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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | IPDI在聚氨酯反应中对选择性温度、催化过程和反应对象的影响显示文摘在一项针对异佛尔酮二异氰酸酯(IPDI)于氨基甲酸酯反应中的选择性之模型研究中,提示了催化剂类型和温度的影响。同时通过选择伯丁醇和仲丁醇作为反应对象,介绍了羟基类型的影响。 需特别指出的是,催化剂的选择对最终产品的组成有着极重大的影响。模型研究的最重要结论在NCO预聚物的合成中得到了肯定。 | Dr.R.Lomlder Mr.F.Plogmann Mr.P.Speier | 2001 | 上海涂料2001，39，5： | 7 |
| 3 | Management of autoimmune hepatitis:Focus on pharmacologic treatments beyond corticosteroids显示文摘In autoimmune hepatitis, patients who are intolerant or with toxicity experience, non-responders, relapsers or refractory are challenging. Non-standard drugs are being tried to preemptively avoid corticosteroid-related side effects. Prognosis and quality of life of life rely on treatment optimization. Recently, emergence of powerful immunosuppressive agents, mainly from liver transplantation, challenged the supremacy of the corticosteroid regime and promise greater immunosuppression than conventional medications, offer site-specific actions and satisfactory patient tolerance. Successes in experimental models of related diseases have primed these molecular interventions. We performed a literature review on alternative treatments. Azatioprine intolerance is the principal indication for mycophenolate use butit can be used as a front-line therapy. Cyclosporine A and tacrolimus have been tested for non-responders or relapsers. Rituximab may be used as salvage therapy. Anti-tumor necrosis factor-alpha agents may be used for incomplete responses or non-responders. Methotrexate is possibly an alternative for induction of remission and maintenance in refractory patients. Cyclophosphamide has been included in the induction regimen with corticosteroids. Ursodeoxycholic acid action is mainly immunomodulatory. Non-standard treatments are coming slowly to the attention, but its use should be cautious performed by experienced centers. | Marta Casal Moura Rodrigo Liberal Hélder Cardoso Ana Maria Horta e Vale Guilherme Macedo | 2014 | World Journal of Hepatology2014，6，6： | 2 |
| 4 | Performance of wavecatcher intakes at angles of attack and sideslip显示文摘A wavecatcher type scramjet intake,that reduces the Mach number number from 4 to 1.552,is used as the basis for a study of flow starting/unstarting as affected by freestream angles of attack and sideslip.The intake design is based on a morphed streamtube consisting of two conical flow streamlines using streamline tracing and osculating axisymmetric design theory.Intake flow and performance is modeled using the numerical CFD code and the k-e turbulence model.The intake unstarts at a sideslip angle of 2,a positive angle of attack of 1.Both positive angle of attack and sideslip angle have an adverse effect on the startability of the MBus intake.At negative angles,the intake initially unstarts at5angle of attack,due to the thickened shear layer induced by the streamwise vortex.Then it re-starts at8angle of attack,mainly due to the expansion fan formed at the leading edge,causing the shock wave structures inside the intake to be reestablished. | Fengyuan ZUO Sannu MO LDER Gang CHEN | 2021 | Chinese Journal of Aeronautics2021，34，7： | 2 |
| 5 | The influence of processing parameters on the ultrasonic degassing of molten AlSi9Cu3 aluminium alloy显示文摘 | Hélder Puga Joaquim Barbosa E. Seabra S. Ribeiro M. Prokic | 2009 | Materials Letters2009，，9： | 2 |
| 6 | Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering显示文摘The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 MPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 MPa and dynamical mechanical properties ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hMCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patient-speci fic approach. | Joao BCosta Joana Silva-Correia Sandra Pina Alain da Silva Morais Sílvia Vieira Hélder Pereira Joao Espregueira-Mendes Rui LReis Joaquim M.Oliveira | 2019 | Bio-Design and Manufacturing2019，2，4： | 2 |
| 7 | Trajectory tracking control of parallel robots in the presence of joint drive flexibility显示文摘 | Kemal lder s Korkmaz O | 2009 | Journal of Sound and Vibra- tion2009，319，： | 1 |
| 8 | Experimental results for 2D magnetic resonance electrical impedance tomography (MR-EIT) using magnetic flux density in one direction 显示文摘 | Birgul O Eyuboglu BM lder YZ | 2003 | Phys Med Biol2003，48，10： | 1 |
| 9 | Design, synthesis, physical and chemical characterisation, and biological interactions of lectin-targeted latex nanoparticles bearing Gd–DTPA chelates: an exploration of magnetic resonance molecular imaging (MRMI)显示文摘 | Irena Paschkunova-Martic Christian Kremser Klaudia Mistlberger Nadezhda Shcherbakova Hermann Dietrich Heribert Talasz Yiping Zou Beate Hugl Markus Galanski Elisabeth S?lder Kristian Pfaller Isabella H?liner Wolfgang Buchberger Bernhard Keppler Paul Debbag | 2005 | Histochemistry and Cell Biology2005，，3： | 1 |
| 10 | Sublayer-Stanton numbers of heat and matter for aerodynamically smooth surfaces: basic considerations and evaluation显示文摘 | G. Kramm R. Dlugi N. M?lders | 2002 | Meteorology and Atmospheric Physics (-)2002，，3： | 1 |
| 11 | Erythropoietin stimulates proliferation of human renal carcinoma cells显示文摘 | lder C Baranowski R L | | 0，，： | 1 |
| 12 | Development of a novel electrospun nanofibrous delivery system for poorly water-soluble β-sitosterol显示文摘Electrospinning was used as a novel technique for fabricating polymeric nanofibers of a serum cholesterol lowering and poorly water-soluble plant sterol, β-sitosterol. Chitosan was used as a stabilizer/carrier polymer. The mean diameters of nanofibers ranged from 150 nm to218 nm. β-sitosterol was in an amorphous form and homogeneously dispersed in the nanofibers. The β-sitosterol-loaded nanofibers were freely water-soluble and exhibited very short lag-time in releasing the plant sterol. The dissolution was associated with an immediate recrystallization of β-sitosterol in submicron level. In conclusion, electrospinning is a promising future technology for the formulation of poorly water-soluble plant sterols. | Urve Paaver Ivo Laidmae Hélder A.Santos Jouko Yliruusi Jaan Aruvali Karin Kogermann Jyrki Heinamaki | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，4： | 1 |
| 13 | RIG-I and MDA-5 detection of viral RNA- dependent RNA polymerase activity restricts positive-strand RNA virus replication 显示文摘 | Andrei Nikonov Tarmo Mo'lder Rein Sikut | 2013 | PLoS Pathog2013，9，10： | 1 |
| 14 | Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats显示文摘 | Bimbo Luis M Sarparanta Mirkka Santos Hélder A | 2010 | ACS NANO2010，4，： | 1 |
| 15 | Successful singlelung transplantation after paraquat intoxication 显示文摘 | Brundler MA Spiliopoulos A | 1997 | Transplantation1997，64，5： | 1 |
| 16 | Busemann inlet for hypersonic speeds显示文摘 | M?lder S Szpiro J | 1966 | Journal of Spacecraft and Rockets1966，3，8： | 1 |
| 17 | Programmable immune activating electrospun fibers for skin regeneration显示文摘Immune cells play a crucial regulatory role in inflammatory phase and proliferative phase during skin healing.How to programmatically activate sequential immune responses is the key for scarless skin regeneration.In this study,an“Inner-Outer”IL-10-loaded electrospun fiber with cascade release behavior was constructed.During the inflammatory phase,the electrospun fiber released a lower concentration of IL-10 within the wound,inhibiting excessive recruitment of inflammatory cells and polarizing macrophages into anti-inflammatory phenotype“M2c”to suppress excessive inflammation response.During the proliferative phase,a higher concentration of IL-10 released by the fiber and the anti-fibrotic cytokines secreted by polarized“M2c”directly acted on dermal fibroblasts to simultaneously inhibit extracellular matrix overdeposition and promote fibroblast migration.The“Inner-Outer”IL-10-loaded electrospun fiber programmatically activated the sequential immune responses during wound healing and led to scarless skin regeneration,which is a promising immunomodulatory biomaterial with great potential for promoting complete tissue regeneration. | Lu Chen Liucheng Zhang Hongbo Zhang Xiaoming Sun Dan Liu Jianming Zhang Yuguang Zhang Liying Cheng Hélder A.Santos Wenguo Cui | 2021 | Bioactive Materials2021，6，10： | 1 |
| 18 | Non-grey gas radiative transfer analyses using the statistical narrow-band model显示文摘 | Liu F S Gü lder Ö L Smallwood G J | 1998 | International Journal of Heat and Mass Transfer1998，41，14： | 1 |
| 19 | Mussel-Inspired and Bioclickable Peptide Engineered Surface to Combat Thrombosis and Infection显示文摘Thrombosis and infections are the two major complications associated with extracorporeal circuits and indwelling medical devices,leading to significant mortality in clinic.To address this issue,here,we report a biomimetic surface engineering strategy by the integration of mussel-inspired adhesive peptide,with bio-orthogonal click chemistry,to tailor the surface functionalities of tubing and catheters.Inspired by mussel adhesive foot protein,a bioclickable peptide mimic(DOPA)4-azidebased structure is designed and grafted on an aminated tubing robustly based on catechol-amine chemistry.Then,the dibenzylcyclooctyne(DBCO)modified nitric oxide generating species of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid(DOTA)chelated copper ions and the DBCO-modified antimicrobial peptide(DBCO-AMP)are clicked onto the grafted surfaces via bio-orthogonal reaction.The combination of the robustly grafted AMP and Cu-DOTA endows the modified tubing with durable antimicrobial properties and ability in long-term catalytically generating NO from endogenous snitrosothiols to resist adhesion/activation of platelets,thus preventing the formation of thrombosis.Overall,this biomimetic surface engineering technology provides a promising solution for multicomponent surface functionalization and the surface bioengineering of biomedical devices with enhanced clinical performance. | Xiaohui Mou Hongbo Zhang Hua Qiu Wentai Zhang Ying Wang Kaiqin Xiong Nan Huang Hélder A.Santos Zhilu Yang | 2022 | Research2022，，3： | 1 |
| 20 | Application of the statistical narrow-band correlated- k method to low-resolution spectral intensity and radiative heat transfer calculations:effects of the quadrature scheme显示文摘 | Liu F S Smallwood G J Gü lder Ö L | 2000 | International Journal of Heat and Mass Transfer2000，43，17： | 1 |
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