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| 1 | Multiplex intermetallic phases in a gravity die-cast Mg-6.0Zn-1.5Nd-0.5Zr(wt%) alloy显示文摘Components and crystal structures of the intermetallic phases in a gravity die-cast Mg-6.0Zn-1.5Nd-0.5Zr(wt%)alloy were investigated using transmission electron microscopy.The results indicate that this alloy has multiple intermetallic phases and various inner faults.Totally,six eutectoid intermetallic phases,namely W(Mg Nd Zn_(3)),T(Mg_(39)Zn_(55)Nd_(6)),(Mg,Zr)Zn_(2),Z(Mg_(28)Zn_(65)Nd_(7)),H_(2)(Mg_(15)Zn_(70)Nd_(15)),and H1(Mg_(24)Zn_(64)Nd_(11)),were simultaneously observed at grain boundaries,and six precipitates(Z,Mg_(7)Zn_(3),T,Mg_(4)Zn_(7),β_(1)-Mg Zn_(2) and β_(2)-Mg Zn_(2))were found inα-Mg grains.Furthermore,faults like sub-grain boundaries,orientation domains(coherent with the same matching plane but with different orientations),stacking faults and twins were observed in the eutectoid intermetallic phases.Finally,some new orientation relationships between the known intermetallic phases were revealed.This paper can provide new insight into alloy design for Mg-Zn-RE(RE:rare earth)based alloys. | Fanzhi Meng Shuhui Lv Qiang Yang Xin Qiu Zixiang Yan Qian Duan Jian Meng | 2022 | Journal of Magnesium and Alloys2022，10，1： | 1 |
| 2 | Mechanical Sensitive Molecule MACF1 Promotes Osteoblast Differentiation显示文摘The decreased osteoblast differentiation associated with reduced bone formation is one main cause of microgravityinduced bone loss.Our previous studies have demonstrated that microtubule actin crosslinking factor 1(MACF1)is downregulated in association with the decreased osteoblast differentiation and bone formation under simulated microgravity conditions.These findings suggest that MACF1 is sensitive to mechanical condition and may be critical for osteoblast differentiation and bone formation.To verify this hypothesis,current study investigates the role and mechanism of MACF1 in regulatingosteoblast differentiation by adopting MACF1 knockdown(MACF1-KD)osteoblasts.The results showed that MACF1 knockdown suppressed mineralized nodules formation,alkaline phosphatase(ALP)activity,osteogenic gene expression andβ-catenin signaling transduction.Moreover,we used RNA sequencing(RNA-seq)and chromatin immunoprecipitation sequencing(ChIP-seq)to investigate further mechanism.Interestingly,we found that MACF1 sequesterd repressors of osteoblast differentiation in cytoplasm.In conclusion,MACF1 is sensitive to mechanical condition and plays key role in activatingβ-catenin signaling transduction and sequestering repressors of osteoblast differentiation,which further promotes osteoblast differentiation. | Lifang Hu Chong Yin Zixiang Wu Zizhang Huang Peihong Su Yan Zhang Zhihao Chen Airong Qian | 2019 | 医用生物力学2019，34，A01： | 0 |
| 3 | Dynamics of particles near the surface of amedium under ultra-strong shocks显示文摘Through nonequilibrium molecular dynamics simulations,we provide an atomic-scale picture of the dynamics of particles near the surface of a medium under ultra-strong shocks.This shows that the measured surface velocity v_(f)under ultra-strong shocks is actually the velocity of the critical surface at which the incident probe light is reflected,and v_(f)has a single-peaked structure.The doubling rule commonly used in the case of relatively weak shocks to determine particle velocity behind the shock front is generally not valid under ultra-strong shocks.After a short period of acceleration,v_(f)exhibits a long slowly decaying tail,which is not sensitive to the atomic mass of the medium.A scaling law for v_(f)is also proposed,and this may be used to improve the measurement of particle velocity u in future experiments. | Zixiang Yan Hao Liu Xinyu Zhang Guoli Ren Jie Liu Wei Kang Weiyan Zhang Xiantu He | 2021 | Matter and Radiation at Extremes2021，6，2： | 0 |
| 4 | Progress and future prospects of decadal prediction and data assimilation:A review显示文摘年代际预测,也称为“近期气候预测”,旨在预测未来1-10年内的气候变化,是气候预测和气候变化研究领域的一个新关注点.它位于季节至年际预测和长期气候变化预测之间,结合了初值问题和外部强迫问题的两个方面.年代际预测的核心技术在于用于模式初始化的同化方法的准确性和效率,其目标是为模式提供准确的初始条件,其中包含观测到的气候系统内部变率,年代际预测的初始化通常涉及在耦合框架内同化海洋观测,其中观测到的信号通过耦合过程传递到其他分量,如大气和海冰.然而,最近的研究越来越关注在海洋-大气耦合模式中探索耦合数据同化(CDA),有人认为CDA有潜力显著提高年代际预测技巧.本文综合评述了该领域的三个方面的研究现状:初始化方法,年代际气候预测的可预测性和预测技巧,以及年代际预测的未来发展和挑战. | Wen Zhou Jinxiao Li Zixiang Yan Zili Shen Bo Wu Bin Wang Ronghua Zhang Zhijin Li | 2024 | Atmospheric and Oceanic Science Letters2024，17，1： | 0 |
| 5 | The nuclear bodies formed by histone demethylase KDM7A显示文摘Dear Editor,In the nucleus of higher eukaryotes,chromatin occupies only a small proportion of the nuclear space,while many proteins and RNAs segregate into membrane-less nuclear bodies(NBs).These NBs follow a stochastic or ordered assembly model and constantly exchange components with the surrounding nucleoplasm(Jain et al.,2016). | Hui Ming Qianfeng Wang Yuwen Zhang Luzhang Ji Lu Cheng Xiangru Huo Zixiang Yan Zhexiao Liu Yongjun Dang Bo Wen | 2021 | Protein & Cell2021，12，4： | 0 |
| 6 | Interfacial precipitation in{1012}twin boundaries of a Mg-Gd-Zn-Zr alloy显示文摘Twinning and precipitation play important roles in deformation and strengthening of magnesium alloys.In this work,interfacial precipitation in{1012}twin boundaries(TBs)of a cold-stamped Mg-12Gd-1.2Zn-0.4Zr alloy was investigated using atomic-resolution high-angle annular dark-field scanning transmission electron microscopy.Extended periodic segregation of Gd+Zn atoms in the~86.2°{1012}TBs with basal-prismatic facets and in the symmetric tilting TBs(obviously>86.2°)frequently occurred,resulted in the formation of new interfacial phases,namelyβ_(TB)’having a monoclinic structure in the TBs with two segregation layers andβ_(TB) having a tetragonal structure in the TBs with three or more segregation layers.The formation ofβ_(TB) clearly accelerates peak-aging and improves the alloy’s strength. | Zixiang Yan Qiang Yang Fanzhi Meng Rui Ma Rirong Bao Xiaojuan Liu Jian Meng Xin Qiu | 2021 | Journal of Materials Science & Technology2021，，34： | 0 |
| 7 | A lysosomal polarity-specific two-photon fluorescent probe for visualization of autophagy显示文摘Autophagy plays a vital role in maintaining the balance of normal physiological state of living cells.In this paper,a polarity-specific two-phot on fluorescent probe Lyso-NA based on naphthalimide was synthesized for the purpose of monitoring autophagy during biological research.The results of photophysical properties and theoretical calculation con firmed that different polarities of solvents mainly effected fluorescent intensities of probe.Fluoresce nt intensity,quantum yield and fluorescence lifetime of probe kept a good linear relationship with polarity respectively.In addition,due to its low toxicity and selective accumulation in lysosomes,Lyso-NA is suitable for detecting changes in lysosomal polarity of living cells.Compare with the imaging results of plasmid transfection,a better performed realtime long-term fluoresce nt visualization of autophagy in living cells was achieved.Probe Lyso-NA can work as an efficient and cost effective imaging tool for visualizing autophagy in living cells. | Zixiang Yuan Jun Chen Qin Zhou Ao Liu Zeming Qiang Min Fang Man Chen Yan Feng Haizhu Yu Xiuli Yang Xiangming Meng | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
| 8 | Exceptional reversed yield strength asymmetry in a rare-earth free Mg alloy containing quasicrystal precipitates显示文摘This work reports an exceptional reversed yield strength asymmetry at room temperature for a rare-earth free magnesium alloy containing a mass of fine dispersed quasicrystal(I-phase)precipitates.Although exhibiting traditional basal texture,it owns an exceptional CYS/TYS as high as~1.17.Electron back-scattered diffraction(EBSD)and transmission electron microscopy(TEM)examinations indicate pyramidal and prismatic dislocations plus tensile twinning being activated after immediate yielding in compression while basal and non-basal dislocations in tension.I-phase particles transferred the concentrated stress by self-twinning to provide the driving force for tensile twin initiating in neighboring grains,thereby significantly increasing the critical resolved shear stress of tensile twinning to possibly the level of pyramidal slip,finally leading to the dominance of pyramidal slip plus tensile twinning in texture grains.This results in a higher contribution on yield strength by~55 MPa in compression than in tension,which reasonably agrees with the experimental yield strength difference(~38 MPa).It can be concluded that I-phase particles influence deformation modes in tension and in compression,finally result in reversed yield strength asymmetry. | Qiang Yang Shuhui Lv Zixiang Yan Zefeng Xie Xin Qiu | 2024 | Journal of Magnesium and Alloys2024，12，2： | 0 |
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