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| 1 | Mitochondrial sirtuins,metabolism,and aging显示文摘Maintaining metabolic homeostasis is essential for cellular and organismal health throughout life.Multiple signaling pathways that regulate metabolism also play critical roles in aging,such as PI3K/AKT,mTOR,AMPK,and sirtuins(SIRTs).Among them,sirtuins are known as a protein family with versatile functions,such as metabolic control,epigenetic modification and lifespan extension.Therefore,by understanding how sirtuins regulate metabolic processes,we can start to understand how they slow down or accelerate biological aging from the perspectives of metabolic regulation.Here,we review the biology of SIRT3,SIRT4,and SIRT5,known as the mitochondrial sirtuins due to their localization in the mitochondrial matrix.First,we will discuss canonical pathways that regulate metabolism more broadly and how these are integrated with aging regulation.Then,we will summarize the current knowledge about functional differences between SIRT3,SIRT4,and SIRT5 in metabolic control and integration in signaling networks.Finally,we will discuss how mitochondrial sirtuins regulate processes associated with aging and aging-related diseases. | Zhejun Ji Guang-Hui Liu Jing Qu | 2022 | Journal of Genetics and Genomics2022，49，4： | 10 |
| 2 | Flexible polyimide-based hybrid optoelectric neural interface with 16 channels of micro-LEDs and electrodes显示文摘In this paper,a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrO_(x)-modified microelectrodes for synchronous photostimulation and neural signal recording is presented.The 4×4 micro-LEDs(dimensions of 220×270×50μm^(3),700μm pitch)are fixed in the SU-8 fence structure on a polyimide substrate and connected to the leads via a wire-bonding method.The recording electrodes share a similar fabrication process on the polyimide with 16 microelectrode sites(200μm in diameter and 700μm in pitch)modified by iridium oxide(IrO_(x)).These two subparts can be aligned with alignment holes and glued back-to-back by epoxy,which ensures that the light from the LEDs passes through the corresponding holes that are evenly distributed around the recording sites.The long-term electrical and optical stabilities of the device are verified using a soaking test for 3 months,and the thermal property is specifically studied with different duty cycles,voltages,and frequencies.Additionally,the electrochemical results prove the reliability of the IrO_(x)-modified microelectrodes after repeated pressing or friction.To evaluate the tradeoff between flexibility and strength,two microelectrode arrays with thicknesses of 5 and 10μm are evaluated through simulation and experiment.The proposed device can be a useful mapping optogenetics tool for neuroscience studies in small(rats and mice)and large animal subjects and ultimately in nonhuman primates. | Bowen Ji Zhejun Guo Minghao Wang Bin Yang Xiaolin Wang Wen Li Jingquan Liu | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 3 | Recent advances in wireless epicortical and intracortical neuronal recording systems显示文摘An implantable brain-computer interface(BCI)has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders.Using a BCI recording system,we can transform current methods of human interaction with machines and the environment,especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society.However,most reported work has focused on a simple aspect of the whole system,such as electrodes,circuits,or data transmission,and only a very small percentage of systems are wireless.A miniature,lightweight,wireless,implantable microsystem is key to realizing long-term,real-time,and stable monitoring on freely moving animals or humans in their natural conditions.Here,we summarize typical wireless recording systems,from recording electrodes,processing chips and controllers,wireless data transmission,and power supply to the system-level package for either epicortical electrocorticogram(ECoG)or intracortical local field potentials(LFPs)/spike acquisition,developed in recent years.Finally,we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications. | Bowen JI Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG Jingquan LIU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
| 4 | Stretchable Parylene-C electrodes enabled by serpentine structures on arbitrary elastomers by silicone rubber adhesive显示文摘The delicate serpentine structures are widely used in high-performance stretchable electronics over the past decade.The metal interconnects encapsulated in biocompatible polymer Parylene-C film is a superior choice for long-term implantation in vivo,especially as neural interface to acquire electrophysiological signals or apply electrical stimulation.To avoid the physical contact damages from the neural tissues such as the brain or peripheral nerves,serpentine interconnects are utilized as stretchable electrodes and usually bonded to the soft elastomer substrate.The adhesion strength between the serpentine interconnects and the elastomer substrate becomes a considerable issue to ensure reliability and structural integrity.In this paper,the stretchable Parylene-C electrodes can be transfer printed onto arbitrary elastomer substrates by a thin layer of silicone rubber adhesive with low modulus for electrocorticogram(ECoG)recording.Mechanical simulation of serpentine structures consisting of same periodic arcs and different straight segments is investigated by uniaxial stretching.Then,the elastic stretchability of serpentine electrodes is further studied by simulation and experiments.After 5000 repetitive stretching cycles,the electrochemical impedance of microelectrodes remains in steady states.These results prove that the silicone rubber adhesive facilitates the interfacial bonding in the structure of stretchable electrodes as the compliant and reliable neural interface. | Bowen Ji Zhaoqian Xie Wen Hong Chunpeng Jiang Zhejun Guo Longchun Wang Xiaolin Wang Bin Yang Jingquan Liu | 2020 | Journal of Materiomics2020，6，2： | 1 |
| 5 | Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis显示文摘Dear Editor,Stem cell therapy holds enormous and revolutionary promise to treat various age-related diseases,such as diabetes,heart failure,and Parkinson’s disease.However,low retention and survival rate of delivered stem cells,partially due to immunological rejection,constitute major hurdles for the clinical implementation of stem cell therapy(Lei et al.,2021a).Since mounting evidence showed that several types of stem cells mainly exert their therapeutic effects through the secretion of paracrine effects,exosomes,which are released by stem cells and execute most paracrine functions,have begun to draw attention in the field(Tran and Damaser,2015).Exosomes are membrane-enclosed vesicles with an average diameter of∼100 nanometers secreted by the cells,containing cytokines. | Jinghui Lei Xiaoyu Jiang Wei Li Jie Ren Datao Wang Zhejun Ji Zeming Wu Fang Cheng Yusheng Cai Zheng-Rong Yu Juan Carlos Izpisua Belmonte Chunyi Li Guang-Hui Liu Weiqi Zhang Jing Qu Si Wang | 2022 | Protein & Cell2022，13，3： | 1 |
| 6 | Low-dose chloroquine treatment extends the lifespan of aged rats显示文摘Dear Editor,Chloroquine(CQ)has long been used as an anti-malarial agent(Wellems and Plowe,2001).Recently,CQ has also been applied to treat viral infection and related diseases(Wellems and Plowe,2001;Huang et al.,2020).However,the safety and efficacy of its applications are still under extensive debate(Solomon and Lee,2009).Here,we discovered that low-dose CQ has a geroprotective effect on physiologically aged rats.Low-dose CQ prolonged lifespan,repressed systemic inflammation,and inhibited fibrosis across multiple tissue types in aged rats.Furthermore,we constructed transcriptomic maps for 6 tissues(kidney,small intestine,liver,heart,lung,and aorta)upon CQ treatment,thus revealing the effects of CQ at a systemic level.CQ treatment mitigated age-related molecular changes and repressed genes linked to fibrosis and the inflammatory response.Altogether,our data provide a valuable resource for investigating the impact of CQ on multiple aged tissues,which may facilitate the development of clinical applications that mitigate age-related changes in the elderly. | Wei Li Zhiran Zou Yusheng Cai Kuan Yang Si Wang Zunpeng Liu Lingling Geng Qun Chu Zhejun Ji Piu Chan Guang-Hui Liu Moshi Song Jing Qu Weiqi Zhang | 2022 | Protein & Cell2022，13，6： | 1 |
| 7 | Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells显示文摘Dear Editor,The interventions that slow aging or promote healthy aging may provide preventative measures for age-related diseases(Zhang et al.,2015).Therefore,it is crucial to identify drugs that target aging-related pathologies and improve health-span in geroscience research.Using model organisms such as C.elegans and rodents,several small molecules capable of alleviating the onset or progression of aging,including rapamycin,nicotinamide mononucleotide,and metformin,have been discovered(Partridge et al.,2020).However,the safety and efficacy of these chemicals still need in-depth evaluation before clinical applications(Partridge et al.,2020).As a result,it is necessary to identify additional compounds with geroprotective effects for human cells to counteract the general trend of populational aging.However,transforming a promising compound into an approved drug requires enormous resources.Alternatively,repurposing previously approved drugs for new clinical applications offers a more efficient and less costly path toward drug develop-ment.Therefore,testing U.S.Food and Drug Administration(FDA)-approved drugs for geroprotective effects may dis-covernew therapeutics that have already been stringently tested in humans for safety. | Hezhen Shan Lingling Geng Xiaoyu Jiang Moshi Song Jianxun Wang Zunpeng Liu Xiao Zhuo Zeming Wu Jianli Hu Zhejun Ji Si Wang Piu Chan Jing Qu Weiqi Zhang Guang-Hui Liu | 2022 | Protein & Cell2022，13，7： | 1 |
| 8 | Hyperthermia differentially affects specific human stem cells and their differentiated derivatives显示文摘Dear Editor,The human body operates optimally at a core temperature of 37 degrees Celsius.Homeostasis at this temperature is essential for cellular and physiological functions(Cheshire,2016).However,infectious diseases,inflammation,injury,neoplasia,and elevated climate temperature can cause a regulated rise in body core temperature,i.e.,fever(Pasi-khova et al,2017).Indeed,an acute or chronic increase in temperature leads to detrimental effects on vasculature by altering a number of indices of vascular structure and function(DuBose et al.,1998). | Si Wang Fang Cheng Qianzhao Ji Moshi Song Zeming Wu Yiyuan Zhang Zhejun Ji Huyi Feng Juan Carlos Izpisua Belmonte Qi Zhou Jing Qu Wei Li Guang-Hui Liu Weiqi Zhang | 2022 | Protein & Cell2022，13，8： | 0 |
| 9 | Single-cell transcriptomic atlas of mouse cochlear aging显示文摘Progressive functional deterioration in the cochlea is associated with age-related hearing loss(ARHL).However,the cellular and molecular basis underlying cochlear aging remains largely unknown.Here,we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging,in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time points.Overall,our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging,highlights unexpected age-related transcriptional fluctuations in intermediate ceils localized in the stria vascularis(SV)and demonstrates that upregulation of endoplasmic reticulum(ER)chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with aging.Our work suggests that targeting unfolded protein response pathways may help alleviate aging-related sVatrophyand hencedelay theprogressionofARHL. | Guoqiang Sun Yandong Zheng Xiaolong Fu Weiqi Zhang Jie Ren Shuai Ma Shuhui Sun Xiaojuan He QiaoranWang zhejun ji Fang Cheng KaowenYan Ziyi Liu Juan Carloszpisuaemonte Jing Qu Si Wang Renjie Chai Guang-Hui Liu | 2023 | Protein & Cell2023，14，3： | 0 |
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