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| 1 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 2 | Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment显示文摘 | BRANDON E F A OOMEN A G ROMPELBERG C J M | 2006 | Regulatory Toxicology and Pharmacology2006，44，： | 1 |
| 3 | Antimalarial quinolines and artemisinin inhibit endocytosis in plasmodium falciparum显示文摘 | Heinrich C Donelly A Ursula M Sandra A Joanne E Brandon W | 2004 | Antimicro Agents Chemother2004，48，： | 1 |
| 4 | Subpopulation of lymphocytes in the mammary gland of sheep显示文摘 | Lee C S Meeusen E Brandon M R | 1989 | Immunology1989，66，： | 1 |
| 5 | Development of an industrializable fermentation process for propionic acid production显示文摘 | STOWERS C C BRANDON B M RODRIGUEZ A | 2014 | Journal of Industrial Microbiology & Biotechnology2014，3，： | 1 |
| 6 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 7 | Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2显示文摘 | Sos Brandon C Harris Charles Nordstrom Sarah M Tran Jennifer L Balázs Mercedesz Caplazi Patrick Febbraio Maria Applegate Milana A B Wagner Kay-Uwe Weiss Ethan J | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 8 | Consumer product in vitro digestion model:bioaccessibility of contaminants and its application in risk assessment显示文摘 | Brandon E F A Oomen A G Rompelberg C J M | 2006 | Regulatory Toxicology and Pharmacology2006，44，2： | 1 |
| 9 | Hsp70 inhibits aminoglycoside induced hair cell death and is necessary for the protective effect of heat shock显示文摘 | Taleh M Brandon C S Lee F S | 2008 | Journal of the Association for Research in Otolaryngology2008，9，3： | 1 |
| 10 | Self-control relies on glucose as a limited energy source: willpower is more than a metaphor显示文摘 | Gailliot Matthew T Baumeister Roy F DeWall C Nathan Maner Jon K Plant E Ashby Tice Dianne M Brewer Lauren E Schmeichel Brandon J | 2007 | Journal of Personality and Social Psychology2007，92，2： | 1 |
| 11 | In situ studies of ion transport in microporous supercapacitor electrodes at ultralow temperatures 显示文摘 | KORENBLIT Y KAJDOS A WEST W C SMART M C BRANDON E J KVIT A JAGIELLO J YUSHIN G | 2012 | Advanced Functional Materials2012，22，8： | 1 |
| 12 | Hsp70 inhibits amino glycoside-induced hair cell death and is necessary for the protective effect of heat shock 显示文摘 | Taleb M Brandon C S Lee F S | 2008 | Journal of the Association for Research in Otolaryngology2008，9，3： | 1 |
| 13 | MITOMAP:a h- uman mitoehondrial genome database-2004 update显示文摘 | Brandon M C Lott M T Nguyen K C | 2005 | Nu- cleic Acids Res2005，33，： | 1 |
| 14 | Post-orogenic evolution of the Dabie Shan,Eastern China,from (U-Th)/He and fission-track thermochronology显示文摘 | Reiners P W Zhou Z Y Ehlers T A Xu C H Brandon M T Donelick R A Nicolescu S | 2003 | American Journal of Science2003，303，： | 1 |
| 15 | A new method for visualizing sediment particle size distributions显示文摘 | Brandon D B Scott F L Jaelyn M H C | 2002 | Journal of Paleolimnology2002，27，： | 1 |
| 16 | The knowledge,attitude,and self-efficacy asthma questionnaire显示文摘 | Wigal JK Stout C Brandon M | 1993 | Chest1993，104，4： | 1 |
| 17 | The plasminogen activator system and cancer显示文摘 | Brandon M Hau C K | 2008 | Pathophysiol Haemost Thromb2008，36，34： | 1 |
| 18 | Data structures and compression algorithms for genomic sequence data 显示文摘 | Brandon M C Wallace D C Baldi P | 2009 | Bioinformatics2009，25，14： | 1 |
| 19 | Vanadium in peridotites as a proxy of Paleo-fo2 during partial melting, prospects, limitations and implications显示文摘 | Lee C T A Brandon AD Norman M | 2003 | Geochimica et Cosmochimica Acta2003，67，16： | 1 |
| 20 | Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment显示文摘 | BRANDON E F A OOMEN A F ROMPELBERG C J M | 2006 | Regul Toxicol Pharmacol2006，44，： | 1 |
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