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| 1 | The combined effects of the ENSO and the Arctic Oscillation on the winter climate anomalies in East Asia显示文摘With the warm/cold phases of the El Ni o and Southern Oscillation (ENSO) as a background, the impacts of monthly variation in the Arctic Oscillation (AO) on the winter climate anomalies in East Asia are studied with the NCEP/DOE Reanalysis 2 data and the Chinese station data regarding temperature and rainfall. The combined effects of ENSO and the AO indicate that the winter climate anomalies are mainly influenced by the AO in northern China and the ENSO in southern China, when an El Ni o couples with a negative AO month or a La Ni a couples with a positive AO month. These climate anomalies in China are consistent with the mechanisms proposed in previous studies. However, most of China presents a different pattern of climate anomalies if an El Ni o couples with a positive AO month or a La Ni a couples with a negative AO month, with the exception of the temperature anomalies in northern China, which are still affected dominantly by the AO. Further analysis suggests that the causes are attributed to the differences in both the stratosphere-troposphere interaction and the extratropics-tropics interaction. In the former cases, zonal symmetric circulation prevails in the winter and the extratropics-tropics interaction is weakened. Thus, the influences of the ENSO and the AO on the East Asian climate mainly present linear combination effects. On the contrary, an annular mode of atmospheric circulation is not favored in the latter cases and the extratropics-tropics interaction is strong. Hence, the combined effects of the ENSO and the AO on the winter climate in East Asia present nonlinear characteristics. | CHEN Wen LAN XiaoQing WANG Lin MA Yin | 2013 | Chinese Science Bulletin2013，58，12： | 30 |
| 2 | One-step strategy to graphene/Ni(OH)2 composite hy- drogels as advanced three-dimensional supercapacitor electrode materials显示文摘基于 Graphene 三维(3D ) 宏观的材料最近在电气化学的精力变换和存储由他们的令人激动的潜力的优点吸引了增加的兴趣。这里,我们报导灵巧的一步舞策略准备机械地强壮、电子上传导性的 graphene/Ni (哦) 有一个互连的多孔的网络的 2 合成 hydrogels。没有增加任何另外的文件夹或传导性的添加剂,合成 hydrogels 直接被用作 3D supercapacitor 电极材料。包含 82 wt.% Ni 的优化合成 hydrogel (哦) 2 与优秀骑车在 40 mV/s (63% 电容保留) 以 5 mV/s 和 785 F/g 的扫描率展出了 1,247 F/g 的一个特定的电容稳定性。3D hydrogels 的能力极大地超过 graphene 表和 Ni 的物理混合物的(哦) 2 nanoplates (在 40 mV/s 的 309 F/g ) 。一样的策略也被使用制作 graphene 碳 nanotube/Ni (哦) 有进一步改进的特定的电容(在 5 mV/s 的 1,352 F/g ) 和率能力(在 40 mV/s 的 66% 电容保留) 的 2 第三的合成 hydrogels。这里获得的两合成 hydrogels 能交付高精力密度(43 和 47 Wh/kg,分别地) 并且力量密度(8 和 9 kW/kg,分别地) ,为 supercapacitor 应用使他们成为吸引人的电极材料。这研究打开一条新小径到功能的 3D graphene 的设计和制造合成材料,和罐头显著地包括精力存储并且在以外影响宽广区域。 | Yuxi Xu Xiaoqing Huang Zhaoyang Lin Xing Zhong Yu Huang Xiangfeng Duan | 2013 | Nano Research2013，6，1： | 28 |
| 3 | Neuroprotective effect of ethyl acetate extract from gastrodia elata against transient focal cerebral ischemia in rats induced by middle cerebral artery occlusion显示文摘OBJECTIVE: To investigate the protective effect of neuroprotection against transient focal cerebral ischemia of the extract from Tianma(Rhizoma Gastrodiae) and the possible mechanisms underlying the action.METHODS: Cerebral ischemia-reperfusion injury was induced through middle cerebral artery occlusion(MCAO). Adult male Sprague-Dawley rats were randomly divided into four groups: sham-operated,ischemia-reperfusion model, 102.6 mg/kg extract treated and 11.4 mg/kg extract treated groups. The extract was prepared from gastrodia elata with ethyl acetate. The effect of the extract tested on rat neurological de fi cits and Cerebral index, cerebral infarct volume, brain injury, terminal dexynucleotidyl transferase-mediated d UTP nick end labeling(TUNEL) and B-cell lymphoma-2(Bcl-2) positive cells.RESULTS: The extract was able to reduce neurological scores, cerebral index and cerebral infarction rate. The brain injury was also relieved by the extract. The results of immunofluorescence staining analysis indicated that the extract increased the expression of Bcl-2 and reduced TUNEL-positive cells significantly in the extract treated groups.CONCLUSION: These results suggested that the extract relieved ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect might be partially due to the attenuated apoptosis pathway. | Duan Xiaohua Wang Weili Liu Xiaoqing Yan Hanwen Dai Rong Lin Qing | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 18 |
| 4 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 5 | Exosomes: roles and therapeutic potential in osteoarthritis显示文摘Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis(OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling.This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future. | Zhenhong Ni Siru Zhou Song Li Liang Kuang Hangang Chen Xiaoqing Luo Junjie Ouyang Mei He Xiaolan Du Lin Chen | 2020 | Bone Research2020，8，2： | 10 |
| 6 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 7 | Development and validation of an ocean wave retrieval algorithm for VV-polarization Sentinel-1 SAR data显示文摘The purpose is to study the accuracy of ocean wave parameters retrieved from C-band VV-polarization Sentinel-1Synthetic Aperture Radar(SAR) images, including both significant wave height(SWH) and mean wave period(MWP), which are both calculated from a SAR-derived wave spectrum. The wind direction from in situ buoys is used and then the wind speed is retrieved by using a new C-band geophysical model function(GMF) model,denoted as C-SARMOD. Continuously, an algorithm parameterized first-guess spectra method(PFSM) is employed to retrieve the SWH and the MWP by using the SAR-derived wind speed. Forty–five VV-polarization Sentinel-1 SAR images are collected, which cover the in situ buoys around US coastal waters. A total of 52 subscenes are selected from those images. The retrieval results are compared with the measurements from in situ buoys. The comparison performs good for a wind retrieval, showing a 1.6 m/s standard deviation(STD) of the wind speed, while a 0.54 m STD of the SWH and a 2.14 s STD of the MWP are exhibited with an acceptable error.Additional 50 images taken in China's seas were also implemented by using the algorithm PFSM, showing a 0.67 m STD of the SWH and a 2.21 s STD of the MWP compared with European Centre for Medium-range Weather Forecasts(ECMWF) reanalysis grids wave data. The results indicate that the algorithm PFSM works for the wave retrieval from VV-polarization Sentinel-1 SAR image through SAR-derived wind speed by using the new GMF C-SARMOD. | LIN Bo SHAO Weizeng LI Xiaofeng LI Huan DU Xiaoqing JI Qiyan CAI Lina | 2017 | Acta Oceanologica Sinica2017，36，7： | 7 |
| 8 | Quasi-stationary planetary wave-mean flow interactions in the Northern Hemisphere stratosphere and their responses to ENSO events显示文摘Based on the ERA-40 reanalysis data from the European Centre for Medium-Range Weather Forecasts and the output of ECHAM5/MPI-OM, this study investigated the interactions between the quasi-stationary planetary wave (SPW) and mean flow, and their responses to El Ni o-Southern Oscillation (ENSO) events in the northern hemispheric stratosphere. Results show that the activity of SPW is the strongest in winter, when the SPW propagates along the polar waveguide into the stratosphere and along the low-latitude waveguide to the subtropical tropopause. The analysis of three dimensional SPW structure indicates that the main sources of SPW activity are located over the Eurasian continent and the North Pacific north of 45°N. On the one hand, the two waveguides of the SPW reflect the influence of mean flow on the propagation of the SPW. On the other hand, the upward propagating SPW can interact with the stratospheric mean flow, leading to deceleration of the zonal mean westerly. Furthermore, the SPW exhibits clear responses to ENSO events. During El Ni o winters, the SPW in the stratosphere tends to propagate more upward and poleward. Its interactions with mean flow can induce a dipole pattern in zonal mean zonal winds, with accelerated westerly winds at low-middle latitudes and decelerated westerly winds at high latitudes. The ECHAM5/MPI-OM model reproduces the climatology of the SPW well. Although the simulated SPW is slightly weaker than the observations in the stratosphere, the model's performance has significant improvements compared with other GCMs used in previous studies. However, there are still some problems in the responses of the SPW to ENSO in the model. Although the model reproduces the responses of both the amplitude and the SPW-mean flow interactions to ENSO well in the troposphere, the stratospheric responses are quite weak. Therefore, further studies are needed to improve the simulation of the stratospheric atmospheric circulation and related dynamical processes. | LAN XiaoQing CHEN Wen WANG Lin | 2012 | Science China Earth Sciences2012，55，3： | 6 |
| 9 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 10 | Removal of PCDD/Fs and PCBs from flue gas using a pilot gas cleaning system显示文摘A 100 Nm3 /hr capacity pilot scale dual bag filter (DBF) system was tested on the flue gas from an actual hazardous waste incinerator (HWI), the removal efficiency of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) was also studied. The first filter collected most of the fly ash and associated chlorinated organic; then activated carbon (AC) was injected and used to collect phase chlorinated organic from the gas. Concentrations of PCDD/Fs and PCBs after the DBF system were 0.07 and 0.01 ng TEQ/Nm3 , respectively, which were both far below the national emission standard. Comparing with the original single bag filter system, the PCDD/Fs concentration dropped a lot from 0.36 to 0.07 ng TEQ/Nm3 . Increasing AC feeding rate enhanced their collection efficiency, yet reduced the AC utilization efficiency, and it still needs further study to select an appropriate feeding rate in the system. These results will be useful for industrial application and assist in controlling emissions of PCDD/Fs and other persistent organic pollutions from stationary sources in China. | Xiaoqing Lin Yuqi Jin Hailong Wu Tong Chen Xiaodong Li Shengyong Lu Xuguang Jiang Jianhua Yan | 2013 | Journal of Environmental Sciences2013，25，9： | 5 |
| 11 | An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing显示文摘Moderately regulating vascularization and immune microenvironment of wound site is necessary to achieve scarless wound healing of the skin.Herein,we have prepared an angiogenesis-promoting and scar-preventing band-aid with a core-shell structure,that consists of MXene-loaded nanofibers(MNFs)as the core and dopamine-hyaluronic acid hydrogel(H)as the shell(MNFs@V-H@DA)to encapsulate a growth factor(vascular endothelial growth factor,VEGF,abbreviated as V)and H2S donor(diallyl trisulfide,DATS,abbreviated as DA).The continuous release of DA from this system produced H2S,which would successfully induce macrophages to polarize into M2-lile phenotype,regulating the immune microenvironment and inhibiting an excessive inflammatory response at the wound sites.It is conducive to the proliferation of skin cells,facilitating the wound healing.In addition,an appropriate amount of VEGF can be released from the MXene nanofibrous skeleton by adjusting the time of near-infrared(NIR)light exposure,preventing excessive neovascularization and extracellular matrix deposition at the wound sites.Collectively,this NIR photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue. | Lin Jin Xiaoqing Guo Di Gao Yan Liu Jiahua Ni Zhiming Zhang Yiqiao Huang Guibin Xu Zhe Yang Xingcai Zhang Xianhan Jiang | 2022 | Bioactive Materials2022，7，10： | 4 |
| 12 | A post-GWAS confirming the genetic effects and functional polymorphisms of AGPAT3 gene on milk fatty acids in dairy cattle显示文摘Background: People are paying more attention to the healthy and balanced diet with the improvement of their living standards. Milk fatty acids(FAs) have been reported that they were related to some atherosclerosis and coronary heart diseases in human. In our previous genome-wide association study(GWAS) on milk FAs in dairy cattle, 83 genomewide significant single nucleotide polymorphisms(SNPs) were detected. Among them, two SNPs, ARS-BFGL-NGS-109493 and BTA-56389-no-rs associated with C18 index(P = 0.0459), were located in the upstream of 1-acylglycerol-3-phosphate O-acyltransferase 3(AGPAT3) gene. AGPAT3 is involved in glycerol-lipid, glycerol-phospholipid metabolism and phospholipase D signaling pathways. Hence, it was inferred as a candidate gene for milk FAs. The aim of this study was to further confirm the genetic effects of the AGPAT3 gene on milk FA traits in dairy cattle.Results: Through re-sequencing the complete coding region, and 3000 bp of 5′ and 3′ regulatory regions of the AGPA T3 gene, a total of 17 SNPs were identified, including four in 5′ regulatory region, one in 5′ untranslated region(UTR),three in introns, one in 3′ UTR, and eight in 3′ regulatory region. By the linkage disequilibrium(LD) analysis with Haploview4.1 software, two haplotype blocks were observed that were formed by four and 12 identified SNPs,respectively. Using SAS9.2, we performed single locus-based and haplotype-based association analysis on 24 milk FAs in 1065 Chinese Holstein cows, and discovered that all the SNPs and the haplotype blocks were significantly associated with C6:0, C8:0 and C10:0(P < 0.0001–0.0384). Further, with Genomatix, we predicted that four SNPs in 5′ regulatory region(g.146702957 G > A, g.146704373 A > G, g.146704618 A > G and g.146704699 G > A) changed the transcription factor binding sites(TFBSs) for transcription factors SMARCA3, REX1, VMYB, BRACH, NKX26, ZBED4, SP1, USF1, ARNT and FOXA1. Out of them, two SNPs were validated to impact transcriptional activity by performing luciferase assay that the alleles A of both SNPs, g.146704373 A > G and g.146704618 A > G, increased the transcriptional activities of AGPAT3 promoter compared with alleles G(P = 0.0004).Conclusions: In conclusion, our findings first demonstrated the significant genetic associations of the AGPAT3 gene with milk FAs in dairy cattle, and two potential causal mutations were detected. | Lijun Shi Xin Wu Yuze Yang Zhu Ma Xiaoqing Lv Lin Liu Yanhua Li Feng Zhao Bo Han Dongxiao Sun | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
| 13 | Study on the relationship between waste classification,combustion condition and dioxin emission from waste incineration显示文摘Domestic waste in China is mainly collected as a combination of different types of materials.The components are variable and complex,with very different combustion characteristics making it difficult to optimize the burning to reduce pollution.There are still some controversies about the accuracy of using carbon monoxide(CO)emission to characterize waste incineration performance.Here,we investigated the relationship between waste classification,incineration conditions and dioxin emission and concluded that the concentration of CO in flue gas could not be used as the only criterion of combustion efficiency and safety.Considering the close relationship between the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs)and products of incomplete combustion,the relatively low concentrations of CO are not a reliable indicator that an incinerator equipped with an activated carbon injection system and fabric filter could achieve the national standards for PCDD/F emission.The goal,therefore,is not only to lower the emission of PCDD/Fs and other pollutants through clas-sifying the waste components at the source,but also to reduce the need for the treatment of incinerated waste to protect the environment and to increase the power generation efficiency of municipal solid waste incineration(MSWI)plants.As the demand for waste disposal continues to rapidly increase,the need for a safe waste incineration system with dioxin emission controls makes the classification of waste an indispensable part of future MSWI systems. | Xiaodong Li Yunfeng Ma Mengmei Zhang Mingxiu Zhan Peiyue Wang Xiaoqing Lin Tong Chen Shengyong Lu Jianhua Yan | 2019 | Waste Disposal and Sustainable Energy2019，1，2： | 3 |
| 14 | Estimation on organic carbon content of source rocks by logging evaluation method as exemplified by those of the 4^(th) and 3^(rd) members of the Shahejie Formation in western sag of the Liaohe Oilfield显示文摘One of the most important tasks of evaluating natural resources of petroliferous basins is to determine the organic matter abundance of source rocks in the basin.The usual method for assessing the organic carbon content of source rocks is based on laboratory analyses.There is a deviation in calculating organic carbon content due to the heterogeneous distribution of organic matter and the artificial factors when sampling.According to the continuous characteristics of information logging,the conventional logging curves(mainly acoustics and resistivity,etc.) were calibrated with the organic carbon experimental data of cores,cuttings or sidewall cores.The organic carbon content of source rocks of the 4 th(Es 4) and 3 rd(Es 3) members of the Shahejie Formation in western sag in the Liaohe depression was estimated directly by a great amount of continuous data including resistivity and acoustic logging,etc.Comparison between the results from computer processing and lab analysis of logging data shows that the organic carbon contents derived from the computer processing of logging data have the same reliability and accuracy as the lab analysis results.The present data show that this method is suitable to evaluate the source rocks of western sag in the Liaohe depression and has great potential in evaluating natural resources of sedimentary basins in the future.On the basis of logging data of source rocks,experimental data and existing geochemical analyses of the Liaohe Oilfield,the corresponding total organic carbon(TOC) isograms of source rocks were plotted.The source rocks of Es 4 and Es 3 of the Shahejie Formation are thought to be beneficial to hydrocarbon accumulation due to the high TOC. | LIU Luofu SHANG Xiaoqing WANG Ping GUO Yongqiang WANG Weili WU Lin | 2012 | Chinese Journal Of Geochemistry2012，31，4： | 3 |
| 15 | Ultra-stable silica-coated chiral Au-nanorod assemblies: Core-shell nanostructures with enhanced chiroptical properties显示文摘 | Bing Han Lin Shi Xiaoqing Gao Jun Guo Ke Hou Yonglong Zheng Zhiyong Tang | 2016 | Nano Research2016，9，2： | 3 |
| 16 | The LTR of endogenous retrovirus ev21 retains promoter activity and exhibits tissue specific transcription in chicken显示文摘Endogenous viruses integrate into the host genome and influence the expression of neighboring genes through their long terminal repeats (LTRs). In this study, we analyzed the promoter, enhancer and transcriptional activities of the chicken endogenous retrovirus ev21 LTR. The LTR was cloned into pGL3-basic and pGL3-promoter luciferase vectors in forward and reverse orientation separately. The luciferase activities were detected respectively in chicken embryonic fibroblast cell, human embryonic kidney cell line, human lung carcinoma cell line, Chinese hamster ovary cell line, and murine melanoma cell line. Relative luciferase activity analysis indicated that the ev21 LTR retained bi-directional promoter activity but no detectable enhancer activity in these cells. The constructs containing the LTR and F1 region show stronger promoter activity than the constructs containing only LTR. The transcriptional pattern of ev21 LTR varied in tissues of late feathering White Leghorn chicken at post-hatch day one. Skin exhibits the highest expression in the tissues examed. Collectively, our results indicate that the ev21 LTR exhibits tissue-type specific expression in White Leghorn chicken, and it also have regulatory potential. | LU XiaoQing HAN JinRun LIU XiaoFang LIN TongHui LI YuLin HU XiaoXiang LI Ning | 2009 | Chinese Science Bulletin2009，54，24： | 3 |
| 17 | Ultralow friction polymer composites incorporated with mono-dispersed oil microcapsules显示文摘Ultralow friction polymer composites were prepared by adding oil-loaded microcapsules into epoxy(EP)resin.Mono-dispersed polystyrene(PS)/poly alpha olefin(PAO)microcapsules with a diameter of~2μm and a shell thickness of~30 nm were prepared by solvent evaporation method in an oil-in-water emulsion.The lubrication behaviors of the EP resin composites with oil-loaded microcapsules have been investigated under different loads and sliding speeds.As compared with the pure EP resin,the friction coefficient of the composite could be reduced to 4%(from 0.71 to 0.028)and the wear rate could be decreased up to two orders of magnitude.It was demonstrated that the released PAO oil from the microcapsules during the friction process produced a boundary lubricating film,which could prevent the direct contact of two rubbing surfaces,and thus leading to an extremely low friction coefficient and wear rate.Moreover,the composites with microcapsules could achieve comparable lubrication properties to the case under the external lubrication condition,while the former case could effectively minimize the lubricant leakage and improve the lubrication efficiency. | Lin ZHANG Guoxin XIE Shuai WU Shiguang PENG Xiaoqing ZHANG Dan GUO Shizhu WEN Jianbin LUO | 2021 | Friction2021，9，1： | 3 |
| 18 | Pattern Scan Laser Photocoagulator on Retinopathy: an annual clinical application summary显示文摘Purpose:To evaluate the clinical efficacy of Pattern Scan Laser Photocoagulator (PASCAL) by observing the efficacy of PASCAL on retinopathy.Methods:A total of 92 patients with retinopathy (121 eyes) who underwent PASCAL between December 2008 and February 2009 in our center were retrospectively analyzed to evaluate the visual acuity changes and recovery conditions of the patients from baseline to posterior to the treatment.The retinopathy included:diabetic retinopathy,ischemic retinal vein occlusion.(IRVO),central serous chorioretinopathy (CSC),retinal periphlebitis (Eales disease) and retinal degeneration /holes.Results:The patients were subject to a 12-month follow up after PASCAL.The visual acuity findings were stated as below:for diabetic retinopathy.(73 eyes),10 eyes had improved visual acuity;55 eyes were stabilized and 8 eyes progressed;for IRVO (13 eyes),4 eyes showed improvement,6 eyes were stabilized and 3 eyes progressed;for CSC (9 eyes),6 eyes were alleviated and 3 eyes progressed;for retinal periphlebitis (5 eyes),2 eyes had enhanced visual acuity and 3 eyes showed stable visual acuity;for retinal degeneration /holes (21 eyes),5 eyes presented improved visu-al acuity,16 eyes were stabilized and no eye progressed.Indirect ophthalmoscopic reexamination confirmed secured blockage by laser spots and favorable absorption of the retinal edema and newborn capillaries.No obvious leakage was observed during fundus fluorescein angiography and no laser-related ocular adverse effect was reported.Conclusion:PASCAL is accurate,effective and well-tolerated.The duration of short laser pulse falls within the safety range,ensuring the stabilization and improvement in the pa-tient's visual acuity.The parameters,long-term efficacy and complications of PASCAL should be further demonstrated by performing long-term clinical trials with larger sample size. | Haiyun Ye Chenjin Jin Xiaoqing Zhong Zhen Tian Wanyi Lin | 2011 | Eye Science2011，26，2： | 3 |
| 19 | Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells显示文摘Fe-based single-atomic site catalysts(SASCs),with the natural metalloproteases-like active site structure,have attracted widespread attention in biocatalysis and biosensing.Precisely,controlling the isolated single-atom Fe-N-C active site structure is crucial to improve the SASCs’performance.In this work,we use a facile ion-imprinting method(IIM)to synthesize isolated Fe-N-C single-atomic site catalysts(IIM-Fe-SASC).With this method,the ion-imprinting process can precisely control ion at the atomic level and form numerous well-defined single-atomic Fe-N-C sites.The IIM-Fe-SASC shows better peroxidase-like activities than that of non-imprinted references.Due to its excellent properties,IIM-Fe-SASC is an ideal nanoprobe used in the colorimetric biosensing of hydrogen peroxide(H_(2)O_(2)).Using IIM-Fe-SASC as the nanoprobe,in situ detection of H_(2)O_(2)generated from MDA-MB-231 cells has been successfully demonstrated with satisfactory sensitivity and specificity.This work opens a novel and easy route in designing advanced SASC and provides a sensitive tool for intracellular H_(2)O_(2)detection. | Zhaoyuan Lyu Shichao Ding Maoyu Wang Xiaoqing Pan Zhenxing Feng Hangyu Tian Chengzhou Zhu Dan Du Yuehe Lin | 2021 | Nano-Micro Letters2021，13，9： | 2 |
| 20 | Enhancing hydrogen evolution on the basal plane of transition metal dichacolgenide van der Waals heterostructures显示文摘Recent years have seen a surge in the use of low-dimensional transition metal dichacolgenides,such as MoS_(2),as catalysts for the electrochemical hydrogen evolution reaction.In particular,sulfur vacancies in MoS_(2)can activate the inert basal plane,but that requires an unrealistically high defect concentration(~9%)to achieve optimal activity.In this work,we demonstrate by firstprinciples calculations that assembling van der Waals heterostructures can enhance the catalytic activity of MoS_(2)with low concentrations of sulfur vacancies.We integrate MoS_(2)with various two-dimensional nanostructures,including graphene,h-BN,phosphorene,transition metal dichacolgenides,MXenes,and their derivatives,aiming to fine-tune the free energy of atomic hydrogen adsorption.Remarkably,an optimal free energy can be achieved for a low sulfur vacancy concentration of~2.5%in the MoS_(2)/MXene-OH heterostructure,as well as high porosity and tunability.These results demonstrate the potential of combining two-dimensional van der Waals assembly with defect engineering for efficient hydrogen production. | Faling Ling Wei Kang Huirong Jing Wen Zeng Yankun Chen Xiaoqing Liu Yixin Zhang Lin Qi Liang Fang Miao Zhou | 2019 | npj Computational Materials2019，，1： | 2 |
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