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| 1 | Framework and evolution of the middle Paleozoic orogenic belt between Siberian and North China Plates in northern Inner Mongolia显示文摘A middle Paleozoic subduction-collision orogenic belt between the Siberian and North China Plates has been recognized in Xilinhot-the south of Sonid Left Banner-Erdaojing area, northern Inner Mongolia, China. It comprises five subunits: melange belt, foreland deformation belt, molasse and littoral basin, arc diorite series and syn-collision granitoid series. Evolution history of the orogenic belt can be divided into subduction stage (500-400 Ma) and collision stage (400-320 Ma). The formation of the orogenic belt caused the convergence between the Siberian and North China Plates during the late Devonian. Suture zone corresponding to the melange belt extends from Erdao-jing, Qagan Ura to Honggor. | 徐备 陈斌 | 1997 | Science China Earth Sciences1997，40，5： | 63 |
| 2 | Function of lncRNAs and approaches to lncRNA-protein interactions显示文摘Long non-coding RNAs(lncRNAs),which represent a new frontier in molecular biology,play important roles in regulating gene expression at epigenetic,transcriptional and post-transcriptional levels.More and more lncRNAs have been found to play important roles in normal cell physiological activities,and participate in the development of varieties of tumors and other diseases.Previously,we have only been able to determine the function of lncRNAs through multiple mechanisms,including genetic imprinting,chromatin remodeling,splicing regulation,mRNA decay,and translational regulation.Application of technological advances to research into the function of lncRNAs is extremely important.The major tools for exploring lncRNAs include microarrays,RNA sequencing(RNA-seq),Northern blotting,real-time quantitative reverse transcription-polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),RNA interference(RNAi),RNA-binding protein immunoprecipitation(RIP),chromatin isolation by RNA purification(ChIRP),crosslinking-immunopurification(CLIP),and bioinformatic prediction.In this review,we highlight the functions of lncRNAs,and advanced methods to research lncRNA-protein interactions. | ZHU JuanJuan FU HanJiang WU YongGe ZHENG XiaoFei | 2013 | Science China(Life Sciences)2013，56，10： | 54 |
| 3 | Precipitation variation in the northeastern Tibetan Plateau recorded by the tree rings since 850 AD and its relevance to the Northern Hemisphere temperature显示文摘Three well-dated Sabina Przewalskii ring-width chronologies from Dulan, China, have been used to reconstruct annual precipitation (from prior July to current June) variations on the northeast Tibetan Plateau since 850 AD. The reconstructions account of the instrumentally recorded precipitation variance are: 54.7% for the period of 1385-2000AD; 50.5% for 1099-1384AD and 45.7% for 850-1098AD. On the millenary scale, the precipitation variation over this region displays “W” shape, which has three peaks and two valleys. The precipitation is low during 1571-1879 AD, and high during 1880-2000 AD. 1900-2000 AD is the century with the highest precipitation over the northeast Tibetan Plateau in the last 1000 years, and 1962-2000 is the period with the highest pre- cipitation, and the highest variability of precipitation as well in the last 1000 years. The reconstructed series also reveals that the variability of annual precipitation is large when the precipitation is more, and contrarily, variability is small when the precipitation is low. With the temperature increasing obvi- ously in the 20th century, the precipitation in the study region significantly increased too, the variability of precipitation became larger, and drought and flooding occurred more frequently. The yearly tree-ring width (high frequency signal) series in this region reflects the local annually precipitation variation. However, the series with 40-year moving average (low frequency signal) cor- responds to the Northern Hemisphere temperature variations on the decadal to centurial scale. It correlates significantly with seven temperature curves of the Northern Hemisphere in the different time spans. For example, the correlation coefficients with the most temperature curves are around 0.9 during the period of 1852-1982 AD. In general, the temperature and the precipitation change syn- chronously in the Dulan region. It means that low temperature corresponds to low precipitation, andvice versa. This relationship may indicate that the climatic pattern is the combination of warm-wet and cold-dry on centenary to millenary scale over the Northern Tibetan Plateau in the past 1000 years. The departure series of 40-year moving average could be regarded as the millenarian temperature curve with annual resolution over the northeast Tibetan Plateau region. | John K. Kutzbach | 2006 | Science China Earth Sciences2006，49，4： | 44 |
| 4 | Impacts of thermodynamic processes over the Tibetan Plateau on the Northern Hemispheric climate显示文摘We here report our recent research results on the climatic features of Tibetan thermodynamic functions and their impacts on the regional climates of the Northern Hemisphere. The results show that the thermodynamic processes over the Tibetan Plateau not only strongly influence the Asian monsoon and precipitation, but also modulate the atmospheric circulation and climate over North America and Europe through stimulating the large-scale teleconnections such as the Asian-Pacific oscillation and affect the atmospheric circulation over the southern Indian Ocean. The Tibetan climate may be affected by sea surface temperatures over the tropical Pacific. On the other hand, the Tibetan climate also affects the atmosphere-ocean interactions in the tropics and mid-latitudes of the Pacific by the atmospheric circulation over the North Pacific. In spring and summer, the thermodynamic anomalies on the plateau affect the subtropical high pressure, the Hadley circulation, and the intertropical convergence zone over the Pacific, and then modulate the development of the El Ni-o/Southern Oscillation (ENSO). It is necessary to study the forecasting methods for the development of ENSO from the Tibetan climate anomaly. This result also embodies the essence of interactions among land, atmosphere, and ocean over the Northern Hemisphere. Since the previous studies focused on impacts of the plateau on climates in the Asian monsoon regions, it is essential to pay more attention to studying the roles of the plateau in the Northern Hemispheric and even global climates. | ZHOU XiuJi ZHAO Ping CHEN JunMing CHEN LongXun LI WeiLiang | 2009 | Science China Earth Sciences2009，52，11： | 42 |
| 5 | Dynamic changes of typeⅠ,Ⅲand N collagen synthesis and distribution of collagen-producing cells in carbon tetrachloride-induced rat liver fibrosis显示文摘AIM To find out the relationship between the gene transcription of different types ofprocollagen and the deposition of the relevant collagens in the liver tissue and to confirm the types of collagen producing cells in liverfibrogenesis.METHODS Dynamic changes of the expression of α1(Ⅰ ), α1 (Ⅲ ) and α1 (Ⅳ) procollagen mRNAand relevant collagens and the distribution ofcollagen producing cells during liver fibrogenesis of rat induced by CCl4 (20 weeks)were investigated with Northern blot analysis,in situ hybridization and immunohistochemicaltechniques.RESULTS The increased expression of α1 (Ⅲ)procollagen mRNA by Northern blot analysis was the most predominant one among the threemRNAs during fibrogenesis. However, theenhanced expression of al (Ⅳ) procollagenmRNA occurred very early while the expressionof α1 (Ⅰ) mRNA was not enhanced much until themiddle stage of the exPeriment. D6smin (Dm)positive hepatic stellate cells (HSCs) and fewmyofibroblasts (MFs) in and around the necrotic areas expressed α1 (Ⅰ), α1 (Ⅲ) and α1 (Ⅳ)procollagen mRNA signals detected by in situhybridization at the early stage of theexperiment. All the three procollagen mRNAsignals thereafter mainly localized in fibroblasts (Fbs) and MFs in fibrotic septa during the middle and late stages of fibrosis, which distributedparallel to the corresponding collagens detected by immunohistochemical study. ln addition, the endothelial cells of sinusoids and the small blood vessels within the septa also showed α1(Ⅳ) procollagen mRNA and type Ⅳ collagen expressionCONCLUSION It is considered that 'HSC-MF-Fb' effect cell system is the major cellularsource of collagen production in liver fibrosis, in which HSCs are collagen producing precursor cells in the early liver fibrogenesis, thereafter the synthesis of type Ⅰ, Ⅲ and Ⅳ collagens (Col Ⅰ, Col Ⅲ and Col Ⅳ) mainly derives fromMFs and Fbs, which play a very important role in the progress of liver fibrosis. The endothelialcells along sinusoids, as another source of Col Ⅳ production, might participate in the capillization of liver sinusoids. | DU Wei-Dong ZHANG Yue-E ZHAl Wei-Rong and ZHOU Xiao-Mei(Department of Pathology, Shanghai Medical University, Shanghai200032, China)(National Laboratory for Oncogenes and Related Genes, ShanghaiCencer Institute)See invited commentary on page 388 | 1999 | World Journal of Gastroenterology1999，5，5： | 47 |
| 6 | Quantitative relationship between pollen and vegetation in northern China显示文摘205 surface pollen samples from different communities in Northern China were analyzed to understand the quantitative relationship between pollen and its original vegetation. Pollen analysis and vegetation investigation show that the pollen assemblages differ a lot in different vegetation regions. Arboreal pollen account for more than 30% in temperate broad-deciduous forests region. In temperate steppe regions, herb pollen percentages are more than 90%, where Artemisia and Chenopodiaceae are domi- nant pollen types with Artemisia percentages more than 30%. In temperate desert, Chenopodiaceae pollen percentages are more than Artemisia, where ferns are rare. Cyperaceae pollen percentages are more than 20% in sub-alpine or cold meadows. The relations between pollen percentages and vegeta- tion cover indicate that most arboreal pollen shows a close relationship with parent plant covers, most shrubby pollen types have more or less correlations, but most herbs do not show clear correlations. For arboreal pollen types, Picea pollen shows the closest correlation with spruce trees coverage, then is Quercus and Carpinus. Betula, Larix and Juglans have also high correlation coefficients with their plants coverage, but Betula pollen is of overrepresented pollen type and more than 40% in birch forest, while Larix and Juglans pollen is underrepresented and pollen percentages are more than 10% in Larix or Juglans pure forests. Pinus is of overrepresented pollen type, and pollen percentages have some relations with plants cover. Pine forest might present when Pinus pollen percentages are more than 30%. The relations between Ulmus and Populus pollen percentages and vegetation cover are not close, where they are mixed with other arbors, they cannot be recorded easily, but if their pollen percentages are more than 1%, Ulmus or Populus trees should exist. For shrubby pollen types, the correlation be- tween Vitex pollen percentages and vegetation cover is the highest, then is Corylus, Tamariaceae and Nitraria, and their pollen percentages are less than 1% where original plant are absent. Caragana and Spiraea pollen percentages have some relations with vegetation cover. The relations between pollen percentages and vegetation cover are not clear for Rosaceae and Saxifragaceae. For herb pollen types, Cyperaceae pollen has the closest correlation with vegetation cover, where pollen percentages are more than 20% when Cyperaceae are constructive or dominant species in vegetation, and pollen per- centages are less than 5% where Cyperaceae are not constructive or dominant species (cover less than 30%). Artemisia and Chenopodiaceae pollen percentages mainly have close relations with ecological regions. The relations between pollen percentages and cover are not clear for Gramineae, Legumi- nosae and Compositae. | XU QingHai LI YueCong YANG XiaoLan ZHENG ZhenHua | 2007 | Science China Earth Sciences2007，50，4： | 41 |
| 7 | Eolian evidence from the Chinese Loess Plateau: the onset of the Late Cenozoic Great Glaciation in the Northern Hemisphere and Qinghai-Xizang Plateau uplift forcing显示文摘On the basis of a newly-constructed record of magnetic susceptibility (SUS) and the depositional rate change of eolian loess-red clay sequences in the last 7.2 Ma BP from the Loess Plateau, together with a comparison of a record of δ18O values from the equatorial East Pacific Ocean and eolian Quartz flux variations from the North Pacific Ocean, the evolutionary process of the Late Cenozoic Great Glaciation in the Northern Hemisphere can be divided into three stages: the arrival stage around 7.2—3.4 Ma BP, the initial stage at about 3.4—2.6 Ma BP, and the Great Ice Age since 2.6 Ma BP. The evolution of the East Asian monsoon is characterized by paired winter and summer monsoons, and it is basically composed of the initial stage of weak winter and summer monsoons, the transitional stage of simuhaneous increase in intensity of winter and summer monsoons, and the prevailing stage of strong winter and weak summer monsoons, or weak winter and strong summer monsoons. The Late Cenozoic global tectonic | 安芷生 王苏民 吴锡浩 陈明扬 孙东怀 刘秀铭 王富葆 李力 孙有斌 周卫健 周杰 刘晓东 鹿化煜 张云翔 董光荣 强小科 | 1999 | Science China Earth Sciences1999，42，3： | 39 |
| 8 | 藏北羌塘中部绒玛地区蓝片岩岩石学、矿物学和^(40)Ar/^(39)Ar年代学显示文摘藏北羌塘中部沿龙木错-双湖-线出露一条低温高压变质带,目前已有多处蓝片岩的报道。然而,除冈玛错地区产有典型的蓝闪石外,多数地区并没有典型蓝闪石的报道。绒玛蓝片岩位于羌塘中部高压变质带的中段,是该带中规模最大、保存最好的蓝片岩,对蓝片岩进行了详细的岩石学和矿物学研究,钠质角闪石主要为蓝闪石、青铝闪石、钠闪石和镁钠闪石。对蓝片岩中蓝闪石和多硅白云母进行了^(40)Ar/^(39)Ar定年,获得了227.3±3.8Ma和215±1.5Ma的坪年龄,分别代表蓝片岩快速俯冲消减和俯冲作用结束开始折返抬升的时代。绒玛蓝片岩岩石学、矿物学和^(40)Ar/^(39)Ar年代学研究为羌塘中部高压变质带的研究提供了新的资料。 | 翟庆国 李才 王军 陈文 张彦 | 2009 | 岩石学报2009，25，9： | 38 |
| 9 | Discovery of the eclogite and its petrography in the Northern Dabie Mountain显示文摘Eclogite from the Northern Dabie Mountain is a new finding by the authors. These eclogites in foliated perdotite are enveloped by banded gneiss and occur in the mafic-ultramafic rock belt. They are mainly composed of omphacite, garnet, diopside, orthopyroxene, amphibole, plagioclase and magnetite, and a small amount of rutile, spinel, olivin and 鏾rundum. The mineral association of peak metamorphism of the eclogite is omphacite+garnet+rutile. The existence of eclogite in the Northern Dabie Mountain implies that there was an eclogitic metamorphism prior to the granulitic facies one in the mafic-ultramafic rock belt. | XU Shutong LIU Yican SU Wen WANG Rucheng JIANG Laili WU Weiping | 2000 | Chinese Science Bulletin2000，45，3： | 39 |
| 10 | 构造应变与砂岩成岩的构造非均质性——以塔里木盆地库车坳陷研究为例显示文摘孔隙性砂岩在应变过程中首先发生应变局域化并形成肉眼不易识别的变形条带(deforrnation band),这与低孔隙性的碳酸盐岩的应变效应迥然不同。实例分析说明,天山南缘库车坳陷后期构造变形强烈,自白垩纪以来构造应变具有南北分带、东西分异的显著特征。结合盆地构造格架以及砂岩物性分布特征,本文提出了该区六类砂岩储层改造的构造样式,并描述了其中砂岩的构造非均质性。其中深层卷入型(3类)主要发育于盆地西部,而浅层卷入型发育于盆地东部,其分布受基底构造、盐煤等滑脱层、近南北向的调节断裂、盆山边界接触方式的控制。除变形条带外,研究发现本区最大埋深大于6500~7000m的白垩系致密砂岩的应变属性亲近灰岩,其由于后期抬升或深层次构造应变将容易导致裂隙的发育,这一点在有效储层预测中值得重视。 | 李忠 张丽娟 寿建峰 韩登林 沈杨 张惠良 | 2009 | 岩石学报2009，25，10： | 34 |
| 11 | Pathways of Influence of the Northern Hemisphere Mid–high Latitudes on East Asian Climate: A Review显示文摘This paper reviews recent progress made by Chinese scientists on the pathways of influence of the Northern Hemisphere mid-high latitudes on East Asian climate within the framework of a“coupled oceanic-atmospheric(land-atmospheric or seaice-atmospheric)bridge”and“chain coupled bridge”.Four major categories of pathways are concentrated upon,as follows:Pathway A—from North Atlantic to East Asia;Pathway B—from the North Pacific to East Asia;Pathway C—from the Arctic to East Asia;and Pathway D—the synergistic effects of the mid-high latitudes and tropics.In addition,definitions of the terms“combined effect”,“synergistic effect”and“antagonistic effect”of two or more factors of influence or processes and their criteria are introduced,so as to objectively investigate those effects in future research. | Jianping LI Fei ZHENG Cheng SUN Juan FENG Jing WANG | 2019 | Advances in Atmospheric Sciences2019，36，9： | 27 |
| 12 | Tillage and straw mulching impacts on grain yield and water use efficiency of spring maize in Northern Huang–Huai–Hai Valley显示文摘A two-year field experiment(2012–2013) was conducted to investigate the effects of two tillage methods and five maize straw mulching patterns on the yield, water consumption,and water use efficiency(WUE) of spring maize(Zea mays L.) in the northern Huang–Huai–Hai valley of China. Compared to rotary tillage, subsoil tillage resulted in decreases in water consumption by 6.3–7.8% and increases in maize yield by 644.5–673.9 kg ha-1, soil water content by 2.9–3.0%, and WUE by 12.7–15.2%. Chopped straw mulching led to higher yield,soil water content, and WUE as well as lower water consumption than prostrate whole straw mulching. Mulching with 50% chopped straw had the largest positive effects on maize yield, soil water content, and WUE among the five mulching treatments. Tillage had greater influence on maize yield than straw mulching, whereas straw mulching had greater influence on soil water content, water consumption, and WUE than tillage. These results suggest that 50% chopped straw mulching with subsoil tillage is beneficial in spring maize production aiming at high yield and high WUE in the Huang–Huai–Hai valley. | Zhiqiang Tao Congfeng Li Jingjing Li Zaisong Ding Jie Xu Xuefang Sun Peilu Zhou Ming Zhao | 2015 | The Crop Journal2015，3，5： | 26 |
| 13 | ^(40)Ar/^(39)Ar and Rb-Sr isochron dating of the gold deposits on northern margin of the Jiaolai Basin,Shandong,China显示文摘The Pengjiakuang, Dazhuangzi and Fayunkuang gold deposits, located on the northern margin of the Mesozoic Jiaolai Basin, east of Shandong Province, are controlled by a low-angle normal fault. Gold ores are typically brecciated, veinlet and disseminated. The Ar-Ar and Rb-Sr isochron dating methods were adopted to date ores and lamprophyre dike. The results indicate that the age of the Pengjiakuang gold deposit is 117.33—118.42 Ma, that of the Dazhuangzi gold deposit is 117.39 Ma, and that of the Fayunkuang gold deposit is (128.49±7.2) Ma. The consistency in metallogenic age between the gold deposits on the margin of the Jiaolai Basin and the gold deposits (115—126 Ma) of the northern uplift area suggests that both were formed in the same metallogenic period. That is to say, the large-scale metallogeny of the Jiaodong region took place in late-Yanshannian ((120±10) Ma). | 张连昌 沈远超 刘铁兵 曾庆栋 李光明 李厚民 | 2003 | Science China Earth Sciences2003，46，7： | 24 |
| 14 | Geological effects in tectonic superposition of Paleo-Pacific domain and Paleo-Asian domain in northern part of North China显示文摘The northern part of North China is located where the Paleo-Asian domain is superposed by the Pa-leo-Pacific domain. The period from the end of the Late Paleozoic to the beginning of the Mesozoic is important for the superposition of the two domains. It is demonstrated according to the coupling of the superficial and deep geological effects that in this period begins the lithosphere modulation, hot interface uprising, and crust extension in this area. Thus a new understanding about the Indo-China movement has arisen. | 邵济安 牟保磊 何国琦 张履桥 | 1997 | Science China Earth Sciences1997，40，6： | 22 |
| 15 | 2013年美国阴道镜及宫颈病理协会宫颈癌筛查新指南解读和启示显示文摘宫颈癌(cervical cancer)是导致全球女性死亡的第3大恶性肿瘤。全世界每年约50万例新发病例,其中80%在发展中国家,且宫颈癌发病趋于年轻化。中国每年有超过13万宫颈癌新发病例,约占全世界的1/3,宫颈癌已成为严重威胁我国妇女生殖健康的恶性疾病之一。美国阴道镜及宫颈病理协会(American Society for Colposcopy and Cervical Pathology,ASCCP),美国癌症协会(American Cancer Society,ACS),美国临床病理协会(American Society for Clinical Pathology,ASCP)在累积了9年,共计140万妇女参与的北加利福尼亚Kaiser医疗保健项目(Kaiser Permanente Northern California Medical Care Plan,KPNC)宫颈癌前病变临床管理数据的基础上, | 马丁 李双 | 2014 | 中华妇幼临床医学杂志(电子版)2014，10，5： | 23 |
| 16 | 外源乙烯对月季(Rosa hybrida)切花花朵开放的影响与乙烯生物合成相关基因表达的关联显示文摘以探讨外源乙烯对月季切花花朵开放的影响及其与花瓣内源乙烯生物合成相关基因表达之间的关联为目的.试材选用外源乙烯对花朵开放进程影响截然相反的两个品种,其中,Samantha明显被促进,而Kardinal则明显被抑制.经外源乙烯处理,两品种花瓣乙烯生成量、1-氨基环丙烷-1-羧酸(1-aminocyclopropane-1-carboxylate,ACC)合成酶(ACC synthase,ACS)和ACC氧化酶(ACC oxidase,ACO)活性都被诱导升高.但是,以上指标两品种间变化有差异,其中,Samantha主要表现为峰值提前,即由未经处理对照的盛开期(开花级数4级)提早到初开期(3级);而Kardinal主要表现为绝对值剧烈升高,且远高于Samantha.从花瓣中克隆到3个ACS(Rh-ACS1,Rh-ACS2和Rh-ACS3)和1个ACO(Rh-ACO1)基因的cDNA,非放射性Northern检测结果表明,Rh-ACS3和Rh-ACO1基因的表达受到乙烯的诱导,并且其表达变化在两个品种中都与ACS活性和乙烯生成量相一致.由此推测,外源乙烯对切花月季品种间花朵开放影响的差异,可能与花瓣内乙烯生物合成关键酶转录水平上的诱导差异有关,并且Kardinal可能对外源乙烯更为敏感.还明确了月季切花3个ACS基因之间的表达存在发育时间和诱导方式上的特异性. | 马男 蔡蕾 陆旺金 谭辉 高俊平 | 2005 | 中国科学(C辑)2005，35，2： | 21 |
| 17 | 桐柏地区高压变质地体在地壳中的抬升机制显示文摘桐柏杂岩位于秦岭与大别造山带之间,南北两侧为NWW-SEE向延伸的含榴辉岩高压变质地体,其构造就位过程及其与高压变质地体的构造关系为地质学家们所关注。本文研究表明,所谓的桐柏杂岩实际上是一个早白垩世花岗质片麻岩杂岩体,其内包裹一定数量的三叠纪中高级变质岩石。桐柏杂岩南北两条边界韧性剪切带具有相反的运动学指向,分别为大型右行和左行韧性剪切带,其形成时代为131Ma。这两条韧性剪切带中的剪切面理分别朝SSW和NNE向倾斜,韧性剪切带及杂岩体内部发育的拉伸线理均稳定地朝SEE方向缓倾伏。而在杂岩体的东端发育低角度近南北向韧性剪切变形带,其糜棱面理朝SEE方向低角度缓倾斜,矿物拉伸线理也朝SEE方向低角度缓倾伏,运动学标志指示东侧地质体朝295°~310°的方向逆冲。因此,桐柏杂岩实际上被一个顺造山带的韧性剪切带所围限,这个韧性剪切带及杂岩体内部韧性变形运动学指示了一个早白垩世由东向西的低角度抬升过程,而这一过程直接导致了含榴辉岩高压变质地体沿着造山带的方向从地壳深部抬升到近地表。这一研究结果对理解和认识桐柏-大别-苏鲁地区高压-超高压变质地体的晚期抬升过程具有重要意义。 | 崔建军 胡健民 刘晓春 | 2009 | 岩石学报2009，25，9： | 21 |
| 18 | Chronology and geochemistry of the volcanic rocks in Woruo Mountain region,Northern Qiangtang depression:Implications to the Late Triassic volcanic-sedimentary events显示文摘A suite of sedimentary-volcaniclastic rocks intercalated with the volcanic rocks unconformably overlies the Triassic Xiaochaka Formation in the Woruo Mountain region, Qiangtang Basin, northern Tibet. The vitric tuff from the base of these strata gives a SHRIMP zircon U-Pb age of 216 ± 4.5 Ma, which represents the age of the Late Triassic volcanic-sedimentary events in the Woruo Mountain region, and is consistent with that of the formation of the volcanic rocks from the Nadi Kangri Formation in the Nadigangri-Shishui River zone. There is a striking similarity in geochemical signatures of the volcanic rocks from the Woruo Mountain region and its adjacent Nadigangri-Shishui River zone, indicating that all the volcanic rocks from the Qiangtang region might have the same magmatic source and similar tectonic setting during the Late Triassic. The proper recognition of the Late Triassic large-scale volcanic eruption and volcanic-sedimentary events has important implications for the interpretation of the Late Triassic biotic extinction, climatic changes and regressive events in the eastern Tethyan domain, as well as the understanding of the initiation and nature, and sedimentary features of the Qiangtang Basin during the Late Triassic-Jurassic. | WANG Jian FU XiuGen CHEN WenXi WANG ZhengJiang TAN FuWen CHEN Ming ZHUO JieWen | 2008 | Science China Earth Sciences2008，51，2： | 21 |
| 19 | KAI1 gene is differently expressed in papillary and pancreatic cancer:influence on metastasis显示文摘AIM To compare KAI1 in cancer of papilla ofVater and pancreas to evaluate whether there aredifferences in biologic behavior which mightaccount for prognosis.METHODS We compared the expression in 24papillay and 29 pancreatic cancers usingNorthern blot analysis,immunochemical assayand in situ hybridization,and investigatedwhether early diagnosis or molecular differencespredict the outcome in these tumor entities.RESULTS By Northern blot analysis there is nostatistical difference of KAI1 levels in normaland cancerous papilla.No association betweenKAI1 mRNA expression and tumor stage or tumordifferentiation was found in the tumors.Byimmunohistochemical assay,KAI1 staining incytoplasm of papillary cancer cells was similarto that of normal papillary cells.By in situhybridization,the results of KAI1 mRNAexpression in normal and cancerous papilla weresimilar to those with immunohistochemicalassay.The normal and cancerous pancreastissues were also analyzed by the methods usedin papillary samples.CONCLUSION Although the biologic roles of KAI1 have not been clarified, our results suggest that KAI1 may restrict the progression of malignant papillary cancer, but its expression might not have any effect on the characteristics of papillary tumor, whereas by the analysis of KAl1 gene, its reduced expression is closely related to the progression and metastases of pancreatic cancer. | Helmut Friess Markus W.Buchler | 2000 | World Journal of Gastroenterology2000，6，6： | 20 |
| 20 | East-west crustal structure and “down-bowing” Moho under the northern Tibet revealed by wide-angle seismic profile显示文摘We recognized 6 sets of reflecting P- and S-wave events from Moho and other interfaces within the crust, respectively, with the wide-angle seismic data acquired from 510 km-long Selincuo-Ya'anduo profile in the northern Tibet, fitted the observed events with forward modeling, and interpreted crustal structure of P- and S-wave velocities and Poisson's ratio under the profile. The results demonstrate that the crustal structure between Yarlungzangbo and Bangong-Nujiang sutures changes abruptly, and the crust is the thickest at the middle part of the profile with thickness of 80 km or more. The 'down-bowing' Moho is the striking feature for the crustal variation along the west-east direction. The Moho uplifts with steps, and the uplifting rate westward is greater than that eastward. The heterogeneity of P- and S-wave velocities exists both vertically and horizontally, and one lower velocity layer (LVL) exists with the depth range of 27-34 km and the thickness range of 5-7 km. For the upper crust, Poisson's ratio is the lowest at the middle part of the profile; for the lower crust, the Poisson's ratio at the east segment is lower than that at west segment, which means that the crustal rigidity for the upper crust is different from the lower crust, and the lower crust under the east segment of the profile is more ductile. We infer that the substance in the lower crust endured eastward flow along with the collision between Eurasian and Indian plates, and the 'down-bowing' Moho is attributable to the multi-phase E-W tectonic processes. | 张中杰 李英康 王光杰 滕吉文 S.Klemperer 李敬卫 范进义 陈赟 | 2002 | Science China Earth Sciences2002，45，6： | 19 |
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