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| 1 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 2 | The International Position on Laparoscopic Liver Surgery: The Louisville Statement, 2008显示文摘 | Joseph F. Buell Daniel Cherqui David A. Geller Nicholas O’Rourke David Iannitti Ibrahim Dagher Alan J. Koffron Mark Thomas Brice Gayet Ho Seong Han Go Wakabayashi Giulio Belli Hironori Kaneko Chen-Guo Ker Olivier Scatton Alexis Laurent Eddie K. Abdalla Pr | 2009 | Annals of Surgery2009，，3： | 2 |
| 3 | The International Position on Laparoscopic Liver Surgery: The Louisville Statement, 2008显示文摘 | Joseph F. Buell Daniel Cherqui David A. Geller Nicholas O'Rourke David Iannitti Ibrahim Dagher Alan J. Koffron Mark Thomas Brice Gayet Ho Seong Han Go Wakabayashi Giulio Belli Hironori Kaneko Chen-Guo Ker Olivier Scatton Alexis Laurent Eddie K. Abdalla Pr | 2009 | Annals of Surgery2009，，3： | 2 |
| 4 | The inflammatory response to cardiopulmonary bypass:part 1-mechanisms of pathogenesis 显示文摘 | Warren O J Smith A J Alexiou C | 2009 | Cardiothorac Vase Anesth2009，23，2： | 1 |
| 5 | The management of sickness absence in the NHS 显示文摘 | Alexis O | 2011 | Br J Nurs2011，20，22： | 1 |
| 6 | The effects of va- rious leukocyte filtration strategies in cardiac surgery 显示文摘 | WARREN O ALEXIOU G MASSEY R | 2007 | Eur J Cardiothorac surg2007，31，4： | 1 |
| 7 | Organizational identity and capability development in internationalization: transfer- ence,splicing and enhanced imitation in Tesco's US market entry显示文摘 | LOWE M GEORGE G ALEXY O | 2012 | Journal of Economic Geography2012，12，5： | 1 |
| 8 | Managing the business risks of open innovation显示文摘 | Alexy O Reitzig M | 2012 | McKinsey Quarterly2012，，1： | 1 |
| 9 | Secondary stresses in closed orthotropic deck ribs at floor beams 显示文摘 | Roman W Alexis O | 1992 | Journal of Structural Engineering1992，118，2： | 1 |
| 10 | The effects of various leukocyte filtration strategies in cardiac surgery显示文摘 | Warren O Alexiou C Massey R | 2007 | Eur J Cardiothorac Surg2007，31，4： | 1 |
| 11 | International Entrepreneurship and Capability Development : Qualitative Evidence and Future Research Directions 显示文摘 | AUTIO E GEORGE G ALEXY O | 2011 | Entrepreneurship Theory and Practice2011，35，1： | 1 |
| 12 | The inflammatory response to car- diopulmonary bypass: Part 1 - - mechanisms of pathogenesis 显示文摘 | Warren O J Smith A J Alexiou C | 2009 | J Cardiothorac Vasc Anesth2009，23，2： | 1 |
| 13 | Cui Bono? The selective revealing of knowledge and its implications for innovative activity显示文摘 | Alexy O George G Salter A | 2013 | Academy of Management Review2013，38，2： | 1 |
| 14 | Does IP sttrategy have to cripple open innovation?显示文摘 | Alexy O Criscuolo P Salter A | 2009 | MIT Sloan Management Review2009，51，1： | 1 |
| 15 | The inflammatory response to cardiopulmonary hypass: part 1-mechanisms of pathogenesis显示文摘 | Warren O J Smith A J Alexiou C | 2009 | J Cardiothorac Vasc Anesth2009，23，2： | 1 |
| 16 | Cui bono? The selec- tive revealing of knowledge and its implications for innovative activity显示文摘 | Alexy O George G Salter A J | 2013 | Academy of Management Re- view2013，38，2： | 1 |
| 17 | Cui Bono? The Selective Revea-ling of Knowledge and Its Implications for Innovative Activity 显示文摘 | ] Alexy O George G Salter A J | 2013 | Academy of Management Review2013，38，2： | 1 |
| 18 | Effect of the addition of soy flour and whey protein concentrate on bread quality and min- eral dialyzability 显示文摘 | Alexis N V Silvina R D Carlos A O | 2009 | Archivos Latinoamericanos de Nutricion2009，59，3： | 1 |
| 19 | 查看详情显示文摘 | Alexis F Pridgen E Molnar L K Farokhzad O C | | 0，，04： | 1 |
| 20 | Measurement of uncertainty in peptide molecular weight determination using size-exclusion chromatography with multi-angle laser lightsattering detection and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry显示文摘 | Alexis O Jose B.F Matias L | | 0，，： | 1 |
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