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| 1 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 2 | Comparison of esophageal capsule endoscopy and esophagogastroduodenoscopy for diagnosis of esophageal varices显示文摘AIM: To investigate the utility of esophageal capsule endoscopy in the diagnosis and grading of esophageal varices. METHODS: Cirrhotic patients who were undergo-ing esophagogastroduodenoscopy (EGD) for variceal screening or surveillance underwent capsule endos-copy. Two separate blinded investigators read each capsule endoscopy for the following results: variceal grade, need for treatment with variceal banding or prophylaxis with beta-blocker therapy, degree of portal hypertensive gastropathy, and gastric varices. RESULTS: Fifty patients underwent both capsule and EGD. Forty-eight patients had both procedures on the same day, and 2 patients had capsule endoscopy within 72 h of EGD. The accuracy of capsule endos- copy to decide on the need for prophylaxis was 74%, with sensitivity of 63% and specificity of 82%. Inter-rater agreement was moderate (kappa = 0.56). Agree-ment between EGD and capsule endoscopy on grade of varices was 0.53 (moderate). Inter-rater reliability was good (kappa = 0.77). In diagnosis of portal hyper-tensive gastropathy, accuracy was 57%, with sensitiv-ity of 96% and specificity of 17%. Two patients had gastric varices seen on EGD, one of which was seen on capsule endoscopy. There were no complications from capsule endoscopy.CONCLUSION: We conclude that capsule endoscopy has a limited role in deciding which patients would benefit from EGD with banding or beta-blocker thera-py. More data is needed to assess accuracy for staging esophageal varices, PHG, and the detection of gastric varices. | Catherine T Frenette John G Kuldau Donald J Hillebrand Jill Lane Paul J Pockros | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | 动态增强磁共振成像对恶性血液病骨髓肿瘤浸润监测的初步研究显示文摘目的本研究旨在利用动态增强MR成像技术(DCE-MR)检测血液病患者骨髓强化特征变化,研究其与骨髓肿瘤细胞浸润状态的相关性。方法25例血液病经DCE-MR成像及髂嵴穿刺活检,测定骨髓灌注的最大强化率(PER),最大强化斜率值(Slopemax),峰值时间(TTP),平均时间(MT),以及骨髓活检分析肿瘤分数(TF)。结果肿瘤浸润组较缓解期组PER高(临床缓解期为0.252±0.156,肿瘤组为0.592±0.433),统计学上有显著性差异(P<0.05)。肿瘤浸润组较缓解期组的Slopemax高肿瘤组:(0.561±0.634)/s;缓解期组:(0.204±0.105)/s、TTP缩短肿瘤组:(68.12±42.18)s;缓解期组:(81.52±38.49)s,但统计学上无显著性差异(P>0.05),MT值两组差异不明显(P>0.05)。结论动态增强MR成像能够监测血液病骨髓肿瘤细胞浸润状态,为恶性血液病治疗随访提供了一种新的无创性监测手段。 | 张蕾 Catherine Mandel 杨振燕 Qing Yang Richard Nibbs David Westerman Alex G Pitman | 2006 | 中国医学影像技术2006，22，7： | 4 |
| 4 | Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice显示文摘 | Tiphaine Le Roy Marta Llopis Patricia Lepage Aurélia Bruneau Sylvie Rabot Claudia Bevilacqua Patrice Martin Catherine Philippe Francine Walker André Bado Gabriel Perlemuter Anne-Marie Cassard-Doulcier Philippe Gérard | 2013 | Gut2013，，12： | 3 |
| 5 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 6 | Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer显示文摘17β-hydroxysteroid dehydrogenase(17β-HSD)type 1 is known as a critical target to block the final step of estrogen production in estrogen-dependent breast cancer.Recent confirmation of the role of dyhydroxytestosterone(DHT)in counteracting estrogeninduced cell growth prompted us to study the reductive 17β-HSD type 7(17β-HSD7),which activates estrone while markedly inactivatingDHT.The role ofDHTin breast cancer cell proliferation isdemonstratedby its independent suppression of cell growthin the presence of a physiological concentration of estradiol(E2).Moreover,an integral analysis of a large number of clinical samples in Oncomine datasets demonstrated the overexpression of 17β-HSD7 in breast carcinoma.Inhibition of 17β-HSD7 in breast cancer cells resulted in a lower level of E2 and a higher level of DHT,successively induced regulation of cyclinD1,p21,Bcl-2,and Bik,consequently arrested cell cycle in the G0/G1 phase,and triggered apoptosis and auto-downregulation feedback of the enzyme.Such inhibition led to significant shrinkage of xenograft tumors with decreased cancer cell density and reduced 17β-HSD7 expression.Decreased plasma E2 and elevated plasma DHT levels were also found.Thus,the dual functional 17β-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of E2 andDHT.Thisdemonstrates aconceptual advance on the general belief that the major role of this enzyme is in cholesterol metabolism. | Xiaoqiang Wang Catherine Gérard Jean-Francois Thériault Donald Poirier Charles J.Doillon Sheng-Xiang Lin | 2015 | Journal of Molecular Cell Biology2015，7，6： | 2 |
| 7 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 8 | 血液病骨髓动态增强MRI特征的初步研究显示文摘目的 探讨血液病患者骨髓动态增强MRI(DCE-MRI)与骨髓细胞构成的关系。方法对25例恶性血液病患者进行DCE-MRI检查,测定骨髓灌注的最大强化率(PER)、最大强化斜率(Slopemax)、峰值时间(哪)和平均时间(MT);30min后进行髂嵴穿刺活检,分析细胞构成。结果 25例血液病患者中,正常细胞数型骨髓20例,细胞数增多型骨髓3例,细胞数减少型骨髓2例。DCE-MRI骨髓时间.信号强度曲线(TIC)B型3例,C型7例,D型13例,E型2例。细胞数增多型骨髓PER、Slopemax均高于正常细胞数型骨髓和细胞数减少型骨髓;细胞数增多型骨髓,TTP短于正常细胞数型骨髓和细胞数减少型骨髓;细胞数减少型骨髓MT短于正常细胞数型骨髓和细胞数增多型骨髓。结论 DCE-MRI可以作为无创、有效监测血液病骨髓细胞构成变化的手段之一。 | 张蕾 Catherine Mandel 杨振燕 王培军 Alex G Pitman | 2007 | 中华肿瘤杂志2007，29，3： | 2 |
| 9 | Atmospheric lead and heavy metal pollution records from a Belgian peat bog spanning the last two millenia:Human impact on a regional to global scale显示文摘 | FRANCOIS DE VLEESCHOUWER LATITIA GRARD CATHERINE GOORMAGHTIGH | 2007 | The Science of the Total Environment2007，297，： | 1 |
| 10 | Antibiosis revisited: bacterio- cins produced by dairy starter cultures显示文摘 | Susan F B Catherine G N | 1993 | Journal of Dairy Science1993，76，8： | 1 |
| 11 | Directions for productivity measurement in fisheries显示文摘 | Felthovena R G Catherine J Morrison P | 2004 | Marine Policy2004，28，： | 1 |
| 12 | Sensory Evaluation ofFruit Quality and Nutritional Composition of 20 Breadfruit(Artocarpus, Moraceae) Cultivars显示文摘 | Diane Ragone Catherine G Cavaletto | 2006 | Economic Botany2006，60，4： | 1 |
| 13 | Mental health outcome of Job stress among Chinese teachers:role of stress resource Factors and burnout显示文摘 | Catherine S K T Wing T A RalfS G S | 2001 | Journal of Organizational Behavior2001，，22： | 1 |
| 14 | Tissue and cell specific expression of a cinnamul alchol dehydrogenase promoter in transgenic poplar plant显示文摘 | VIVGINIE L CHRISTIN D | 1995 | Plant Molecular Biology1995，27，： | 1 |
| 15 | Mutational analysis of the catalytic centre of the Citrobacter freundii AmpD N - acetylmuramyl - L - alanine amidase 显示文摘 | Catherine G Dominique D Bart D | 2004 | Biochemical Society2004，377，11： | 1 |
| 16 | Hyperosmotic and thermal stresses activate p38-MAPK in the perfused amphibian heart显示文摘 | IOANNA K S CATHERINE G ANTIGONE L | 2002 | The Journal of Experimental Biology2002，205，： | 1 |
| 17 | Some Antecedents and Effects of Trust in Virtual Commu- nities显示文摘 | RIDINGS CATHERIN M DAVID G | 2002 | Journal of Strategic Information Systems2002，11，34： | 1 |
| 18 | Influence of sputtering gases on the properties of magnetron sputtere tungsten films显示文摘 | Paturaud C Farges G Sainte Catherine M C | 1996 | Surf Coat Technol1996，8687，1： | 1 |
| 19 | Forces on adhesive contacts a ffect cell function显示文摘 | Catherine G Galbraith Michael P Sheetz | 1998 | Cell Biology1998，10，： | 1 |
| 20 | The estrogenic activity of phthalate esters in vitro显示文摘 | Harrs Catherine A Henttu Pirkko Parker Malcolm G | | 0，，08： | 1 |
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