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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 3 | Autonomic nervous system dysfunction in Parkinson' s disease 显示文摘 | Zesiewicz TA Baker MJ Wahba M el al | 2003 | Curr Treat Options Neurol2003，5，2： | 1 |
| 4 | Sulforaphane en- hances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells显示文摘 | MATSUI TA SOWA Y YOSHIDA T el al | 2006 | Carcinogenesis2006，27，9： | 1 |
| 5 | Mitochondrial content reflects oocyte variability and fertilization outcome 显示文摘 | Santos TA El Shourbagy S St John JC | 2006 | Fertil Steril2006，85，3： | 1 |
| 6 | Less postoperative nausea and vomiting after propofol + remitkentanil versus propofol + fentanyl anaesthesia during plastic: surgery 显示文摘 | Rama- Maeeiras P Ferreira TA Molins N el al | 2005 | Acla Anaesthesiol Seand2005，49，3： | 1 |
| 7 | Green fluorescenl protein for delection of the probiotic microorganism Escherichia coli strain Nissle 1917 (EcN) in vivo 显示文摘 | Schuhz M Watzl S Delschlaeger TA el al | 2005 | Journal of Microbiological Methods2005，61，3： | 1 |
| 8 | I{elatinnship be2 tween exacerbation frequency and lung function decline in chronic obstructive pulmonary disease 显示文摘 | Donaldson GC Seemungal TA Bhowmik A et 'el | 2002 | Thorax2002，57，10： | 1 |
| 9 | Liquid chromatographic assay of nifedipine in human plasma and its application to pharmackokinet studies显示文摘 | Abou-Auda HS Najjar TA Al-Khamis KI el al | 2000 | J Pharm Biomed Anal2000，22，2： | 1 |
| 10 | Enteral nutritionn is superior to parentera;nutrition in severe acute pancreatitis:results of a randomized prospective trial显示文摘 | Kehagias J Mead N el ta | 1997 | Br J Surg,1997，84，7： | 1 |
| 11 | Contrast enhanced spiral computerized tomography in patients with chronic obstructive uropathy and normal serum creatinine:a single session for anatomical and functional assessment显示文摘 | El-Ghar ME Shokeir AA El Diasty TA | 2004 | Urol2004，172，3： | 1 |
| 12 | Human promyelocytic leukemia HL-60 cellproliferation and c-myc protein expression are inhibited by an antisensepentadecadeoxynucleotide targeted against c-myc mRNA显示文摘 | Wickstrom EL Bacon TA Gonzalez A | 1988 | Proc Natl Acad SciUSA1988，85，： | 1 |
| 13 | Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance : the Australian Dia- betes, Obesity, and Lifestyle Study ( AusDiab ) 显示文摘 | Barr EL Zimmet PZ Welbom TA | 2007 | Circulation2007，116，： | 1 |
| 14 | Screening of surface properties and antagonistic substances production by lactic acid bacteria isolated from the mammary gland of healthy and mastitic cows显示文摘 | ESPECHE M C OTERO M C SESMA F el ta | 2009 | Veterinary Microbiology2009，135，34： | 1 |
| 15 | Human brain language areas identified by functional magnetic resonance imaging显示文摘 | Binder JR Frost JA Hammeke TA el al | 1997 | J Neurosci1997，17，： | 1 |
| 16 | Improving glycemic control in adults with diabetes mellitus:shared responsibility in primary care practices显示文摘 | Graber AL Elasy TA Quinn D el a1 | 2002 | South Med J2002，，： | 1 |
| 17 | Amino acid and albumin losses during hemodialysis显示文摘 | Ikizler TA Flakoll PJ Parker RA el at | | 0，，03： | 1 |
| 18 | Cancer-and cancer treatment asso- ciated cognitive change: an update on the state of the science显示文摘 | Ahles TA Root JC Ryan EL | 2012 | J Clin Oncol2012，30，： | 1 |
| 19 | Risk factor analysis of ortho-topic heart transplantation显示文摘 | Minami K Bothing D el ta | 2003 | Asian Cardiovasc Thorac Ann2003，11，1： | 1 |
| 20 | MRP as a new predictive marker of tamoxifen efficiency in lreatmenl of estrogen receptor -positive breast cancer显示文摘 | Bogush TA Dudko EA Bogush EA el al | 2010 | Dokl Biochem Biophys2010，430，： | 1 |
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