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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | A review of rescue regimens after clarithromycin-containing triple therapy failure (for Helicobacter pylori eradication)显示文摘 | Alicia C Marin Adrian G McNicholl Javier P Gisbert | 2013 | Expert Opinion on Pharmacotherapy2013，，7： | 2 |
| 3 | Some Recent Designs and Developments of Screen-Printed Carbon Electrochemical Sensors/Biosensors for Biomedical,Environmental,and Industrial Analyses显示文摘 | John P H Adrian C Kevin C H | 2004 | Analytical Lett2004，37，5： | 1 |
| 4 | New gene cassettes for trimethoprim resistance, dfr13 ,and Streptomycin-Spectinomytin resistance, aadA4,inserled on a class 1 integron 显示文摘 | ADRIAN P V THOMSON C J KLUGMAN K P | 2000 | Antimicrob Agents Cheroother2000，44，2： | 1 |
| 5 | Generation of DNA profiles from fabrics without DNA extraction 显示文摘 | Adrian L Vera P Yuvaneswari C S | 2010 | Forensic Sci Int(Genetics)2010，4，： | 1 |
| 6 | Highly Ef- ficient Cu( In, Ga)Se2 Solar Cells Grown on Flexible Pol- ymer Films 显示文摘 | ADRIAN C STEPHAN B FABIAN P | 2011 | NATURE MATERIALS2011，10，11： | 1 |
| 7 | HPLC analysis of grapevine phytoalexins coupling photodiode array detection and fluorometry显示文摘 | JEANDET P BREUIL A C ADRIAN M WESTON L A DEBORD S MEUNIER P MAUME G BESSIS R | 1997 | Analytical Chemistry1997，69，24： | 1 |
| 8 | Determination of critical head in soil piping显示文摘 | OJHA C S P SINGH V P ADRIAN D D | 2003 | Journal of Hydraulic Engineering2003，129，7： | 1 |
| 9 | Implementation of com- pressed sensing in telecardiology sensor networks显示文摘 | Eduardo C Adrian P O Pedro S | 2010 | Inter- national Journal of Telemedicine and Applications2010，，： | 1 |
| 10 | IL - 10 selectively induces HLA -Gexpression in human trophoblasts and monocytes显示文摘 | Moreau P Adrian Cabestre F Menier C | 1999 | Int Immunol1999，11，5： | 1 |
| 11 | Developing pharmacy studentcommunication skills through role-playing and active learning显示文摘 | Luiz Adrian J A Zeszotarski P Ma C | 2015 | Am JPharai Educ2015，79，3： | 1 |
| 12 | Phytoalexins from the Vitaceae:biosynthesis,phytoalexin gene expression in transgenic plants,antifungal activity and metabolism显示文摘 | JEANDET P DOUILLET-BREUIL A C BESSIS R DEBORD S SBAGHI M ADRIAN M | 2002 | J Agric Food Chem2002，50，： | 1 |
| 13 | The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking hu- man disease显示文摘 | Dierks C Adrian F Fisch P | 2010 | Cancer Res2010，70，15： | 1 |
| 14 | Plant regeneration from seedling explants of Eucalyptus grandis of Europhylla 显示文摘 | Luis P B C Adriane C M G Silvia B R C | 1999 | Plant Cell Tissue and Organ Culture1999，56，： | 1 |
| 15 | Basic of diffusion and perfusion MRI显示文摘 | ADRIAN P C JULEIN P PAUI F | 2003 | Radiology2003，11，2： | 1 |
| 16 | On the distribution and revocation of cryptographic keys in sen- sor networks显示文摘 | Haowen C Virgil D G Adrian P | 2005 | IEEE Transactions on Dependable and Secure Computing2005，2，3： | 1 |
| 17 | The importance of benthos in weight of evidence sediment assessments: a case study 显示文摘 | McPherson C Chapman P Adrian M H | 2008 | Science of the Total Environment2008，394，23： | 1 |
| 18 | Composition of oils derived from the batch pyrolysis of tyres显示文摘 | Adrian M C Williams P T | 1998 | J of Analytical and Apphed Pyrolysis1998，44，2： | 1 |
| 19 | Mi-crostructured Optical Fibers as High-Pressure Mi- crofluidie Reactors 显示文摘 | Sazio P J A Adrian A C Chris E F John R H | 2006 | Science2006，311，5767： | 1 |
| 20 | Determination of critical head in soil piping显示文摘 | OJHA C S P SINGH V E ADRIAN D D | 2003 | Journal of Hydraulic Engineering ASCE2003，129，7： | 1 |
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