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| 1 | Impact of RAS and BRAF mutations on carcinoembryonic antigen production and pattern of colorectal metastases显示文摘AIM: To investigate the impact of RAS and BRAF mutations on the pattern of metastatic disease and carcinoembryonic antigen(CEA) production.METHODS: In this retrospective study, we investigated the impact of RAS and BRAF mutational status on pattern of metastatic disease and CEA production. Only patients presenting with a newly diagnosed metastatic colorectal cancer(CRC) were included. Patients' characteristics, primary tumor location, site of metastatic disease and CEA at presentation were compared between those with and without RAS and BRAF mutations.RESULTS: Among 174 patients, mutations in KRAS, NRAS and BRAF were detected in 47%, 3% and 6% respectively. RAS mutations(KRAS and NRAS) were more likely to be found in African American patients(87% vs 13%; P value = 0.0158). RAS mutations were associated with a higher likelihood of a normal CEA(< 5 ng/mL) at presentation. BRAF mutations were more likely to occur in females. We were not able to confirm any association between mutational status and site of metastatic disease at initial diagnosis.CONCLUSION: No association was found between RAS and BRAF mutations and sites of metastatic disease at the time of initial diagnosis in our cohort. Patients with RAS mutations were more likely to present with CEA levels < 5 ng/mL. These findings may have clinical implications on surveillance strategies for RAS mutant patients with earlier stages of CRC. | may cho chie akiba cecilia lau david smith milhan telatar michelle afkhami stephen sentovich kurt melstrom marwan fakih | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 3 |
| 2 | Fibrin glue for all anal fistula 显示文摘 | STEPHEN M SENTOVICH MD | 2001 | J Gastrointest Surg2001，5，2： | 1 |
| 3 | Fibrin Glue for All Anal Fistulas显示文摘 | Stephen M Sentovich MD | 2001 | J Gastrointest Sur g2001，5，： | 1 |
| 4 | Fibrin glue for atl anal fistulas显示文摘 | Stephen M Sentovich MD | 2001 | J Gastrointest Surg2001，5，2： | 1 |
| 5 | Transjugular intrahepatic portosystemic shunt for treatment of bleeding ectopic varices with portal hypertension显示文摘 | David Shibata M.D. David P. Brophy M.D. Fredric D. Gordon M.D. Harry T. Anastopoulos M.D. Stephen M. Sentovich M.D. Dr. Ronald Bleday M.D | 1999 | Diseases of the Colon & Rectum1999，，12： | 1 |
| 6 | Simultaneous dynamic proctography and peritoneography for pelvic floor disorders显示文摘 | Stephen M. Sentovich M.D. Lucian J. Rivela M.D. Dr. Alan G. Thorson M.D. Mark A. Christensen M.D. Garnet J. Blatchford M.D | 1995 | Diseases of the Colon & Rectum1995，，9： | 1 |
| 7 | Fibrin glue for M1 anal fistulas显示文摘 | Stephen M Sentovich MD | 2001 | Gastrointest Surg2001，5，： | 1 |
| 8 | Fibrin Glue for All Anal Fistulas 显示文摘 | Stephen M Sentovich M D | 2001 | Journal of Gastrointestinal Surgery2001，，5： | 1 |
| 9 | Transjugular intrahepatic portosystemic shunt for treatment of bleeding ectopic varices with portal hypertension显示文摘 | David Shibata M.D. David P. Brophy M.D. Fredric D. Gordon M.D. Harry T. Anastopoulos M.D. Stephen M. Sentovich M.D. Dr. Ronald Bleday M.D | 1999 | Diseases of the Colon & Rectum1999，，12： | 1 |
| 10 | Fibrin Glue for All Anal Fistulas显示文摘 | Stephen M Sentovich MD | 2001 | J Gastrointest Surg2001，5，： | 1 |
| 11 | Fibrin Glue for All Anal Fistulas显示文摘 | Stephen M Sentovich MD | 2001 | Gastrointest Surg2001，5，： | 1 |
| 12 | Fibrin glue for M1 anal fi- stulas显示文摘 | Stephen M Sentovich MD | 2001 | Gastrointest Surg2001，21，5： | 1 |
| 13 | Fibrin glue for all anal fistulas 显示文摘 | Stephen M Sentovich MD | 2001 | J Gastrointest Surg2001，5，2： | 1 |
| 14 | Accuracy of computed tomography in nodal staging of colon cancer patients显示文摘AIM: To predict node-positive disease in colon cancer using computed tomography(CT).METHODS: American Joint Committee on Cancer stage Ⅰ-Ⅲ colon cancer patients who underwent curavtiveintent colectomy between 2007-2010 were identified at a single comprehensive cancer center. All patients had preoperative CT scans with original radiology reports from referring institutions. CT images underwent blinded secondary review by a surgeon and a dedicated abdominal radiologist at our institution to identify pericolonic lymph nodes(LNs). Comparison of outside CT reports to our independent imaging review was performed in order to highlight differences in detection in actual clinical practice. CT reviews were compared with final pathology. Results of the outside radiologist review, secondary radiologist review, and surgeon review were compared with the final pathologic exam to determine sensitivity, specificity, positive and negative predictive values, false positive and negative rates, and accuracy of each review. Exclusion criteria included evidenceof metastatic disease on CT, rectal or appendiceal involvement, or absence of accompanying imaging from referring institutions.RESULTS: From 2007 to 2010, 64 stageⅠ-Ⅲ colon cancer patients met the eligibility criteria of our study. The mean age of the cohort was 68 years, and 26(41%) patients were male and 38(59%) patients were female. On final pathology, 26 of 64(40.6%) patients had nodepositive(LN+) disease and 38 of 64(59.4%) patients had node-negative(LN-) disease. Outside radiologic review demonstrated sensitivity of 54%(14 of 26 patients) and specificity of 66%(25 of 38 patients) in predicting LN+ disease, whereas secondary radiologist review demonstrated 88%(23 of 26) sensitivity and 58%(22 of 38) specificity. On surgeon review, sensitivity was 69%(18 of 26) with 66% specificity(25 of 38). Secondary radiology review demonstrated the highest accuracy(70%) and the lowest false negative rate(12%), compared to the surgeon review at 67% accuracy and 31% false negative rate and the outside radiology review at 61% accuracy and 46% false negative rate.CONCLUSION: CT LN staging of colon cancer has moderate accuracy, with administration of NCT based on CT potentially resulting in overtreatment. Active search for LN+ may improve sensitivity at the cost of specificity. | Audrey H Choi Rebecca A Nelson Hans F Schoellhammer Won Cho Michelle Ko Amanda Arrington Christopher R Oxner Marwan Fakih Jimmie Wong Stephen M Sentovich Julio Garcia-Aguilar Joseph Kim | 2015 | World Journal of Gastrointestinal Surgery2015，7，7： | 0 |
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