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| 1 | IGF-1R as an anti-cancer target—trials and tribulations显示文摘Type I insulin-like growth factor receptor (IGF-1R) has long been recognized for its role in tumorigenesis and growth, but only recently have the tools for targeting the IGF pathway become available. More than 10 IGF/IGF-1R inhibitors have entered clinical trials, and these belong to three main classes: (1) monoclonal antibodies against IGF-1R, (2) monoclonal antibodies against IGF-1R ligands (IGF-1 and IGF- 2), and (3) IGF-1R tyrosine kinase inhibitors. These IGF-1R-targeting agents share common effects on IGF-1R signaling but differ in mechanisms of action, spectrum of target inhibition, and pharmacological features. Clinical activity of IGF-1R inhibitors has been demonstrated with sustained responses in a small number of patients with select tumor types, such as Ewing sarcoma and thymoma. However, many large clinical trials involving patients with adult tumors, including non-small cell lung cancer, breast cancer, and pancreatic cancer, failed to show clinical benefit in the overall patient population. Possible reasons for failure include the complexity of the IGF-1R/insulin receptor system and parallel growth and survival pathways, as well as a lack of patient selection markers. While IGF-1R remains a valid target for selected tumor types, identification of predictive markers and rational combinations will be critical to success in future development. | Helen X. Chen Elad Sharon | 2013 | Chinese Journal of Cancer2013，32，5： | 16 |
| 2 | Single-atom heterogeneous catalysts based on distinct carbon nitride scaffolds显示文摘Carbon nitrides integrating macroheterocycles offer unique potential as hosts for stabilizing metal atoms due to their rich electronic structure. To date, only graphitic heptazine-based polymers have been studied.Here, we demonstrate that palladium atoms can be effectively isolated on other carbon nitride scaffolds including linear melem oligomers and poly(triazine/heptazine imides). Increased metal uptake was linked to the larger cavity size and the presence of chloride ions in the polyimide structures. Changing the host structure leads to significant variation in the average oxidation state of the metal, which can be tuned by exchange of the ionic species as evidenced by X-ray photoelectron spectroscopy and supported by density functional theory. Evaluation in the semi-hydrogenation of 2-methyl-3-butyn-2-ol reveals an inverse correlation between the activity and the degree of oxidation of palladium, with oligomers exhibiting the highest activity. These findings provide new mechanistic insights into the influence of the carbon nitride structure on metal stabilization. | Zupeng Chen Evgeniya Vorobyeva Sharon Mitchell Edvin Fako Núria López Sean M.Collins Rowan K.Leary Paul A.Midgley Roland Hauert Javier Pérez-Ramírez | 2018 | National Science Review2018，5，5： | 4 |
| 3 | Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients with HCV Genotype 1 Infection显示文摘 | Daryl T.-Y. Lau Amina Negash Jie Chen Nanette Crochet Mala Sinha Yuhong Zhang Jeremie Guedj Sharon Holder Takeshi Saito Stanley M. Lemon Bruce A. Luxon Alan S. Perelson Michael Gale | 2012 | Gastroenterology2012，，： | 2 |
| 4 | Cultural Differences in Consumer Impatience显示文摘 | Chen Haipeng Sharon Ng Akshay R Rao | 2005 | Journal of Marketing Research2005，42，8： | 1 |
| 5 | Spontaneous hepatic rupture: 13-year experience of a single center显示文摘 | Daniel Maoz Eran Sharon Yakov Chen Franklin Grief | 2010 | European Journal of Gastroenterology & Hepatology2010，，8： | 1 |
| 6 | A Rat Model of Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) and The Effect of Dietary Protein Source显示文摘 | Sharon M.Moe Neal X Chen | | 0，，02： | 1 |
| 7 | Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases 显示文摘 | Sharon M Wahl Wanjun Chen | 2005 | Arthritis Research & Therapy2005，7，2： | 1 |
| 8 | BRCA1, BRCA2, BRCA2 and Rad51 operale in a common DNA damage responee pathway显示文摘 | Chen JJ Danicel Silver Sharon Canter | 1999 | Cancer Res(suppl)1999，59，： | 1 |
| 9 | Polymorphisms in the FGF2 gene and risk of serous ovarian cancer:resultsfrom the Ovarian Cancer Association Consortium 显示文摘 | SHARON E J JONATHAN B XIAOQING CHEN | 2009 | Twin Res Hum Genet2009，12，3： | 1 |
| 10 | Regulated expression of surface AMPA receptors reduces excitotoxicity in auditory neurons 显示文摘 | Chen Z Peppi M Sharon SG | 2009 | J Neurophysiol2009，102，2： | 1 |
| 11 | Role of endothelium-derived relaxing factor in the maintenance of renal blood flow in a rodent model of chronic hydronephrosis显示文摘 | Chen RN Sharon R | 1995 | Urology1995，46，2： | 1 |
| 12 | Activation of Arterial Matrix Metalloproteinases Leads to Vascular Calcification in Chronic Kidney Disease显示文摘 | Chen Neal X O’neill Kalisha D Chen Xianming Kiattisunthorn Kraiwiporn Gattone Vincent H Moe Sharon M | 2011 | EN2011，，3： | 1 |
| 13 | Fuzzy c means clustering with spatial information for image segmentation 显示文摘 | Keh-Shih Chuang Hong Long Tzeng Sharon Chen | 2006 | Computerized Medical Imaging and Graphics2006，，30： | 1 |
| 14 | Inner ear drug delivery via a reciprocating perfusion system in the guinea pig显示文摘 | Zhiqiang Chen Sharon G. Kujawa Michael J. McKenna Jason O. Fiering Mark J. Mescher Jeffrey T. Borenstein Erin E. Leary Swan William F. Sewell | 2005 | Journal of Controlled Release2005，，1： | 1 |
| 15 | Local surgical resection of gangliocytic paraganglioma of the duodenal papilla显示文摘 | Chen J Sharon E Morgenslern S | 2009 | Isr Med As- soc J2009，11，5： | 1 |
| 16 | Multiplex tandem PCR: a novel platform for rapid detection and identification of fungal pathogens from blood culture specimens显示文摘 | Lau A Sorrell TC Chen Sharon | 2008 | J Clin Microbiol2008，46，9： | 1 |
| 17 | Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes显示文摘 | Fasolo J Sboner A Sun M G Yu H Chen R Sharon D Kim P M Gerstein M Snyder M | | 0，，07： | 1 |
| 18 | VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization显示文摘 | Sharon Lim Yin Zhang Danfang Zhang Fang Chen Kayoko Hosaka Ninghan Feng Takahiro Seki Patrik Andersson Jingrong Li Jingwu Zang Baocun Sun Yihai Cao | 2014 | Cell Reports2014，，： | 1 |
| 19 | Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea显示文摘 | Amselem J Cuomo C A van Kan J A Viaud M Benito E P Couloux A Coutinho P M de Vries R P Dyer PS Fillinger S Fournier E Gout L Hahn M Kohn L Lapalu N Plummer K M Pradier J M Quévillon E Sharon A Simon A ten Have A Tudzynski B Tudzynski P Wincker P Andrew M Anthouard V Beever R E Beffa R Benoit I Bouzid O Brault B Chen Z Choquer M Collémare J Cotton P Danchin E G Da Silva C Gautier A Giraud C Giraud T Gonzalez C Grossetete S Güldener U Henrissat B Howlett B J Kodira C Kretschmer M Lappartient A Leroch M Levis C Mauceli E Neuvéglise C Oeser B Pearson M Poulain J Poussereau N Quesneville H Rascle C Schumacher J Ségurens B Sexton A Silva E Sirven C Soanes D M Talbot N J Templeton M Yandava C Yarden O Zeng Q Rollins J A Lebrun M H Dickman M | 2011 | PLoS Genetics2011，7，10： | 1 |
| 20 | Dissolved organic carbon (DOC) as a parameter of compost maturity显示文摘 | Sharon Zmora-Nahum Omer Markovitch Jorge Tarchitzky Yona Chen | 2005 | Soil Biology and Biochemistry2005，，11： | 1 |
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