|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells显示文摘Macrophages play critical roles in innate immune and acquired immune via secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of transforming growth factor β (TGF-β) superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC II expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages. | Jingyan Ge Yinan Wang Ye Feng Haiyan Liu Xueling Cui Guixiang Tai Zhonghui Liu | 2009 | Cellular & Molecular Immunology2009，6，2： | 4 |
| 3 | Plasminogen Activator Inhibitor-1 Regulates LPS-Induced TLR4/MD-2 Pathway Activation and Inflammation in Alveolar Macrophages显示文摘 | Weiying Ren Zhonghui Wang Feng Hua Lei Zhu | 2015 | Inflammation2015，，： | 1 |
| 4 | An Incremental Algorithm of Text Clustering Based on Semantic Sequences显示文摘This paper proposed an incremental textclustering algorithm based on semantic sequence. Using similarity relation of semantic sequences and calculating the cover of similarity semantic sequences set, the candidate cluster with minimum entropy overlap value was selected as a result cluster every time in this algorithm. The comparison of experimental results shows that the precision of the algorithm is higher than other algorithms under same conditions and this is obvious especially on long documents set. | FENG Zhonghui SHEN Junyi BAO Junpeng | 2006 | Wuhan University Journal of Natural Sciences2006，11，5： | 1 |
| 5 | Progress and perspective of interface design in garnet electrolyte-based all-solid-state batteries显示文摘Inorganic solid-state electrolytes(SSEs)are nonflammable alternatives to the commercial liquid-phase electrolytes.This enables the use of lithium(Li)metal as an anode,providing high-energy density and improved stability by avoiding unwanted liquid-phase chemical reactions.Among the different types of SSEs,the garnet-type electrolytes witness a rapid development and are considered as one of the top candidates to pair with Li metal due to their high ionic conductivity,thermal,and electrochemical stability.However,the large resistances at the interface between garnet-type electrolytes and cathode/anode are the major bottlenecks for delivering desirable electrochemical performances of all-solid-state batteries(SSBs).The electrolyte/anode interface also suffers from metallic dendrite formation,leading to rapid performance degradation.This is a fundamental material challenge due to the poor contact and wettability between garnet-type electrolytes with electrode materials.Here,we summarize and analyze the recent contributions in mitigating such materials challenges at the interface.Strategies used to address these challenges are divided into different categories with regard to their working principles.On one hand,progress has been made in the anode/garnet interface,such as the successful application of Li-alloy anode and different artificial interlayers,significantly improving interfacial performance.On the other hand,the desired cathode/garnet interface is still hard to reach due to the complex chemical and physical structure at the cathode.The common methods used are nanostructured cathode host and sintering additives for increasing the contact area.On the basis of this information,we present our views on the remaining challenges and future research of electrode/garnet interface.This review not only motivates the need for further understanding of the fundamentals,stability,and modifications of the garnet/electrode interfaces but also provides guidelines for the future design of the interface for SSB. | Junrun Feng Zhonghui Gao Lin Sheng Zhangxiang Hao Feng R.Wang | 2021 | Carbon Energy2021，3，3： | 1 |
| 6 | Crowdsourcing or witkey,which leads?显示文摘 | LIN SUFEN OUYANG ZHONGHUI LIN FENG | 2013 | Journal of Applied Sciences2013，13，12： | 1 |
| 7 | Current strategies for improving limitations of proteolysis targeting chimeras显示文摘Proteolysis targeting chimeras(PROTACs)are bifunctional degrader molecules via hijacking the ubiquitinproteasome system(UPS)to specifically eliminate targeted proteins.PROTACs have gained momentum as a new modality of attractive technologies in the drug discovery landscape,since it allows to degrade disease-related proteins effectively.Although some PROTACs drugs reached the clinical research,they are still facing some bottlenecks and challenges that should not be neglected,such as poor oral bioavailability and potential toxic side effects.To overcome these limitations,herein,we provide an overview of recent strategies for improving the durability of PROTACs by enhancing cell permeability and reducing toxic side effects.Meanwhile,the impact of these strategies on improving oral bioavailability as well as their advantages and drawbacks will also be discussed.This review will give a useful reference toolbox for PROTACs design and further promote its clinical application. | Chunlan Pu Shirui Wang Lei Liu Zhonghui Feng Hongjia Zhang Qianyuan Gong Yueshan Sun Yuanbiao Guo Rui Li | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员