoid reduces to a sphere,the result we obtained is in good agreement with the previous theoretical and experimental results.An experiment on the elongated Rankine ovoid is also carried out to validate the theoret-ical results. | Zhaoting Xu Qun Li V.A. Gorodtsov | 2008 | Progress in Natural Science:Materials International2008，18，6： | 0 |
| 6 | Numerical Simulation on the Interaction of an Internal Solitary Wave with a Step-Type Topography显示文摘Based on a nonhydrostatic numerical ocean model developed by one of the authors, the interaction of an internal solitary wave with a step-type topography was investigated. Over the step topography, the flow pattern could be classified into three catego- ries: 1) the propagation and spatial structure of the internal solitary wave was little influenced by the bottom topography, 2) the in- ternal solitary wave was significantly distorted by the blocking effect of the topography without the occurrence of wave breaking and 3) the internal solitary wave was broken as it encountered and passed over the bottom topography. A detailed description of the processes leading to wave breaking is given in this paper together with energy budget analysis. The results revealed that the maxi- mum of the energy dissipation rate is no more than 40%, which is consistent with available experimental data. | XU Zhaoting LI Qun CHEN Xu YU Jia | 2008 | Journal of Ocean University of China2008，7，2： | 0 |
| 7 | The role of dendritic cells in the immunomodulation to implanted biomaterials显示文摘Considering the substantial role played by dendritic cells(DCs) in the immune system to bridge innate and adaptive immunity,studies on DC-mediated immunity toward biomaterials principally center on their adjuvant effects in facilitating the adaptive immunity of codelivered antigens. However, the effect of the intrinsic properties of biomaterials on dendritic cells has not been clarified. Recently, researchers have begun to investigate and found that biomaterials that are nonadjuvant could also regulate the immune function of DCs and thus affect subsequent tissue regeneration. In the case of proteins adsorbed onto biomaterial surfaces,their intrinsic properties can direct their orientation and conformation, forming “biomaterial-associated molecular patterns(BAMPs)”. Thus, in this review, we focused on the intrinsic physiochemical properties of biomaterials in the absence of antigens that affect DC immune function and summarized the underlying signaling pathways. Moreover, we preliminarily clarified the specific composition of BAMPs and the interplay between some key molecules and DCs, such as heat shock proteins(HSPs) and high mobility group box 1(HMGB1). This review provides a new direction for future biomaterial design, through which modulation of host immune responses is applicable to tissue engineering and immunotherapy. | Siyuan Wang Yanqi Chen Zhaoting Ling Jia Li Jun Hu Fuming He Qianming Chen | 2022 | International Journal of Oral Science2022，14，4： | 0 |
| 8 | Nano-STING agonist-decorated microrobots boost innate and adaptive anti-tumor immunity显示文摘Activating the cyclic guanosine monophosphate-adenosine monophosphate synthase/stimulator of interferon genes(cGAS/STING)signaling has emerged as a promising anti-tumor strategy due to the important role of the pathway in innate and adaptive immunity,yet the selective delivery of STING agonists to tumors following systemic administration remains challenging.Herein,we develop a nano-STING agonist-decorated microrobot platform to achieve the enhanced anti-tumor effect.Fe ions and the STING agonist 2’3’-cyclic guanosine monophosphate-adenosine monophosphate(cGAMP)are co-encapsulated in the mitochondria-targeting nanoparticles(mTNPs),which can trigger the release of mitochondrial DNA(mtDNA)by Fenton reactioninduced mitochondria oxidative damage.The exogenous cGAMP and the endogenous mtDNA can work synergistically to induce potent cGAS/STING signaling activation.Furthermore,we decorate mTNPs onto Salmonella typhimurium VNP20009(VNP)bacteria to facilitate tumor accumulation and deep penetration.We demonstrate that the systemic administration of this microrobot activates both innate and adaptive immunity,improving the immunotherapeutic efficacy of the STING agonists. | Yixin Wang Zhaoting Li Yu Chen Allie Barrett Fanyi Mo Quanyin Hu | 2023 | Nano Research2023，16，7： | 0 |
| 9 | A survey of learning-based robot motion planning显示文摘A fundamental task in robotics is to plan collision-free motions among a set of obstacles.Recently,learning-based motion-planning methods have shown significant advantages in solving different planning problems in high-dimensional spaces and complex environments.This article serves as a survey of various different learning-based methods that have been applied to robot motion-planning problems,including supervised,unsupervised learning,and reinforcement learning.These learning-based methods either rely on a human-crafted reward function for specific tasks or learn from successful planning experiences.The classical definition and learning-related definition of motion-planning problem are provided in this article.Different learning-based motion-planning algorithms are introduced,and the combination of classical motion-planning and learning techniques is discussed in detail. | Jiankun Wang Tianyi Zhang Nachuan Ma Zhaoting Li Han Ma Fei Meng Max Q.-H.Meng | 2021 | IET Cyber-Systems and Robotics2021，3，4： | 0 |
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