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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | A single measurement of CD38CD3 cells in HIV+,long-term surviving injecting drugs uses distinguishes these who will progress to AIDS from those who will remain stable显示文摘 | Forebel KS Raab GM D'Alessandro C | 2000 | Clin Exp Immunol2000，122，1： | 1 |
| 3 | Physical activity and exercise training:a relevant aspect of the dialysis patient's care 显示文摘 | Cupisti A D'Alessandro C Bottai A | 2013 | Intern Emerg Med2013，8，1： | 1 |
| 4 | Nutrition knowledge and dietary composition in Italian adolescent female ath- letes and non-athletes显示文摘 | Cupisti A D'Alessandro C Castrogiovanni S | 2002 | International Journal of Sport Nutrition & Exercise Metabolism2002，12，2： | 1 |
| 5 | Food intake and nutritional status in stable hemodialysis patients显示文摘 | Cupisti A D'Alessandro C Valeri A | 2010 | Ren Fail2010，32，： | 1 |
| 6 | Physical activity and exercise training:a relevant aspect of the dialysis patient’s care显示文摘 | Cupisti A D’alessandro C Bottai A | 2013 | Internal and Emergency Medicine2013，8，1： | 1 |
| 7 | Design and Construction of Arbritrary Waveform Generator显示文摘 | Daniele D C Alessandro D G Giuliano D | 1983 | IEEE Trans on Instrumentation and Measurement1983，32，3： | 1 |
| 8 | Infraredproperties of chemical-vapor deposition polycrystallinediamond windows显示文摘 | Paolo D Alessandro N Daniele C | 1998 | Appl Optics1998，37，24： | 1 |
| 9 | Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro显示文摘 | Tassone P Tagliaferri P Viscomi C Palmieri C Caraglia M D' Alessandro A | 2003 | Br J Cancer2003，88，： | 1 |
| 10 | Impmving Usage of Podiatric Information on the Internet:The Virtual Children's Hospital显示文摘 | D'Alessandro D M Kreiter C D | 1999 | PEDIATRICS1999，104，5： | 1 |
| 11 | Experimental study of lightning rods using long sparks in air 显示文摘 | D' Alessandro F Kossmann C J Gaivoronsky A S | 2004 | IEEE Trans on Dielectrics and Electrical Insulation2004，11，4： | 1 |
| 12 | Nutrition survey in elite rhythmic gynmasts显示文摘 | CUPISTI A D'ALESSANDRO C D CASTROGVANNI S | 2000 | J Sports Med Phys Fitness2000，，40： | 1 |
| 13 | Nutritional status and dietary manipulation in predialysis chronic renal failure patients显示文摘 | Cupisti A D'Alessandro C | 2004 | J Ren Nutr2004，14，3： | 1 |
| 14 | Nutritional knowledge in hemodialysis patients and nurses:focus on phosphorus 显示文摘 | Cupisti A Ferretti V D' Alessandro C | 2012 | Journal of Renal Nutrition2012，22，6： | 1 |
| 15 | Strict glycemic control reduces EuroS CORE expected mortality in diabetic patients undergoing myocardial revascularization显示文摘 | D'Alessandro C Leprince P Golmard JL | 2007 | J Thorac Cardiovasc Surg2007，134，1： | 1 |
| 16 | Hepatitis B and C virus infection, alcohol drinking, hepatocellular carcinoma: a case control study in Italy显示文摘 | Farucesco D Alessandro T Roberta C | 1997 | Hapatology1997，26，3： | 1 |
| 17 | Predominant-period site classification for response spectra Prediction equations in Italy显示文摘 | Alessandro C D Bonilla F L Boore D M | 2012 | Bulle- tin of the Seismological Society of America2012，102，2： | 1 |
| 18 | Signal transducers and activators of transcription 3 signaling pathway an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation 显示文摘 | Alessandro M Patrizia D Alessandra C | 2005 | Inflamm Bowel Dis2005，11，2： | 1 |
| 19 | Antagonism of sorafenib and regorafenib actions by platelet factors in hepatocellular carcinoma cell lines 显示文摘 | D'Alessandro R Refolo MG Lippolis C | 2014 | BMC Cancer2014，14，： | 1 |
| 20 | Promotional Effect of Rare Earths and Transition Metals in the Combustion of Diesel Soot over CeO2 and CeO2-ZrO2显示文摘 | Eleonora Aneggi C d L Giuliano Dolcetti Alessandro Trovarelli | 2006 | Catalysis Today2006，111，： | 1 |
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