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| 1 | Chronic hepatitis C virus infection:Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients显示文摘AIM: To assess the prevalence of extrahepatic manifestations in Bulgarian patients with chronic hepatitis C virus (HCV) infection and identify the clinical and biological manifestations associated with cryoglobulinemia. METHODS: The medical records of 136 chronically infected HCV patients were reviewed to assess the prevalence of extrahepatic manifestations. Association between cryoglobulin-positivity and other manifestations were identified using χ2 and Fisher’s exact test. Risk factors for the presence of extrahepatic manifestations were assessed by logistic regression analysis. RESULTS: Seventy six percent (104/136) of the patients had at least one extrahepatic manifestation. Clinical manifestations included fatigue (59.6%), kidney impairment (25.0%), type 2 diabetes (22.8%), paresthesia (19.9%), arthralgia (18.4%), palpable purpura (17.6%), lymphadenopathy (16.2%), pulmonary fi brosis (15.4%), thyroid dysfunction (14.7%), Raynaud’s phenomenon (11.8%), B-cell lymphoma (8.8%), sicca syndrome (6.6%), and lichen planus (5.9%). The biological manifestations included cryoglobulinproduction (37.5%), thrombocytopenia (31.6%), and autoantibodies: anti-nuclear (18.4%), anti-smooth muscle (16.9%), anti-neutrophil cytoplasm (13.2%) and anti-cardiolipin (8.8%). All extrahepatic manifestations showed an association with cryoglobulin-positivity, with the exception of thyroid dysfunction, sicca syndrome, and lichen planus. Risks factors for the presence of extrahepatic manifestations (univariate analysis) were: age ≥ 60 years, female gender, virus transmission by blood transfusions, longstanding infection (≥ 20 years), and extensive liver fi brosis. The most signifi cant risks factors (multivariate analysis) were longstanding infection and extensive liver fi brosis. CONCLUSION: We observed a high prevalence of extrahepatic manifestations in patients with chronic HCV infection. Most of these manifestations were associated with impaired lymphoproliferation and cryoglobulin production. Longstanding infection and extensive liver fi brosis were signifi cant risk factors for the presence of extrahepatic manifestations in HCV patients. | Diana V Stefanova-Petrova Anelia H Tzvetanska Elisaveta J Naumova Anastasia P Mihailova Evgenii A Hadjiev Rumiana P Dikova Mircho I Vukov Konstantin G Tchernev | 2007 | World Journal of Gastroenterology2007，13，48： | 5 |
| 2 | Cord blood leptin concentrations in relation to intrauterine growth显示文摘 | ANASTASIA V CHRISTOS S | 1999 | Clinical Endocrinology1999，50，： | 1 |
| 3 | Distinct Characteristics and Complex Evolution of PEDV Strains,North America,May 2013-February 2014 显示文摘 | Anastasia N V Douglas M Arthaler Wang Qiuhong et a/ | 2014 | Emerging itrfectious dis- eases2014，20，10： | 1 |
| 4 | Determination of phenolic and steroid endocrine disrupting compounds in environmental matrices显示文摘 | ANASTASIA A DIMITRA V | 2008 | Environmental Science and Pollution Research International2008，15，3： | 1 |
| 5 | Single-stage tubular urethral reconstruction using oral grafts is an alternative to classical staged approach for selected penile urethral strictures显示文摘Penile urethral strictures have been managed by a staged surgical approach.In selected cases,spongiofibrosis can be excised,a neo-urethral plate created using buccal mucosa graft(BMG)and tubularized during the same procedure,performing a“twoin-one”stage approach.We aim to identify stricture factors which indicate suitability for this two-in-one stage approach.We assess surgical outcome and compare with staged reconstruction.We conducted an observational descriptive study.The data were prospectively collected from two-in-one stage and staged penile urethroplasties using BMG in a single center between 2007 and 2017.The minimum follow-up was 6 months.Outcomes were assessed clinically,radiologically,and by flow-rate analysis.Failure was defined as recurrent stricture or any subsequent surgical or endoscopic intervention.Descriptive analysis of stricture characteristics and statistical comparison was made between groups.Of 425 penile urethroplasties,139 met the inclusion criteria:59 two-in-one stage and 80 staged.The mean stricture length was 2.8 cm(single stage)and 4.5 cm(staged).Etiology was lichen sclerosus(LS)52.5%(single stage)and 73.8%hypospadias related(staged).40.7%of patients had previous failed urethroplasties in the single-stage group and 81.2%in the staged.The most common stricture locations were navicular fossa(39.0%)and distal penile urethra(59.3%)in the single-stage group and mid or proximal penile urethra(58.7%)in the staged group.Success rates were 89.8%(single stage)and 81.3%(staged).A trend toward a single-stage approach for select penile urethral strictures was noted.We conclude that a single-stage substitution penile urethroplasty using BMG as a“two-in-one”approach is associated with excellent functional outcomes.The most suitable strictures for this approach are distal,primary,and LS-related strictures. | Felix Campos-Juanatey Simon Bugeja Mariya Dragova Anastasia V Frost Stella L Ivaz Daniela E Andrich Anthony R Mundy | 2020 | Asian Journal of Andrology2020，22，2： | 1 |
| 6 | Acaricide resistance mechanisms in the two-spotted spider mite Tetranychus urticae and other important Acari: A review显示文摘 | Thomas V L John V Anastasia T | 2010 | Insect Biochemistry and Molecular Biology2010，，40： | 1 |
| 7 | DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic - ischemic injury显示文摘 | Andrew M Schumacher Anastasia V Velentza D Manin Watterson | 2002 | Biochimica et Biophysica Acta(BBA) - Proteirls & Proteomics2002，1600，1： | 1 |
| 8 | Tgfb/Alk5 signaling is required for shear stress induced Klf2 expression in embryonic endothelial cells显示文摘 | Anastasia D Kim V Simone V | 2011 | Dev Dyn2011，240，7： | 1 |
| 9 | Determination of okadaic acid, dinophysistoxin-1 and related esters in Greek mussels using HPLC with fluorometric detection, LC-MS/MS and mouse bioassay 显示文摘 | Artemis P L Anastasia V B Panagiota K | 2010 | Toxicon2010，55，4： | 1 |
| 10 | Changes in flavour volatiles of whole pasteurized milk asaffected by packing material and storage time显示文摘 | ANDREAS E K ANASTASIA V B KYRIAKO A R etal | 2009 | InternationalDairy Journal2009，，16： | 1 |
| 11 | Human Rotavirus Virus-Like Particle Vaccines Evaluated in a Neonatal Gnotobiotic Pig Model of Human Rotavirus Disease显示文摘 | MARLI P A ANASTASIA N V? LINDA J S | 2013 | Expert Review of Vaccines2013，12，2： | 1 |
| 12 | Titania nanotubes, nanorods and nanopowder in the carbon monoxide oxidation process显示文摘 | Anastasia V Grigorieva Eugene A Goodilin Ksenia L Dubova | 2010 | Solid State Sciences2010，12，： | 1 |
| 13 | Changes in flavour volatiles of whole pasteurized milk as affected by packaging material and storage time显示文摘 | Andreas E K Anastasia V B Kyriakos A R | 2006 | International Dairy Journal2006，16，： | 1 |
| 14 | Probiotics and autoprobiotics for treatment of Helicobacter pylori infection显示文摘The article discusses various approaches for probiotic treatment of Helicobacter pylori(H.pylori)infection:Probiotics as an adjuvant treatment in the standard eradication therapy;probiotic strains as a monotherapy;and autoprobiotics as a monotherapy.Autoprobiotics refer to indigenous bifidobacteria,lactobacilli,or enterococci isolated from a specific individual,intended to restore his/her microbiota and improve his/her health.The potential mechanisms of probiotic action against H.pylori include correction of the gut microbiota,immunological effects(enhancement of humoral and cellular immunity,and reduction of oxidative stress),direct antagonistic effects against H.pylori(such as colonization resistance and bacteriocin synthesis),and stimulation of local immunological protection(strengthening of the mucous protective barrier and reduction of gastric mucosa inflammation).The incorporation of probiotics into comprehensive eradication therapy shows promise in optimizing the treatment of H.pylori infection.Probiotics can enhance the eradication rates of H.pylori,reduce the occurrence and severity of side effects,and improve patient compliance.Probiotic or autoprobiotic monotherapy can be considered as an alternative treatment approach in cases of allergic reactions and insufficient effectiveness of antibiotics.We recommend including probiotics as adjunctive medications in anti-H.pylori regimens.However,further randomized multicenter studies are necessary to investigate the effects of probiotics and autoprobiotics against H.pylori,in order to gain a better understanding of their mechanisms of action. | Natalia V Baryshnikova Anastasia S Ilina Elena I Ermolenko Yury P Uspenskiy Alexander N Suvorov | 2023 | World Journal of Clinical Cases2023，11，20： | 0 |
| 15 | Semen microbiota and cytokines of healthy and infertile men显示文摘In this study,we determined the levels of cytokine secretory inhibitors and the microbiota biofilms of semen from healthy and infertile subjects.A total of 118 clinical bacterial isolates were isolated and tested.Cytokine secretory inhibitors were determined based on the difference in cytokine content between the control and experimental samples of cell-free supernatants of isolated microorganisms.Biofilm formation was studied by determining the adhesion of microorganisms to the surface of a 96-well sterile plate and expressed as the optical density at 630 nm(OD_(630)).Cell-free supernatants of Staphylococcus contained higher levels of secretory inhibitor of cytokines in conditionally healthy than in infertile patients.In contrast,in infertile men,the ability to reduce cytokine levels was more characteristic of Enterococcus and Corynebacterium.Seminal Staphylococcus,Corynebacterium,and Enterococcus isolated from infertile subjects showed a greater ability to form biofilms than the same bacteria isolated from healthy men.Further research is needed on this topic,since it is necessary to determine the relationships between decreased secretory inhibitors of cytokines,production of biofilms by bacteria in semen,and infertility.It is likely that the ability of microorganisms to change the concentration of cytokines and increase the level of biofilm formation in semen may be associated with minimal impairments of fertilizing ability,which are not detected using other methods. | Oleg V Bukharin Natalya B Perunova Elena V Ivanova Irina N Chaynikova Anastasia V Bekpergenova Taisiya A Bondarenko Michael D Kuzmin | 2022 | Asian Journal of Andrology2022，24，4： | 0 |
| 16 | Structural traits of woody plants and geomorphological conditions to the vegetation recovery at Ksudach caldera(Southern Kamchatka) since the explosive eruption in 1907显示文摘This study considers the restoration of the plant cover destroyed by a catastrophic volcano eruption in the south of Kamchatka Peninsula(the Ksudach caldera,Shtyubel cone),with a particular attention to the role of woody plants.It aims to qualitatively estimate(at a qualitative level)the rate of the primary succession development depending on the microrelief and the modern relief-forming processes.The vegetation recovery in the caldera after the Shtyubel cone eruption 109 years ago proceeds slowly and irregularly.It proceeds most slowly on a thick tephra mantle continuously disturbed by water and wind erosion,lahars,debris flows,landslides,etc.Such conditions are most typical of the western part of the caldera dominated by pumice fields with occasional patches of pioneer herbs and dwarf shrubs.Alpine tundra communities with gradually expanding patches of shrub alder develop in the southern,eastern and northeastern parts of the Ksudach caldera.Since 1997 the area of the shrub alder communities has increased by 1.9 times,while the alpine tundra–by 1.3 times only.The woody plants(dwarf shrubs and prostrate shrubs)are of particular importance in the process of the vegetation recovery on pumice fields.We suggest that the bark thickness of woody plants is an integrated indicator,which may serve for estimating the state of ecosystem in the course of the primary succession development on juvenile sediments.The extremely inhospitable environments cause changes in physiological processes in the plant body and in its bark in particular.The results show that woody plants have a'thin'bark and develop some structural-functional arrangements for keeping bark tissues at their minimum.So,the woody plant structure and the rate of changes in plant communities are under control of the geomorphic conditions and primarily–of physicochemical features of the pyroclastic cover. | KOPANINA Anna V LEBEDEVA Ekaterina V VLASOVA Inna I TALSKIKH Anastasia V | 2020 | Journal of Mountain Science2020，17，7： | 0 |
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