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| 1 | Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133显示文摘 | KOV S V JUN L st CLAIR R | 2004 | Blood2004，103，6： | 1 |
| 2 | A histological study of shell disease syndrome in the edible crab Cancer pagurus 显示文摘 | CLAIRE L V CAROLINA C R ANDREW F R | 2001 | Diseases of Aquatic Organisms2001，47，： | 1 |
| 3 | Asignalling role for muscle glycogen in the regulation of pace during prolonged exercise 显示文摘 | Rauch H G L St Clair Gibson A Lambert E V | 2005 | Br J Sports Meal2005，39，1： | 1 |
| 4 | The role of information processing between the brain and peripheral physiological systems in pacing and perception of effort显示文摘 | ST CLAIR GIBON A LAMBERT E V RAUCH L H G | 2006 | Sports Med2006，36，8： | 1 |
| 5 | Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133显示文摘 | Shmelkov S V Jun L St Clair R | 2004 | {H}Blood2004，，6： | 1 |
| 6 | The role of information processing between the brain and pe- ripheral physiological systems in pacing and perception of effort 显示文摘 | ST CLAIR GIBSON A LAMBERT E V RAUCH L H | 2006 | Sports Med2006，36，8： | 1 |
| 7 | Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133显示文摘 | Shmelkov S V Jun L St Clair R | 2004 | Blood2004，103，6： | 1 |
| 8 | The Social Dimension of Network Ties between Entrepreneurial Firms:Implications for Information Acquisition显示文摘 | Nguyen T V Claire L Bryant S E | 2003 | Journal of Applied Management and Entrepreneurship2003，82，： | 1 |
| 9 | The evolution of CANMAT Bipolar Disorder Guidelines: past, present, and future显示文摘 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Schaffer Serge Beaulieu Martin Alda Claire O’Donovan Glenda MacQueen Roger S McIntyre Verinder Sharma Arun Ravindran L Trevor Young Roumen Milev David J Bond Benicio N Frey Benjamin I Goldstein | 2013 | Bipolar Disorders2013，，： | 1 |
| 10 | A signalling role for muscle glycogen in the regulation of pace during prolonged exercise显示文摘 | RAUCH H G L ST CLAIR GIBSON A LAMBERT E V | 2005 | Br J Sports Med2005，39，1： | 1 |
| 11 | The role of information processing between the brain and pe- ripheral physiological systems in pacing and perception of effort 显示文摘 | ST CLAIR GIBSON A LAMBERT E V RAUCH L H | 2006 | Sports Med2006，36，8： | 1 |
| 12 | Characterization of resistin exepression and secretion in human adipose tissue显示文摘 | Philip G M Claire L M George V | 2003 | Diabetes2003，52，2： | 1 |
| 13 | The social dimen- sion of network ties between entrepreneurial firms: Im- plications for information acquisition显示文摘 | Nguyen T V Claire L Bryant S E | 2003 | Journal of Ap- plied Management and Entrepreneurship2003，，8： | 1 |
| 14 | The PRA1 gene family in Arabidopsis 显示文摘 | Claire L A K Joanna B Klaas V | 2008 | Plant Physiol2008，147，： | 1 |
| 15 | Potential of damage associated molecular patterns in synergising radiation and the immune response in oesophageal cancer显示文摘BACKGROUND There is an intimate crosstalk between cancer formation,dissemination,treatment response and the host immune system,with inducing tumour cell death the ultimate therapeutic goal for most anti-cancer treatments.However,inducing a purposeful synergistic response between conventional therapies and the immune system remains evasive.The release of damage associated molecular patterns(DAMPs)is indicative of immunogenic cell death and propagation of established immune responses.However,there is a gap in the literature regarding the importance of DAMP expression in oesophageal adenocarcinoma(OAC)or by immune cells themselves.AIM To investigate the effects of conventional therapies on DAMP expression and to determine whether OAC is an immunogenic cancer.METHODS We investigated the levels of immunogenic cell death-associated DAMPs,calreticulin(CRT)and HMGB1 using an OAC isogenic model of radioresistance.DAMP expression was also assessed directly using ex vivo cancer patient T cells(n=10)and within tumour biopsies(n=9)both pre and post-treatment with clinically relevant chemo(radio)therapeutics.RESULTS Hypoxia in combination with nutrient deprivation significantly reduces DAMP expression by OAC cells in vitro.Significantly increased frequencies of T cell DAMP expression in OAC patients were observed following chemo-(radio)therapy,which was significantly higher in tumour tissue compared with peripheral blood.Patients with high expression of HMGB1 had a significantly better tumour regression grade(TRG 1-2)compared to low expressors.CONCLUSION In conclusion,OAC expresses an immunogenic phenotype with two distinct subgroups of high and low DAMP expressors,which correlated with tumour regression grade and lymphatic invasion.It also identifies DAMPs namely CRT and HMGB1 as potential promising biomarkers in predicting good pathological responses to conventional chemo(radio)therapies currently used in the multimodal management of locally advanced disease. | Noel E Donlon Maria Davern Andrew Sheppard Fiona O'Connell Brendan Moran Timothy S Nugent Aisling Heeran James J Phelan Anshul Bhardwaj Christine Butler Narayanasamy Ravi Claire L Donohoe Niamh Lynam-Lennon Stephen Maher John V Reynolds Joanne Lysaght | 2023 | World Journal of Gastrointestinal Oncology2023，15，8： | 0 |
| 16 | 溶酶体酸化可增强吞噬性星形胶质细胞的消化功能显示文摘低效的溶酶体降解是多种脑部疾病发展的中心环节,但其具体机制及参与的细胞种类仍不清楚。既往研究显示,星形胶质细胞大量吞噬死亡的细胞,但将这些吞噬的物质储存在细胞内而不是进行降解。本研究对星形胶质细胞降解消化功能减弱的原因进行研究,并探索增强星形胶质细胞降解消化功能的方法。结果显示,长期存在于吞噬泡周围的肌动环阻碍了溶酶体的吞噬溶解作用。此外,Rab27a蛋白可以通过Nox2减少溶酶体的酸化,而星形胶质细胞高表达Rab27a蛋白,阻碍抗原呈递。本研究还发现,Nox2与星形胶质细胞摄取的物质共定位,且表达主要组织相容性复合体II,提示这可能影响星形胶质细胞内的抗原呈递。使用酸化纳米粒子对星形胶质细胞溶酶体进行长时间的酸化处理,能增加星形胶质细胞对所摄取物质和死亡细胞的消化。但随着酸化时间的延长,星形胶质细胞的消化能力再次回复到较低水平,提示随着酸化作用的增强,细胞的对抗酸化的通路也相应增强了。 | Kelly R.Monk M.Laura Feltri Carla Taveggia Camilla Lv Claire H.Mitchell Martin Simonsson Anna Erlandsson 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，5： | 0 |
| 17 | 吉非替尼与多西紫杉醇在化疗后非小细胞肺癌患者中的疗效对比(INTEREST):一项随机Ⅲ期临床试验显示文摘背景两项在既往接受过治疗的晚期非小细胞肺癌患者中进行的Ⅱ期临床试验结果表明,吉非替尼的疗效优于化疗,且毒副作用更小:局部晚期或转移性非小细胞肺癌患者在接受以铂类药物为基础的化疗后,继续使用吉非替尼和多西紫杉醇进行治疗,观察并比较两类药物的疗效:方法2004年3月1日至2006年2月17日,采用开放标记的Ⅲ期临床研究的方法,在全球24个国家的149家中心招募受试者。1466例晚期非小细胞肺癌患者在接受铂类药物化疗后(铂类药物化疗至少1个疗程),经随机分组,分别接受吉非替尼(250mg口服,每日1次;n=733)或多西紫杉醇(75mg/m^2静脉注射,1h注射完毕,每3周1次;n=733)治疗,并保持两组间样本数量的动态平衡。本研究的主要目的是采用协同主要分析法,比较两组间的存活情况,以此评估吉非替尼在总体符合方案人群中的非劣效性,在意向治疗人群高表皮生长因子受体(EGFR)基因拷贝数患者中的优效性。本临床研究在ClinicalTrials.gov上注册,编号为NCT00076388。结果本研究分析了两种治疗方案下的共计1433例患者(吉非替尼组723例,多西紫杉醇组710例)。总体存活情况确认了吉非替尼相对于多西紫杉醇的非劣效性(事件593例Fs576例,HR1.020,96%C10.905~1.150,达到预定非劣效性标准;中位存活时间7.6月 vs8.0月):具有高EGFR基因拷贝数的患者(85例 vs 89例)未显示出吉非替尼治疗的优效性证据(事件72例vs 71例,HR1.09,95%C10.78-1.51,P=0.62;中位存活时间8.4个月Fs7.5个月)?在吉非替尼治疗组中,最常见的不良事件包括皮疹或痤疮[360例(49%)vs 73例(10%)]以及腹泻[255例(35%)vs 177例(25%)];然而,在多西紫杉醇治疗组中,中性粒细胞减少症[35例(5%)vs 514例(74%)]、乏力不适[182例(25%)vs 334例(47%)]以及脱发[23例(3%)vs 254例(36%)1是最常见的不良事件。结论INTEREST研究确立了吉非替尼与多西紫杉醇相比在存活率方面的非劣效性,提示吉非替尼对于既往接受过治疗的晚期非小细胞肺癌患者是一项有效的治疗措施。 | Edward SKim Vera Hirsh Tony Mok Mark A Socinski Radj Gervais Yi-Long Wu Long-Yun Li Claire L Watkins Mark V Sellers Elizabeth S Lowe Yan Sun Mei-Lin Liao Kell Osterlind Martin Reck Alison A Armour Frances A Shepherd Scott M Lippman lean-Yves Douillard | 2009 | 世界临床医学2009，，7： | 0 |
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