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| 1 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 2 | Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue显示文摘 | Leandro Luongo de Matos Gabriel Manfro Ricardo Vieira dos Santos Elaine Stabenow Evandro Sobroza de Mello Venancio Avancini F. Alves Fábio Roberto Pinto Marco Aurélio Vamondes Kulcsar Lenine Garcia Brand?o Cláudio Roberto Cernea | 2014 | Oral Surgery Oral Medicine Oral Pathology and Oral Radiology2014，，： | 1 |
| 3 | Effect of specific exercise training on bone mineral density in women with postmenopausal osteopenia or osteoporosis显示文摘 | de Matos O Lopes da Silva DJ Martinez de Oliveira J | | 0，，09： | 1 |
| 4 | Effect of specific exercise Raining on bone mineral density in women with postmenopausal osteopenia or osteoporosis显示文摘 | de Matos O Lopes da Silva DJ Martinez de Oliveira J | 2009 | Gynecol Endocrinol2009，25，9： | 1 |
| 5 | Rescaled range analysis and detrended fluctuation analysis study of cast irons ultrasonic backscattered signals 显示文摘 | MAURICIO J MATOS O ELINEUDO P MOURA de SILVIO KRUGER E MACCOS J REBELLO A | 2004 | CHAOS SOLITIONS & FRACTALS2004，，19： | 1 |
| 6 | Effect of specific exercise training on bone mineral density in women with postmenopausal osteopenia or oste- oporosis显示文摘 | de Matos O Lopes da Silva DJ Martinez de Oliveira J | 2009 | Gynecological Endocrinology2009，25，9： | 1 |
| 7 | Crack tip deformation -elds and fatigue crack growth rates in Ti-6Al-4V显示文摘 | KORSUNSKY A M SONG X BELNOUE J JUN T HOFMANN F DE MATOS P F P NOWELL D DINI D APRICIO-BLANCO O WALSH M J | 2009 | International Journal of Fatigue2009，31，1112： | 1 |
| 8 | Oral myiasis in an elderly patitent 显示文摘 | Ribeiro MC Pepato Ade O De Matos FP | 2012 | Gerodontology2012，29，2： | 1 |
| 9 | Evaluation and determination of chloride in crude oil based on the counterions Na, Ca, Mg, Sr and Fe, quantified via ICP-OES in the crude oil aqueous extract显示文摘 | Murilo de Oliveira Souza Maria Aparecida Ribeiro Maria Tereza Weitzel Dias Carneiro Geisamanda Pedrini Brand?o Athayde Eustáquio Vinícius Ribeiro de Castro Francisco Luan Fonseca da Silva Wladiana Oliveira Matos Rafael de Queiroz Ferreira | 2015 | Fuel2015，，： | 1 |
| 10 | Determination of synthetic food dyes in commercial soft drinks by TLC and ion-pair HPLC显示文摘 | Francisca Ivani de Andrade Maria Izabel Florindo Guedes ícaro Gusm?o Pinto Vieira Francisca Noélia Pereira Mendes Paula Alves Salmito Rodrigues Carla Soraya Costa Maia Maria Marlene Marques ávila Luzara de Matos Ribeiro | 2014 | Food Chemistry2014，，： | 1 |
| 11 | Comparison of four botulinum neurotoxin type A preparations in the treatment of hyperdynamic forehead lines in men: a pilot study 显示文摘 | Oliveira de Morais O Matos Reis-Filho E Vilela Pereira L | 2012 | J Drugs Dermatol2012，11，2： | 1 |
| 12 | Effect of specific exercise training on bone mineral density in women with postmenopausal osteopenia or osteoporosis 显示文摘 | de Matos O Lopes da Silva DJ Martinez de Oliveira J | 2009 | Gynecological Endocrinology2009，25，9： | 1 |
| 13 | Determination of synthetic food dyes in commercial soft drinks by TLC and ion-pair HPLC显示文摘 | Francisca Ivani de Andrade Maria Izabel Florindo Guedes ícaro Gusm?o Pinto Vieira Francisca Noélia Pereira Mendes Paula Alves Salmito Rodrigues Carla Soraya Costa Maia Maria Marlene Marques ávila Luzara de Matos Ribeiro | 2014 | Food Chemistry2014，，： | 1 |
| 14 | Immunohistochemical expression of MMP-9 and VEGF in squamous cell carcinoma of the tongue显示文摘 | Henriques AC de Matos FR Galv?o HC | | 0，，1： | 1 |
| 15 | Effect of specific exercise training on bone mineral density in women with postmenopausal osteopenia or osteoporosis显示文摘 | de Matos O Lopes da Silva DJ Martinez de Oliveira J | 2009 | Gynecol Endocrinol2009，25，9： | 1 |
| 16 | Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy 显示文摘 | De Matos PS Ferreira AP de O liveira Facuri F | 2005 | Histopathology2005，47，4： | 1 |
| 17 | Comparison of four botulinum neurotoxin type A preparations in the treatment of hyperdynamic forehead lines in men: a pilot study 显示文摘 | Oliveira de Morais O Matos Reis-Filho E Vilela Pereira L | 2012 | J Drugs Dermatol2012，11，2： | 1 |
| 18 | Trypsin inhibitor from Dimorphandra mollis seeds:purification and properties显示文摘 | Macedo M L de Matos D G Machado O L | | 0，，： | 1 |
| 19 | Effect of specific exercise training on bone mineral density in women with postmenopausal osteopenia or oste- oporosis 显示文摘 | de Matos O Lopes da Silva D J Martinez de Oliveira J | 2009 | Gynecological Endocrinology2009，25，9： | 1 |
| 20 | Expression of CK-19, Galectin-3 and HBME-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis显示文摘 | de Matos L L Del Giglio A B Matsubayashi C O | 2012 | Diagn Pathol2012，7，1： | 1 |
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