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| 1 | Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia显示文摘高分辨率的 nanosized photoacoustic 对比代理人的发展是令人激动的还挑战性的工艺的进展。此处,抗体(胸联系癌症的抗原 1 (Brcaa1 ) monoclonal 抗体)- 并且肽(RGD )-functionalized 金牌 nanoprisms (AuNprs ) 被用作组合方法论为在使用的 situ photoacoustic 成像, angiography,和局部性的过高热, orthotopic 和下的鼠科的胃的癌当模特儿。结合 RGD 的 PEGylated AuNprs 为结合抗体的 PEGylated AuNprs 被用于指向的肿瘤 angiography,和 Brcaa1 monoclonal 并且为是可得到的在在 orthotopic 的胃的癌的 situ 成像,肿瘤当模特儿。在 situ photoacoustic 成像允许在肿瘤地点的解剖、功能的成像。在 vivo 肿瘤 angiography,成像以一种时间依赖者方式显示出 photoacoustic 信号的改进。而且, photoacoustic 成像证明肿瘤容器清楚地在局部性的过高热以后被损坏。这作为高度敏感的对比和治疗学的代理人是用二根 AuNprs 探针的第一 proof-of-concept 为在 situ 肿瘤察觉和抑制。这些聪明的抗体 / 肽 AuNprs 能被用作一个有效 nanotheranostic 平台为在局部性的过高热处理以后在有高敏感的 vivo 肿瘤察觉,以及为指向治疗,与单个剂量的注射,它导致肿瘤的肿瘤缩放减小和增加老鼠幸存。 | Chenchen Bao Joao Conde Fei Pan Chao Li Chunlei Zhang Furong Tian Shujing Liang Jesus M. de la Fuente Daxiang Cui | 2016 | Nano Research2016，9，4： | 9 |
| 2 | New approach to determine common weights in DEA efficiency evaluation model显示文摘Data envelopment analysis(DEA) is a mathematical programming approach to appraise the relative efficiencies of peer decision-making unit(DMU),which is widely used in ranking DMUs.However,almost all DEA-related ranking approaches are based on the self-evaluation efficiencies.In other words,each DMU chooses the weights it prefers to most,so the resulted efficiencies are not suitable to be used as ranking criteria.Therefore this paper proposes a new approach to determine a bundle of common weights in DEA efficiency evaluation model by introducing a multi-objective integer programming.The paper also gives the solving process of this multi-objective integer programming,and the solution is proven a Pareto efficient solution.The solving process ensures that the obtained common weight bundle is acceptable by a great number of DMUs.Finally a numeral example is given to demonstrate the approach. | Feng Yang Chenchen Yang Liang Liangc Shaofu Du | 2010 | Journal of Systems Engineering and Electronics2010，21，4： | 7 |
| 3 | PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer显示文摘Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear.Through comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy.Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant.Mechanistically,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with chemo-resistance.Such chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors.Our findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment. | Xuefeng Li Cheng Li Chenchen Guo Qiqi Zhao Jiayu Cao Hsin-Yi Huang Meiting Yue Yun Xue Yujuan Jin Liang Hu Hongbin Ji | 2021 | Journal of Genetics and Genomics2021，48，7： | 5 |
| 4 | Sedimentary filling and sequence structure dominated by T-R cycles of the Nenjiang Formation in the Songliao Basin显示文摘The Nenjiang Formation in the Songliao Basin is a symmetrical sequence of progradation-retrogradation,and is formed in the transgression cycle and regression cycle(T-R cycles)of the base level of deposition.We analyzed the drilling,well logging,core data,and seismic profiles of basin level,and by using the sequence stratigraphy,identified one secondary sequence boundary,two third-order sequence boundaries,and eight fourth-order sequence boundaries in the Nenjiang Formation.These eleven sequence boundaries can be divided into structural unconformity,depositional unconformity,flooding surface,and forced regression surface.Therefore the Nenjiang Formation can be subdivided into one secondary sequence,three third-order sequences,and ten fourth-order sequences.We have restored the sedimentary filling evolution within the stratigraphic framework of fourth-order sequences in the Nenjiang Formation.The sedimentary period of the first member of the Nenjiang Formation was corresponded to the global transgression period,which is also the development period of transgression cycle(T cycle),when the lake basin had the largest scope and deepest sedimentary water,the SB07(the maximum flooding surface)was formed on the top of strata during this period;covering above the SB07,there developed a set of condensation layer-oil shale,which is distributed in the whole basin and is the important source bed and regional cover.Therefore,a retrogradation sequence was formed in the T cycle of the first member of the Nenjiang Formation,characterized by the retrograding delta at a low angle.The delta has a giant front,a small plain,and many underwater distributary channels.Meanwhile,large gravity flow channels and sublacustrine fans are developed in the front of the delta.During the depositional period of the second member of the Nenjiang Formation,the R cycle began to develop due to the compression of the pacific tectonic domain;the source direction rotated 90°along with the eastern uplifting of the basin,and formed a series of east-west prograded and forced retrogradations.The prograding delta at high angel was developed in the interior of the sequence;the delta had a small front,a giant plain,and fewer underwater distributary channels,with the collapse at the foreslope,forming a series of slump fans.The slump fans can be divided into three types:discrete type,superimposed type,and fluid type.We built a whole'triad model'of the slump fan.Pointed out that the sequence of forced retrogradation formed by R cycle is a good structural mark of basin optimization,and rejected the viewpoint of'transgression'in the Nenjiang Formation of the Songliao Basin. | ZHANG ChenChen ZHANG Shun WEI Wei WU ChaoDong LIANG JiangPing NIU Wen DU JinXia FU XiuLi CUI KunNing WANG Chao WANG Hui | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 5 | Modifiedintelligentgeneticalgorithmbasedadaptiveneuralnetworkcontrolforuncertainstructuralsystems显示文摘 | CHENChenwu CHENPochen CHIANGWeiliang | 2013 | JournalofVibrationandControl2013，19，9： | 1 |
| 6 | Construction of nanoreactors on TiO_(2)nanotube arrays as a POCT device for sensitive colorimetric detection显示文摘With increasing attention to personalized healthcare,miniaturized and easily implementable devices are desired for point-of-care testing(POCT).Herein,hydrophilic patterns were designed on freestanding TiO_(2)nanotube arrays(Ti NTs)as nanoreactors for a naked-eye colorimetric assay.With a high aspect ratio,TiN Ts can provide a long observation length combined with a limited volume.Moreover,by combining the photocatalytic property of TiO_(2)and spatiotemporal controllability of light,hydrophilic nanoreactors were fabricated with minimal volume,and thus the indicator and analyte are limited in a confined void by the hydrophobic surroundings,thus allowing a higher sensitivity for sensing.We believe the proposed sensing platform could provide a promising strategy in developing POCT devices for routine health monitoring. | Jingwen Xu Chenchen Liang Zhida Gao Yan-Yan Song | 2023 | Chinese Chemical Letters2023，34，5： | 1 |
| 7 | Effects of casein glycomacropeptide on the early development of primary colorectal cancer in rats显示文摘In this paper,we utilized dimethylhydrazine(DMH)-induced colorectal cancer(CC)model rats to explore the effects of casein glycomacropeptide(CGMP)on colorectal cancer.Rats with CC were orally administrated with 10,50,or 100 mg/kg bw d CGMP,or the same volume of phosphatebuffered saline for 15 weeks.The total numbers of aberrant crypt foci(ACF)and crypts per focus in colon were scored using a light microscope at low magnification after the colon was stained with methylene blue solutions.The methylation level of DNA extracted from colon was detected using methylation-specific PCR.The expression of p16 and mucin 2(MUC2)proteins were measured by immunohistochemistry.The results showed that although ACF were found in rats treated with CGMP,their number was significantly decreased compared to that of model rats.In addition,methylation and expression levels of p16 and MUC2 were also inhibited by CGMP,which were more obvious in rats treated with 50 mg/kg bw d CGMP.In conclusion,CGMP has potential application as nutritional therapy for preventing colorectal cancer.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Qingsen Chen Yun Liang Chenchen Zhu Yali Yan Guangchang Pang | 2013 | Food Science and Human Wellness2013，2，3： | 1 |
| 8 | Optimal Pricing Swategy Bttsed on Market Segmen- tation for Service Products Using Online Reservation Systems: An Application to Hotel Rooms显示文摘 | Xiaolong Guo Liuyi Ling Chenchen Yang Zhaoqiong Li Liang Liang | 2013 | International Journal of Hos- pitality Management2013，，35： | 1 |
| 9 | Generation and application of replication-competent Venus-expressing H5N1,H7N9,and H9N2 influenza A viruses显示文摘The generation and application of replication-competent influenza A virus(IAV) expressing a reporter gene represent a valuable tool to elucidate the mechanism of viral pathogenesis and establish new countermeasures to combat the threat of influenza. Here, replication-competent IAVs with a neuraminidase(NA) segment harboring a fluorescent reporter protein, Venus, were generated in the background of H5N1, H7N9, and H9N2 influenza viruses, the three subtypes of viruses with imminent pandemic potential. All three reporter viruses maintained virion morphology, replicated with similar or slightly reduced titers relative to their parental viruses, and stably expressed the fluorescent signal for at least two passages in embryonated chicken eggs. As a proof of concept, we demonstrated that these reporter viruses,used in combination with a high-content imaging system, can serve as a convenient and rapid tool for the screening of antivirals and host factors involved in the virus life cycle. Moreover, the reporter viruses demonstrated similar growth properties and tissue tropism as their parental viruses in mice, among which the H7N9 NA-Venus virus could potentially be used in ex vivo studies to better understand H7N9 pathogenesis or to develop novel therapeutics. | guangwen wang jie zhang fandi kong qibing li jinliang wang shujie ma yuhui zhao libin liang junping li nan sun lizheng guan yuan zhou chenchen zhou shanyu huang zhigao bu li jiang hualan chen chengjun li | 2018 | Science Bulletin2018，63，3： | 1 |
| 10 | Bio-template Synthesis of Spirulina/a-Fe2O3 Composite with Improved Surface Wettability显示文摘 | MENG Qingling XIE Chenchen DING Ran CAO Liang MA Ke LI Li WENG Zhankun WANG Zuobin | 2018 | Chemical Research in Chinese Universities2018，34，6： | 0 |
| 11 | NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease显示文摘The NLRP3 inflammasome is a multiprotein binding compound comprising NLRP3,connector protein ASC,and effector protein pro-caspase-1.When the NLRP3 inflammasome senses a danger signal from the host or pathogen,activated caspase-1 cleaves the precursors of interleukin(IL)-1βand IL-18 into mature proinflammatory cytokines,simultaneously causing lysis via the pore-forming protein gasdermin D.This induction of cell inflammatory pyroptosis suggests that it is a key process in the innate immune response to pathogens or cellular stress.Recent studies have shown that NLRP3 inflammasome also plays an important role in regulating autoimmune liver diseases,including autoimmune hepatitis,primary biliary cholangitis,and primary sclerosclerotic cholangitis.In this review,we summarize the structure,activation and modulation of the NLRP3 inflammasome,highlight the progress in research on the role of NLRP3 inflammasome in the occurrence and development of autoimmune liver diseases,and discuss potential strategies for targeting the NLRP3 inflammasome in the treatment of autoimmune liver diseases. | Yanling Guan Yiyue Gu Hao Li Bo Liang Chenchen Han Yu Zhang Qian Liu Wei Wei Yang Ma | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 12 | The effect of volatile components in oil on evolutionary character- istics of diamondoids during oil thermal pyrolysis显示文摘On the basis of the results of simulation experiments, now we better understand the contribution of high carbon number hydrocarbons to diamondoid generation during thermal pyrolysis of crude oil and its sub-fractions(saturated, aromatic, resin, and asphalene fractions). However, little is known about the effect of volatile components in oil on diamondoid generation and diamondoid indices due to the lack of attention to these components in experiments. In this study, the effect of volatile components in oil on diamondoid generation and maturity indices was investigated by the pyrolysis simulation experiments on a normal crude oil from the HD23 well of the Tarim Basin and its residual oil after artificial volatilization, combined with quantitative analysis of diamondoids. The results indicate that the volatile components(≤n C12) in oil have an obvious contribution to the generation of adamantanes, which occurs mainly in the early stage of oil cracking(Easy Ro<1.0%), and influences the variations in maturity indices of adamantanes; but they have no obvious effect on the generation and maturity indices of diamantanes. Therefore, some secondary alterations e.g., migration, gas washing, and biodegradation, which may result in the loss of light hydrocarbons in oil under actual geological conditions, could affect the identification of adamantanes generated during the late-stage cracking of crude oil, and further influence the practical application of adamantane indices. | FANG ChenChen XIONG YongQiang LI Yun LIANG QianYong WANG TongShan LI YongXin | 2016 | Science China Earth Sciences2016，59，2： | 0 |
| 13 | Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis显示文摘Small-cell lung cancer(SCLC)is a recalcitrant cancer characterized by high metastasis.However,the exact cell type contributing to metastasis remains elusive.Using a Rb1^(L/L)/Trp53^(L/L) mouse model,we identify the NCAM^(hi)CD44^(lo/–) subpopulation as the SCLC metastasizing cell(SMC),which is progressively transitioned from the non-metastasizing NCAM^(lo)CD44^(hi) cell(non-SMC).Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex,and knockout of its central component,Brg1,significantly inhibits such phenotypic transition and metastasis.Mechanistically,TAZ is silenced by the SWI/SNF complex during SCLC malignant progression,and its knockdown promotes SMC transition and metastasis.Importantly,ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates metastasis.Single-cell RNA-sequencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis,and immunostaining data show a positive correlation between TAZ and patient prognosis.These data uncover high SCLC plasticity and identify TAZ as the key molecular switch in orchestrating SCLC phenotypic transition and metastasis. | Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman KThomas Kwok-Kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji | 2022 | National Science Review2022，9，7： | 0 |
| 14 | Correction to:Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis显示文摘This is a correction to:Yujuan Jin,Qiqi Zhao,Weikang Zhu,Yan Feng,Tian Xiao,Peng Zhang,Liyan Jiang,Yingyong Hou,Chenchen Guo,Hsinyi Huang,Yabin Chen,Xinyuan Tong,Jiayu Cao,Fei Li,Xueliang Zhu,Jun Qin,Dong Gao,Xin-Yuan Liu,Hua Zhang,Luonan Chen,Roman K Thomas,Kwok-Kin Wong,Lei Zhang,Yong Wang,Liang Hu,Hongbin Ji,Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis,National Science Review,Volume 9,Issue 7,July 2022,nwab232,http://gffzzd3cc09b8251d45dfsnbwvk55wkvkx6w9k.ffgz.tsg.suse.edu.cn/10.1093/nsr/nwab232. | Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman KThomas Kwok-Kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji | 2023 | National Science Review2023，10，12： | 0 |
| 15 | Study on sedimentation distribution based on cooperative analysis of geologic-geophysical in less well area: A case study of Suweiyi sandstone in the DB area, Kuqa Depression in Tarim Basin显示文摘The Kuqa Depression in Tarim Basin develops fan deltaic,braided river deltaic,and lacustrine sedi-mentation,espeially extensive braided river deltaic sedimentation,in the Cretaceous-Paleogene Sys-tems.However,fine sedimentary pattern of the Kuqa Depression and North Tarim Uplift belt since the Middle Cenozoic still needs to be studied.As a combination zone of the Kuqa Depression and North Tarim Uplift,the sedimentary characteristics of the DB area in the southern margin of the east of the Kuqa depression have been paid more attention.To better understand the sedimentary framework in the Kuqa Depression and North Tarim Uplift in the Mesozoic and Cenozoic,through joint geologic-geophysical study,sedime ntation of sandstone at the bottom of the Paleogene Suweiyi Formation in the DB area and its peripheral area is investigated.Sedimentary facies and sandstone distribution in the area are identified through core observation,component analysis,logging interpretation and seismic inversion.Based on seismic facies analysis,sedimentary facies distribution in the area is delineated.Results show that sandstone at the bottom of the Paleogene Suweiyi Fommation in the DB area and its peripheral area is developed in shore shallow lacustrine beach-bar facies.The beach-bar arenaceous sediments are mainly distnibuted in the southern DB area and the shallow lacustrine mudstone is developed in northern DB area,showing obvious north south di ferentiation charactenistics. | Huiling Niu Lixia Liang Linbo Wang Chenchen Wang Juan Zhang | 2020 | Petroleum Research2020，5，4： | 0 |
| 16 | First-Principles Investigation on Phase Stability,Elastic and Magnetic Properties of Boron Doping in Ni-Mn-Ti Alloy显示文摘The all-d-metal Ni-Mn-Ti Heusler alloy has giant elastocaloric eff ect and excellent mechanical properties,which is diff erent from the conventional Ni-Mn-based Heusler alloys.In this work,the preferred site occupation,phase stability,martensitic transformation,magnetic properties,and electronic structure of the B-doped Ni_(2)Mn_(1.5)Ti_(0.5)alloys are systematically investigated by the fi rst-principles calculations.The results show that B atoms preferentially occupy the octahedral interstitial.The doped B atoms tend to exist in the(Ni_(2)Mn_(1.5)Ti_(0.5))_(1-x)B_(x)(x=0.03,0.06,0.09)alloy in the form of aggregation distribution,and the martensitic transformation temperature decreases with the increase in the B content.For octahedral interstitial doping,the toughness and plasticity of the(Ni_(2)Mn_(1.5)Ti_(0.5))_(1-x)B_(x) alloys decrease,but the strength and rigidity are greatly enhanced.This is because a small part of the d-d hybridization in ternary Ni-Mn-Ti alloy is replaced by the p-d hybridization in Ni-Mn-Ti-B alloy. | Chenchen Xiong Jing Bai Yansong Li Jianglong Gu Xinzeng Liang Ziqi Guan Yudong Zhang Claude Esling Xiang Zhao Liang Zuo | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，7： | 0 |
| 17 | Supramolecular assembly-derived carbon-nitrogen-based functional materials for photo/electrochemical applications: progress and challenges显示文摘Supramolecular chemistry during the synthesis of carbon-nitrogen-based materials has recently experienced a renaissance in the arena of photocatalysis and electrocatalysis.In this review,we start with the discussion of supramolecular assemblies-derived carbon-nitrogen-based materials’regulation from the aspect of morphology,chemical composition,and micro/nanostructural control.Afterwards the recent advances of these materials in energy and environment related applications,including degradation of pollutants,water splitting,oxygen reduction reactions,CO_(2) reduction reactions along with organic synthesis are summarized.The correlations between the structural features and physicochemical properties of the carbonnitrogen-based materials and the specific catalytic activity are discussed in depth.By highlighting the opportunities and challenges of supramolecular assembly strategies,we attempt an outlook on possible future developments for highly efficient carbon-based photo/electrocatalysts. | Fanglei Yao Chenchen Fang Junjie Cui Liming Dai Xiaoyuan Zhang Liang Xue Pan Xiong Yongsheng Fu Wenyao Zhang Jingwen Sun Junwu Zhu | 2023 | National Science Open2023，2，4： | 0 |
| 18 | Understanding SCLC heterogeneity and plasticity in cancer metastasis and chemotherapy resistance显示文摘Small cell lung cancer(SCLC)accounts for approximately 15%of all lung cancer cases and features a strong predilection for early metastasis and extremely poor prognosis.Despite being highly sensitive to chemotherapy and/or radiotherapy initially,most SCLC patients develop therapeutic resistance within one year and die of distant metastases.Multiple studies have revealed the high heterogeneity and strong plasticity of SCLC associated with frequent metastases and early development of therapeutic resistance as well as poor clinical outcome.Importantly,different SCLC subtypes are associated with different therapeutic vulnerabilities,and the inflamed subtype tends to have the best response to immunotherapy,which highlights the importance of precision medicine in the clinic.Here,we review recent advances in ScLc heterogeneity and plasticity and their link to distant metastases and chemotherapy resistance.We hope that a better understanding of the molecular mechanisms underlying SCLC malignant progression will help to develop better intervention strategies for this deadly disease. | Yujuan Jin Yanxu Chen Zhen Qin Liang Hu Chenchen Guo Hongbin Ji | 2023 | Acta Biochimica et Biophysica Sinica2023，55，6： | 0 |
| 19 | A mesenchymal-like subpopulation in non-neuroendocrine SCLC contributes to metastasis显示文摘Small cell lung cancer(SCLC)is the most aggressive lung cancer with high heterogeneity.Mouse SCLC cells derived from the Rb1L/L/Trp53L/L(RP)autochthonous mouse model grew as adhesion or suspension in cell culture,and the adhesion cells are defined as non-neuroendocrine(non-NE)SCLC cells.Here,we uncover the heterogenous subpopulations within the non-NE cells and referred to them as mesenchymallike(Mes)and epithelial-like(Epi)SCLC cells.The Mes cells have increased capability to form colonies in soft agar and harbored stronger metastatic capability in vivo when compared with the Epi cells.Gene Set Enrichment Analysis reveals that the transforming growth factor(TGF)-βsignaling is enriched in the Mes cells.Importantly,inhibition of the TGF-βsignaling through ectopic expression of dominant-negative Tgfbr2(Tgfbr2-DN)or treatment with Tgfbr1 inhibitor SD-208 consistently abrogates tumor metastasis in nude mouse allograft assays.Moreover,genetic deletion of Tgfbr2 or Smad4,the key components of the TGF-βsignaling pathway,dramatically attenuates SCLC metastasis in the RP autochthonous mouse model.Collectively,our results uncover the high heterogeneity in non-NE SCLC cells and highlight an important role of TGF-βsignaling in promoting SCLC metastasis. | Yujuan Jin Tian Xiao Yan Feng Jinhua Yang Chenchen Guo Liang Hu Hongbin Ji | 2021 | Journal of Genetics and Genomics2021，48，7： | 0 |
| 20 | Biocatalytic Buoyancy‑Driven Nanobots for Autonomous Cell Recognition and Enrichment显示文摘Autonomously self-propelled nanoswimmers represent the nextgeneration nano-devices for bio-and environmental technology.However,current nanoswimmers generate limited energy output and can only move in short distances and duration,thus are struggling to be applied in practical challenges,such as living cell transportation.Here,we describe the construction of biodegradable metal-organic framework based nanobots with chemically driven buoyancy to achieve highly efficient,long-distance,directional vertical motion to“find-and-fetch”target cells.Nanobots surface-functionalized with antibodies against the cell surface marker carcinoembryonic antigen are exploited to impart the nanobots with specific cell targeting capacity to recognize and separate cancer cells.We demonstrate that the self-propelled motility of the nanobots can sufficiently transport the recognized cells autonomously,and the separated cells can be easily collected with a customized glass column,and finally regain their full metabolic potential after the separation.The utilization of nanobots with easy synthetic pathway shows considerable promise in cell recognition,separation,and enrichment. | Ziyi Guo Chenchen Zhuang Yihang Song Joel Yong Yi Li Zhong Guo Biao Kong John MWhitelock Joseph Wang Kang Liang | 2023 | Nano-Micro Letters2023，15，12： | 0 |
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