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| 1 | Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma显示文摘Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells (RGCs) in a rat chronic ocular hypertension (COH) model. Here, we investigated the expression of endothelin-1 (ET-1), a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure (IOP) was induced in the right eye of SD rats using argon laser photocoagulation. (1) The expression of ET-1, ETA and ETB in normal and COH retinas was studied. (2) Some COH rats were fed daily with Lycium barbarum Polysaccharides (LBP) using 1 mg/kg or phosphate-buffered saline (PBS) for 3 weeks (started 1 week before photocoagulation). The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that (1) Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. (2) After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. (3) By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature. | Xue-Song Mi Kin Chiu Geoffrey Van Justin Wai Chung Leung Amy Cheuk Yin Lo SookjaKim Chung Raymond Chuen-Chung Chang Kwok-Fai So | 2012 | Neural Regeneration Research2012，7，9： | 14 |
| 2 | Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma显示文摘Monocyte chemoattractant protein-1(MCP-1)/CCL2 is a C–C chemokine involved in the activation and recruitment of monocytic cells to injury sites.MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro,depending on the experimental model.We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells(RGCs)is exacerbated or attenuated in an experimental glaucoma model.While a high concentration(1000 ng)of MCP-1/CCL2 and lipopolysaccharide(LPS)-exacerbated RGC loss,100 ng MCP-1/CCL2 provided neuroprotection towards RGC.Neuroprotective MCP-1/CCL2(100 ng)also upregulated insulin-like growth factor-1(IGF-1)immunoreactivity in the RGCs.The neuroprotective effect of MCP-1/CCL2 was not due to the massiveinfiltration of microglia/macrophages.Taken together,this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. | Kin Chiu Sze-Chun Yeung Kwok-Fai So Raymond Chuen-Chung Chang | 2010 | Cellular & Molecular Immunology2010，7，1： | 6 |
| 3 | Modulation of Neuroimmune Responses on Glia in the Central Nervous System: Implication in Therapeutic Intervention against Neuroinflammation显示文摘大脑是处于正常条件的一个 immunologically 给予优惠的地点,这长被知道了。尽管只要有 neuronal 损害或有势力免疫者刺激,有免疫力的回答的串联能发生,大脑怎么把 glial 房间放在一个静止状态,仍然是不清楚的。增加的努力被几作了实验室阐明有免疫力的回答的压抑怎么在 neuronal 环境被完成。抑制因素经由粘附分子或 CD200 受体包括 neurotransmitters,神经激素,神经营养的因素,反煽动性的因素,和房间房间接触。因为上面列出的单个因素都不能充分说明有免疫力的抑制,这评论讨论这些因素怎么影响服的有免疫力的回答的串联。当几个因素贡献有免疫力的回答的抑制时,只要有 neuronal 损害, glial 房间和他们支持 inflammatory 因素的生产的激活确实发生,建议一些 neuronal 部件便于有免疫力的回答。这评论也讨论信号哪个开始或扩充服的有免疫力的回答以便 stimulatory 信号制服镇压信号。证据的增加的线证明了在大脑的有免疫力的回答不对神经原总是有害。简单地在 CNS 变清离开煽动性的因素的尝试不能为在神经病学的混乱的神经原是适当的。在 CNS 的有免疫力的房间的适当控制可能对神经原或甚至 neuroregeneration 有益。因此,理解位于有免疫力的抑制下面的机制可以帮助我们在许多神经病学的混乱对发炎重塑药理学干预。 | Raymond Chuen-Chung Chang Kin Chiu Yuen-Shan Ho Kwok-Fai So | 2009 | Cellular & Molecular Immunology2009，6，5： | 5 |
| 4 | Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells显示文摘Lycium barbarum(LB)is a traditional Chinese medicine that has been demonstrated to exhibit a wide variety of biological functions,such as antioxidation,neuroprotection,and immune modulation.One of the main mechanisms of Alzheimer’s disease is that microglia activated by amyloid beta(Aβ)transform from the resting state to an M1 state and release pro-inflammatory cytokines to the surrounding environment.In the present study,immortalized microglial cells were pretreated with L.barbarum extract for 1 hour and then treated with oligomeric Aβfor 23 hours.The results showed that LB extract significantly increased the survival of oligomeric Aβ-induced microglial cells,downregulated the expression of M1 pro-inflammatory markers(inducible nitric oxide synthase,tumor necrosis factorα,interleukin-6,and interleukin-1β),and upregulated the expression of M2 anti-inflammatory markers(arginase-1,chitinase-like protein 3,and interleukin-4).LB extract also inhibited the oligomeric Aβ-induced secretion of tumor necrosis factorα,interleukin-6,and interleukin-1βin microglial cells.The results of in vitro cytological experiments suggest that,in microglial cells,LB extract can inhibit oligomeric Aβ-induced M1 polarization and concomitant inflammatory reactions,and promote M2 polarization. | Zhong-Qing Sun Jin-Feng Liu Wei Luo Ching-Hin Wong Kwok-Fai So Yong Hu Kin Chiu | 2022 | Neural Regeneration Research2022，17，1： | 4 |
| 5 | More than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration显示文摘Artemisinin,also called qinghaosu,is originally derived from the sweet wormwood plant(Artemisia annua),which is used in traditional Chinese medicine.Artemisinin and its derivatives(artemisinins)have been widely used for many years as anti-malarial agents,with few adverse side effects.Interestingly,evidence has recently shown that artemisinins might have a therapeutic value for several other diseases beyond malaria,including cancers,inflammatory diseases,and autoimmune disorders.Neurodegeneration is a challenging age-associated neurological disorder characterized by deterioration of neuronal structures as well as functions,whereas neuroinflammation has been considered to be an underlying factor in the development of various neurodegenerative disorders,including Alzheimer’s disease.Recently discovered properties of artemisinins suggested that they might be used to treat neurodegenerative disorders by decreasing oxidation,inflammation,and amyloid beta protein(Aβ).In this review,we will introduce artemisinins and highlight the possible mechanisms of their neuroprotective activities,suggesting that artemisinins might have therapeutic potential in neurodegenerative disorders. | Bing-Wen Lu Larry Baum Kwok-Fai So Kin Chiu Li-Ke Xie | 2019 | Neural Regeneration Research2019，14，9： | 4 |
| 6 | Mechanisms of electrical stimulation in eye diseases:A narrative review显示文摘Background:In the last two decades,electrical stimulation(ES)has been tested in patients with various eye diseases and shows great treatment potential in retinitis pigmentosa and optic neuropathy.However,the clinical application of ES in ophthalmology is currently limited.On the one hand,optimization and standardization of ES protocols is still an unmet need.On the other hand,poor understanding of the underlying mechanisms has hindered clinical exploitation.Main Text:Numerous experimental studies have been conducted to identify the treatment potential of ES in eye diseases and to explore the related cellular and molecular mechanisms.In this review,we summarized the in vitro and in vivo evidence related to cellular and tissue response to ES in eye diseases.We highlighted several pathways that may be utilized by ES to impose its effects on the diseased retina.Conclusions:Therapeutic effect of ES in retinal degenerative diseases might through preventing neuronal apoptosis,promoting neuronal regeneration,increasing neurotrophic factors production in Müller cells,inhibiting microglial activation,enhancing retinal blood flow,and modulating brain plasticity.Future studies are suggested to analyse changes in specific retinal cells for optimizing the treatment parameters and choosing the best fit ES delivery method in target diseases. | Jinfeng Liu Andre K.H.Ma Kwok Fai So Vincent W.H.Lee Kin Chiu | 2022 | Advances in Ophthalmology Practice and Research2022，2，2： | 1 |
| 7 | Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model显示文摘 | Kin Chiu Hiu-Chi Chan Sze-Chun Yeung Wai-Hung Yuen Sze-Yong Zee Raymond Chuen-Chung Chang Kwok-Fai So | 2009 | Journal of Ocular Biology Diseases and Informatics2009，，3： | 1 |
| 8 | The Selective Vulnerability of Retinal Ganglion Cells in Rat Chronic Ocular Hypertension Model at Early Phase显示文摘 | Xue-Gang Luo Kin Chiu Flora H. S. Lau Vincent W. H. Lee Ken K. L. Yung Kwok-Fai So | 2009 | Cellular and Molecular Neurobiology2009，，8： | 1 |
| 9 | Cost of ownership model for the RFID logistics system applicable to u-city显示文摘 | Hong Sik Kin So Young Sohn | 2007 | European Journal of Operational Research2007，194，2009： | 1 |
| 10 | Surgical manage, merit of- congenital aural atresial 显示文摘 | Chang SO Min YG Kin CS | 1994 | Laryngoscope1994，104，： | 1 |
| 11 | Angiopoietin-1 induces en-dothelial cell sprouting through the activation of focal adhesion kinase and piasmin secretion显示文摘 | Kim I Kin HG Moon SO | 2000 | Circ Res2000，86，： | 1 |
| 12 | Osteopontin promotes CCLS-mesenchymal stromal cell-mediated breast cancer metastasis显示文摘 | Mi Z Bhattacharga SO Kin VM | 2011 | Carcinogenesis2011，32，4： | 1 |
| 13 | An Efficient Class of P,N‐Type “PhMezole‐phos” Ligands: Applications in Palladium‐Catalyzed Suzuki Coupling of Aryl Chlorides显示文摘 | Shun Man Wong Chau Ming So Kin Ho Chung Chak Po Lau Fuk Yee Kwong | 2012 | Eur J Org Chem2012，，22： | 1 |
| 14 | Modified distally based sural neuro-veno-fasciocutaneous flap:anatomical study and clinical applications 显示文摘 | Zhang FH Chang SM kin SO | | Microsurgery0，25，7： | 1 |
| 15 | The Effect of Menopause on the Metabolic Syndrome Among Korean Women 显示文摘 | Hee Man Kin MD Jong Park MD PHD So Yeon Ryu MD PHD | 2007 | Diabetes Care2007，30，3： | 1 |
| 16 | Surgical manage, ment of congenital aural atresial显示文摘 | Chang SO Min YG Kin CS | 1994 | Laryngoscope1994，104，： | 1 |
| 17 | Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma显示文摘 | Hiu-Chi Chan Raymond Chuen-Chung Chang Angel Koon-Ching Ip Kin Chiu Wai-Hung Yuen Sze-Yong Zee Kwok-Fai So | 2006 | Experimental Neurology2006，，1： | 1 |
| 18 | Socioenvironmental Factors Associated With Constipation in Hong Kong Children and Rome III Criteria显示文摘 | Yuk H. Tam Albert M. Li Hung K. So Kam Y. Shit Kristine K. Pang Yuen S. Wong Siu Y. Tsui Jennifer W. Mou Kin W. Chan Kim H. Lee | 2012 | Journal of Pediatric Gastroenterology and Nutrition2012，，1： | 1 |
| 19 | Protease catalyzed tripeptide(RGD)synthesis显示文摘 | So JE Shin JS Kin BG | 2000 | Enzyme and Microbial Technology2000，26，2： | 1 |
| 20 | Retinal safety and toxicity study of artesunate in vitro and in vivo显示文摘Background:Artesunate(ART),a member of the artemisinin family,possesses multi-properties,including antiinflammation,anti-oxidation,and anti-tumor.ART was recently reported to show anti-neovascularization effect on the cornea,iris,and retina.Compared to the expensive anti-VEGF treatment,this versatile,economical treatment option is attractive in the ophthalmic field.The safety and toxicity profile of ART intravitreal application are in utmost need.Methods:In this study,immortalized microglial(IMG)cells were treated with ART to determine the safe concentrations without inducing overt inflammatory reactions.Reverse transcription-polymerase chain reaction analysis was used to detect the cytokine expressions in IMG cells in response to ART stimulation.Various doses of ART were intravitreally injected into the right eyes of C57BL/6 mice.Retinal function was tested by electroretinogram,and retinal ganglion cell(RGC)survival was evaluated by counting Brn3a stained cells in flat-mounted retinas at 7 days after ART injection.Results:ART below 5μM was safe for IMG cells in vitro.Both 2.5 and 5μM ART treatment increased IL-10 gene expression in IMG cells while not changing IL-1β,IL-6,TNF-α,and Arg-1.In the in vivo study,intravitreal injection of ART below 100μM did not cause deterioration in the retinal function and RGC survival of the mouse eyes,while 1 mM ART treatment significantly attenuated both the scotopic and photopic b-wave amplitudes and impaired RGC survival.In addition,treatment with ART of 25,50,and 100μM significantly decreased TNF-αgene expression while ART of 100μM significantly increased IL-10 in the mouse retina.Conclusions:Intravitreal injection of 100μM ART could downregulate TNF-αwhile upregulate IL-10 in the mouse retina without causing retinal functional deterioration and RGC loss.ART might be used as anti-inflammatory agent for retinal disorders. | Bing-Wen Lu Yu-Xiang Liang Jin-Feng Liu Zhong-Qing Sun Kwok-Fai So Kin Chiu | 2023 | Advances in Ophthalmology Practice and Research2023，3，2： | 0 |
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