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| 1 | Recent advances in autofluorescence-free biosensing and bioimaging based on persistent luminescence nanoparticles显示文摘Persistent luminescence nanoparticles (PLNPs) are a series of emerging luminescent nanomaterials which can emit persistently after ceasing the external excitation. Due to the long decay time of persistent luminescence, the background autofluorescence in complex sample and tissues can be effectively eliminated, thus significantly improving the sensitivity of bioanalysis. Besides, such a long decay time of luminescence also makes PLNPs valuable for long-term bioimaging. Benefiting from these merits, PLNPs have been widely used for biomedical applications, especially biosensing and bioimaging. In this review,we conclude the progress in the application of PLNPs at biosensing and bioimaging in recent years, and also provide our understanding of the prospects. | Qiaosong Lin Zhihao Li Quan Yuan | 2019 | Chinese Chemical Letters2019，30，9： | 5 |
| 2 | A Potential Global Standard Stratotype-Section and Point of the Moscovian Stage(Carboniferous)显示文摘Conodonts 和 fusulinids 是为细分和相关 Bashkirian 和 Moscovian 阶层的二个最广泛地使用的关於生命的组。因为在存在边界定义建议,其各个有劣势之中有许多争论,全球 Moscovian 阶段的底的定义是未定的。Declinognathodus donetzianus 容易在它的 paleogeographic 分发被认出,但是有点限制了。Idiognathoides postsulcatus 是稍微更普遍的,但是它不太容易被识别,它的出现可以是从区域的 diachronous 到区域。Diplognathodus ellesmerensis 容易被认出并且甚至更普遍,但是它通常是稀罕的,它的祖先足够地不被知道。南方贵州的 Naqing 节,华南包含多样的 conodont 在不同 taxa,包括的 Idiognathoides, Idiognathodus, Diplognathodus, Neognathodus, Gondolella 和 Mesogondolella 之中的进化的系。在有众多的过渡形式几乎 Naqing 节的每个系,哪个为华南的前景上演在决定基础 Moscovian 起一个关键作用的表演定义好。 | WANG Xiangdong QI Yuping Lance LAMBERT WANG Zhihao WANG Yue HU Keyi LIN Wei CHEN Bo | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 3 |
| 3 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
| 4 | Retrospective study of cetuximab in combination with chemotherapy for patients with colorectal cancer显示文摘Objective: To evaluate the efficacy and safety of cetuximab combined with chemotherapy in colorectal cancer (CRC). Methods: 35 cases of CRC were retrospectively analyzed. Efficacy and adverse events were observed. Results: 29 cases of CRC were evaluated by RECIST criteria, showing 7 PR (partial response, 24.1%) and 15 SD (stable disease, 51.8%), disease control rate (DC) was 75.9%. Subgroup analysis showed response rate (RR) of 36.4% and DC of 91% in the 1st line therapy, RR of 20% and DC of 70% in the 2nd line therapy, RR of 12.5% and DC of 62.5% in heavily pretreated cases. Rash appeared in 74.3% of patients (grade 3 was 8.6%), and the severity was relevant with disease control rate (DC). Neutropenia of grade 3/4 was 14.3%, and infusion related reaction (IRR) of grade 3 happened in 1 case (2.9%). Conclusion: Cetuximab combined with chemotherapy is safe and effective for patients with metastatic colorectal cancer. The combination therapy shows high DC, especially in 1st line therapy. Severity of rash may predict efficacy. | Zhihao Lu Xiaotian Zhang Lin Shen Xiaodong Zhang Jie Li Zhongtao Zhang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，7： | 2 |
| 5 | Modification of Hole Transport Layers for Fabricating High Performance Non-fullerene Polymer Solar Cells显示文摘Interfacial engineering is expected to be a feasible strategy to improve the charge transport properties of the hole transport layer(HTL),which is of crucial importance to boost the device performance of organic solar cells(OSCs).In this study,two types of alcohol soluble materials,2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane(F4-TCNQ)and di-tetrabutylammoniumcis-bis(isothiocyanato)bis(2,2'-bipyridyl-4,4'-dicarboxylato)ruthenium(ll)(N719)dye were selected as the dopant for HTL.The doping of F4-TCNQ and N719 dye in poly(ethylenedioxythiophene):poly(styrene sulfonate)(PEDOT:PSS)with and without integrating a graphene quantum-dots(G-QDs)layer has been explored in poly[[2,6'-4-8-di(5-ethylhexylthienyl)benzo[1,2-b:3,3-b]dithiophene][3-fluoro-2[(2-ethylhexyl)carbonyl]thieno[3,4-b]thio-phenediyl:(2,2'-((2Z,2'Z)-(((4,4,9,9-tetrakis(4-hexylphenyl)-4,9-dihydro-s-indaceno[1,2-b:5,6-b']dithiophene-2,7-diyl)bis(4-((2-ethylhexyl)oxy)thiophene-5,2-diyl))bis(methanylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile(PTB7-Th:IEICO-4F)OSCs.The power conversion efficiency of the non-fullerene OSCs has been increased to 10.12%from 8.84%.The influence of HTL modification on the nano-morphological structures and photophysical properties is analyzed based on the comparative studies performed on the control and modified devices.The use of chemical doping and bilayer strategy optimizes the energy level alignment,nanomorphology,hole mobility,and work-function of HTL,leading to considerable reduction of the leakage current and recombination losses.Our work demonstrates that the doping of HTL and the incorporation of G-QDs layer to constitute a bilayer HTL is an promising strategy to fabricate high performance non-fullerene polymer solar cells. | B.Hari Babu Chengkun Lyu Hongwei Zhang Zhihao Chen Fenghong Li Lin Feng Xiao-Tao Hao | 2020 | Chinese Journal of Chemistry2020，38，8： | 2 |
| 6 | Current Status and Future Perspective of Immunotherapy in Gastrointestinal Cancers显示文摘Gastrointestinal(GI)cancers represent a major public health problem worldwide.Due to the late detection and high heterogeneity of GI cancers,traditional treatments,including surgery,radiotherapy,chemotherapy,and targeted therapy,have shown limited effects,and the overall prognosis of these patients remains poor.Recently,immunotherapy,involving programmed cell death-1(PD-1)and its ligand(PD-L1),has shown promising efficacy in several solid cancers and seems to have become a potential treatment option for GI cancers This review focuses on data on the development of immunotherapy-based clinical trials in esophageal cancer,gastric cancer,and colorectal cancer.The predictive biomarkers and combination strategies in clinical trials and translational medicine are also discussed.Finally,prospects for immunotherapy in the treatment of GI cancers are described.Although only a small proportion of patients with GI cancers respond to PD-1/PD-L1 blockade,we strongly believe that precision immunotherapy might improve the overall survival of many more GI cancer patients in the future. | Zhihao Lu Zhi Peng Chang Liu Zhenghang Wang Yakun Wang Xi Jiao Jian Li Lin Shen | 2020 | The Innovation2020，1，2： | 1 |
| 7 | BioPPIExtractor:a protein-protein interaction extraction system for biomedical literature显示文摘 | LIN Hongfei WU Baodong | 2007 | Expert Systems with Applications2007，，12： | 1 |
| 8 | Exploiting the contextual cues for bio-entity name recognition in biomedical literature显示文摘 | LIN Hongfei LI Yanpeng | 2008 | Journal of Biomedical Informatics2008，，1： | 1 |
| 9 | Synthesis of diamond using nano-graphite and Fe powder under high pressure and high temperature显示文摘 | Chao Wen Zhihao Jin Xiaoxin Liu Deyu Sun Xun Li Gang Zhou Junde Lin Zhaoyin Hao | 2006 | Materials Letters2006，，29： | 1 |
| 10 | Osteopontin promotesinflammation in patients with acute coronary syndromethrough its activity on IL-17 producing cells 显示文摘 | YING X Z ZHIHAO W LIN D | 2012 | Eur J Immu-nol2012，42，10： | 1 |
| 11 | Serum levels of TUBB3 correlate with clinical outcome in Chinese patients with advanced gastric cancer receiving first-line paclitaxel plus capecitabine显示文摘 | Jingwei Yu Jing Gao Zhihao Lu Yilin Li Lin Shen | 2012 | Medical Oncology2012，，5： | 1 |
| 12 | Effi- cient overlapping community detection in huge real world networks显示文摘 | Wu Zhihao Lin Youfang Wan Huaiyu | 2012 | Physica A2012，391，7： | 1 |
| 13 | BiOPPISVM Extractor:A Protein-protein Interaction Extractor for Biomedical Literature Using SVM and Rich Feature Sets显示文摘 | Yang Zhihao Lin Hongfei Li Yanpeng | 2010 | Journal of Biomedical Informatics2010，43，1： | 1 |
| 14 | High conductivity polymer electrolyte with comb-like structure via a solvent-free UV-cured method for large-area ambient all-solid-sate lithium batteries显示文摘A novel solid polymer electrolyte with comb-like structure is prepared via a solvent-free UV-cured method.The relationship between conductivity and molecular weight is investigated and revealed.The optimal electrolyte presents a considerably high conductivity of 1.44·10^(-4)S·cm^(-1)at 30℃.Meanwhile,it shows excellent compatibility with metallic lithium and wide electrochemical window(>5 V).To investigate the safety and cycling performance,the coin cell and soft package battery are assembled respectively.The LiFePO_(4)/Li coin cells exhibit initial discharge specific capacities of 163.2,147.7,137.3 and 108.7 mA·h·g^(-1)at 0.1,0.2,0.5 and 1C under 60℃,respectively.Notably,when the coin cells work at 30℃,the initial discharge specific capacities at 0.05,0.1,0.2 and 0.5C are 140.5,133.5,107.7 and 55.6 mA·h·g^(-1).Significantly,a 3.5 cm×7 cm solid-state soft pack battery is fabricated and cycling at 30℃.The first discharge capacity reaches to 137.5 mA·h·g^(-1)and the capacity retention is as high as 84.4%after 100 cycles at 0.2C and remain 95.5%after 100 cycles at 0.5C,respectively.These results shows a promising solid polymer electrolyte for solid-state batteries with good cycling and safety performance. | Zhihao Wang Shaojie Chen Zhen Huang Zhenyao Wei Lin Shen Hui Gu Xiaoxiong Xu Xiayin Yao | 2019 | Journal of Materiomics2019，5，2： | 1 |
| 15 | Environmental im- pacts of heavy metals (Co, Cu, Pb, Zn) in surficial sediments of estuary in Daliao River and Yingkou Bay (Northeast Chi- na) : concentration level and chemical fraction 显示文摘 | WU Zhihao HE Mengchang LIN Chunye | 2012 | Environ- mental Earth Sciences2012，66，8： | 1 |
| 16 | Distribution and speciation of four heavy metals (Cd, Cr, Mn and Ni) in the surficial sediments from estuary in Daliao River and Yingkou Bay显示文摘 | WU Zhihao HE Mengchang LIN Chunye | 2011 | Environmental Earth Sciences2011，63，1： | 1 |
| 17 | Biomolecular Event Trigger Detection Using Neighborhood Hash Features显示文摘 | Zhang Yijia Lin Hongfei Yang Zhihao | | 0，，： | 1 |
| 18 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 19 | Zeolite-mediated hybrid Cu^(+)/Cu~0 interface for electrochemical nitrate reduction to ammonia显示文摘The electrocatalytic conversion of reactive nitrogen species to ammonia is a promising strategy for efficient NH_(3) synthesis.In this study,we reveal that the hybrid Cu^(+)/Cu~0 interface is catalytically active for electrochemical ammonia synthesis from nitrate reduction.To maintain the hybrid Cu^(+)/Cu~0 state at negative reaction potentials,hydrophilic zeolite is used to modify Cu/Cu_(2)O electrocatalyst,which demonstrates an impressive NH_(3) production rate of 41.65 mg h^(-1) cm^(-2)with ~100% Faradaic efficiency of ammonia synthesis at-0.6 V vs.RHE.In-situ Raman spectroscopy unveil the high activity originates from the zeolite reconstruction at the electrode–electrolyte interface,which protects the valence state of Cu~0/Cu^(+) site under negative potential and promotes electrochemical activity towards NH_(3) synthesis. | Jiabao Lv Angjian Wu Liang Wang Yunhao Zhong Zhihao Zeng Qunxing Huang Xiaoqing Lin Hao Zhang Shaojun Liu Qian Liu Songqiang Zhu Xiaodong Li Jianhua Yan Zhifu Qi Hao Bin Wu | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 20 | Flexible triboelectric nanogenerator toward ultrahigh-frequency vibration sensing显示文摘Flexible high-frequency vibration sensors are highly desirable in various real-world applications such as structural health monitoring,environmental monitoring,and the internet of things.However,developing a facile and effective method to fabricate vibration sensors simultaneously featuring high vibration frequency response-ability and flexibility remains a grand challenge.Herein,we report a flexible ultrahigh-frequency triboelectric vibration sensor(UTVS)prepared by a layer-particle-layer structure.Owing to the flexibility of the materials(i.e.,polyethylene terephthalate membrane)and the ultrahigh-frequency vibration response-ability of internal microparticles,the flexible UTVS exhibits an enhanced working frequency range of 3–170 kHz,which is much broader than previously reported triboelectric vibration sensors.Moreover,the UTVS can work not only in a flat state but also in a bent state due to its flexibility and the unique layer-particle-layer structural design.The UTVS shows nanometer-level vibration response-ability,omnidirectional response,stability in the temperature range of 10–70°C,good frequency resolution of 0.01 kHz,and excellent performance in burst vibration detection(e.g.,pencil lead break events and impact events from falling steel balls).With a collection of compelling features,the device is successfully demonstrated in vibration monitoring of curved structures(e.g.,real-time water pipeline leak monitoring).Such a flexible ultrahigh-frequency triboelectric vibration sensor holds great potential in a wide range of practical applications,such as communication,health care,and infrastructure monitoring. | Zhiwei Lin Chenchen Sun Gaoqiang Zhang Endong Fan Zhihao Zhou Ziying Shen Jun Yang Mingyang Liu Yushu Xia Shaobo Si Jin Yang | 2022 | Nano Research2022，15，8： | 0 |
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