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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 3 | Relationship between changes in hemoglobin level and quality of life during chemotherapy in anemic cancer patients receiving epoetin alfa therapy显示文摘 | Crawford J Celia D Cleeland C S | 2002 | Cancer2002，95，4： | 1 |
| 4 | Quality of life pre- dicts progression free survival in patients with metastatic renal cellcarcinoma treated with sunitinib versus interferon alfa 显示文摘 | Celia D Cappelleri JC Bushmakin A | 2009 | J On- col Pract2009，5，2： | 1 |
| 5 | Fatigue and cancer:causes,prevalence,and treatment approaches显示文摘 | Wagner LI Celia D | 2004 | Br J Cancer2004，91，5： | 1 |
| 6 | Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes 显示文摘 | Revicki D Hays R D Celia D | 2008 | J Clin Epidemiol2008，61，2： | 1 |
| 7 | The functional assessment of cancer therapy-anemia ( FACT An) scale : a new tool for the assessment of outcomes in cancer anemia and fatigue 显示文摘 | Celia D | 1997 | Semin Hematol1997，34，2： | 1 |
| 8 | Cancer-re- lated fatigue: prevalence of proposed diagnostic criteria in a United States of cancer survivors显示文摘 | Celia D Davis K Breitbart W | 2001 | J Clin Oncol2001，19，14： | 1 |
| 9 | Turbiscan Lab Expert analysis of the stability of ethosomes and ultradeformable liposomes containing a bilayer fluidizing agent 显示文摘 | CELIA C TRAPASSO E COSCO D | 2009 | Colloids and Surfaces B: Biointerfaces2009，72，1： | 1 |
| 10 | Phase Ⅲ trial of doxoru- bicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study显示文摘 | Fleming GF Bmnetto VL Celia D | 2004 | J Clin Oncol2004，22，11： | 1 |
| 11 | The functional assessment of cancer therapy-anemia (FACTAn) scale:a new tool for the qssessment of outcomes in cancer anemia and fatigue显示文摘 | Celia D | 1997 | Semin Hematol1997，34，32： | 1 |
| 12 | Patient, caregiver, and oncologist perceptions of cancer - related fatigue: Results of a tri - part assessment survey显示文摘 | Vogelzang N Breitbart W Celia D | 1997 | Semin Hematpl1997，34，2： | 1 |
| 13 | Phase Ⅲ trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endumetrial carcinoma:a Gynecologic Oncology Group study显示文摘 | Fleming GF Brunetto VL Celia D | 2004 | J Clin Oncol2004，22，： | 1 |
| 14 | Recent advances in designing supcrhydrophobic surfaces 显示文摘 | CELIA E DARMANIN T GIVENCIIY E T D AMIGONI S GU1TTARD F | 2013 | Journal of Colloid and Interface Science2013，402，： | 1 |
| 15 | Local administration of growth hormone enhances periimplant bone reaction in an osteoporotie rabbit model: An histologic, histomophometric and densitometric study 显示文摘 | Isabel FT Celia C Manuel D | 2002 | Clin Oral Impl Res2002，13，： | 1 |
| 16 | Effects of sorafenib on symptoms and quality of life : results from a large randomized placebo-controlled study in renal cancer 显示文摘 | Bukowski R Celia D Gondek K | 2007 | Am J Clin Oncol2007，30，： | 1 |
| 17 | Effects of lipid composition and preparation conditions on physical-chemical properties,technological parameters and in vitro biological activity of gemcitabine-loaded liposomes显示文摘 | Calvagno MG Celia C Paolino D | 2007 | Cur Drug Deliv2007，4，1： | 1 |
| 18 | Validation of FACT/GOG-AD subscale for ovarian cancer-related abdominal discomfort: a Gynecologic Oncology Group study 显示文摘 | Wenzel L Huang HQ Celia D | 2008 | GynecolOncol2008，110，1： | 1 |
| 19 | Advances in quality of life mearuements in oncology patients显示文摘 | Celia D Chang CH Lai JS | 2002 | Semin Oncol2002，29，38： | 1 |
| 20 | Patient care giver and oncologist perceptions of cancer related fatigue: results of a tripart assessment survey显示文摘 | Vogelzang N Breitbsart W Celia D | 1997 | Semin Hema- tol1997，34，32： | 1 |
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