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| 1 | miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ显示文摘 | Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei Liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu Mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen | 2016 | Protein & Cell2016，7，10： | 14 |
| 2 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 3 | Characteristics of air pollution by polychlorinated dibenzo-p-dioxins and dibenzofurans in the typical industrial areas of Tangshan City,China显示文摘The ambient air in vicinity of different industrial sources for PCDD/PCDFs was sampled by TSP/PM 10 active samplers and passive PUF disk samplers in Tangshan City,a metropolis containing clusters of various industrial plants.The ΣTEQ concentrations of ΣPCDD/ΣPCDFs ranged from 44.2 to 394.1 fg I-TEQ/m 3 with an average of 169.9 fg I-TEQ/m 3.2,3,4,7,8-PeCDF was the dominant contributor to TEQ,contributing 41% (12% to 55%),while 1,2,3,4,6,7,8-HpCDF,OCDD and OCDF were the major congeners for the total concentrations.The ratios of PCDF/PCDD reached 2.54 on average,suggesting that de novo synthesis in thermal processes played an important role to the airborne pollution of PCDD/PCDFs.The similarities congener profiles indicated that TSP and PM 10 active sampling methods are comparable for the determination of the PCDD/PCDFs in ambient air,and the ratios of concentrations determined by the two methods suggested that the PCDD/PCDFs tended to stay in fine particles.It was found that 2,3,7,8-TCDF and OCDD were the dominating congeners in the passive PUF disks samples.Through principal components analysis,the coke industry was suggested to be a relatively high potential emission source for PCDD/PCDFs in the ambient air of Tangshan,which was possibly formed by de novo synthesis mechanism.In this study,the atmospheric impacts to the environment from different industrial sources could be ranked as follows (from high to low):coking,iron sintering,steel making,power generation and chlorinate alkali chemical production industries. | Zhiyuan Ren Bing Zhang Pu Lu Cheng Li Lirong Gao Minghui Zheng | 2011 | Journal of Environmental Sciences2011，23，2： | 8 |
| 4 | Cycle stability of lithium/garnet/lithium cells with different intermediate layers显示文摘The garnet-type electrolytes such as Ta-doped Li_7La_3Zr_2O_(12)(LLZTO) have been viewed as the promising electrolytes for solid-state lithium batteries, but it exhibits problem of high interfacial resistance(1960 Ω·cm^2) and short circuit when being cycled in Li/LLZTO/Li cells at the current density above 0.5 mA·cm^(-2). Introduction of intermediate layers in between lithium and LLZTO is helpful for decreasing the interfacial resistance and suppressing the growth of lithium dendrites. In this work, three kinds of intermediate layers of Au, Nb and Si with the thickness of 100 nm were prepared. Although the interfacial resistance with the Au layer decreases from 1960 to 32 Ω·cm^2, the cells can only cycle for 0.67 h at 0.5 mA·cm^(-2), related to the Au peeled off from the LLZTO. The Nb layers lead to the initial interfacial resistance of 14 Ω·cm^2, while showing extension of cycle time to 50 h with the increase in interfacial resistance due to the formation of the resistive Li–Nb–O phase. The Si layers induce the interfacial resistance as low as 5 Ω·cm^2 and the cycles as long as 120 h, which is attributed to the improvement in electrical contact between Li and electrolyte as well as the maintenance of conductive interface during cycles. | Ning Zhao Rui Fang MingHui He Cheng Chen YiQiu Li ZhiJie Bi Xiang-Xin Guo | 2018 | Rare Metals2018，37，6： | 7 |
| 5 | Baicalein suppresses vasculogenic mimicry through inhibiting RhoA/ROCK expression in lung cancer A549 cell line显示文摘Vasculogenic mimicry(VM)refers to a new tubular network of the blood supply system with abundant extracellular matrix.VM is similar to capillaries but does not involve endothelial cells.As a traditional herbal medicine commonly used in China,baicalein possesses anti-inflammatory and lipoxygenase activities.However,the effects of baicalein on the process of VM formation in nonsmall cell lung cancer(NSCLC)and the underlying mechanisms have remained poorly understood.In this study,baicalein was found to inhibit the viability and motility of A549 cells and induced the breakage of the cytoskeletal actin filament network.In addition,baicalein significantly decreased the formation of VM and downregulated the expressions of VM-associated factors,such as VEcadherin,EphA2,MMP14,MMP2,MIVIP9,PI3K and LAMC2,similar to the effects of ROCK inhibitors.In deed,baicalei n inhibited RhoA/ROCK expression in vitro and in vivo,suggesting the underlying mechanisms of reduced VM formation.Collectively,baicalein suppressed the formation of VM in NSCLC by targeting the RhoA/ROCK signaling pathway,indicating that baicalein might serve as an emerging drug for NSCLC. | Zhe Zhang Li Nong Menglei Chen Xiaoli Gu Weiwei Zhao Minghui Liu Wenwu Cheng | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 5 |
| 6 | Highly-anisotropic optical and electrical properties in layered SnSe显示文摘因为他们极化依赖者或方向依赖者的唯一的联合,各向异性的材料具有可观的兴趣电、光、热电的性质。低对称二维(2D ) covalently 结合的原子层叠的货车 der Waals 形成的材料内在地是各向异性的。分层的 SnSe 展出格子对称的低度,与弄歪的 NaCl 结构和在里面飞机 anisotropy。这里,我们报导在里面飞机的系统的研究在分层的 SnSe 的各向异性的性质用散布的解决角度的拉曼,光吸收,和电的运输学习。光、电的描述是方向依赖者,并且成功地在分层的 SnSe 识别了水晶的取向。而且, SnSe 薄片厚度和刺激波长上的 Raman 紧张 anisotropy 的依赖被实验和理论计算调查。最后,电的运输研究证明很少层 SnSe 地效果晶体管(联邦货物税) 有在扶手椅和之字形方向之间的搬运人活动性(5.8 ) 的大各向异性的比率,它是高价值为 2D 报导了的一个记录各向异性的材料。分层的 SnSe 的高度各向异性的性质在新窗户中为各向异性的光学,电子学,和 optoelectronics.Open | Shengxue Yang Yuan Liu Minghui Wu Li-Dong Zhao Zhaoyang Lin Hung-chieh Cheng Yiliu Wang Chengbao Jiang Su-Huai Wei Li Huang Yu Huang Xiangfeng Duan | 2018 | Nano Research2018，11，1： | 4 |
| 7 | Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cell Seeding on Biofunctionalized Calcium Phosphate Cements显示文摘Induced pluripotent stem cells(iPSCs)have great potential due to their proliferation and differentiation capability.The objectives of this study were to generate iPSC-derived mesenchymal stem cells(iPSC-MSCs),and investigate iPSC-MSC proliferation and osteogenic differentiation on calcium phosphate cement(CPC)containing biofunctional agents for the first time.Human iPSCs were derived from marrow CD34+cells which were reprogrammed by a single episomal vector.iPSCs were cultured to form embryoid bodies(EBs),and MSCs migrated out of EBs.Five biofunctional agents were incorporated into CPC:RGD(Arg-Gly-Asp)peptides,fibronectin(Fn),fibronectin-like engineered polymer protein(FEPP),extracellular matrix Geltrex,and platelet concentrate.iPSC-MSCs were seeded on five biofunctionalized CPCs:CPC-RGD,CPC-Fn,CPC-FEPP,CPC-Geltrex,and CPC-Platelets.iPSC-MSCs on biofunctional CPCs had enhanced proliferation,actin fiber expression,osteogenic differentiation and mineralization,compared to control.Cell proliferation was greatly increased on biofunctional CPCs.iPSC-MSCs underwent osteogenic differentiation with increased alkaline phosphatase,Runx2 and collagen-I expressions.Mineral synthesis by iPSC-MSCs on CPC-Platelets was 3-fold that of CPC control.In conclusion,iPSCs showed high potential for bone engineering.iPSC-MSCs on biofunctionalized CPCs had cell proliferation and bone mineralization that were much better than traditional CPC.iPSC-MSC-CPC constructs are promising to promote bone regeneration in craniofacial/orthopedic repairs. | WahWah TheinHan Jun Liu Minghui Tang Wenchuan Chen Linzhao Cheng Hockin H.K.Xu | 2013 | Bone Research2013，1，4： | 3 |
| 8 | Elevated expression of lung development-related protein HSP9O0 indicates poor prognosis in non-small cell lung cancer through affecting the cell cycle and apoptosis显示文摘Dear Editor,Oncogenesis was considered to be similar to the early embryonic development process in a variety of ways.1 Using normal development samples as research models will help us understand tumors and identify potential biomarkers.Heat-shock protein 90 beta(HSP90P,HSP90AB1)is one of the major isoforms of HSP90 and is involved in embryonic development,signal transduction,and cellular adaptability. | Xiang Wang Yaru Wang Lin Feng Minghui Wang Kaitai Zhang Yousheng Mao Ting Xiao Shujun Cheng | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 9 | Four-protein model for predicting prognostic risk of lung cancer显示文摘Patients with lung cancer at the same stage may have markedly different overall outcome and a lack of specific biomarker to predict lung cancer outcome.Heat-shock protein 90β(HSP90β)is overexpressed in various tumor cells.In this study,the ELISA results of HSP90βcombined with CEA,CA125,and CYFRA21-1 were used to construct a recursive partitioning decision tree model to establish a four-protein diagnostic model and predict the survival of patients with lung cancer.Survival analysis showed that the recursive partitioning decision tree could distinguish the prognosis between high-and low-risk groups.Results suggested that the joint detection of HSP90β,CEA,CA125,and CYFRA21-1 in the peripheral blood of patients with lung cancer is plausible for early diagnosis and prognosis prediction of lung cancer. | Xiang Wang Minghui Wang Lin Feng Jie Song Xin Dong Ting Xiao Shujun Cheng | 2022 | Frontiers of Medicine2022，16，4： | 2 |
| 10 | Mesoporous Ternary Nitrides of Earth?Abundant Metals as Oxygen Evolution Electrocatalyst显示文摘As sustainable energy becomes a major concern for modern society,renewable and clean energy systems need highly active,stable,and low-cost catalysts for the oxygen evolution reaction(OER).Mesoporous materials offer an attractive route for generating efficient electrocatalysts with high mass transport capabilities.Herein,we report an efficient hard templating pathway to design and synthesize three-dimensional(3-D)mesoporous ternary nickel iron nitride(Ni3FeN).The as-synthesized electrocatalyst shows good OER performance in an alkaline solution with low overpotential(259 mV)and a small Tafel slope(54 mV dec?1),giving superior performance to IrO2 and RuO2 catalysts.The highly active contact area,the hierarchical porosity,and the synergistic effect of bimetal atoms contributed to the improved electrocatalytic performance toward OER.In a practical rechargeable Zn–air battery,mesoporous Ni3FeN is also shown to deliver a lower charging voltage and longer lifetime than RuO2.This work opens up a new promising approach to synthesize active OER electrocatalysts for energy-related devices. | Ali Saad Hangjia Shen Zhixing Cheng Ramis Arbi Beibei Guo Lok Shu Hui Kunyu Liang Siqi Liu John Paul Attfield Ayse Turak Jiacheng Wang Minghui Yang | 2020 | Nano-Micro Letters2020，12，6： | 2 |
| 11 | Distributed Consensus for Blockchains in Internet-of-Things Networks显示文摘In recent years,due to the wide implementation of mobile agents,the Internet-of-Things(IoT) networks have been applied in several real-life scenarios,servicing applications in the areas of public safety,proximity-based services,and fog computing.Meanwhile,when more complex tasks are processed in IoT networks,demands on identity authentication,certifiable traceability,and privacy protection for services in IoT networks increase.Building a blockchain system in IoT networks can greatly satisfy such demands.However,the blockchain building in IoT brings about new challenges compared with that in the traditional full-blown Internet with reliable transmissions,especially in terms of achieving consensus on each block in complex wireless environments,which directly motivates our work.In this study,we fully considered the challenges of achieving a consensus in a blockchain system in IoT networks,including the negative impacts caused by contention and interference in wireless channel,and the lack of reliable transmissions and prior network organizations.By proposing a distributed consensus algorithm for blockchains on multi-hop IoT networks,we showed that it is possible to directly reach a consensus for blockchains in IoT networks,without relying on any additional network layers or protocols to provide reliable and ordered communications.In our theoretical analysis,we showed that our consensus algorithm is asymptotically optimal on time complexity and is energy saving.The extensive simulation results also validate our conclusions in the theoretical analysis. | Li Yang Yifei Zou Minghui Xu Yicheng Xu Dongxiao Yu Xiuzhen Cheng | 2022 | Tsinghua Science and Technology2022，27，5： | 2 |
| 12 | Development of an oxidation resistant glass–ceramic composite coating on Ti–47Al–2Cr–2Nb alloy显示文摘 | Wenbo Li Shenglong Zhu Minghui Chen Cheng Wang Fuhui Wang | 2013 | Applied Surface Science2013，，： | 1 |
| 13 | A Variational Binary Level Set Method for Structural Topology Optimization显示文摘This paper proposes a variational binary level set method for shape and topology optimization of structural.First,a topology optimization problem is presented based on the level set method and an algorithm based on binary level set method is proposed to solve such problem.Considering the difficulties of coordination between the various parameters and efficient implementation of the proposed method,we present a fast algorithm by reducing several parameters to only one parameter,which would substantially reduce the complexity of computation and make it easily and quickly to get the optimal solution.The algorithm we constructed does not need to re-initialize and can produce many new holes automatically.Furthermore,the fast algorithm allows us to avoid the update of Lagrange multiplier and easily deal with constraints,such as piecewise constant,volume and length of the interfaces.Finally,we show several optimum design examples to confirm the validity and efficiency of our method. | Xiaoxia Dai Peipei Tang Xiaoliang Cheng Minghui Wu | 2013 | Communications in Computational Physics2013，13，5： | 1 |
| 14 | Phylogenetic diversity of bacterial endophytes of Panax notoginseng with antagonistic characteristics towards pathogens of root-rot disease complex 显示文摘 | Ma Li Cao Yonghong Cheng Minghui | 2013 | Antonie van Leeuwenhoek2013，103，2： | 1 |
| 15 | Research on static and dynamic performance of large-span steel trestle 显示文摘 | WANG Hui CHENG Minghui | 2013 | Advanced Materials Research2013，，： | 1 |
| 16 | Long-term persistence of polychlorinated dibenzo- p -dioxins and dibenzofurans in air, soil and sediment around an abandoned pentachlorophenol factory in China显示文摘 | Cheng Li Minghui Zheng Bing Zhang Lirong Gao Lidan Liu Xin Zhou Xiaodong Ma Ke Xiao | 2011 | Environmental Pollution2011，，： | 1 |
| 17 | Iterative algorithms for solving the matrix equation AXB + CX^TD = E显示文摘 | WANG Minghui CHENG Xuehan WEI Musheng | 2007 | Appl Math Comput2007，187，： | 1 |
| 18 | Catholyte engineering to release the capacity of iodide for high-energy-density iodine-based redox flow batteries显示文摘Due to the high solubility,high reversibility,and low cost of iodide,iodine-based redox flow batteries(RFBs)are considered to have great potential for upscaling energy storage.However,their further development has been limited by the low capacity of I−as one-third of the I−is used to form I3−(I2I−)during the charging process.Herein,we have demonstrated that the pseudohalide ion,thiocyanate(SCN−),is a promising complexing agent for catholyte of iodinebased RFBs to free up the I−by forming iodine-thiocyanate ions([I2SCN]−)instead of I3−,unlocking the capacity of iodide.Applying this strategy,we have demonstrated iodine-based RFBs with full utilization of iodide to achieve high capacity and high energy density.Both the zinc/iodine RFB and polysulfide/iodine RFB with SCN−complex agent achieve their theoretical capacity of around 160 A h Lposolyte^(−1)(6.0MI−in catholyte).Therefore,the zinc/iodine RFB delivers a high energy density of 221.34Wh Lposolyte^(−1),and the polysulfide/iodine RFB achieves a highenergy density of 165.62Wh Lposolyte^(−1).It is believed that this effective catholyte engineering can be further generalized to other iodine-based RFBs,offering new opportunities to unlock the capacity of iodide and achieve high energy density for energy storage. | Bo Lu Minghui Yang Mei Ding Su Yan Weizhe Xiang Yuanhang Cheng Hu Fu Zhizhao Xu Chuankun Jia | 2023 | SusMat2023，3，4： | 1 |
| 19 | Iterative algorithms for solving the matrix equation AXB+CXTD=E显示文摘 | Minghui Wang Xuehan Cheng Musheng Wei | 2007 | AppliedMathematics and Computation2007，187，： | 1 |
| 20 | Phylogenetic diversity of bacterial endophytes of Panax notoginseng with antagonistic characteristics towards pathogens of root-rot disease complex显示文摘 | MA Li CAO Yonghong CHENG Minghui | 2013 | Antonie van Leeuwenhoek2013，103，2： | 1 |
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