|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | Regeneration of intervertebral disc by mesenchymal stem ceils : potentials, limitations, and future direction 显示文摘 | Leung VY Chan D Cheung KM | 2006 | Eur Spine J2006，3，： | 1 |
| 3 | Assessment of scoliosis cor-rection in relation to flexibility using the fulcrum bending correc-tion index显示文摘 | Luk KD Cheung KM Lu DS | 1998 | Spine(Phila Pa 1976)1998，23，21： | 1 |
| 4 | Assessment of scoliosis correction in relation to flexibility using the fulcrum bending correction index 显示文摘 | Luk KD Cheung KM Lu DS | 1998 | Spine ( Phila Pa 1976 )1998，23，21： | 1 |
| 5 | Gene therapy for new bone formation using adeno-associated viral bone morphogenetic protein-2 vectors显示文摘 | Chen Y Luk KD Cheung KM | | 0，，16： | 1 |
| 6 | hypokalemic metabolic acidosis attributed to cough mixture abuse显示文摘 | Wong KM Cha KWL Cheung CY | 2001 | Am J Kidney Dis2001，38，2： | 1 |
| 7 | Phenotypic and population differences in the association between CILP and lumbar disc disease显示文摘 | Virtanen IM Song YQ Cheung KM | 2007 | J Med Genet2007，44，4： | 1 |
| 8 | Delayed stimulatory effect of low - intensity shock waves on human periostealcells 显示文摘 | Tam KF Cheung WH Lee KM | 2005 | Clin Orthop Relat Res2005，438，： | 1 |
| 9 | Atypical squamous cells of undetermined significance on cervical smears:follow-up study of an Asian screening population显示文摘 | Cheung AN Szeto EF Ng KM | 2004 | Cancer2004，102，2： | 1 |
| 10 | Adeno-associated virus-mediated bone morphogenetic protein-4 gene therapy for in vivo bone formation显示文摘 | Lok KD Chen Y Cheung KM | | 0，，： | 1 |
| 11 | Lumbar disc de- generation is linked to a carbohydrate sulfotransferase 3 vari- ant显示文摘 | Song YQ Karasugi T Cheung KM | 2013 | J Clin Invest2013，123，11： | 1 |
| 12 | Transvenous embolisation of dural carotid-cavernous fistulas by multiple venous routes:a series of 27 cases显示文摘 | Chan CM Cheung YL | 2003 | Acta Neurochir (Wien)2003，145，： | 1 |
| 13 | Reliability and con-current validity of the adapted Chinese version of ScoliosisResearch Society-22(SRS-22)questionnaire显示文摘 | Cheung KM Senkoylu A Alanay A | 2007 | Spine(PhilaPa 1976)2007，32，10： | 1 |
| 14 | Stepwise decrease in moxifloxacin susceptibility amongst clinical isolates of multidrug-resistant Mycobacterium tuberculosis:correlation with ofloxacin susceptibility显示文摘 | Kam KM Yip CW Cheung TL | | 0，，01： | 1 |
| 15 | Ten-year follow-up study of lower thoracic hemivertebrae treated by convex fusion and concave distraction显示文摘 | Cheung KM Zhang JG Lu DS | 2002 | Spine2002，27，7： | 1 |
| 16 | Outcome assessment of braeing in adolescent idiopathic seoliosis hy the use of the SRS-22 questionnaire 显示文摘 | Cheung KM Cheng EY Chan SC | 2007 | Int Orthop2007，31，4： | 1 |
| 17 | Deeellularization of chondro- cyte - encapsulated collagen microspheres : a three - dimensional model to study the effects of acellular matrix on stem cell fate 显示文摘 | Cheng HW Tsui YK Cheung KM | 2009 | Tissue Eng Part C Methods2009，4，： | 1 |
| 18 | Effect of melatonin suppression on scoliosis development in chickens by either constant light or surgical pinealectomy 显示文摘 | Cheung KM Lu DS Poon AM | 2003 | Spine2003，17，： | 1 |
| 19 | Transvenous embolization of dural carotid cavernous fistulas by multiple venous routes:A series of 27 cases显示文摘 | Cheng KM Chan CM Cheung YL | 2003 | Acta Neurochir2003，145，： | 1 |
| 20 | Prediction of correction of scoliosis with use ofthe fulcrum bending radiograph显示文摘 | Cheung KM Luk KD | 1997 | J Bone Joint Surg(Am)1997，79，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员