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| 1 | New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions显示文摘Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent years.Zhuangguguanjiewan pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)model.This present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS model.Liver function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated rats.Moreover,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated rats.Furthermore,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic hepatotoxicity.Thus,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 inflammasome.In addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic pathways.Therefore,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions. | Yuan Gao Zhilei Wang Jinfa Tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan Wang Yu Pang Ruisheng Li Yaming Zhang Jiabo Wang Ming Niu Zhaofang Bai Xiaohe Xiao | 2020 | Frontiers of Medicine2020，14，1： | 32 |
| 2 | Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis显示文摘光是在 Arabidopsis 通过蓝色和调停 cryptochrome 的 red/far-red 光光敏电阻器和调停 phytochrome 的小径禁止胚轴房间延伸的关键环境暗示。相反,作为枢轴的内长的植物激素,植物生长素通过 AUX/IAA 蛋白质(AUX/IAAs ) 的植物生长素受体 TIR1/AFBs-mediated 降级支持胚轴延伸。然而,位于发信号的光和植物生长素的对抗相互作用下面的分子的机制仍然保持不清楚。这里,我们报导光禁止由 cryptochrome 的蓝、红的轻依赖者的相互作用通过 AUX/IAAs 的稳定发信号的植物生长素 1 (CRY1 ) 并且有 AUX/IAAs 的 phytochrome B 分别地。有 AUX/IAAs 的 CRY1 的蓝被触发光的相互作用与 AUX/IAAs 禁止 TIR1 的协会,导致这些蛋白质的导致植物生长素的降级的压抑。我们的结果显示光敏电阻器下游地直接作为一样与植物生长素受体分享 AUX/IAAs 表明部件。我们建议由光敏电阻器和植物生长素受体的 AUX/IAA 蛋白质稳定性的那条对抗规定允许植物平衡光和植物生长素信号优化他们的生长。 | Feng Xu Shengbo He Jingyi Zhang Zhilei Mao Wenxiu Wang Ting Li Jie Hua Shasha Du Pengbo Xu Ling Li Hongli Lian Hong-Quan Yang | 2018 | Molecular Plant2018，11，4： | 24 |
| 3 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 4 | Electrochemical single nucleotide polymorphisms genotyping on surface immobilized three-dimensional branched DNA nanostructure显示文摘An electrochemical assay for single nucleotide polymorphisms (SNPs) genotyping is reported. Although electrochemical method is sensitive for DNA detection on surfaces, the ability of surface assay to precisely recognize DNA hybridization event is sacrificed to some extent due to the crowded confined surfaces environments that disfavor DNA hybridization. In the present study, we employed branched tetrahedron structure probes (TSPs) to replace regular linear single stranded DNA capture probes that were immobilized on solid surfaces. This three-dimensional DNA nanostructure lowers the density of immobilized DNA probes on confined surfaces, providing a hybridization environment that is similar to homogenous solution. This TSP-based electrochemical assay reveals excellent performance for SNPs genotyping with concentration as low as 1 nM. | GE ZhiLei PEI Hao WANG LiHua SONG ShiPing FAN ChunHai | 2011 | Science China Chemistry2011，54，8： | 13 |
| 5 | Progress in Global Gas Hydrate Development and Production as a New Energy Resource显示文摘Natural gas hydrates have been hailed as a new and promising unconventional alternative energy,especially as fossil fuels approach depletion,energy consumption soars,and fossil fuel prices rise,owing to their extensive distribution,abundance,and high fuel efficiency.Gas hydrate reservoirs are similar to a storage cupboard in the global carbon cycle,containing most of the world's methane and accounting for a third of Earth's mobile organic carbon.We investigated gas hydrate stability zone burial depths from the viewpoint of conditions associated with stable existence of gas hydrates,such as temperature,pressure,and heat flow,based on related data collected by the global drilling programs.Hydrate-related areas are estimated using various biological,geochemical and geophysical tools.Based on a series of previous investigations,we cover the history and status of gas hydrate exploration in the USA,Japan,South Korea,India,Germany,the polar areas,and China.Then,we review the current techniques for hydrate exploration in a global scale.Additionally,we briefly review existing techniques for recovering methane from gas hydrates,including thermal stimulation,depressurization,chemical injection,and CH4-CO2 exchange,as well as corresponding global field trials in Russia,Japan,United States,Canada and China.In particular,unlike diagenetic gas hydrates in coarse sandy sediments in Japan and gravel sediments in the United States and Canada,most gas hydrates in the northem South China Sea are non-diagenetic and exist in fine-grained sediments with a vein-like morphology.Therefore,especially in terms of the offshore production test in gas hydrate reservoirs in the Shenhu area in the north slope of the South China Sea,Chinese scientists have proposed two unprecedented techniques that have been verified during the field trials:solid fluidization and formation fluid extraction.Herein,we introduce the two production techniques,as well as the so-called'fbur-in-one'environmental monitoring system employed during the Shenhu production test.Methane is not currently commercially produced from gas hydrates anywhere in the world;therefore,the objective of field trials is to prove whether existing techniques could be applied as feasible and economic production methods for gas hydrates in deep-water sediments and permafrost zones.Before achieving commercial methane recovery from gas hydrates,it should be necessary to measure the geologic properties of gas hydrate reservoirs to optimize and improve existing production techniques.Herein,we propose horizontal wells,multilateral wells,and cluster wells improved by the vertical and in dividual wells applied during existing field trials.It is noteworthy that relatively pure gas hydrates occur in seafloor mounds,within near-surface sediments,and in gas migration conduits.Their extensive distribution,high saturation,and easy access mean that these types of gas hydrate may attract considerable attention from academia and industry in the future.Herein,we also review the occurrence and development of concentrated shallow hydrate accumulations and briefly introduce exploration and production techniques.In the closing section,we discuss future research needs,key issues,and major challenges related to gas hydrate exploration and production.We believe this review article provides insight on past,present,and future gas hydrate exploration and production to provide guidelines and stimulate new work into the field of gas hydrates. | LIU Liping SUN Zhilei ZHANG Lei WU Nengyou Yichao Qin JIANG Zuzhou GENG Wei CAO Hong ZHANG Xilin ZHAI Bin XU Cuiling SHEN Zhicong JIA Yonggang | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 13 |
| 6 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 7 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 8 | Investigation into co-pyrolysis characteristics of oil shale and coal显示文摘Samples of five types of coal and oil shale from the Daqing region have been subjected to co-pyrolysis in different blending ratios with thermo-gravimetry(TG),given a heating rate of 30 °C/min to a final temperature of 900 °C.Investigations on pyrolysis of mixing coal and oil shale in different proportions were carried out,indicating that the main scope of weight loss corresponding to hydrocarbon oil and gas release was between 350 and 550 °C.At higher temperatures,significant weight loss was attributed to coke decomposition.Characteristic pyrolysis parameters of blends from oil shale and the high ranked XZ coal varied with the blending ratio,but oil shale dominated the process.At the same blending proportions,highly volatile medium and low ranked coal of low moisture and ash content reacted well during pyrolysis and could easily create synergies with oil shale.Medium and high ranked coal with high moisture content played a negative role in co-pyrolysis. | Miao Zhenyong Wu Guoguang Li Ping Meng Xianliang Zheng Zhilei | 2012 | International Journal of Mining Science and Technology2012，22，2： | 9 |
| 9 | Characteristics of pantograph‐catenary arc under low air pressure and strong airflow显示文摘Pantograph‐catenary arc fault is the primary factor threatening the stability of the power transmission for high‐speed railway.The motion characteristics of the pantograph‐catenary arc under low air pressure and strong airflow is significantly different from the case under atmospheric pressure.In this paper,an experimental platform of panto-graph‐catenary arc was built to investigate arc root position‐time and arc column lon-gitudinal drift height‐time characteristic curves under different air pressures and airflow velocites.Via analysing the corresponding results,it can be found that there are different arc root-arc column traction mechanisms at different stages of arc development.The arcing time and arc root stagnation time under low air pressure are significantly longer than the case under atmospheric pressure,resulting in more serious electrode ablation.The arc column longitudinal drift velocity and height are greater with the increase of airflow velocity.Two typical irregular arc motion phenomena-arc root jumping and arc reignition are observed.To clarify the internal mechanism of the above phenomenon,a magnetohydrodynamics(MHD)model of the pantograph‐catenary arc was lauched,the influence mechanism of the pantograph‐catenary arc temperature and voltage are studied,and the physical process of arc temperature oscillation is analysed.The research results provide theoretical support for arc protection in high‐altitude areas. | Zhilei Xu Guoqiang Gao Wenfu Wei Zefeng Yang Wenhan Xie Keliang Dong Yaguang Ma Yan Yang Guangning Wu | 2022 | High Voltage2022，7，2： | 7 |
| 10 | Provenance of Central Canyon in Qiongdongnan Basin as evidenced by detrital zircon U-Pb study of Upper Miocene sandstones显示文摘Deep-water canyon systems can provide important sandstone reservoirs for deep-water oil and gas exploration in the South China Sea;however,the sedimentary provenance of the Central Canyon in the Qiongdongnan Basin remains controversial.In this work,detrital zircon grains from three drilling sandstones in the Upper Miocene Huangliu Formation in the western part of the Central Canyon were analysed by LA-ICP-MS for U-Pb ages,in order to constrain their provenance.One hundred and ninety-one zircon grains yield concordant U-Pb ages ranging from 28.6 to 3285 Ma.Most of them show oscillatory or linear zoning in CL-images and high Th/U ratios(>0.1),suggesting that they are magmatic zircons.Three major age clusters at about30 Ma(N=6),220–270 Ma(N=29),and 420–440 Ma(N=13),and five minor age clusters at 70–110 Ma(N=7),150–170 Ma(N=4),800–850 Ma(N=11),1800–2000 Ma(N=16),and 2400–2600 Ma(N=7),can be identified in the age spectrum,which are very similar to those of the Upper Miocene sandstones and modern river sands in the Red River area,but different from those of other nearby regions(e.g.,Hainan Island,the Pearl River area,and the Mekong River area)in Southeast Asia.The major age peak at about 30 Ma in our samples is consistent with the timing of tectonothermal events in the Red River Fault Zone.Therefore,we suggest that the provenance of the western part of the Central Canyon,in the Qiongdongnan Basin,was fed dominantly by the Paleo-Red River system during the Late Miocene. | CHEN Hui XIE XiNong GUO JingLiang SU Ming ZONG KeQing SHANG Fei HUANG Wei WANG Wei SHANG ZhiLei | 2015 | Science China Earth Sciences2015，58，8： | 6 |
| 11 | Phytochrome B interacts with SWC6 and ARP6 to regulate H2A.Z deposition and photomorphogensis in Arabidopsis显示文摘Light serves as a crucial environmental cue which modulates plant growth and development, and which is controlled by multiple photoreceptors including the primary red light photoreceptor,phytochrome B(phyB). The signaling mechanism of phyB involves direct interactions with a group of basic helix-loop-helix(bHLH) transcription factors, PHYTOCHROME-INTERACTING FACTORS(PIFs), and the negative regulators of photomorphogenesis, COP1 and SPAs. H2 A.Z is an evolutionarily conserved H2 A variant which plays essential roles in transcriptional regulation. The replacement of H2 A with H2 A.Z is catalyzed by the SWR1 complex. Here, we show that the Pfr form of phyB physically interacts with the SWR1 complex subunits SWC6 and ARP6. phyB and ARP6 coregulate numerous genes in the same direction,some of which are associated with auxin biosynthesis and response including YUC9, which encodes a rate-limiting enzyme in the tryptophandependent auxin biosynthesis pathway. Moreover,phyB and HY5/HYH act to inhibit hypocotyl elongation partially through repression of auxin biosynthesis. Based on our findings and previous studies, we propose that phyB promotes H2 A.Z deposition at YUC9 to inhibit its expression through direct phyB-SWC6/ARP6 interactions,leading to repression of auxin biosynthesis, and thus inhibition of hypocotyl elongation in red light. | Xuxu Wei Wanting Wang Peng Xu Wenxiu Wang Tongtong Guo Shuang Kou Minqing Liu Yake Niu Hong-Quan Yang Zhilei Mao | 2021 | Journal of Integrative Plant Biology2021，63，6： | 6 |
| 12 | Pantograph-catenary electrical contact system of high-speed railways:recent progress,challenges,and outlooks显示文摘As the unique power entrance,the pantograph-catenary electrical contact system maintains the efficiency and reliability of power transmission for the high-speed train.Along with the fast development of high-speed railways all over the world,some commercialized lines are built for covering the remote places under harsh environment,especially in China;these environmental elements including wind,sand,rain,thunder,ice and snow need to be considered during the design of the pantograph-catenary system.The pantograph-catenary system includes the pantograph,the contact wire and the interface—pantograph slide.As the key component,this pantograph slide plays a critical role in reliable power transmission under dynamic condition.The fundamental material characteristics of the pantograph slide and contact wire such as electrical conductivity,impact resistance,wear resistance,etc.,directly determine the sliding electrical contact performance of the pantograph-catenary system;meanwhile,different detection methods of the pantograph-catenary system are crucial for the reliability of service and maintenance.In addition,the challenges brought from extreme operational conditions are discussed,taking the Sichuan-Tibet Railway currently under construction as a special example with the high-altitude climate.The outlook for developing the ultra-high-speed train equipped with the novel pantograph-catenary system which can address the harsher operational environment is also involved.This paper has provided a comprehensive review of the high-speed railway pantograph-catenary systems,including its progress,challenges,outlooks in the history and future. | Guangning Wu Keliang Dong Zhilei Xu Song Xiao Wenfu Wei Huan Chen Jie Li Zhanglin Huang Jingwei Li Guoqiang Gao Guozheng Kang Chuanjun Tu Xingyi Huang | 2022 | Railway Engineering Science2022，30，4： | 5 |
| 13 | Machine learning-based predictions of fatigue life and fatigue limit for steels显示文摘To predict the fatigue life for oblique hyperbola-and bilinear-mode S-N curves of metallic materials with various strengths,a machine-learning approach for direct analysis was employed.Additionally,to determine the fatigue limit of the utilized materials(AISI 316,AISI 4140 and CA6 NM series)with different S-N curve modes using finite-fatigue life data,a Bayesian optimization-based inverse analysis was performed.The results indicated that predictions of the fatigue life for the utilized datasets via the random forest(RF)algo rithm for AISI 4140 and CA6 NM,and artificial neural network(ANN)for AISI 316,distribute within 2 factor error lines for most data.In the Bayesian optimization-based inverse analysis,the specific explanatory variables corresponding to the optimized maximum fatigue life were treated as the fatigue limits.The predicted fatigue limits either approximated to or slightly underestimated the experimental results,except for several cases with large errors.Using the inverse analysis to predict the fatigue limit for both S-N curve modes is applicable for current employed data-set.However,the explored maximum fatigue lives via BO corresponding to the predicted fatigue limit were underestimated for AISI 4140 and CA6 NM,and was overestimated for AISI 316 because of effect of shape of S-N curves.By combining the ANN or RF direct and BO inverse algorithms,whole S-N curves(including the fatigue limit)were evaluated for the S-N curve shapes of the oblique hyperbola and bilinear modes. | steelsLei He ZhiLei Wang Hiroyuki Akebono Atsushi Sugeta | 2021 | Journal of Materials Science & Technology2021，，31： | 5 |
| 14 | Numerical simulation for propagation characteristics of shock wave and gas flow induced by outburst intensity显示文摘In order to analyze the propagation characteristics of shock wave and gas flow induced by outburst intensity, the governing equations of shock wave and gas flow propagation were put forward, and the numerical simulation boundary condition was obtained based on outburst characteristics. The propagation characteristics of shock wave and gas flow were simulated by Fluent software, and the simulation results were verified by experiments. The results show that air shock wave is formed due to air medium compressed by the transient high pressure gas which rapidly expands in the roadway; the shock wave and gas flow with high velocity are formed behind the shock wave front, which significantly decays due to limiting effect of the roadway wall. The attenuation degree is greater in the early stage than that in the late stage, and the velocity of gas convection transport is lower than the speed of the shock wave.The greater the outburst intensity is, the greater the pressure of the shock wave front is, and the higher the speed of the shock wave and gas flow is. | Zhou Aitao Wang Kai Wang Li Du Feng Li Zhilei | 2015 | International Journal of Mining Science and Technology2015，25，1： | 5 |
| 15 | Difference in full-filled time and its controlling factors in the Central Canyon of the Qiongdongnan Basin显示文摘Based on the interpretation of high resolution 2D/3D seismic data,sedimentary filling characteristics and fullfilled time of the Central Canyon in different segments in the Qiongdongnan Basin of northwestern South China Sea have been studied.The research results indicate that the initial formation age of the Central Canyon is traced back to 11.6 Ma(T40),at which the canyon began to develop due to the scouring of turbidity currents from west to east.During the period of 11.6–8.2 Ma(T40–T31),strong downcutting by gravity flow occurred,which led to the formation of the canyon.The canyon fillings began to form since 8.2 Ma(T31) and were dominated by turbidite deposits,which constituted of lateral migration and vertical superposition of turbidity channels during the time of8.2–5.5 Ma.The interbeds of turbidity currents deposits and mass transport deposits(MTDs) were developed in the period of 5.5–3.8 Ma(T30–T28).After then,the canyon fillings were primarily made up of large scale MTDs,interrupted by small scale turbidity channels and thin pelagic mudstones.The Central Canyon can be divided into three types according to the main controlling factors,geomorphology-controlled,fault-controlled and intrusionmodified canyons.Among them,the geomorphology-controlled canyon is developed at the Ledong,Lingshui,Songnan and western Baodao Depressions,situated in a confined basin center between the northern slope and the South Uplift Belt along the Central Depression Belt.The fault-controlled canyon is developed mainly along the deep-seated faults in the Changchang Depression and eastern Baodao Depression.Intrusion-modified canyon is only occurred in the Songnan Low Uplift,which is still mainly controlled by geomorphology,the intrusion just modified seabed morphology.The full-filled time of the Central Canyon differs from west to east,displaying a tendency of being successively late eastward.The geomorphology-controlled canyon was completely filled before3.8 Ma(T28),but that in intrusion-modified canyon was delayed to 2.4 Ma(T27) because of the uplifted southern canyon wall.To the Changchang Depression,the complete filling time was successively late eastward,and the canyon in eastern Changchang Depression is still not fully filled up to today.Difference in full-filled time in the Central Canyon is mainly governed by multiple sediment supplies and regional tectonic activities.Due to sufficient supply of turbidity currents and MTDs from west and north respectively,western segment of the Central Canyon is entirely filled up earlier.Owing to slower sediment supply rate,together with differential subsidence by deep-seated faults,the full-filled time of the canyon is put off eastwards gradually. | SHANG Zhilei XIE Xinong LI Xushen ZHANG Daojun HE Yunlong YANG Xing CUI Mingzhe | 2015 | Acta Oceanologica Sinica2015，34，10： | 5 |
| 16 | Rare-earth element geochemistry reveals the provenance of sediments on the southwestern margin of the Challenger Deep显示文摘The hadal zone represents one of the last great frontiers in modern marine science,and deciphering the provenance of sediment that is supplied to these trench settings remains a largely unanswered question.Here,we examine the mineralogical and geochemical composition of a sediment core(core CD-1)that was recovered from the southwestern margin of the Challenger Deep within the Mariana Trench.Major element abundances and rare-earth element patterns from these sediments require inputs from both terrigenous dust and locally sourced volcanic debris.We exploit a two-endmember mixing model to demonstrate that locally sourced volcanic material dominates the sediment supply to the Challenger Deep(averaging^72%).The remainder,however,is supplied by aeolian dust(averaging^28%),which is consistent with adjacent studies that utilized Sr-Nd isotopic data.Building on a growing database,we strengthen our understanding of Asian aeolian dust input into the northwestern Pacific,which ultimately improves our appreciation of sedimentation in,and around,the hadal zone. | JIANG Zuzhou SUN Zhilei LIU Zhaoqing CAO Hong GENG Wei XU Haixia WANG Lisheng WANG Libo | 2019 | Journal of Oceanology and Limnology2019，37，3： | 5 |
| 17 | Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses显示文摘Human skeletal stem cells(SSCs)have been discovered in fetal and adult long bones.However,the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive.Here we map the transcriptional landscape of human limb buds and embryonic long bones at single-cell resolution to address this fundamental question.We found remarkable heterogeneity within human limb bud mesenchyme and epithelium,and aligned them along the proximal-distal and anterior-posterior axes using known marker genes.Osteo-chondrogenic progenitors first appeared in the core limb bud mesenchyme,which give rise to multiple populations of stem/progenitor cells in embryonic long bones undergoing endochondral ossification.Importantly,a perichondrial embryonic skeletal stem/progenitor cell(eSSPC)subset was identified,which could self-renew and generate the osteochondral lineage cells,but not adipocytes or hematopoietic stroma.eSSPCs are marked by the adhesion molecule CADM1 and highly enriched with FOXP1/2 transcriptional network.Interestingly,neural crest-derived cells with similar phenotypic markers and transcriptional networks were also found in the sagittal suture of human embryonic calvaria.Taken together,this study revealed the cellular heterogeneity and lineage hierarchy during human embryonic skeletogenesis,and identified distinct skeletal stem/progenitor cells that orchestrate endochondral and intramembranous ossification. | Jian He Jing Yan Jianfang Wang Liangyu Zhao Qian Xin Yang Zeng Yuxi Sun Han Zhang Zhijie Bai Zongcheng Li Yanli Ni Yandong Gong Yunqiao Li Han He Zhilei Bian Yu Lan Chunyu Ma Lihong Bian Heng Zhu Bing Liu Rui Yue | 2021 | Cell Research2021，31，7： | 5 |
| 18 | Source code fragment summarization with small-scale crowdsourcing based features显示文摘 | Najam NAZAR He JIANG Guojun GAO Tao ZHANG Xiaochen LI Zhilei REN | 2016 | Frontiers of Computer Science2016，10，3： | 5 |
| 19 | Growth model of a hydrothermal low-temperature Si-rich chimney:Example from the CDE hydrothermal field,Lau Basin显示文摘The CDE hydrothermal field was first discovered during a Chinese cruise to the East Lau Basin Spreading Centre in 2007.Apart from significant amounts of loose Fe-Si-Mn(oxyhydr) oxide(referred to as oxide below) precipitates,a small Si-rich oxide chimney was also recovered on this cruise.In this study,we report on the mineralogical and geochemical analyses of this chimney and a model for its growth that has been developed.Based on the mineralogy and O isotope results,the chimney walls can be divided into four growth generations(layers) from the inner to the outer layers:amorphous opal and barite layer(precipitation temperature 68.5°C based on oxygen isotope determinations),a rod-like amorphous layer(precipitation temperature 39.6°C),a filamentous Fe-Si oxide layer,and an outer Fe-Mn oxide layer.Investigations based on SEM and EDS showed that neutrophilic Fe-oxidizing bacteria play an important role in the formation of this chimney,particularly in the outer two generations.In the first stage,the metabolic activity of the microbes results in the pervasive precipitation of the filamentous Fe-rich oxides inside a ring formed by some amorphous opal and barite;therefore,a loose porous layer forms.In the second stage,amorphous opal then precipitates inside this wall as a result of conductive cooling and gradually controls the mixing between the hydrothermal fluids and ambient seawaters.In the third stage,barite and some amorphous opal form from the higher temperature fluids at the summit of the chimney growth history.In the last stage,the chimney wall becomes thicker and denser and the exchange of hydrothermal fluids and seawater ceases.As a result,a Fe-Mn oxide layer precipitates onto the outer surface of the chimney wall as neutrophilic Fe-oxidizing bacteria reoccupy the surface of the chimney.This mineral sequence and the resultant growth generations are confirmed by the chemical characteristics of the chimney wall.Sr isotopes extracted from the Fe oxides of the four-generation wall generally show a decreasing trend of the 87 Sr/86 Sr ratios from the second layer to the inner layer(from 0.707008 to 0.705877) except for the outer layer(0.706502).The Sr isotope and chondrite normalized REE patterns of the corresponding bulk samples from the chimney wall also display a similar trend.Our study shows that the biogenic filament network plays a key role in the formation of the chimney in contrast to previous growth models of higher temperature chimneys,which often ignore the influence of biogenic factors. | SUN ZhiLei ZHOU HuaiYang YANG QunHui YIN XiJie WANG Hu YAO HuiQiang DONG CongFang | 2012 | Science China Earth Sciences2012，55，10： | 4 |
| 20 | High NO_2/NO_X emissions downstream of the catalytic diesel particulate filter:An influencing factor study显示文摘Diesel vehicles are responsible for most of the traffic-related nitrogen oxide(NO x) emissions,including nitric oxide(NO) and nitrogen dioxide(NO2). The use of after-treatment devices increases the risk of high NO2/NO x emissions from diesel engines. In order to investigate the factors influencing NO2/NO x emissions, an emission experiment was carried out on a high pressure common-rail, turbocharged diesel engine with a catalytic diesel particulate filter(CDPF). NO2 was measured by a non-dispersive ultraviolet analyzer with raw exhaust sampling. The experimental results show that the NO2/NO x ratios downstream of the CDPF range around 20%–83%, which are significantly higher than those upstream of the CDPF. The exhaust temperature is a decisive factor influencing the NO2/NO x emissions. The maximum NO2/NO x emission appears at the exhaust temperature of 350°C. The space velocity,engine-out PM/NO x ratio(mass based) and CO conversion ratio are secondary factors. At a constant exhaust temperature, the NO2/NO x emissions decreased with increasing space velocity and engine-out PM/NO x ratio. When the CO conversion ratios range from 80% to 90%,the NO2/NO x emissions remain at a high level. | Chao He Jiaqiang Li Zhilei Ma Jianwei Tan Longqing Zhao | 2015 | Journal of Environmental Sciences2015，27，9： | 4 |
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