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| 1 | Interleukin-1 and estrogen protect against disseminating dentoalveolar infections显示文摘Dentoalveolar bacterial infections cause localized tissue and bone destruction, but usually remain well-localized within teeth in immunocompetent hosts. However, in certain cases these infections may invade head and neck tissues, resulting in orofacial abscesses, cellulitis and sepsis, with resultant high morbidity and even mortality. In the present studies, we developed a novel model of spreading dentoalveolar infections in mice by treatment with neutralizing antibodies against both interleukin-1α(IL-1α)and IL-1β. Surprisingly male but not female mice given anti-IL-1 antibodies developed orofacial abscesses, weight loss,splenomegaly and sepsis. Female mice developed abscesses and sepsis comparable to males following ovariectomy(OVX), which was reversed by estrogen supplementation. Anti-IL-1 blockade inhibited IL-12, interferon γ(IFNγ) and IL-6 but not IL-10 expression in infrabony lesions, suggestive of a local anti-inflammatory response. There was greater infiltration of neutrophils and other inflammatory cells into lesions in anti-IL-1-treated animals; however, blood leukocytes had reduced bacterial phagocytic and killing activity ex vivo. Estrogen directly stimulated IL-1 production by macrophages, suggesting that the resistance of females to disseminating dentoalveolar infections may be due to their heightened pro-inflammatory responses following bacterial challenge, leading to enhanced localization of these infections. | hesham youssef philip stashenko | 2017 | International Journal of Oral Science2017，9，1： | 7 |
| 2 | Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008显示文摘 | Zobair M. Younossi Maria Stepanova Mariam Afendy Yun Fang Youssef Younossi Hesham Mir Manirath Srishord | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 5 |
| 3 | Comparative study between botulinum toxin injection and partial division of puborectalis for treating anismus显示文摘 | Mohamed Farid Tamer Youssef Tarek Mahdy Waleed Omar Hesham Abdul Moneim Ayman El_Nakeeb Mohamed Youssef | 2009 | International Journal of Colorectal Disease2009，，3： | 2 |
| 4 | Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008显示文摘 | Zobair M. Younossi Maria Stepanova Mariam Afendy Yun Fang Youssef Younossi Hesham Mir Manirath Srishord | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 2 |
| 5 | T4 sympathectomy for palmar hyperhidrosis: looking for the right operation显示文摘 | Tarek Mahdy Tamer Youssef Hesham Abd Elmonem Waleed Omar Atef Abd Elateef | 2008 | Surgery2008，，6： | 1 |
| 6 | Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008显示文摘 | Zobair M. Younossi Maria Stepanova Mariam Afendy Yun Fang Youssef Younossi Hesham Mir Manirath Srishord | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 1 |
| 7 | Implementing the Safety Culture Improves the Autonomous Ships Prosperity显示文摘Since that a lot of studies and conventions take a look at the explanations of marine accidents within the maritime sectors,and also the position of the human elements that shoulder the high ratio of accidents reasons.They englobed how we learning and measuring the security culture to the human factors to mitigated the motives of incidents and accidents.the International Safety Management(ISM)Code used to be adopted by the International Maritime Organization(IMO)in order to establish a protection lifestyle inside the global maritime community,the ISM Code states that one of its key goals is to set up a“safety culture”in delivery companies,it does not without a doubt outline the that means and measuring of the term.However,a safety way of life may additionally be described as the values,practices and studying that administration and personnel share to ensure that risks are constantly minimized and mitigated to the best degree possible.The ship management structures are nearly completely computerized and any automation failure may additionally cause accidents with damages to human life,to the environment,to the ships,to the port facilities and so the products transported,Safety administration in transport pursuits to stay removed from or mitigate the implications of any incidents bemused.The lookup is based on a descriptive approach,the qualitative methodology,as this methodology is the most capable of providing a comprehensive image of the effectivity of getting to know and measuring the protection culture.The lookup aimed to existing the amendment that ought to take area in the ISM code and use a new science for monitoring the performance and effectiveness of the code as a guide line and to create a spirit of credibility amongst the our bodies supervising the implementation of the Code to cope the self sufficient ship technology. | Essam Eldin Youssef Abdelraouf Hesham Elsayad | 2020 | Journal of Shipping and Ocean Engineering2020，10，1： | 0 |
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