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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Exome Resequencing Identifies Potential Tumor‐Suppressor Genes that Predispose to Colorectal Cancer显示文摘 | Christopher G. Smith Marc Naven Rebecca Harris James Colley Hannah West Ning Li Yuan Liu Richard Adams Timothy S. Maughan Laura Nichols Richard Kaplan Michael J. Wagner Howard L. McLeod Jeremy P. Cheadle | 2013 | Human Mutation2013，，7： | 2 |
| 3 | p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis显示文摘成红血球细胞的 Enucleation 对哺乳动物在终端区别期间唯一。尽管 erythroid enucleation 广泛地被学习了,包括 retinoblastoma 蛋白质(Rb ) ,仅仅一些基因被识别了调整原子挤出。它由哪个仍然保持大部分未定义发信号的分子,外来的刺激例如 erythropoietin (Epo ) ,是 transduced 导致 enucleation。这里,我们显示出那 p38α,激活 mitogen 的蛋白质 kinase (MAPK ) ,为 erythroid enucleation 被要求。在包含高 Epo 层次并且模仿的一个前 vivo 区别系统强调红血球生成, p38α在 erythroid 区别期间被激活。p38α 的损失;完全堵住主要成红血球细胞的 enucleation。而且, p38α在胎儿、贫血的压力红血球生成期间在 vivo 以一种房间自治的方式调整成红血球细胞 enucleation。显著地, p38α 的损失;导致 p21 目标 Rb 的 p21,和减少的激活的 downregulation,哪个是成红血球细胞 enucleation 的重要管理者。这研究表明那 p38α在压力红血球生成期间是为成红血球细胞 enucleation 的一个关键发信号分子。 | Simon M Schultze Andreas Mairhofer Dan Li Jin Cen Hartmut Beug Erwin F Wagner Lijian Hui | 2012 | Cell Research2012，22，3： | 2 |
| 4 | Restriction-site associated DNA sequencing data reveal a radiation of willow species(Salix L.,Salicaceae)in the Hengduan Mountains and adjacent areas显示文摘The Hengduan Mountains(HDM)in China are an important hotspot of plant diversity and endemism,and are considered to be a secondary diversification center for the woody plant genus Salix L.(Salicaceae).Here we aimed to reconstruct the spatiotemporal evolution of the Salix Chamaetia-Vetrix clade in the HDM and to test for the occurrence of a local radiation.We inferred phylogenetic relationships based on more than 34000 restriction-site associated DNA loci from 27 species.Phylogenetic analyses recovered a well-resolved tree topology with two major clades,the Eurasian clade and the HDM clade,with a divergence time of ca.23.9 Ma.Species in the HDM clade originated in the northern part of the range and adjacent areas,and then dispersed into the southern HDM,westwards to the Himalayas and eastwards to the Qinling Mountains.Niche modelling analyses reveal that range contractions occurred in the northern areas during the last glacial maximum,while southward expansions resulted in range overlaps.Reconstructions of character evolution related to plant height,in florescence,and flower morphology suggest that adaptations to altitudinal distribution contributed to the diversification of the HDM willows.Our data support the occurrence of a radiation in the HDM within the Salix Chamaetia-Vetrix clade.Dispersal within the mountain system,and to adjacent regions,in addition to survival in glacial refugia shaped the biogeographical history of the clade,while adaptations of the HDM willows along an altitudinal gradient could be important ecological factors explaining the high species diversity of Salix in this area. | Li He Natascha Dorothea Wagner Elvira Horandl | 2021 | Journal of Systematics and Evolution2021，59，1： | 2 |
| 5 | Behaviors that predict personality components in adult free-ranging Tibetan macaques Macaca thibetana显示文摘 | Alexander J. PRITCHARD Lori K. SHEERAN Kara I. GABRIEL Jin-Hua LI Ronald S. WAGNER | 2014 | Current Zoology2014，60，3： | 2 |
| 6 | Effect of combined use of nonionic surfactant on formation of oil-in-water mlcroemulsions显示文摘 | Li P Ghosh A Wagner R F | 2005 | Int J Pharm2005，288，1： | 1 |
| 7 | Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions 显示文摘 | LI P GHOSH A WAGNER RF | 2005 | lnt J Pharm2005，288，1： | 1 |
| 8 | Effect of combined use of nonionic surfactant on formation of oilin-water microemulsions显示文摘 | LI Ping GHOSH A WAGNER R F | 2005 | Int J Pharm2005，288，： | 1 |
| 9 | Fatigue and cancer:causes,prevalence,and treatment approaches显示文摘 | Wagner LI Celia D | 2004 | Br J Cancer2004，91，5： | 1 |
| 10 | Mobilization of hematopoietic progenitor cells by yeastderived beta-glucan requires activation of matrix metalloproteinase-9 显示文摘 | Cramer DE Wagner S Li B | 2008 | Stem Cells2008，26，5： | 1 |
| 11 | Dual role of the basic helix-loophelix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis显示文摘 | Brown D Wagner D Li X | 1999 | Development1999，126，19： | 1 |
| 12 | The calcium-binding protein S100A6accelerates human osteosarcoma growth by promoting cell proliferation and inhibiting osteogenic differentiation显示文摘 | Li Y Wagner ER Yan Z | 2015 | Cell Physiol Biochem2015，37，6： | 1 |
| 13 | Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions显示文摘 | Li P Ghosh A Wagner RF | 2005 | Int J Pharm2005，288，1： | 1 |
| 14 | 3-Hydroxy-3- methylglutaryl coenzyme A reductase in the lobster mandibular organ: Regulation by the eyestalk 显示文摘 | Li S Wagner C A Friesen J A | 2003 | General and Comparative Endocrinology2003，134，2： | 1 |
| 15 | Toll-like receptor triggering of a vitamin D-media- ted human antimicrobial response 显示文摘 | Liu PT Stenger S Li H Wenzel L Tan BH Krutzik SR Ochoa MT Schauber J Wu K Meinken C Kamen DL Wagner M Bals R Steinmeyer A Ztigel U Gallo RL Eis- enberg D Hewison M Hollis BW Adams JS Bloom BR Modlin RL | 2006 | Science2006，311，： | 1 |
| 16 | Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions显示文摘 | Li P Ghosh A Wagner RF | 2005 | International Journal ofPharmaceutics2005，288，1： | 1 |
| 17 | Diversion of initial blood flow to prevent whole-blood contamination by skin surface bacteria: an in vitro model显示文摘 | Wagner SJ Robinette D Friedman LI | 2000 | Transfusion2000，40，3： | 1 |
| 18 | myostatin directly regulates skeletal muscle fibrosis显示文摘 | Li Z B Kollias H D Wagner K R | 2008 | J Biol Chem2008，283，19： | 1 |
| 19 | Re- moval of mercury from chemical wastewater by microorgan- isms in technical scale显示文摘 | WAGNER D()BLER I CANSTEIN H V LI Ying | 2000 | Environmental Science and Technolo- gy2000，34，21： | 1 |
| 20 | Myostatin directly regu- lates skeletal muscle fibrosis 显示文摘 | Li Z B Kollias H D Wagner K R | 2008 | Biol Chem2008，283，19： | 1 |
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