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| 1 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 2 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 3 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 4 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 5 | Elisabetta, GiudiceClotting profiles in newborn maltese kids during the first week of life 显示文摘 | Giuseppe P Cristiano B Claudia G | 2008 | J Vet Diagn Investm2008，20，2： | 1 |
| 6 | Scalable production of large quantities of defect-free few-layer graphene by shear exfoliation in liquids 显示文摘 | Keith R P Eswaraiah V Claudia B | 2014 | Nature Materials2014，3，： | 1 |
| 7 | Macrobenthos and multi-molecular markers as indicators of environmental contamina- tion in a South American port (Mar del Plata, Southwest Atlantic)显示文摘 | MARIANO J A PAULO DA C L CLAUDIA B | 2013 | Marine Pollution Bulletin2013，73，： | 1 |
| 8 | Removal of Mn from aqueous solution using fly ash and its hydrothermal synthetic zeolite 显示文摘 | Claudia B Franceseo C Spartaco D G | 2014 | Journal of Environmental Management2014，137，1： | 1 |
| 9 | Elevated jugular venous oxygen saturation after severe head injury显示文摘 | Manuela C Alex B Claudia S | 1999 | J Neurosurg1999，90，1： | 1 |
| 10 | Influence of grain orientation on the local deformation mode induced by cavita- tions erosion in a CuSnNi alloy 显示文摘 | Jorge S Michael P Claudia B | 2014 | Wear2014，316，12： | 1 |
| 11 | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells显示文摘 | Claudia C Gregorio-King Tamara Gough Gavin J Van Der Meer Jane B Hosking Caryll M Waugh Janet L McLeod Fiona Mc Collier Mark A Kirkland | 2004 | Journal of Steroid Biochemistry and Molecular Biology2004，，3： | 1 |
| 12 | Perceived barriers to medicalerror reporting: an exploratory investigation 显示文摘 | Claudia L Uribe Sharon B Schweikhart | 2002 | Joural of Healthcare Management2002，47，4： | 1 |
| 13 | Results of a laboratory experiment relating spectral reflectance to total suspended solids显示文摘 | Carlos A S Evlyn M L Claudia Z F B | 1991 | Remote Sensing of Environment1991，36，： | 1 |
| 14 | Correlates of symptoms of depression and anxiety in chronic hemodialysis patients 显示文摘 | Maurizio B Claudia C Gian C | 2010 | Gen Hosp Psychiatry2010，32，2： | 1 |
| 15 | Physical and biological properties of barium cross-linked alginate membranes 显示文摘 | HEIKO Z FELIX W CLAUDIA B | 2006 | Biomaterials2006，28，7： | 1 |
| 16 | Serum Epstein-Barr Virus DNA Load in Primary Epstein-Barr Virus Infection显示文摘 | Claudia C B Stephan WA Theresia PK | 2005 | J Med Viro2005，75，1： | 1 |
| 17 | The advantage of polymer addi- tion to a non-ionic oil in water microemulsion for the dermal delivery of progesterone显示文摘 | Babette B Claudia V | 2008 | Int J Pharm2008，349，： | 1 |
| 18 | Transformationalleadership,job satisfaction,andteam performance:A multilevel mediation modelof trust 显示文摘 | Susanne B Claudia P Silke W | 2013 | The Leadership Quarterly2013，24，3： | 1 |
| 19 | C terminus-mediated control of voltage and cAMP gating of hyperpolarization-activated cyclic nucleotide-gated channels显示文摘 | Carlo V Claudia A Annalisa B | 2001 | J Biol Chem2001，276，29： | 1 |
| 20 | Fre- quency of duplications in the D-loop in patients with mi- tochondrial DNA deletions 显示文摘 | CELIA H T CLAUDIA F B MARINA C | 2002 | Biochimica et Biophysi- ca Acta (BBA) -Molecular Basis of Disease2002，1588，1： | 1 |
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