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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil显示文摘AIM: To evaluate the demographic characteristics and clinical phenotypes of inflammatory bowel disease(IBD) in a geographic area in Northeastern Brazil.METHODS: This retrospective study was conducted at the Hospital of the Federal University of Piauí in Northeastern Brazil. Demographic characteristics and clinical phenotypes of IBD were analyzed in relation to the time of diagnostic confirmation, which was defined as the date of disease onset. Data were collected between January 2011 and December 2012 and included all census patients 18 years of age or older during that period for whom there was diagnostic confirmation of Crohn's disease(CD), ulcerative colitis(UC), or unclassified colitis according to the Montreal criteria. We also analyzed the period of time between the onset of clinical manifestations and the diagnosis of IBD(delay in the diagnosis). Statistical analyses included means and standard deviations for numeric variables and the Pearson χ2 adherence test for nominal variables. The annual index occurrence and overall prevalence of IBD at our institution were also calculated, with P values < 0.05 indicating statistical significance. This study was approved by the Institutional Ethics and Research Committee.RESULTS: A total of 252 patients with IBD were included, including 152(60.3%) UC patients and 100(39.7%) CD patients. The clinical and demographic characteristics of all patients with IBD showed a female to male ratio of 1.3:1.0 and a mean age of35.2(SD = 14.5) years. In addition, the majority of patients were miscegenated(171, 67.9%), had received higher education(157, 62.4%), lived in urban areas(217, 86.1%), and were under the age of 40 years(97, 62.5%). For patients with CD, according to the Montreal classification, the predominant features present from the onset of disease were an age between 17 and 40 years(A2); colonic disease location(L2); and nonstricturing, nonfistulizing disease behavior(B1). However, approximately one-quarter of all CD patients demonstrated perineal involvement. We also observed considerable delay in the diagnosis of IBD throughout the entire study period(mean = 35.5 mo). In addition, the annual index occurrence rose from 0.08 to 1.53 cases/105 inhabitants/year during the study period, and the prevalence rate was 12.8 cases/105 inhabitants in 2012. Over the last two decades, there was a noted increase in the frequency of IBD in the study area.CONCLUSION: In this study, there was a predominance of patients with UC, young people under 40 years of age, individuals with racial miscegenation, and low annual incomes. | José Miguel Luz Parente Claudio Saddy Rodrigues Coy Viriato Campelo Mírian Perpétua Palha Dias Parente Leonardo Araújo Costa Renata Mendes da Silva Celso Stephan José Murilo Robilotta Zeitune | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 4 | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians显示文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. | Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 5 | In vivo anticancer activity of vanillin semicarbazone显示文摘Objective:To evaluate the anticancer activity of vanillin semicarbazone(VSC) against Ehrlich ascites carcinoma(EAC) cells in Swiss albino mice.Methods:The compound VSC at three doses(5, 7.5 and 10 mg/kg i.p.) was administered into the intraperitoneal cavity of the EAC inoculated mice to observe its efficiency by studying the cell growth inhibition, reduction of tumour weight,enhancement of survival time as well as the changes in depleted hematological parameters. Allsuch parameters were also studied with a known standard drug bleomycin at the dose of 0.3 mg/kg(i.p.).Results:Among the doses studied, 10 mg/kg(i.p.) was found to be quite comparable in potency to that of bleomycin at the dose of 0.3 mg/kg(i.p.). The host toxic effects of VSC was found to be negligible.Conclusions:It can be concluded that VSC can therefore be considered as potent anticancer agent. | Shaikh M Mohsin Ali M Abul Kalam Azad Mele Jesmin Shamim Ahsan M Mijanur Rahman Jahan Ara Khanam M Nazrul Islam Sha M Shahan Shahriar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 6 | Silicone oil in the surgical treatment of endophthalmitis associated with retinal detachment 显示文摘 | Aras C Ozdamar A Karacorlu M | 2001 | lnt Ophthalmol2001，24，3： | 1 |
| 7 | Immunoglobulin G4-related lung disease accompanied by organizing pneumonia 显示文摘 | Suzuki H Wstanabe M Ara T | 2013 | Intern Med2013，52，18： | 1 |
| 8 | Immunoglobulin G4-related lung disease accompanied by organizing pneumonia显示文摘 | Suzuki H Watanabe M Ara T | 2013 | Intern Med2013，52，18： | 1 |
| 9 | Comparison of diode laser and Er:YAG lasers in the treatment of ankyloglossia 显示文摘 | Aras MH Gregen M Giingrma M | 2010 | Photomed Laser Surg2010，28，2： | 1 |
| 10 | The first report of isolation and molectflar charac- terization of Brucella melitensis Rev-1 vaccine strain from an abor- ted sheep fetus in Turkey 显示文摘 | Aras Z Ates M | 2011 | Small Ruminant Res2011，95，23： | 1 |
| 11 | Determination of imbalance between MMP-2 and TIMP-2 in human neuroblastoma by reverse-transcription polymerase chain reaction and its correlation with tumor progression 显示文摘 | Ara T Kusafuka T Inoue M | 2000 | J Pediatr Surg2000，35，3： | 1 |
| 12 | Prevalence of musculoskeletal pain among teachers显示文摘 | Cardoso J P Ribeiro I Q B Araújo T M | 2009 | Revista Brasileira de Epidemiologia2009，，04： | 1 |
| 13 | Immunoglobulin G4-related lung disease accompanied by organizing pneumonia显示文摘 | Suzuki H Watanabe M Ara T | 2013 | Intern Med2013，52，： | 1 |
| 14 | Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment显示文摘 | Santos L H M L M Araújo A N Fachini A Pena A Delerue-Matos C Montenegro M C B S M | | 0，，： | 1 |
| 15 | Detoxification of the herbicide propanil by means of Fenton process and Ti O2-photocatalysis显示文摘 | O M G S Araa J González D O | 2014 | Journal of Photochemistry and Photobiology A2014，219，： | 1 |
| 16 | Increased accumulation of hexak is (2-methoxy isobutylisonitrile) technetium (1) (99Tcm-MIBI) in osteosarcoma and its metastatic lymph nodes显示文摘 | Caner B Kitapci M Aras T | 1992 | J Nucl Med1992，33，3： | 1 |
| 17 | Dissolution kinetics of sphalerite in acidic ferric chloride leaching 显示文摘 | Aydogan S Aras A Canbazoglu M | 2005 | Chemical Engineering Journal2005，114，13： | 1 |
| 18 | Simple rigid plastic model for seismic tilting of rigid walls 显示文摘 | Siddharthan R Ara A Norris G M | 1989 | Journal of Structural Engineering ASCE1989，118，： | 1 |
| 19 | Stored platelets contain residual amounts of tissue factor:evidence from studies on platelet concentrates stored for prolonged periods显示文摘 | Perez-Pujol S Aras O Lozano M | 2005 | Transfusion2005，45，4： | 1 |
| 20 | Recurrent lentigo maligna as amelanotic lentigo maligna melanoma 显示文摘 | Ara M MaiUo C Martin R | 2002 | JEur Acad Derm Venereol2002，16，5： | 1 |
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