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| 1 | Rescue associating liver partition and portal vein ligation for staged hepatectomy after portal embolization: Our experience and literature review显示文摘AIM To report a single-center experience in rescue associating liver partition and portal vein ligation for staged hepatectomy(ALPPS), after failure of previous portal embolization. We also performed a literature review.METHODS Between January 2014 and December 2015, every patient who underwent a rescue ALPPS procedure in Toulouse Rangueil University Hospital, France, was included. Every patient included had a project of major hepatectomy and a previous portal vein embolization(PVE) with insufficient future liver remnant to body weight ratio after the procedure. The ALPPS procedure was performed in two steps(ALPPS-1 and ALPPS-2), separated by an interval phase. ALPPS-2 was done within 7 to 9 d after ALPPS-1. To estimate the FLR, a computed tomography scan examination was performed 3 to 6 wk after the PVE procedure and 6 to 8 d after ALPPS-1. A transcystic stent was placed during ALPPS-1 and remained opened duringthe interval phase, in order to avoid biliary complications. Postoperative liver failure was defined using the 50-50 criteria. Postoperative complications were assessed according to the Dindo-Clavien Classification.RESULTS From January 2014 to December 2015, 7 patients underwent a rescue ALPPS procedure. Median FLR before PVE, ALPPS-1 and ALPPS-2 were respectively 263 cc(221-380), 450 cc(372-506), and 660 cc(575-776). Median FLR/BWR before PVE, ALPPS-1 and ALPPS-2 were respectively 0.4%(0.3-0.5), 0.6%(0.5-0.8), and 1%(0.8-1.2). Median volume growth of FLR was 69%(18-92) after PVE, and 45%(36-82) after ALPPS-1. The combination of PVE and ALPPS induced a growth of median initial FLR of +408 cc(254-513), leading to an increase of +149%(68-199). After ALPPS-2, 4 patients had stage Ⅰ-Ⅱ complications. Three patients had more severe complications(one stage Ⅲ, one stage Ⅳ and one death due to bowel perforation). Two patients suffered from postoperative liver failure according to the 50/50 criteria. None of our patients developed any biliary complication during the ALPPS procedure.CONCLUSION Rescue ALPPS may be an alternative after unsuccessful PVE and could allow previously unresectable patients to reach surgery. Biliary drainage seems to reduce biliary complications. | Charlotte Maulat Antoine Philis Bérénice Charriere Fatima-Zohra Mokrane Rosine Guimbaud Philippe Otal Bertrand Suc Fabrice Muscari | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 2 | Contribution of alpha-fetoprotein in liver transplantation for hepatocellular carcinoma显示文摘Alpha-fetoprotein(AFP) is the main tumor biomarker available for the management of hepatocellular carcinoma(HCC). Although it is neither a good screening test nor an accurate diagnostic tool for HCC, it seems to be a possible prognostic marker. However, its contribution in liver transplantation for HCC has not been fully determined, although its use to predict recurrence after liver transplantation has been underlined by international societies. In an era of organ shortages, it could also have a key role in the selection of patients eligible for liver transplantation. Yet unanswered questions remain. First, the cut-off value of serum AFP above which liver transplantation should not be performed is still a subject of debate. We show that a concentration of 1000 ng/m L could be an exclusion criterion, whereas values of < 15 ng/m L indicate patients with an excellent prognosis whatever the size and number of tumors. Monitoring the dynamics of AFP could also prove useful. However, evidence is lacking regarding the values that should be used. Today, the real input of AFP seems to be its integration into new criteria to select patients eligible for a liver transplantation. These recent tools have associated AFP values with morphological criteria, thus refining pre-existing criteria, such as Milan, University of California, San Francisco, or 'up-to-seven'. We provide a review of the different criteria submitted within the past years. Finally, AFP can be used to monitor recurrence after transplantation, although there is little evidence to support this claim. Future challenges will be to draft new international guidelines to implement the use of AFP as a selection tool, and to determine a clear cut-off value above which liver transplantation should not be performed. | Bérénice Charrière Charlotte Maulat Bertrand Suc Fabrice Muscari | 2016 | World Journal of Hepatology2016，8，21： | 3 |
| 3 | Corrosion rate determination of rare-earth Mg alloys in a Na_(2)SO_(4)solution by electrochemical measurements and inductive coupled plasma-optical emission spectroscopy显示文摘The corrosion resistance of three Mg alloys containing rare-earth elements(WE43,EV31 and ZE41)was studied and compared to that of two Mg-Al alloys(AZ31 and AZ91)and of pure Mg(99.95 wt.%).Current-voltage curves and electrochemical impedance measurements were performed with rotating disk electrodes in an aerated 0.1 M Na_(2)SO_(4)solution.For all the alloys,it was confirmed that the intermetallic particles acted as local cathodes and that more protective films were formed on the alloys surface by comparison with the pure Mg.Corrosion rates were determined from inductive coupled plasma-optical emission spectroscopy measurements and from the electrochemical measurements.Higher corrosion rates were observed for the rare-earth Mg alloys compared to the AZ series alloys.These data allowed the corrosion mechanisms to be discussed. | Samuel Leleu Bertrand Rives Nicolas Causse Nadine Pébère | 2019 | Journal of Magnesium and Alloys2019，7，1： | 3 |
| 4 | Glutamine synthetase and glutamate dehydrogenase isoforms in maize leaves:Localization,relative proportion and their role in ammonium assimilation or nitrogen transport显示文摘 | Thomas W B Elisa C Bertrand H | 2000 | Planta2000，211，： | 1 |
| 5 | Metal Determination and Quantification in Biological Material Using PIXE显示文摘 | Bertrand M Weber G Schoefs B | 2003 | Trends in Anal Chem2003，22，： | 1 |
| 6 | Disease complex in coffee involving Meliodogyne arabicida and Fusarium oxysporus 显示文摘 | BERTRAND B NUNEZ C SARAH J L | 2000 | Plant Pathology2000，49，： | 1 |
| 7 | Adhesion improvement of plasmadeposited silica thin films on stainless steel substrate studied by x-ray photoemission spectroscopy and in situ infrared ellipsometry显示文摘 | Bertrand N Drevillon B | 1998 | Journal of vacuum science and technology1998，16，1： | 1 |
| 8 | Diagenetic albitization of K-feldspar and plagioclase in sandstone reservoirs: thermodynamic and kinetic modeling显示文摘 | Mohamed B B Bertrand F Benoit M | 1993 | Journal of Sedimentary Research1993，，6： | 1 |
| 9 | Mutation of calmodulin-binding site renders the Na^+/H^+ exchanger( NHE1 ) highly H^+ -sensitive and Ca^2 + regulation-defective显示文摘 | Wakahayashi S Bertrand B ikeda T | 1994 | J Biol Chem1994，269，13： | 1 |
| 10 | Experimental study of phase relations involving osumilite in the system K2O-FeO-MgO-Al2O3-SiO2-H2O at high pressure and temperature显示文摘 | Audibert N Hensen B J Bertrand P | 1995 | J Metamorphic Geol1995，13，： | 1 |
| 11 | Spontaneous spi- nal epidural Hematoma causing paraplegia : resolution and recovery without surgical decompression 显示文摘 | CLARKE D B BERTRAND G TAMPIERI ID | 1992 | Neurosurgery1992，30，1： | 1 |
| 12 | Is septal deviation a risk factor for chronic sinusitis? Review of literature显示文摘 | Collet S Bertrand B Cornu S | 2001 | Acta Otorhinolaryngol Belg2001，55，4： | 1 |
| 13 | Eulerian simulation ofdense solid-liquid suspension in mult-i stage stirred vessel显示文摘 | Barrue H Bertrand J Cristol B | 2001 | Journal of Chemical Engineering of Japan2001，34，5： | 1 |
| 14 | Chemotherapy in locally advanced nasopharyngeal carcinoma:an individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand B Helene A Jean B | 2006 | Int J Radiat Oncol Biol Phys2006，64，1： | 1 |
| 15 | Rapid assessment of drug metabolism in the drug discovery process 显示文摘 | Bertrand M Jackson P Walther B | 2000 | Eur J Pharm Sci2000，11，2： | 1 |
| 16 | Specific regulation of cyclins D1 and D2 by FGF and Shh signaling coordinates cell cycle progression,patterning and differentiation during early steps of spinal cord development显示文摘 | Lobjois V Benazeraf B Bertrand N | 2004 | Dev Biol2004，273，2： | 1 |
| 17 | Beneficial effects of humidified high flow nasal oxygen in critical care patients:a prospective pilot study显示文摘 | Sztrymf B Messika J Bertrand F | 2011 | Intensive Care Med2011，37，11： | 1 |
| 18 | Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study显示文摘 | Sztrymf B Messika J Bertrand F | 2011 | Intensive Care Med2011，37，11： | 1 |
| 19 | A link between chemokine levels and disease severity in human African trypanosomiasis显示文摘 | Bertrand C Caroline B Ge'de'on | 2006 | Intern J Parasitol2006，36，： | 1 |
| 20 | A vector - perturbation technique for near - capacity multi antenna mul- tiuser communication part II : perturbation 显示文摘 | BERTRAND M H CHRISTIAN B P LEE S A | 2005 | Communica- tions IEEE Transactions2005，53，7： | 1 |
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