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| 1 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 2 | Optimized Nonbismuth Quadruple Therapies Cure Most Patients With Helicobacter pylori Infection in Populations With High Rates of Antibiotic Resistance显示文摘 | Javier Molina–Infante Marco Romano Miguel Fernandez–Bermejo Alessandro Federico Antonietta G. Gravina Liliana Pozzati Elena Garcia–Abadia Gema Vinagre–Rodriguez Carmen Martinez–Alcala Moises Hernandez–Alonso Agnese Miranda Maria Rosaria Iovene Carmen Pazo | 2013 | Gastroenterology2013，，1： | 8 |
| 3 | Nonbismuth Quadruple (Concomitant) Therapy: Empirical and Tailored Efficacy versus Standard Triple Therapy for Clarithromycin‐Susceptible Helicobacter pylori and versus Sequential Therapy for Clarithromycin‐Resistant Strains显示文摘 | Javier Molina‐Infante Carmen Pazos‐Pacheco Gema Vinagre‐Rodriguez Belen Perez‐Gallardo Carmen Due?as‐Sadornil Moisés Hernandez‐Alonso Guadalupe Gonzalez‐Garcia Jose M. Mateos‐Rodriguez Miguel Fernandez‐Bermejo Javier P. Gisbert | 2012 | Helicobacter2012，，4： | 4 |
| 4 | Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma?显示文摘Metastatic renal cell carcinoma(m RCC) is a challenging disease. Despite the new targeted therapies, complete remissions occur only in 1%-3% of the cases, and the most effective first-line treatment drugs have reached a ceiling in overall survival(ranging from 9 to 49 mo). Metastasectomy remains to be the only curative option in most patients with m RCC. Prognostic nomograms have been recently published, so we have tools to classify patients in risk groups, allowing us to detect the cases with the higher risk of recurrence after metastasectomy. Although sparse, there is some evidence of effectiveness of neoadjuvant targeted therapy before metastasectomy; but with an increase in surgical complications due to the effects of these new drugs in tissue healing. We have aimed to answer the question: Is there a role for systemic targeted therapy after surgical treatment for metastases of renal cell carcinoma? We have made a search in Pubmed database. As far as we know, evidence is low and it's based in case reports and small series of patients treated with adjuvant drugs after neoadjuvant therapy plus metastasectomy in cases of partial response to initial systemic treatment. Despite the limitations and high risk of bias, promising results and cases with longterm survival with this approach have been described. Two ongoing clinical trials may answer the question that concerns us. | Adrian Husillos Alonso Manuel Carbonero García Carmen González Enguita | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 5 | Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress显示文摘 | María Vicario Mar Guilarte Carmen Alonso Pinchang Yang Cristina Martínez Laura Ramos Beatriz Lobo Ana González Meritxell Guilà Marc Pigrau Esteban Saperas Fernando Azpiroz Javier Santos | 2010 | Brain Behavior and Immunity2010，，7： | 1 |
| 6 | Bone pain palliation with strontium-89 in breast cancer patients with bone metastases and refractory bone pain显示文摘 | Lluis Berna Ignasi Carrio Carmen Alonso Josep Ferré Montserrat Estorch Gustavo Torres | 1995 | European Journal of Nuclear Medicine1995，，10： | 1 |
| 7 | Optimized Nonbismuth Quadruple Therapies Cure Most Patients With Helicobacter pylori Infection in Populations With High Rates of Antibiotic Resistance显示文摘 | Javier Molina–Infante Marco Romano Miguel Fernandez–Bermejo Alessandro Federico Antonietta G. Gravina Liliana Pozzati Elena Garcia–Abadia Gema Vinagre–Rodriguez Carmen Martinez–Alcala Moises Hernandez–Alonso Agnese Miranda Maria Rosaria Iovene Carmen Pazo | 2013 | Gastroenterology2013，，1： | 1 |
| 8 | Simultaneous indoor and outdoor on-line hourly monitoring of atmospheric volatile organic compounds in an urban building. The role of inside and outside sources显示文摘 | Maite de Blas Marino Navazo Lucio Alonso Nieves Durana Maria Carmen Gomez Jon Iza | 2012 | Science of the Total Environment2012，，： | 1 |
| 9 | Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles显示文摘 | Rocío Fernández-Urrusuno Pilar Calvo Carmen Remu?án-López Jose Luis Vila-Jato María José Alonso | 1999 | Pharmaceutical Research1999，，10： | 1 |
| 10 | Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines显示文摘 | Pilar Calvo Carmen Remu?an-López Jose Luis Vila-Jato María José Alonso | 1997 | Pharmaceutical Research1997，，10： | 1 |
| 11 | Esophageal Eosinophilic Infiltration Responds to Proton Pump Inhibition in Most Adults显示文摘 | Javier Molina–Infante Lucia Ferrando–Lamana Cristina Ripoll Moises Hernandez–Alonso Jose M. Mateos Miguel Fernandez–Bermejo Carmen Due?as Nuria Fernandez–Gonzalez Eva M. Quintana Maria Angeles Gonzalez–Nu?ez | 2011 | Clinical Gastroenterology and Hepatology2011，，2： | 1 |
| 12 | Laparoscopic surgery in situs inversus: a literature review and a report of laparoscopic sigmoidectomy for diverticulitis in situs inversus显示文摘 | Christian Kobus Eduardo M. Targarona Galit Even Bendahan Verónica Alonso Carmen Balagué Sandra Vela Jordi Garriga Manuel Trias | 2004 | Langenbeck’s Archives of Surgery2004，，5： | 1 |
| 13 | Circulatory Antigen Processing by Mucosal Dendritic Cells Controls CD8 + T Cell Activation显示文摘 | Sun-Young Chang Joo-Hye Song Bayasi Guleng Carmen Alonso Cotoner Seiji Arihiro Yun Zhao Hao-Sen Chiang Michael O’Keeffe Gongxian Liao Christopher L. Karp Mi-Na Kweon Arlene H. Sharpe Atul Bhan Cox Terhorst Hans-Christian Reinecker | 2013 | Immunity2013，，： | 1 |
| 14 | Recycling of an electric arc furnace flue dust to obtain high grade ZnO 显示文摘 | Oscar Ruiz Carmen Clemente Manuel Alonso | 2007 | Joumal of Hazardous Materials2007，141，7： | 1 |
| 15 | Microwave - assisted alkaline digestion combined with microwave - assisted distillation for the determination of iodide and total iodine in edible seaweed by catalytic spectrophotometry显示文摘 | Diego Gamallo- Lorenzo Maria del Carmen Barciela- Alonso Antonio Moreda etc | 2005 | Analytica Chimica Acta2005，542，2： | 1 |
| 16 | Enhancement of Nasal Absorption of Insulin Using Chitosan Nanoparticles显示文摘 | Rocío Fernández-Urrusuno Pilar Calvo Carmen Remu?án-López Jose Luis Vila-Jato María José Alonso | 1999 | Pharmaceutical Research1999，，10： | 1 |
| 17 | Intraosseous Access EZ-IO in a Prehospital Emergency Service显示文摘 | Francisco Torres Maria Dolores Galán Maria del Mar Alonso Rosa Suárez Carmen Camacho Veronica Almagro | 2012 | Journal of Emergency Nursing2012，，： | 1 |
| 18 | Chitosan and Chitosan/Ethylene Oxide-Propylene Oxide Block Copolymer Nanoparticles as Novel Carriers for Proteins and Vaccines显示文摘 | Pilar Calvo Carmen Remu?an-López Jose Luis Vila-Jato María José Alonso | 1997 | Pharmaceutical Research1997，，10： | 1 |
| 19 | Randomized Controlled Trial of Aspiration Needle versus Automated Biopsy Device for Transjugular Liver Biopsy显示文摘 | Rafael Ba?ares Sonia Alonso María-Vega Catalina Marta Casado Diego Rincón Magdalena Salcedo Emilio Alvarez Carmen Guerrero Antonio Echenagusía Fernando Camú?ez Gonzalo Simó | 2001 | Journal of Vascular and Interventional Radiology2001，，5： | 1 |
| 20 | Tau, neurodegeneration and Alzheimer's disease 显示文摘 | Del Carmen Alonso A | 2010 | Curr Alzheimer Res2010，7，8： | 1 |
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