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18篇 您的检索式：作者名="dubray G"

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		题名	作者	年代	出处	被引量
	1	Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model显示文摘AIM: To evaluate the antiviral potency of a new antihepatitis C virus(HCV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HCV Con1b/C3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HCV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HCV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HCV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 EC50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine EC50 = 1.17 μmol/L).CONCLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HCV infection in a dosedependent manner without cytotoxic effect.	Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska Claire Camus Clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault Jerome Courcambeck Firas Bassisi Philippe Halfon Stanislas Pol	2016	World Journal of Hepatology2016，8，21：	5
	2	Sodium dodecyl Sulfate-polyacrylamide gel electrophoresis and immunoblotling analysis of smooth-lipopolysaccharide heterogeneity among Brucella biovars related to A and M specificities显示文摘	Garin-Bastuji B Bowden G A dubray G	1990	J Clin Microbiol1990，28，10：	1
	3	Competitive enzyme-linked immunosorbent assay using monoclonal antibodies to the Brucella melitensis BP26 protein to evaluate antibody responses in infected and B. melitensis Rev.1 vaccinated sheep显示文摘	Hanane Salih-Alj Debbarh Michel S. Zygmunt Gérard Dubray Axel Cloeckaert	1996	Veterinary Microbiology1996，，3：	1
	4	Antibody responses in the serum and gut of chicken lines differing in cecal carriage of Salmonella enteritidis显示文摘	Florence Berthelot-Hérault Florence Mompart Michel S Zygmunt Gérard Dubray Marion Duchet-Suchaux	2003	Veterinary Immunology and Immunopathology2003，，1：	1
	5	Sodium dodeeyl sulfate-polyacrylamide gel eleetrophoresis and immunoblotting analysis of smooth-lipopolysaeeharide heterogeneity among Brucella biovars related to A and M specifieities显示文摘	Bastuji B G R Bowden A Dubray G	1990	J Clin Microbiol1990，28，10：	1
	6	Morphological description of surface structures on strain B41 of bovine enterotoxigenic Escherichia coli bearing both K99 and F41 antigens显示文摘	Benin A Dubray G	1988	J Gen Microbiol1988，134，4：	1
	7	Low genotyping error rates in wild ungulate faeces sampled in winter 显示文摘	Maudet C Luikart G Dubray D	2004	Molecular Ecology Notes2004，4，4：	1
	8	Efficacy of ELISA compared to conventional tests(RBPT and CFT)for the diagnosis of Brucella melitensis infection in sheep显示文摘	Jacques I Olivier-Bemardin V Dubray G	1998	Vet microbiol1998，64，1：	1
	9	Efficacy of ELISA compared to conventional tests( RBPT and CFT) for the diagnosis of Brucella melitensis infection in sheep显示文摘	JACQUES I OLIVIER- BERNARDIN V DUBRAY G	1998	Vet Microbiol1998，64，：	1
	10	Sodium dodecyl sulfate-polyacrylamide gel eleetrophoresis and immunoblotling analysis of smooth-lipopolysaccharide heterogeneity amony Brueella biovars related to A and M specificities 显示文摘	Garin-Bastuji B Bowden G A Dubray G	1990	J Clin Microbiol1990，28，10：	1
	11	Identification of seven surface-exposed Brucella outer membrane proteins by use of monoclonal antibodies:immunogold labeling for electron microscopyand enzyme-linked immunosorbent assay显示文摘	Cloeckaert A de Wergifosse P Dubray G	1990	Infect Immun1990，58，：	1
	12	Isolation of three protective cell-wall antigens of Brucella abortus in experimental brucellosis in mice 显示文摘	Dubray Bezard G	1980	Ann Rech Vet1980，11，：	1
	13	Sodium dodeeyl sulfate-polyacrylamide gel electrophoresis and imrnunoblotting analysis of smooth lipopolysaccharide hetero geneity among Brucella biovars related to A and M speeificities 显示文摘	GARIN-BASTUJI B BOWDEN R A DUBRAY G	1990	J Clin Microbiol1990，28，10：	1
	14	Evidence of three major polypeptide and two major polysaccharide species in the Brucella outer membrane 显示文摘	Dubray G Charriaut C	1983	Ann Rech Vet1983，14，：	1
	15	Identification of seven surface-exposed BruceUa outer membrane proteins by use of monoclonal antibodies: immunogold labeling for electron microscopy and enzyme-linked immunosorbent assay 显示文摘	Cloeckaert A de Wergifosse P Dubray G	1990	Infect lmmun1990，58，12：	1
	16	Brucella melitensis cell envelope protein and lipopolysaccharide epitopes involved in immune responses of naturally and experimentally infected sheep 显示文摘	Zygmunt MS Cloeckaert A Dubray G	1994	Clin Microbiol1994，32，：	1
	17	Efficacy of ELISA compared to conventional tests (RBPT and CFY) for the diagnosis of Brucella melitensis infection in sheep显示文摘	JACQUES I OLIVIER-BERNARDIN V DUBRAY G	1998	Vet Microbiol1998，64，：	1
	18	Protective antigens in brucellosis显示文摘	Dubray G	1987	Ann Inst Pas- teur mierobiol1987，138，：	1

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