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3篇 您的检索式:作者名="Alexander Hoetzel"
    题名 作者 年代 出处 被引量
1Nitric oxide-deficiency regulates hepatic heme oxygenase-1显示文摘Alexander Hoetzel Armin Welle René Schmidt Torsten Loop Matjaz Humar Stefan W. Ryter Klaus K. Geiger Augustine M.K. Choi Benedikt H.J. Pannen 2007Nitric Oxide2007,,1:1
2Carbon monoxide protects against ventilator-induced lung injury via PPAR-g and inhibition of Egr-1显示文摘ALEXANDER HOETZELL TAMAS DOLINAYL SIMONE VALLBRACHT 2008Am J Res Cri Care Med2008,177,11:1
3Hepatic steatosis prevents heme oxygenase-1 induction by isoflurane in the rat liver显示文摘AIM:To characterize the inductive effects of isoflurane(ISO) on hepatic heme oxygenase-1(HO-1) in an animal model of hepatic steatosis.METHODS:Lean(LEAN) and obese(FAT) Zucker rats were randomized into 4 groups:1:LEAN + pentobarbital sodium(PEN);2:LEAN + ISO;3:FAT + PEN;4:FAT + ISO.The animals were mechanically ventilated for 6 h.In vitro analyses of liver tissue included determination of HO-1 mRNA and protein expression as well as measurement of HO enzyme activity and immunohistochemical analyses.RESULTS:Compared to PEN treatment,ISO administration profoundly induced hepatic HO-1 mRNA and protein expression and significantly increased HO enzyme activity in lean Zucker rats.In contrast,no difference in HO-1 gene expression was observed after ISO or PEN anesthesia in obese Zucker rats.CONCLUSION:The present study demonstrates that ISO is an inducer of hepatic HO-1 gene expression in non-steatotic organs but failed to upregulate HO-1 in steatotic livers.Patrick Stoll Christian I Schwer Ulrich Goebel Hartmut Buerkle Alexander Hoetzel Rene Schmidt 2011World Journal of Gastroenterology2011,17,37:0
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