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| 1 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 2 | Expression Patterns of ABA and GA Metabolism Genes and Hormone Levels during Rice Seed Development and Imbibition: A Comparison of Dormant and Non-Dormant Rice Cultivars显示文摘Seed dormancy is an important agronomic trait in cereals. Using deep dormant(N22), medium dormant(ZH11), and non-dormant(G46B)rice cultivars, we correlated seed dormancy phenotypes with abscisic acid(ABA) and gibberellin(GA) metabolism gene expression profiles and phytohormone levels during seed development and imbibition. A time course analysis of ABA and GA content during seed development showed that N22 had a high ABA level at early and middle seed developmental stages, while at late developmental stage it declined to the level of ZH11; however, its ABA/GA ratio maintained at a high level throughout seed development. By contrast, G46 B had the lowest ABA content during seed development though at early developmental stage its ABA level was close to that of ZH11, and its ABA/GA ratio peaked at late developmental stage that was at the same level of ZH11. Compared with N22 and G46 B, ZH11 had an even and medium ABA level during seed development and its ABA/GA ratio peaked at the middle developmental stage. Moreover, the seed development time-point having high ABA/GA ratio also had relatively high transcript levels for key genes in ABA and GA metabolism pathways across three cultivars. These indicated that the embryo-imposed dormancy has been induced before the late developmental stage and is determined by ABA/GA ratio. A similar analysis during seed imbibition showed that ABA was synthesized in different degrees for the three cultivars. In addition, water uptake assay for intact mature seeds suggested that water could permeate through husk barrier into seed embryo for all three cultivars; however, all three cultivars showed distinct colors by vanillin-staining indicative of the existence | Yang Liu Jun Fang Fan Xu Jinfang Chu Cunyu Yan Michael R.Schlappi Youping Wang Chengcai Chu | 2014 | Journal of Genetics and Genomics2014，41，6： | 7 |
| 3 | Effect of Ti-V-Nb-Mo addition on microstructure of high chromium cast iron显示文摘The effects of trace additions of multi-alloying elements(Ti,Nb,V,Mo)on carbides precipitation and as- cast microstructure of eutectic high chromium cast iron containing 2.85wt.%C and 31.0wt.%Cr were investigated from thermodynamic and kinetic considerations.The thermodynamic calculations show that Ti and Nb exist in the multi-alloying system in the forms of TiC and NbC.The formation of VC during the solidification is not feasible from the thermodynamic consideration.XRD analysis shows that the V exists in alloy compounds(VCr2C2,VCrFe8).The first precipitated high melting point particles(TiC,NbC)can act as the heterogeneous substrate of M7C3 carbides, which results in significant refinement of the M7C3 carbides.After the addition of alloying elements,C atom diffusion is hindered due to the strong affinities of the strong carbide forming elements for carbon,which decreases the growth rate of carbides.The combined roles of the increase of nucleation rate and the decrease of carbides growth rate lead to the finer microstructure. | Ma Youping Li Xiulan Liu Yugao Zhou Shuyi Dang Xiaoming | 2012 | China Foundry2012，9，2： | 6 |
| 4 | Assessment on alien herbicide-resistant gene flow among crucifers by sexual compatibility显示文摘Cross-pollination and high cross-compatibility are frequently found in many cruciferous plants, which im-plies that there might be potential risk of alien gene flow among crucifers. In this work, the alien glyphosate-resistant gene flow between GM (Genetically modified) rapeseed vari-ety Q3 (Brassica napus) and 6 varieties from 5 cruciferous species was assessed by sexual compatibility through aniline blue fluorescence observation, manual cross, mentor pollina-tion with the mixture pollen and DNA identification. The results indicated that the compatibility indices of two B. napus varieties, B. juncea var. multiceps Tsen et Lee and Chinese cabbage (B. chinensis) (as female) with Q3 (as male) were 16.15, 12.77, 2.345 and 0.85, respectively. F1 plants were examined by PCR and all of these samples were confirmed as positive. Crossing between Orychophragmus violaceus, Des-curainia sophia (as female) and Q3 (as male) expressed high cross-incompatibility. Fluorescence microscope observation indicated that growing of pollen tube terminated at the upper 1/3 part of the style of O. violaceus and on the stigma surface of D. sophia. The mentor plants were further analyzed by PCR and all were shown to be negative. Under the neighboring growth and natural pollination conditions, the rates of gene flow to two B. napus varieties were 2.3278% and 2.1487%, respectively, B. juncea var. multiceps Tsen et Lee and Chinese cabbage were 1.0157% and 0.9236%, re-spectively. No gene flow was observed in O. violaceus and D. sophia. Frequency of gene flow was highly correlated with sexual compatibility. Due to possible alien gene flow among crucifers, special consideration and care should be taken to grow GM rapeseed. | ZHAO Xiangxiang LU Weiping QI Cunkou PU Huiming XIA Qiuxia LU Dalei LIU Geshan WANG Youping | 2005 | Chinese Science Bulletin2005，50，15： | 6 |
| 5 | Impact of clinical research on public health policy of neonatal screening for congenital heart disease in China显示文摘Congenital heart disease(CHD)is one of the most common congenital malformations,with a prevalence of approximately 1%in live births.[1,2]Among them,1/4 to 1/3 are major CHD,including critical CHD(CCHD)and serious CHD,which require surgical or catheter intervention before 1 year of age.[3]Major CHD,if left untreated,may cause serious outcomes,such as heart failure,cardiogenic shock,acidosis,and hypoxic-ischemic brain damage,and is one of the leading causes of infant death and childhood disability.[4]The missed diagnosis rate of CCHD in four nurseries ranges from 13%to 48%in developed countries,[4,5]but in China,is>71%before serious symptoms occur after birth.[6]Therefore,screening for CHD is useful for early detection,diagnosis,and treatment and helps to improve prognosis and reduces the medical,economic,and mental burden to both the family and the society.[5,7] | Miao Yang Youping Tian Pin Jia Xiaojing Ma Xiaoling Ge Xiaojing Hu Quming Zhao Fang Liu Bing Jia Weili Yan Qing Gu Guoying Huang | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 6 | Gene flow from genetically modified herbicide-resistant rapeseed to cruciferous weeds显示文摘性相容性在之间遗传上修改了(美国通用汽车公司)glyphosate 抵抗的油菜籽变化 Q3 (Brassica 马来麝 L.) 和 5 棵饰有十字架的杂草通过荧光显微镜学的观察被学习并且在用手的授粉以后跨富饶。结果显示了那 Q3 (同样男性) 与 Thlaspi arvense L. 高度不兼容, Capsella bursa-pastoris (L.) 苜蓿, Cardamine hirsuta L。并且 Rorippa palustris (L.) Besser (作为女性) 。荧光显微镜的观察显示出那成长在耻辱表面上或在风格的上面的 1/3 部分终止的花粉试管。然而, B。juncea x Q3 是兼容的,并且相容性索引是 1.65。在附近的生长和自然授粉条件下面,基因的率从 Q3 流动到 T。arvense, C。bursa-pastoris, C。多毛并且 R。palustris 都是 0,当它为 B 是 0.86% 时。juncea。这些结果显示处于在美国通用汽车公司油菜籽之间的基因流动的率有差别,基因流动的饰有十字架的野杂草。 | ZHAO Xiangxiang XIA Oiuxia LU Dalei LU Weiping QI Cunkou PU Huiming LIU Geshan ZHAO Jian WANG Youping | 2006 | Progress in Natural Science:Materials International2006，16，9： | 3 |
| 7 | UHPLC-MS/MS analysis of cAMP and cGMP in rat plasma as potential biomarkers of Yin-Yang disharmony in traditional Chinese medicine显示文摘Cyclic 3’,5’-adenosine monophosphate(cAMP)and cyclic 3’,5’-guanosine monophosphate(cGMP)are considered as potential biomarkers for Yin-Yang disharmony in traditional Chinese medicine.However,phosphodiesterase-mediated ex vivo degradation of these molecules in biological samples may result in their underestimation.In the present study,a ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS)method was developed for determination of cAMP and cGMP in rat plasma,with special consideration of their stability ex vivo.Following precipitation of proteins from plasma samples with 0.4 M perchloric acid,the analytes were chromatographed on a Shimadzu Shimpack-XR-ODS II column with 2.5 mM ammonium acetate and methanol in gradient mode.The MS/MS detection was performed using multiple reaction monitoring in the positive electrospray ionization mode.The lower limit of quantification was 0.27 ng/mL for cAMP and 0.37 ng/mL for cGMP.The method was used to determine the plasma cAMP and cGMP levels in normal and Yin deficiency diabetic rats treated with or without Rehmannia glutinosa.The developed method may be useful for evaluating the regulatory effects of Chinese herbal medicine on the levels of cAMP and cGMP in the body. | Xin Wang Yue Du Cuiting Wu Ming Xu Youping Liu Xin Di | 2021 | Journal of Pharmaceutical Analysis2021，11，4： | 3 |
| 8 | STRESS FIELD ANALYSIS OF EXTRA-HEIGHT FORGING DIE USING FINITE ELEMENT METHOD显示文摘TheextraheightforgingdieinSouthewestAluminiumFabricationPlantisaspecialdieformakingarmamentandspecialcivilproductsinChina.A... | Xiaobo Liu Jianping Tan Youping Yi | 1999 | Journal of Central South University1999，11，1： | 3 |
| 9 | Surface Charging Phenomena on HVDC Spacers for Compressed SF_(6) Insulation and Charge Tailoring Strategies显示文摘Surface flashover of spacers is a key factor limiting the application of HVDC GIS/GIL,while the charge accumula-tion on the surface of the spacer could have a potential adverse effect on the surface flashover voltage.This paper discusses the laws regarding distribution patterns of surface charges and the related mechanisms.The field-dependent property is discussed in detail to comprehensively illustrate the charge transport mecha-nism and explain the research differences regarding different surface charge patterns obtained by previous researchers.In addition,the main surface charge control methods for epoxy resin are summarized and discussed.The potential research directions of charge control methods and key points in manufacturing of spacers used in HVDC GIS/GIL are also explored. | Chuanyang Li Yuan Xu Chuanjie Lin Geng Chen Youping Tu Yao Zhou Zhipeng Lei Tao Han Simone Vincenzo Suraci Jian Wang Weidong Liu M.Tariq Nazir Shun He Andrea Cavallini Giovanni Mazzanti Davide Fabiani Jinliang He | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 3 |
| 10 | A sensitive and selective liquid chromatography?tandem mass spectrometry method for simultaneous determination of five isoquinoline alkaloids from Chelidonium majus L. in rat plasma and its application to a pharmacokinetic study显示文摘 | Qiuhong Zhou Youping Liu Xin Wang Xin Di | 2013 | J Mass Spectrom2013，，1： | 1 |
| 11 | Emergency medical rescue efforts after a major earthquake: lessons from the 2008 Wenchuan earthquake显示文摘 | Lulu Zhang Xu Liu Youping Li Yuan Liu Zhipeng Liu Juncong Lin Ji Shen Xuefeng Tang Yi Zhang Wannian Liang | 2012 | The Lancet2012，，9818： | 1 |
| 12 | Study on the influencing factors to reduce the recovery time of superconducting tapes and coils for the DC superconducting fault current limiter applications显示文摘Superconducting fault current limiters(SFCLs)are important in improving the stability of electrical power systems.However,the existing resistive-type DC SFCL has a long re-covery time,which cannot meet the requirements of power system auto-reclosure.Thus,it is necessary to investigate the methods of reducing recovery time of SFCLs.In the simulations on superconducting tapes,there is a lack of investigation about the effects of design factors of superconducting tapes and coils such as material,thickness,coil radius,coil winding method on recovery characteristics.The objective of this study is to obtain the effects of material and geometric properties of superconducting tapes and coils on recovery characteristics and obtain methods to reduce the recovery time.The recovery times under different conducting currents are also compared by simulations and exper-iments to verify simulation accuracy.The maximum error is below 40%and most of the cases have an error below 10%.Besides,by increasing tape thickness,the recovery time can be reduced by 22%.Tape materials and coil winding methods can be designed ac-cording to the auto-reclosure and current-limiting requirements of the power systems.The research provided directions for the design of superconducting tape and super-conducting coil for resistive-type DC SFCLs. | Bin Xiang Wenqing Wang Hongxu Li Lei Gao Zhiyuan Liu Yingsan Geng Jianhua Wang Youping Tu | 2022 | High Voltage2022，7，3： | 1 |
| 13 | Comparison of the crystalline properties and structural changes of starches from high-amylose transgenic rice and its wild type during heating显示文摘 | Cunxu Wei Fengling Qin Weidong Zhou Bin Xu Chong Chen Yifang Chen Youping Wang Minghong Gu Qiaoquan Liu | 2011 | Food Chemistry2011，，3： | 1 |
| 14 | Facile synthesis of Co 3 O 4 nanoflowers grown on Ni foam with superior electrochemical performance显示文摘 | Xiaoxia Qing Suqin Liu Kelong Huang Kezhen Lv Youping Yang Zhouguang Lu Dong Fang Xinxing Liang | 2011 | Electrochimica Acta2011，，14： | 1 |
| 15 | The analysis of gales over the “Maritime Silk Road” with remote sensing data显示文摘The 21st century 'Maritime Silk Road' strategy is a significant part of the belt and road initiatives of China. The cognition and investigation of ocean environment is essential and necessary in these regions which will provide scientific reference for many fields such as navigation, ocean engineering, and disaster prevent and reduction. A high-resolution cross-calibrated multi-platform wind product is used to analyze gales over the Maritime Silk Road. The yearly mean speed and space distribution of gale, and the frequencies and trends of gale and extreme wind speed are analyzed. The results show that relatively high pools of gale are mainly located in the waters of the Arabian Sea, the Somali Sea, Indo-China Peninsula sea area, and Bay of Bengal in the summer. The gale frequency of the Somali Sea is more than 90%. Overall, the gale days increase year by year in the majority of the South China Sea and the northern Indian Ocean, especially in the autumn and the winter. | LIU Yuanxin YIN Xiaobin XU Youping | 2017 | Acta Oceanologica Sinica2017，36，9： | 1 |
| 16 | 大熊猫保护区的生态系统服务价值显示文摘文章简介全球生态系统服务价值估计每年为125万亿美元,相似的国家和区域层面的评估也显示生态系统服务价值足以支撑我们的生活。所有的生态系统服务价值评估都肯定了生物多样性的重要作用. | 魏辅文 Robert Costanza Qiang Dai Natalie Stoeckl Xiaodong Gu Stephen Farber Yonggang Nie Ida Kubiszewski Yibo Hu Ronald Swaisgood Xuyu Yang Michael Bruford Youping Chen Alexey Voinov Dunwu Qi Megan Owen Li Yan Daniel C.Kenny Zejun Zhang Rong Hou Shiwei Jiang Hongbo Liu Xiangjiang Zhan Li Zhang Biao Yang Lianjun Zhao Xiaoguang Zheng Wenliang Zhou Yali Wen Heran Gao Wen Zhang | 2019 | 科学新闻2019，0，2： | 1 |
| 17 | Analysis of plasma proteome from cases of the different traditional Chinese medicine syndromes in patients with chronic hepatitis B显示文摘 | Youping Liu Peng Liu Rongyang Dai Jing Wang Yibin Zheng Jiyang Shen Fanghong Guo Leiqiong Wang Hong Li Mei Wei | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，，： | 1 |
| 18 | Modeling the time to corrosion cracking of the cover con- crete in chloride contam/nated reinforced concrete structures显示文摘 | Liu Youping | 1998 | ACt Materials Journal1998，95，6： | 1 |
| 19 | Transplantation of neural progenitor cells differentiated from adipose tissue-derived stem cells for treatment of sciatic nerve injury显示文摘Objectives: Currently, the clinical repair of sciatic nerve injury remains difficult.Previous studies have confirmed that transplantation of adipose tissue-derived stem cells promotes nerve regeneration and restoration at peripheral nerve injury sites. Methods: In this study, adipose tissue-derived stem cells were induced to differentiate into neural progenitor cells, transfected with a green fluorescent protein-containing lentivirus, and then transplanted into the lesions of rats with sciatic nerve compression injury. Results: Fluorescence microscopy revealed that the transplanted cells survived,migrated, and differentiated in rats. At two weeks post-operation, a large number of transplanted cells had migrated to the injured lesions; at six weeks post-operation, transplanted cells were visible around the injured nerve and several cells were observed to express a Schwann cell marker. Sciatic function index and electrophysiological outcomes of the transplantation group were better than those of the control group. Cell transplantation promoted the recovery of motor nerve conduction velocity and compound muscle action potential amplitude, and reduced gastrocnemius muscle atrophy.Conclusions: Our experimental findings indicate that neural progenitor cells,differentiated from adipose tissue-derived stem cells, are potential seed stem cells that can be transplanted into lesions to treat sciatic nerve injury. This provides a theoretical basis for their use in clinical applications. | Shasha Dong Na Liu Yang Hu Ping Zhang Chao Pan Youping Zhang Yingxin Tang Zhouping Tang | 2016 | Translational Neuroscience and Clinics2016，2，2： | 1 |
| 20 | Experiences and Lessons of Combating COVID-19 that Chinese Experts Shared with the World显示文摘At the end of 2019,a novel viral pneumonia was detected in Wuhan City(1)and has spread rapidly throughout 215 countries,areas,and territories with more than 3.8 million cases and over 260,000 deaths as of May 8,2020.This pneumonia,later named coronavirus disease 2019(COVID-19),has become a global public security challenge. | Tao Liu Jiufeng Sun Miaoyun Wen Youping Zhang Xiaodan Luo Xiangxin Liu Shifang Yang Jun Li | 2020 | China CDC weekly2020，2，43： | 1 |
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