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	题名	作者	年代	出处	被引量
1	Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer显示文摘AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. CONCLUSION: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer.	Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Laboratory of Oncology in South China, Biotherapy Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Ying-Bo Chen, Zhi-Wei Zhou, State Key Laboratory of Oncology in South China, Department of Gastric and Pancreatic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Rong Zhang, State Key Laboratory of Oncology in South China, Department of Endoscopy, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Xing-Juan Yu, Yi-Xin Zeng, State Key Laboratory of Oncology in South China, Department of Experimental Research, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China	2010	World Journal of Gastroenterology2010，16，19：	16
2	Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10, an immunodiagnostic antigen missing in Mycobacterium boris BCG显示文摘	Dillon DC Alderson MR Day CH Bement T Campos Neto A Skeiky YA Vedvick T Badaro R Reed SG Houghton R	2000	J Clin Microbiol2000，38，9：	1
3	Association of oligohy-dramnios in women with preterm premature rupture of mem- branes with an inflammatory response in fetal amniotic and maternal compartments 显示文摘	Yoon BH Kim YA Romero R	2009	Am J Obstet Gynecol2009，181，4：	1
4	Effect of titanium on the structure and properties of maraging tool steel 05Kh12N6D2SGTMF显示文摘	Zykova R A Ya I Spektor Yu M Politaev	1986	Metallovedenie i Termicheskaya Obrabotka Metallov1986，，9：	1
5	Application of the ATC/DDD methodology to monitor antibiotic drug use 显示文摘	Natsch S Hekster YA de Jong R	1998	Eur J Clin Microbiol Infect Dis1998，17，1：	1
6	Unmet needs among disabled elderly Malaysians显示文摘	Momtaz YA Hamid TA Ibrahim R	2012	Soc Sci Med2012，75，5：	1
7	Role of nitric oxide - derived oxidants in vascular injury from carbon monoxide in the rat 显示文摘	Fisher D Xu Ya	1999	Am J Physiol1999，276，3：	1
8	Heavy Precipitation and High Streamflow in the Contiguous United S taates: Trends i n the Twentieth Century 显示文摘	GROISMAN PAVEL YA KNIGHT RICHARD W KARL THOMAS R	2001	Bulleti n of the American Meteorological Soeiety2001，82，2：	1
9	Seasons but not ethnicity influence urinary iodine concentrations in Belgian adults显示文摘	Moreno-Reyes R Carpentier YA Maeours P	2011	Eur J Nutr2011，50，：	1
10	Scaling of soil water retention using a fractal model 显示文摘	Pachepsky Ya A Sncherbakov R A Korsunskaya L P	1995	Soil Sci1995，159，2：	1
11	Peripheral morphine analgesia: synergy with central sites and a target of morphine tolerance 显示文摘	Kolesnikov YA Jain S Wilson R	1996	Pharmacol Exp Ther1996，279，2：	1
12	Documenting and detecting longterm precipitation trends:where we are and what should be done显示文摘	Groisman P Ya Legates D R	1995	Climatic Change1995，31，：	1
13	Biodiversity and fermentative activity of caecal microbial communities in wild and farm rabbits from Spain显示文摘	Abecia L Rodríguez-Romero N Ya(n)ez-Ruiz D R	2012	Anaerobe2012，18，：	1
14	Impact of molecular imaging on the diagnostic process in a memory clinic 显示文摘	Ossenkoppele R Prins ND Pijnenburg YA	2013	Alzheimers Dement2013，9，4：	1
15	Changes in the probability of heavy precipitation: Important indicators of climatic change显示文摘	Groisman P Ya R E David	1999	Climatic Change1999，42，：	1
16	Device-associatedinfections rates in adult,pediatric,and neonatalintensive careunits of hospitals in the Philippines:international nosocomialinfection control consortium(NINCC)findings显示文摘	Navoa-Ng JA Berba R Galapia YA	2011	Am J In-fect Control2011，39，7：	1
17	Observed variability and trends in extreme climate events: A brief review显示文摘	Easterlling D R J L Evans P Ya Groisman	2000	Bull Amer Meteor Soc2000，81，3：	1
18	Vestsi Akad Navuk BSSR显示文摘	Bel'skaya R I Golubev N A Alefirova T Ya	1981	SerKhimNavauk1981，，6：	1
19	Heavy precipitation andhigh streamflow in the contiguous United States:Trends in the 20th century显示文摘	Groisman P Ya Knight R W Karl T R	2001	Bulletin of the American Meteorological Society2001，82，：	1
20	Changes in the probability of heavy precipitation: important indicators of climatic change 显示文摘	Groisman P Ya Karl T R Easterling D R	1999	Climatic Change1999，42，：	1

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